1.The Effect of Behavioral Relaxation Training on Distress and Cancer Screening Intention of Patients with Upper Gastrointestinal Endoscopy
Journal of Korean Academic Society of Nursing Education 2019;25(4):414-423
PURPOSE: This study evaluates the effect of behavioral relaxation training on distress and cancer screening intention of patients with upper gastrointestinal endoscopy.METHODS: The research was conducted in a non-equivalent control group posttest design. Data were collected from endoscopy subjects in B city from October to November of 2018. Fifteen minutes of behavioral relaxation training were provided to the experimental group (n=40) and traditional relaxation therapy methods were provided to the control group (n=40). Outcome measures were distress and cancer screening intention of patients with upper gastrointestinal endoscopy. Data were analyzed with a χ²-test, independent t-test, Fisher's exact test with SPSS/PC version 23.0.RESULTS: The objective discomfort (t=8.81, p<.001) of the experimental group was lower than that of the control group; there were no significant differences in the subjective discomfort (t=1.73, p=.088). The cancer screening intention (t=−5.85, p<.001) of the experimental group was significantly higher than that of the control group.CONCLUSION: Behavioral relaxation training was effective in heightening cancer screening intention. Therefore it can be usefully applied to increase cancer screening intention.
Early Detection of Cancer
;
Education
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Endoscopy
;
Endoscopy, Gastrointestinal
;
Humans
;
Intention
;
Outcome Assessment (Health Care)
;
Relaxation Therapy
;
Relaxation
2.A Case of Acute Respiratory Muscle Weakness Complicated by Sjogren Syndrome.
Hyo Suk NAM ; Bum Chun SUH ; Jeong Hee CHO ; Yeon Kyung JUNG ; Seung Min KIM ; Il Nam SUNWOO
Journal of the Korean Neurological Association 2007;25(2):240-243
Sjogren syndrome is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands resulting in dry mouth and eyes. Approximately one-third of patients present with systemic manifestations, but respiratory muscle involvements have been rarely reported. We report a case of acute respiratory failure complicated by primary Sjogren syndrome. Muscle biopsy revealed perivascular lymphocytic infiltrations. Corticosteroid therapy improved respiratory muscle weakness. Sjogren syndrome should be considered as one of the underlying diseases causing acute respiratory failure.
Autoimmune Diseases
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Biopsy
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Exocrine Glands
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Humans
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Mouth
;
Muscular Diseases
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Respiratory Insufficiency
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Respiratory Muscles*
;
Respiratory Paralysis
;
Sjogren's Syndrome*
3.Age of menarche and near adult height after long-term gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty.
Joon Woo BAEK ; Hyo Kyoung NAM ; Dahee JIN ; Yeon Joung OH ; Young Jun RHIE ; Kee Hyoung LEE
Annals of Pediatric Endocrinology & Metabolism 2014;19(1):27-31
PURPOSE: Gonadotropin-releasing hormone agonist (GnRHa) is known for improving final adult height in patients with central precocious puberty (CPP). This study aimed to investigate the age of menarche and near adult height in girls with CPP who had been treated with GnRHa. METHODS: In this retrospective study, we reviewed the medical records of 71 Korean girls with CPP who had started menarche or reached over 13 years of bone age after long-term GnRHa treatment. We estimated near adult height using the Bayley-Pinneau method and identified the age of menarche in girls with CPP. RESULTS: Mean chronological and bone age at menarche were 11.9+/-0.7 and 12.8+/-0.4 years, respectively. The period between menarche and the end of treatment was 14.0+/-5.6 months. Posttreatment near adult height was 163.8+/-4.7 cm, which was significantly greater than pretreatment predicted adult height (158.7+/-4.1 cm). CONCLUSION: GnRHa treatment in girls with CPP could improve final adult height and made the age of menarche close to that of the general population.
Adult*
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Female
;
Gonadotropin-Releasing Hormone*
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Humans
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Medical Records
;
Menarche*
;
Puberty, Precocious*
;
Retrospective Studies
4.Role of 3-D CT Reconstruction of Laryngeal IVlucosal Surface in Preoperative Staging of Laryngeal Cancer.
