1.Diagnosis of x-linked ichthyosis and detection of its carriers with southern blot hybidization.
Hyo Su HAN ; Kyung Hoon KIM ; Ki Beom SUHR ; Jeung Hoon LEE ; Jang Kyu PARK
Korean Journal of Dermatology 1993;31(6):857-865
BACKGROUND: The skin changes of X-linked recessive ichthyosis are cnused by the deficiency of the enzyme steroid sulfatase, which usually results from deletions of this gene in Caucasian populations. OBJECTIVE AND MEHTODS: To disgnose X-linked recessive ichthyosis and detect its carrier, we have investigated distinctive gene deletion and measured gene dosage of steroid sulfatase gene by southern blot hybridization in Korean patients with X-linked recessive ichthyosis. RESULTS: Patients from 8 of 9 unrelated families exhibited deletions, if the steroid sulfatase gene. Of 6 families showing a family history compatible with X-linked recessive inheritance, One family exhibited a normal pattern of hybridization. All but one family showed deletion of steroid sulfatase gene. All three patients lacking a fami1y history of the disease exhibited gene deletions. The ratio of the steroid sulfatsse specific band density to the Factor VIII specific band density was measured in 8 obligate carriers using a laser densitometer. The average ratio exhibited by the car riers was less than half that of normal women. Conclusian: These results suggest that the X-linked recessive ichth osis patient and its carrier can also be diagnosed and detected by Southern blot hybridization of steroid sulfatase gene in Korea.
Blotting, Southern*
;
Diagnosis*
;
Factor VIII
;
Female
;
Gene Deletion
;
Gene Dosage
;
Humans
;
Ichthyosis*
;
Korea
;
Skin
;
Steryl-Sulfatase
;
Wills
2.Two Cases of Pachyonychia Congenita.
Ja Kyeong KOO ; Hyo Su HAN ; Jeung Hoon LEE ; Jang Kyu PARK
Korean Journal of Dermatology 1987;25(1):156-160
We report herein two cases of pachyonychia congenita in 19-month-old and 7-year-old girls. In addition to severely deformed nails, both had white plaques on the tongue and keratotic papules on the elbows and knees. In the 19-month-old girl, her father showed deformity of the nails and severe hyperkeratosis of the palms and soles, The family history was normal in other case.
Child
;
Congenital Abnormalities
;
Elbow
;
Fathers
;
Female
;
Humans
;
Infant
;
Knee
;
Nails, Malformed*
;
Pachyonychia Congenita*
;
Tongue
3.Transient Lower Esophageal Sphincter Relaxation and the Related Esophageal Motor Activities.
The Korean Journal of Gastroenterology 2012;59(3):205-210
Transient lower esophageal sphincter (LES) relaxation (TLESR) is defined as LES relaxation without a swallow. TLESRs are observed in both of the normal individuals and the patients with gastroesophageal reflux disorder (GERD). However, TLESR is widely considered as the major mechanism of the GERD. The new equipments such as high resolution manometry and impedance pH study is helped to understand of TLESR and the related esophageal motor activities. The strong longitudinal muscle contraction was observed during development of TLESR. Most of TLESRs are terminated by TLESR related motor events such as primary peristalsis and secondary contractions. The majority of TLESRs are associated with gastroesophageal reflux. Upper esophageal sphincter (UES) contraction is mainly associated with liquid reflux during recumbent position and UES relaxation predominantly related with air reflux during upright position. The frequency of TLESR in GERD patients seems to be not different compared to normal individuals, but the refluxate of GERD patients tend to be more acidic during TLESR.
Esophageal Sphincter, Lower/*physiology
;
Esophagogastric Junction/physiology
;
Esophagus/*physiology
;
Gastroesophageal Reflux/*physiopathology
;
Humans
;
Muscle Relaxation/physiology
4.Baha Attract Implantation Using a Small Incision: Initial Report of Surgical Technique and Surveillance
Dong Su JANG ; Dong Hyo SHIN ; Woojae HAN ; Tae Hoon KONG ; Young Joon SEO
Clinical and Experimental Otorhinolaryngology 2020;13(1):15-22
Objectives:
. To determine the appropriate anatomical borders of implantation on the temporal bone in a cadaver study, and to develop a simplified surgical technique for Baha Attract implantation through a small incision along the hairline using anatomical evidence and a navigation system.
Methods:
. In a cadaver study, 20 human adult dry skulls were used to find flat areas of the temporal bone for Baha Attract magnet implantation. Four borders of the “optimal surgical site” were defined: Asterion line, occipitomastoid suture line, sigmoid sinus line, and digastric groove line. In three patients, we implanted the Baha Attract according to the newly developed surgical procedure and validated the feasibility of this technique with a navigation system.
