1.A case of bone marrow necrosis in acute lymphoblastic leukemia.
Mee Ran KIM ; Hye Lim JUNG ; Hong Hoe KOO ; Hee Young SHIN ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1991;34(8):1163-1168
No abstract available.
Bone Marrow*
;
Necrosis*
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
2.A clinical study of childhood soft tissue sarcoma.
Hye Lim JUNG ; Hong Heo KOO ; Hee Young SHIN ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1993;36(9):1258-1270
To study the clinical characteristics and treatment results of childhood soft tissue sarcoma, the retrospective study was performed on 67 patients with soft tissue sarcoma, experienced at the Department of Pediatrics, Seoul National University Hospital from January, 1982 to July, 1990. The median age of 67 soft tissue sarcoma patients was 4 years 5 months and age distribution showed that 0-4 year age group was most common (55.2%). The sex ratio of male to female was 1.2:1. There were 3 cancers among relatives of soft tissue sarcoma patients, including one cancer among first-degree relatives. As for pathological classification, rhabdomyosarcoma (67.1%) was the most common childhood soft tissue sarcoma, followed by malignant Schwannoma (8.9%), extraskeletal Ewing's sarcoma (6.0%), infantile fibrosarcoma (4.5%), malignant fibrous histiocytoma (3.0%), malignant hemangiopericytoma (3.0%), and there were 1 case each of angiosarcoma, leiomyosarcoma, synovial sarcoma, malignant mesenchymoma and mesenchymal chondrosarcoma. The median age of 45 rhabdomyosarcoma patients was 3 years 8 months and age distribution showed that 0-4 year age group was most common (64.5%). Twenty three patients were male and 22 were female. The histologic subtype of rhabdomyosarcoma was embryonal type in 38 patients (84.5%), alveolar type in 5 patients (11.1%) and unclassified type in 2 patients (4.4%). As for primary site of soft tissue sarcomas, the most frequent site was the head and neck region (32.8%) including parameningeal region (13.4%) and orbit (6.0%), followed by extremities (20.9%), trunk (19.4%), retroperitoneum and pelvis (11.9%), urogenital region (7.5%), perineum and perianal region (4.5%) and other region (3.0%). As for primary site of 45 rhabdomyosarcoma cases, the most frequent site was also the head and neck region (37.8%). The most common initial symptom of soft tissue sarcoma patients was mass (68.7%). As for Intergroup Rhabdomyosarcoma Study clinical grouping system of 67 soft tissue sarcoma patients, clinical group III (58.2%) was most common, followed by clinical group II(20.9%), IV (14.9%) and I (6.0%). Of 10 cases of clinical group IV with distant metastasis, lung (8 cases) was the most common metastaic region and other metastatic regions were bone, kidney, liver and bone marrow. As for IRS clinical grouping system of 45 rhabdomyosarcoma patients, clinical group III was most common (68.9%). Of 6 cases of clinical group IV, lung (5 cases) was also the most common metastatic region, followed by kidney and liver. From 1982 to 1985, chemotherapy was done with pulse VAC or pulse VAdrC-VAC regimen based on IRS-I and IRS-II. From 1986, patients in clinical group I and II received vincristine and actinomycin-D for 1 year and patients in clinical group III, IV and II with alveolar histologic subtype(unfavorable histologic group) received vincristine, actinomycin-D, adriamycin, cyclophosphamide and cisplatinum based on IRS-III. Radiation therapy was administered to patients in clinical group II, III and IV. Of 67 cases of soft tissue sarcoma, 54 case were eligible for treatment analysis. The 3 year disease free survival (DFS) of all 54 cases was 54.1%, 3 year DFS of clinical group I and II was 83.9%,3 year DFS of clinical group III and IV before 1986 was 35.7% and after 1986 was 48.2%. Of 45 cases of rhabdomyosarcoma, 41 cases were eligible for treatment analysis. The 3 year DFS of all 41 cases was 49.1%,3 year DFS of clinical group I and II was 87.5%,3 year DFS of clinical group III and IV before 1986 was 27.2% and after 1986 was 45.0%. Patients in clinical group I and II who had no gross residual tumor after primary surgical excision had best prognosis with 3 year DFS approximating 90% with only 2 drugs regimen, significantly better than patients in clinical group III and IV with 3 year DFS below 50% even after intensifying chemotherapy since year 1986. This analysis suggests that total surgical removal is very important for improving prognosis and should be undertaken where possible in all patients without distant metastasis. Treatment results also showed that after year 1986 with intensification of chemotherapy, 3 year DFS of clinical group III and IV as well as early toxic deaths increased, and after lowering doses of chemotherapeutic agents of regimen 35 of IRS-III, treatment results improved much. Therfore to improve prognosis of patients with gross residual tumor after surgical excision of biopsy and patients with distant metastasis at diagnosis, intensified multiagent chemcherapeutic regimen with adequate dose modification should be done to lower early toxic deaths.