Byung Soo KIM ; Young Jun LEE ; Sang Hwa NAM ; Jong Yeon PARK ; Chang Hyo SOL ; Kun Il KIM ; Soo Guen WANG
Journal of the Korean Radiological Society 1994;30(1):33-38
PURPOSE: CT or MRT is performed in preoperative staging of laryngeal cancer. These methods are used in assessment of the deep tissues and cartilage of the larynx, but cannot compete with laryngoscopy in the evaluation of the laryngeal surface. The purpose of this study is to evaluate feasibilty and clinical value of the 3-D reconstruction of the mucosal surface in laryngeal cancer. METHODS AND MATERIALS: Twenty two patients with laryngeal cancer proved by means of surgical.exploration (pathologic) or clinical examinations including laryngoscope, imaging studies and biopsy underwent preoperative staging with computed tomography(G-P);and three dimensional(3D) CT reconstruction. The TNM classification of the American Joint Committee on Cancer was used to compare the imaging findings with pathologic or clinical staging. RESULTS: When the extension of primary tumor(T staging) was evaluated, the findings at only transaxial CT and those at pathologic or clinical examination were concordant in 8 of 14 cases(57.1%) of supraglottic tumor, and 3 of 6 cases(50%) of glottic tumor. The overall accuracy of CT with additional 3D-reconstruction was 85.7% for assessment of supraglottic tumor, and 66.6% for glottic tumor. CONCLUSION: 3D CT reconstruction after transaxial CT may improve outcome in preoperative staging of laryngeal cancer and has a potential value in guiding management decisions.
Biopsy
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Cartilage
;
Classification
;
Humans
;
Joints
;
Laryngeal Neoplasms*
;
Laryngoscopes
;
Laryngoscopy
;
Larynx
5.The Characteristics of RNA Vaccine; its Strengths and Weaknesses.
Hyo Jung PARK ; Hae Li KO ; Seo Yeon JUNG ; Han Byeol JO ; Jae Hwan NAM
Journal of Bacteriology and Virology 2016;46(3):115-127
Since 1990 when Wolff and co-authors proved that both RNA and DNA expression vectors containing interest gene were directly injected into mouse muscle and expressed the protein in vivo, the concept of gene vaccine has been broadly tested in the vaccine field. However, due to the limitations of technology and the misconception about RNA, most previous studies have focused on the DNA vaccine. Recently, the RNA vaccine has emerged as a new game-changing disruptive innovation technology in the vaccine field. This review has covered the characteristics of the RNA vaccine, including its strengths and weaknesses. Finally, we have suggested future directions for the RNA vaccine.
Animals
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DNA
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Mice
;
RNA*
6.Association Between IL-13 Polymorphism (-1512A/C) and Atopic Dermatitis in Korean Children.
Kyung Won KIM ; Mi Jin KANG ; Hyo Bin KIM ; So Yeon LEE ; Nam Chul KIM ; Seong Ok JANG ; Soo Jong HONG
Pediatric Allergy and Respiratory Disease 2005;15(2):126-132
PURPOSE: Interleukin (IL) -13 plays a pivotal role in the induction of immunoglobulin E (IgE) and in the pathogenesis of atopic dermatitis (AD). Recently, an association was reported between the polymorphism of the IL-13 promoter region (-1512A/C) and atopic asthma. We investigated the association between the IL-13 single nucleotide polymorphism (SNP) in the promoter region (-1512A/C) and atopic dermatitis in Korean children with AD. METHODS: We enrolled 204 allergic AD, 92 non-allergic AD, and 116 non-atopic healthy children. Evaluated phenotypes of atopic dermatitis included total IgE, total eosinophil count, and eosinophil fraction. We used a PCR-RFLP method to identify IL-13 genotypes. RESULTS: The allele frequencies of the IL-13 promoter polymorphism (-1512A/C) did not differ statistically among the three groups. Children with one or two copies of risk alleles in the promoter region (-1512C) did not show any significant association with the clinical phenotypes of atopic dermatitis including total IgE, eosinophil phenotypes and SCORAD score in the allergic or non-allergic atopic dermatitis. CONCLUSION: These data suggest that the -1512A/C polymorphism of IL-13 gene may not be associated with neither the development nor the clinical phenotypes of atopic dermatitis in Korean children.