Results:
. We identified the appropriate position of the implant on the temporal bone, suggesting a simplified surgical technique for Baha Attract with a small incision. We determined the spot of implantation, and the implants were inserted through a small surgical incision (<2.5 cm) under local anesthesia; the procedure lasted approximately 30 minutes.
Conclusion
. The optimal surgical site of the temporal bone is a safe and easily accessible location for implantation of the Baha Attract.
5.Comparison of Lacrimal Scintigraphy and Contrast Dacryocystography in Epiphora.
Young Min HAN ; Ki Chul CHOI ; Chong Soo KIM ; Gyung Ho CHUNG ; Myung Hee SOHN ; Eui Il HWANG ; Su Hyun JEONG ; Chun Su RYU ; Hyo Suk AN
Journal of the Korean Radiological Society 1995;32(4):563-569
PURPOSE: Conventional contrast dacryocystography(C-DCG) has been used mainly for anatomical assessment of the lacrimal drainage apparatus, due to its limited information on the dynamics of the lacrimal system, and thus correlation role in epiphora. The purpose of study was to improve the diagnostic value in epiphora by utilizing RI dacryocystography(RI-DCG) with quantitative criteria. MATERIALS AND METHODS: The patient for RI dacryocystography set erect with the head fixed in front of gamma camera fitted with a standard 6 mm pinhole collimater. Both eyes of 85 patients(170 eyes) were scanned with 99rnTc-pertechnetate followed by conventional dacryocystography. The data from gamma camera were recorded simultaneously on a computer system for subsequent quantitative analysis. RESULTS: In 94 of 96 eyes without epiphora, RI-DCG was correlated with normal C-DCG and % of emptying was at least over 50%. In 58 of 74 eyes with epiphora, RI-DCG was correlated with abnormal C-DCG and % of emptying was at most below 50%. In 16 eyes with functional block, quantitative RI-DCG showed abnormal % of emptying. CONCLUSION: Nuclear DCG with quantitation had higher diagnostic yield in functional block and correlated higher with epiphora. Thus nuclear DCG with quantitation would be a valuable functional test after postprocedures such as dacryocystoplasty.
Computer Systems
;
Drainage
;
Gamma Cameras
;
Head
;
Humans
;
Lacrimal Apparatus Diseases*
;
Radionuclide Imaging*
6.Sinusitis Managment Associated with Maxillary Sinus Augmentation: Case Report
Su Ryeon HONG ; Yong Wuk LEE ; Kyung Sung YOON ; Ji Hye CHOE ; Ju Hyo HA ; In Ho KIM ; Su Jin JUNG ; Hyun Su LEE ; Soo Nam YANG
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 2010;32(6):558-562
7.A Case of Mesalazine-induced Eosinophilic Pneumonia in a Patient with Ulcerative Colitis.
Ji Young PARK ; Hong Mo KANG ; Su Young KIM ; Yo Seb HAN ; Yong Seon CHO ; Hyo Jong KIM ; Jee Hong YOO
Tuberculosis and Respiratory Diseases 2001;51(5):474-481
Measlazine(5-Aminosalicylic acid, 5-ASA), a component of Sulfasalazine (sulfapyridine bound to 5-ASA), is used to treat inflammatory bowel disease. Most adverse pulmonary effects caused by sulfasalazine have been attributed to sulfapyridine. However, lung toxicity associated with measlazine(5-ASA) is rare. Here we report a case of eosinophilic pneumonia in a 44-year-old woman with ulcerative colitis, who was treated with mesalazine. She developed symptoms of a dry cough, mild night fever, and evertional dyspnea. Bilateral peripheral pulmonary infiltrates, peripheral blood eosinophilia, and histologic features were consistent with eosinophilic pneumonia. The symptoms improved quite rapidly after the discontinuation of mesalazine and initiation of steroid therapy. Therefore, adverse pulmonary reactions to mesalazine must be considered in a differential diagnosis of pulmonary involvement in patients with inflammatory bowel disease who are receiving with measlazine therapy.
Adult
;
Colitis, Ulcerative*
;
Cough
;
Diagnosis, Differential
;
Dyspnea
;
Eosinophilia
;
Eosinophils*
;
Female
;
Fever
;
Humans
;
Inflammatory Bowel Diseases
;
Lung
;
Mesalamine
;
Pulmonary Eosinophilia*
;
Sulfapyridine
;
Sulfasalazine
;
Ulcer*
8.Two Cases of Necrotizing Fasciitis in Patients with SLE.