Age Distribution
;
Biopsy
;
Bone Marrow
;
Chondrosarcoma, Mesenchymal
;
Classification
;
Cyclophosphamide
;
Diagnosis
;
Disease-Free Survival
;
Doxorubicin
;
Drug Therapy
;
Extremities
;
Female
;
Fibrosarcoma
;
Head
;
Hemangiopericytoma
;
Hemangiosarcoma
;
Histiocytoma, Malignant Fibrous
;
Humans
;
Kidney
;
Leiomyosarcoma
;
Liver
;
Lung
;
Male
;
Mesenchymoma
;
Neck
;
Neoplasm Metastasis
;
Neoplasm, Residual
;
Neurilemmoma
;
Orbit
;
Pediatrics
;
Pelvis
;
Perineum
;
Prognosis
;
Retrospective Studies
;
Rhabdomyosarcoma
;
Sarcoma*
;
Sarcoma, Ewing
;
Sarcoma, Synovial
;
Seoul
;
Sex Ratio
;
Survival Rate
;
Vincristine
3.Clinical considerations of the mediastinal tumors in children.
Eun Joo KIM ; Gye Lim JUNG ; Hong Hoe KOO ; Hee Young SHIN ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1992;35(1):98-107
No abstract available.
Child*
;
Drug Therapy
;
Humans
4.CT and MR findings of mycotic infection of the paranasal sinus: differentiation from sinonasal neoplasm.
Kil Woo LEE ; Hyo Keun LIM ; Gwy Suk SEO ; Suk Soo BAE ; Shin Hyung LEE
Journal of the Korean Radiological Society 1992;28(2):176-181
When a soft tissue mass in the bony wall of the paranasal sinus is present, it is difficult to make a distinction between tumor and inflammatory mass on CT. Fungal sinusitis may have soft tissue attenuation on the bony wall of the sinus, bony sclerosis, focal bony destruction, and calcific area on CT. This is a report of four proven cases of fungal sinusitis, asperogillosis in 3 cases and mucormycosis in 1 case, All 4 patients had CT and one patient had MRI, On CT, bony sclerosis and destruction were well visualized in all cases. On MRI, mycetoma in the maxillary sinus was hypointense on T1 weighted images and more hypointense on T2 weighted images. Although CT appears to be the best modality for initial examination of the patient with sinusitis, the differentiation of fungal sinusitis from tumor mass or other entity may be better accomplished with MRI.
Humans
;
Magnetic Resonance Imaging
;
Maxillary Sinus
;
Mucormycosis
;
Mycetoma
;
Sclerosis
;
Sinusitis
5.Carcinomas in childhood.
Hong Hoe KOO ; Kyung Duk PARK ; Hee Young SHIN ; Hyo Seop AHN ; Sang Kyu PARK ; Hye Lim JUNG
Journal of the Korean Pediatric Society 1992;35(10):1369-1376
No abstract available.
6.Clinical considerations of acute leukemia or transient myeloprolifo- rative disorder in Down syndrome.
Eun Sil DONG ; Sung Hee JANG ; Hong Hoe KOO ; Hye Lim JUNG ; Hee Young SHIN ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1991;34(1):74-82
No abstract available.
Down Syndrome*
;
Leukemia*
7.Clinical Approach of Ultrasonography in the Diagnosis of Intussusception in Infant and Children.
Hee Tang LIM ; Jin Kil PARK ; Hong Ju CHOI ; Jae Sam KIM ; Hyo Kyung SHIN ; Chul Hoi GU
Journal of the Korean Pediatric Society 1994;37(5):649-654
Thirty consecutive patient seen in a pediatric out patient and emergency department, in whom the diagnosis of intussusception was considered, had an ultrasound examination of the abdomen before the barium enema. The peak age was 5~12 month (range 4~34 month). Intussusception was detected by ultrasonography in all 25 cases proved by barium enema (sensitivity 100%). Normal findings on ultrasonography correlated with a negative barium enema results in 5 of 5 cases (negative predictive value=100%). No intussusception was missed by ultrasonography. To determine which patient would most benefit from ultrasonography, we divided patients into either a high risk group (100% intussusception) or a low risk group (37.5% intussusception) on the basis of clinical symptoms. We conclude that ultrasonography can be used as a rapid sensitive screening procedure in the diagnosis or exclusion of childhood intussusception. Probability of surgical reduction was associated with size of of total thickness and external rim thickness.