Alleles
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Asthma
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Child*
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Dermatitis, Atopic*
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Eosinophils
;
Gene Frequency
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Genotype
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Humans
;
Immunoglobulin E
;
Immunoglobulins
;
Interleukin-13*
;
Interleukins
;
Phenotype
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Polymorphism, Single Nucleotide
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Promoter Regions, Genetic
7.The Prediction of Changes in Mean Corneal Refractive Power by Pterygium Size after Pterygium Surgery.
Ki Tae NAM ; Young Sub EOM ; Jay Won RHIM ; Su Yeon KANG ; Hyo Myung KIM ; Jong Suk SONG
Journal of the Korean Ophthalmological Society 2014;55(11):1613-1617
PURPOSE: To assess the changes in mean corneal refractive power (DeltaK) following pterygium surgery and to predict DeltaK in cases of combined cataract and pterygium surgery. METHODS: Thirty-seven eyes of unilateral pterygium patients who underwent pterygium surgery were analyzed retrospectively with at least more than 1 month of follow-up. Preoperative and postoperative 1 month corneal refractive power was measured using auto-keratometer (RK-F1, Canon, Tokyo, Japan). Pterygium horizontal extension, width, and area were measured and correlation with DeltaK before and after surgery analyzed. We also compared DeltaK of the contralateral normal eye. RESULTS: The mean corneal refractive (Km) power measured before and 1 month after surgery was 43.30 +/- 1.66 D and 44.07 +/- 1.42 D, respectively. The Km significantly increased at 4 weeks after surgery (p < 0.001). However, postoperative Km was not significantly different when compared with the contralateral normal eye (43.86 +/- 1.34 D; p = 0.59). All parameters of pterygium size including horizontal extension, width, and area were positively correlated with the mean DeltaK. Among parameters, horizontal extension was best correlated with mean DeltaK (p < 0.001). The mean DeltaK with horizontal extension was predicted using linear regression (2.5 mm to 1 D, 4.0 mm to 1.8 D). CONCLUSIONS: We recommend contralateral corneal refractive power or prediction of corneal refractive power using linear regression with pterygium horizontal extension for determining intraocular lens power in cases of combined cataract and pterygium surgery.
Cataract
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Follow-Up Studies
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Humans
;
Lenses, Intraocular
;
Linear Models
;
Pterygium*
;
Retrospective Studies
8.Genetic Variations of the KISS1R Gene in Korean Girls with Central Precocious Puberty.
Yeon Joung OH ; Young Jun RHIE ; Hyo Kyoung NAM ; Hye Ryun KIM ; Kee Hyoung LEE
Journal of Korean Medical Science 2017;32(1):108-114
The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study aimed to identify the kisspeptin receptor (KISS1R) gene variations and to investigate the associations between these variations and central precocious puberty (CPP). Korean girls with CPP (n = 194) and their healthy controls (n = 99) were included in this study. The entire coding region and the exon-intron boundaries (exon 1 through 5) of the KISS1R gene were directly sequenced. Seven polymorphisms were identified in the KISS1R gene. A missense change c.1091T>A, and an intron variant c.738+64G>T showed significantly higher allele frequencies in CPP patients than in controls (c.1091T>A: 30.7% vs. 22.2%, P = 0.031; c.738+64G>T: 45.6% vs. 35.9%, P = 0.023). The missense variant (c.1091T>A) was a nonsynonymous polymorphism that induces amino acid substitution of p.Leu364His. The haplotype CAGTGTC was detected more frequently in the CPP group (P = 0.042). The sequence variants of the KISS1R gene can be inducible factors in the development of CPP. The association between sequence variants and CPP should be validated by further evidence obtained from larger samples of children with CPP.