Dong su SHIN ; Mi ryeong SEO ; Hyung jeong CHO ; Hyo jin CHOI ; Eun bong LEE ; Han joo BAEK
Journal of Rheumatic Diseases 2011;18(2):132-136
Necrotizing fasciitis (NF) is an uncommon, life-threatening infection of the subcutaneous tissue and superficial fascia. The clinical course of NF is rapid and progressive, and it is often fatal despite the appropriate therapy. The prognosis of NF depends on a timely diagnosis and then proper treatment. At onset it may not be possible to clearly distinguish NF from minor soft-tissue infections. Although infection are common due to the use of steroids and immunosuppressive agents in patients with systemic lupus erythematous (SLE), it is interesting that NF has rarely been reported with SLE. Here, we present two cases of NF with SLE.
Fasciitis, Necrotizing
;
Humans
;
Immunosuppressive Agents
;
Prognosis
;
Steroids
;
Subcutaneous Tissue
9.Role of the Peripheral Vestibular System on Neuroplasticity Induced by Hypergravity Stimulation .
Jae Hyo LEE ; Gyoung Wan LEE ; Han Su PARK ; Jae Hee LEE ; Dong Ok CHOI ; Myoung Ae CHOI ; Byung Rim PARK
Journal of the Korean Balance Society 2006;5(2):213-223
BACKGROUND AND OBJECTIVES: Altered environmental gravity, including both hypo- and hypergravity, may result in space adaptation syndrome. To explore the characteristics of this adaptive plasticity, the expression of immediate early gene c-fos mRNA in the vestibular system following an exposure to hypergravity stimulus was determined in rats. MATERIALS AND METHOD: The animals were subjected to 2 G force (two-fold earth's gravity) stimulus for 3 hours, and were examined at post-stimulus hours 0, 2, 6, 12, and 24. Real time reverse transcription-polymerase chain reaction (RT-PCR) was adopted to analyze temporal changes in the expression of c-fos mRNA. RESULTS: The hypergravity stimulation produced the expression of c-fos mRNA in the vestibular ganglion, medial vestibular nucleus, inferior vestibular nucleus, hippocampus, vestibulocerebellum, and vestibular cortex. The peak expression occurred at hour 6 in the animals hypergravity-stimulated for 3 hours. Bilateral labyrinthectomy significantly attenuated the degree of up-regulation in c-fos mRNA expression. MK-801, an NMDA receptor antagonist, also significantly attenuated the degree of up-regulation in c-fos mRNA expression. CONCLUSION: These results indicate that the adaptive neuroplasticity in response to an altered gravity occurs in the vestibular-related organs in the central nervous system, in which peripheral vestibular receptors and NMDA receptors play an important role.
Animals
;
Central Nervous System
;
Dizocilpine Maleate
;
Ganglion Cysts
;
Genes, fos
;
Gravitation
;
Hippocampus
;
Hypergravity*
;
N-Methylaspartate
;
Neuronal Plasticity*
;
Plastics
;
Rats
;
Receptors, N-Methyl-D-Aspartate
;
RNA, Messenger
;
Space Motion Sickness
;
Up-Regulation
;
Vestibular Nuclei
10.Pulmonary Function Changes during Spinal Anesthesia - Bupivacaine vs. Tetracaine -.
Jeon Jin LEE ; Woo Jae JOUN ; Chung Su KIM ; Gaab Soo KIM ; Tae Soo HAHM ; Heyn Sung JO ; Tae Hyung HAN ; Baek Hyo SHIN
Korean Journal of Anesthesiology 1997;33(6):1109-1115
BACKGROUND: Although degree of motor blockade during high thoracic spinal anesthesia is difficult to determine, pulmonary function may reflect the level of motor blockade. So we checked pulmonary function during spinal anesthesia with two different local anesthetic agents. METHODS: 50 patients, ASA PS 1-2, were randomly divided into two groups. After basal pulmonary function test (FVC: forced vital capacity, FEV1: forced expiratory volume in one second, PEFR: peak expiratory flow rate, PEP: peak expiratory pressure, PIP: peak inspiratory pressure.), the patients received spinal anesthesia with either 0.5% hyperbaric bupivacaine or 0.5% hyperbaric tetracaine. Thirty minutes after injection, level of sensory blockade was checked by pinprick test and pulmonary function test was performed. RESULTS: Almost all the values of pulmonary function reduced after spinal anesthesia, but the degrees of reduction were not differ in two groups except PEP, which reduced more profoundly in tetracaine group than bupivacaine group. CONCLUSIONS: It is more desirable that we use bupivacaine rather than tetracaine as spinal anesthetic agent in the patient with poor pulmonary function.
Anesthesia, Spinal*
;
Anesthetics
;
Bupivacaine*
;
Forced Expiratory Volume
;
Humans
;
Peak Expiratory Flow Rate
;
Respiratory Function Tests
;
Tetracaine*
;
Vital Capacity