1.Interplay between Inflammatory Responses and Lymphatic Vessels.
Immune Network 2014;14(4):182-186
Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lymphatic endothelial cell proliferation and chemokine production, thereby resulting in lymphangiogenesis. Furthermore, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on how inflammatory cytokines affect lymphangiogenesis and the roles of lymphatic vessels in modulating immune responses.
Cytokines
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Drainage
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Emigration and Immigration
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Endothelial Cells
;
Inflammation
;
Leukocytes
;
Lymphangiogenesis
;
Lymphatic Vessels*
2.Macular Hemorrhage after Laser in Situ Keratomileusis.
Heon Seung HAN ; Hyun Young SHIN ; Hyo Myung KIM
Journal of the Korean Ophthalmological Society 2000;41(1):264-267
Macular hemorrhage which result from breaks of Bruch's membrane or from choroidal neovascularization can develop in high degenerative myopia, but its occurrence after photorefractive surgery has rarely been reported. We experienced a case of macular hemorrhage after laser in situ keratomileusis[LASIK]:A 28-year-old female patient with high myopia of -16.5 diopters, who had received successful LASIK operation on her left eye.complained of a sudden drop in vision 20 days postoperatively.On fundus examination, macular hemorrhages were detected on her left eye.Eventually the hemorrhages resolved, but more than 2 lines of her best corrected visual acuity were lost.During follow-up, a new hemorrhagic lesion was incidently found on the other eye. This case demonstrates that macular hemorrhages may develop after LASIK in eyes with high degenerative myopia, and lead to a permanent reduction in visual acuity.We should be alert to any potential retinal pathology in patients having refractive surgery.
Adult
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Bruch Membrane
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Choroidal Neovascularization
;
Female
;
Follow-Up Studies
;
Hemorrhage*
;
Humans
;
Keratomileusis, Laser In Situ*
;
Myopia
;
Myopia, Degenerative
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Pathology
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Refractive Surgical Procedures
;
Retinaldehyde
;
Visual Acuity
3.MR Findings of Knee Injuries in Skiing: Relation with the Mechanism of Injury.
Myung Jin SHIN ; Seung Mun JUNG ; Hyo Jeong LEE ; Soon Tae KWON
Journal of the Korean Radiological Society 1995;33(2):307-312
PURPOSE: To evaluate the MR findings of knee injuries in skiing and to explain the mechanism of injury with MR findings. MATERIALS AND METHODS: We reviewed MR findings of 18 patients with history of knee injuries in skiing. The MR images were evaluated retrospectively to identify the ligament injuries, bone lesions and meniscal injuries. RESULTS: Ligament injuries were seen in 16 patients, bone contusions in 16 patients, meniscal lesions in two patients. The most common group of injury was anterior cruciate ligament (ACL) and roedial collateral ligament (MCL) injuries with bone contusion on posterior lip of the lateral tibial plateau (LTP). The second common group of injury was isolated ACL injury with bone contusions on the lateral fernoral condyle (LFC) and posterior lip of the LTP. We considered that the mechanism of injury of the former group may be correlated with the valgus torque with secondary anterior displacement of the tibia and the latter group may be correlated with the pivot shift phenomenon. CONCLUSION: MR may play an important role in the diagnosis of knee injuries in skiing and its findings may explain the mechanism of injury.
Anterior Cruciate Ligament
;
Collateral Ligaments
;
Contusions
;
Diagnosis
;
Humans
;
Knee Injuries*
;
Knee*
;
Ligaments
;
Lip
;
Retrospective Studies
;
Skiing*
;
Tibia
;
Torque
5.Chancre Presenting as Nipple Eczema.
Seung Hyun SOHNG ; Byeong Su KIM ; Jin Hwa CHOI ; Hyo Jin LEE ; Dong Hoon SHIN ; Jong Soo CHOI
Korean Journal of Dermatology 2013;51(12):993-994
6.A case of Rothmund-Thomson syndrome.
Seung Hyo KIM ; Choong Ho SHIN ; Sei Won YANG
Korean Journal of Pediatrics 2006;49(5):565-569
Rothmund-Thomson syndrome (RTS), is a rare autosomal recessive disorder, characterized by:skin photosensitivity, poikiloderma, sparse hair, sparse eyebrows/lashes, short stature, skeletal abnormalities, cataracts, and an increased risk of malignancy. Skeletal abnormalities include:dysplasia, absent or malformed bones, such as absent radii, osteopenia, and delayed bone formation. RTS is thought to result from chromosomal instability, and children with RTS are at risk of cancer. Reported cancers in children with RTS include:basal cell carcinoma, squamous cell carcinoma of the skin and osteosarcoma of bone. We report an 11 year-old boy, who presented to our institution with poikilodermatous skin change with telangiectasia and hyperpigmentation, absence of radius and thumb, and the development of osteosarcoma of the left tibia. The patient is now receiving supportive care and is receiving maintenance chemotherapy after surgery for osteosarcoma.