Adolescent
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Amino Acid Substitution
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Child
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Clinical Coding
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Female*
;
Gene Frequency
;
Genetic Variation*
;
Haplotypes
;
Humans
;
Introns
;
Puberty
;
Puberty, Precocious*
9.Significance of Microalbuminuria in Relation to Subclinical Coronary Atherosclerosis in Asymptomatic Nonhypertensive, Nondiabetic Subjects.
Hyo Eun PARK ; Nam Ju HEO ; Minkyung KIM ; Su Yeon CHOI
Journal of Korean Medical Science 2013;28(3):409-414
We aimed to investigate the significance of microalbuminuria and its relationship with subclinical atherosclerosis in nonhypertensive and nondiabetic patients, by using coronary artery computed tomography (CT). A total of 1,318 nonhypertensive and nondiabetic subjects who had taken coronary artery CT and measured spot urine albumin to creatinine ratio (UACR) were evaluated. The atherosclerotic changes of coronary arteries were greater in subjects with microalbuminuria, reflected by coronary artery calcium score (CACS) and significant coronary artery stenosis (CACS > or = 100 in 15.3% vs 7.6% and stenosis > or = 50% in 11.5% vs 4.9% of patients with vs without microalbuminuria, P = 0.008 and P = 0.011, respectively). Among various parameters that are known as a risk factor or possible biomarkers of coronary artery disease, presence of microalbuminuria, age and Framingham risk score were significantly related to coronary artery stenosis. Among them the presence of microalbuminuria showed stronger correlation than others to the coronary artery stenosis detected by CT, even after adjusting confounding factors (OR 3.397, 95% confidence interval 1.138 to 10.140, P = 0.028). The presence of microalbuminuria by UACR was significantly associated with presence of coronary artery stenosis > or = 50% in asymptomatic, nonhypertensive and nondiabetic general population. Our study suggests that the presence of microalbuminuria may imply subclinical coronary artery disease, even in asymptomatic population.
Adult
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Age Factors
;
Aged
;
Albuminuria/*complications
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Blood Pressure
;
Calcium/analysis
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Coronary Artery Disease/complications/*radiography
;
Coronary Stenosis/complications
;
Coronary Vessels/chemistry
;
Creatinine/urine
;
Female
;
Humans
;
Male
;
Middle Aged
;
Odds Ratio
;
Retrospective Studies
;
Risk Factors
;
Sex Factors
;
Tomography, X-Ray Computed
10.Influence of Bottle-Feeding on Serum Bisphenol A Levels in Infants.
Young Jun RHIE ; Hyo Kyoung NAM ; Yeon Joung OH ; Ho Seong KIM ; Kee Hyoung LEE
Journal of Korean Medical Science 2014;29(2):261-264
Exposure to endocrine disrupting chemicals (EDCs), particularly during developmental periods, gives rise to a variety of adverse health outcomes. Bisphenol A (BPA) is a well-known EDC commonly found in plastic products including food and water containers, baby bottles, and metal can linings. This study investigates infant exposure to BPA and the effect of bottle-feeding on serum BPA levels in infants. Serum BPA levels in normal healthy infants 6 to 15 months of age (n=60) were evaluated by a competitive ELISA. BPA was detected in every study sample. Serum BPA levels of bottle-fed infants (n=30) were significantly higher than those of breast-fed infants (n=30) (96.58+/-102.36 vs 45.53+/-34.05 pg/mL, P=0.014). There were no significant differences in serum BPA levels between boys (n=31) and girls (n=29). No significant correlations were found between serum BPA levels and age, body weight, birth weight, and gestational age. Bottle-feeding seems to increase the risk of infant exposure to BPA. Establishment of health policies to reduce or prevent BPA exposure in infants is necessary.
Benzhydryl Compounds/*blood
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Birth Weight
;
Body Weight
;
Bottle Feeding
;
Endocrine Disruptors/*blood
;
Environmental Exposure
;
Female
;
Humans
;
Infant
;
Male
;
Phenols/*blood