Abdomen
;
Barium
;
Child*
;
Diagnosis*
;
Emergency Service, Hospital
;
Enema
;
Humans
;
Infant*
;
Intussusception*
;
Mass Screening
;
Ultrasonography*
8.Intracranial hemorrhage in the prematurity and small for gestational age an attempt of clinico-ultrasonographic correlation.
Kwang Sup KIM ; You Seop SHIN ; Jong Wan KIM ; Kwang Nam KIM ; Ki Yang RYOO ; Hyo Keun LIM
Journal of the Korean Pediatric Society 1991;34(1):49-56
No abstract available.
Gestational Age*
;
Intracranial Hemorrhages*
9.Comparison of Choroidal Thickness in Patients with Diabetes by Spectral-domain Optical Coherence Tomography.
Hyo Kyung LEE ; Ji Won LIM ; Min Cheol SHIN
Korean Journal of Ophthalmology 2013;27(6):433-439
PURPOSE: To evaluate choroidal thickness in diabetes patients using spectral-domain optical coherence tomography. METHODS: We examined 203 eyes of 203 diabetic participants and 48 eyes of 48 healthy controls. The choroidal thickness at the foveal lesion was measured by enhanced-depth imaging optical coherence tomography. The participants were grouped according to diabetic retinopathy grade: no diabetic change, mild-to-moderate or severe non-proliferative, or proliferative diabetic retinopathy. The study parameters included history, age, axial length, intraocular pressure, central retinal thickness, fasting glucose, and blood pressure. RESULTS: The subfoveal choroidal thickness was thinner in eyes with non-proliferative or proliferative diabetic retinopathy than in normal eyes (p < 0.01). However, there was no difference between eyes with non-proliferative and proliferative diabetic retinopathy or between eyes with no diabetic change and the controls. Eyes exhibiting macular edema showed no significant difference in choroidal thickness compared with eyes having normal macular contours. CONCLUSIONS: The central choroid is thinner when eyes show diabetic changes on the retina. However, the presence of diabetic macular edema or proliferative change is not associated with more pronounced choroidal thinning.
Adult
;
Aged
;
Choroid/*pathology
;
Diabetic Retinopathy/*diagnosis
;
Female
;
Follow-Up Studies
;
Humans
;
Male
;
Middle Aged
;
Reproducibility of Results
;
Retrospective Studies
;
Seveso Accidental Release
;
Tomography, Optical Coherence/*methods
10.Image-Guided Percutaneous Biopsies with a Biopsy Gun.
Hyung Sik SHIN ; Sang Hoon BAE ; Kyung Hwan LEE ; Ku Sub YUN ; Hyo Keun LIM ; Eun Ah KIM
Journal of the Korean Radiological Society 1994;31(1):125-130
PURPOSE:We report the results of image-guided percutaneous biopsies with a biopsy gun and evaluate the clinical usefullness. MATERIALS AND METHODS: One hundred and five biopsies under ultrasonographic or fiuoroscopic guidance were performed. Various anatomic sites were targeted (liver;50, chest;22, kidney;12, pancreas;8, intraperitoneum;7, retroperitoneum; ). RESULTS:Obtained tissue was diagnostic in 98 of the 105 biopsies(93%). In each instance, representative core tissue specimens were obtained. Evaluation of the core tissue by pathologist revealed consistent, uniform specimens that contained significant crush artifact in no case. Five biopsies yielded inadeguate tissues which were too small for histopathologic interpretation or were composed of necrotic debris. Two biopsies yielded adequate tissues, but tissues were not of the target. The diagnoses were malignancy in 77 biopsies and benign disease in 21 biopsies. No complications other than mild, localized discomfort were encountered except a transient hemoptysis and pneumothorax which was observed in two patients. CONCLUSION:Cutting biopsy with a biopsy gun provided sufficient amount of target tissue for an accurate diagnosis of malignant and benign disease. It was a safe and useful procedure for percutaneous biopsy.
Artifacts
;
Biopsy*
;
Diagnosis
;
Hemoptysis
;
Humans
;
Pneumothorax