Bone Diseases, Metabolic
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Carcinoma, Squamous Cell
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Cataract
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Child
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Chromosomal Instability
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Hair
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Humans
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Hyperpigmentation
;
Maintenance Chemotherapy
;
Male
;
Osteogenesis
;
Osteosarcoma
;
Radius
;
Rothmund-Thomson Syndrome*
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Skin
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Telangiectasis
;
Thumb
;
Tibia
7.A Case of Herpes Zoster Oticus Involving Glossopharyngeal Nerve without Facial Nerve Palsy.
Seung Hyun SOHNG ; Jin Hwa CHOI ; Hyo Jin LEE ; Dong Hoon SHIN ; Jong Soo CHOI ; Ki Hong KIM
Korean Journal of Dermatology 2012;50(7):656-657
No abstract available.
Deglutition Disorders
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Facial Nerve
;
Glossopharyngeal Nerve
;
Herpes Zoster
;
Herpes Zoster Oticus
;
Paralysis
8.CLINICAL ASSESSMENT OF THE VELOPHARYNGEAL INCOMPETENCY SPEAKERS WITH SPEECH AIDS.
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2000;26(4):414-421
The objective evaluation of velopharyngeal closure function is the key to diagnosis and therapy control of velopharyngeal incompetency. The aim of this study is to evaluate the aerodynamic and acoustic characteristics of the velopharyngeal closure function of patients who have developed velopharyngeal incompetency after management with speech aids. The test words were composed of sustained vowels /a/, /i/, /e/, /u/, /ja/, /je/, /wi/ and polysyllabic words /p'ap'i/, /siso/, /mami/ for measuring nasalance, The data was collected before the placement of the speech aids and one to three months after. The results were as follows:The nasalance score of the velopharyngeal incompetency speakers was higher than that of the normal control group, except for nasal sounds, and was decreased after placement of the speech aids, especially in high vowels /i/ (P<.01) and /wi/ (P<.05).
Acoustics
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Diagnosis
;
Humans
9.A case of neuroblastoma with multiple skin metastases.
Koo Il SEO ; Seung Yong JUNG ; Kyu Han KIM ; Jai IL YOUN ; Yoo Shin LEE ; Hyo Seop AHN
Korean Journal of Dermatology 1993;31(2):264-268
We report a case of neuroblastoma with multiple skin metastases as a chief complaint in a 2-month-old girl. the skin lesions were rnultiple, pea-sized, bluish, nontender, moable subcutaneous nodules on abdomen, back and scalp. Histopathology showed small round or poly gonal tumor cells which have deeply stained, basophilic, hyperchromatic nuclei with some mitoses. Th.se tumor cells showed clumping tendency which is one of early menifestations of rosette formation. Immunohistochemically positive reaction was demonstrated by anti-NSE(neuron specific enolase) antilody but negative reaction by anti-NFP (neurofilament proteiin ) antibody. She has been succesfully treated with combined chemotherapy for 10 months without relapse.
Abdomen
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Basophils
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Drug Therapy
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Female
;
Humans
;
Infant
;
Mitosis
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Neoplasm Metastasis*
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Neuroblastoma*
;
Phosphopyruvate Hydratase
;
Recurrence
;
Rosette Formation
;
Scalp
;
Skin*
10.A Clinical Study of Palatal lift for treatment of velopharyngeal incompetency.
Bo Keun YOON ; Seung O KO ; Hyo Keun SHIN
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2001;27(1):92-96
Velopharyngeal function refers to the combined activity of the soft palate and pharynx in closing and opening the velopharyngeal port to the required degree. In normal speech, various muscles of palate & pharynx function as sphincter and occlude the oropharynx from the nasopharynx during the production of oral consonant sounds. Inadequate velopharyngeal function caused by neurologic disorder-cerebral apoplexy, regressive diseases-disseminated sclerosis, Parkinson's disease, congenital deformity-cleft palate, cerebral palsy and etc. may result in abnormal speech characterized by hypernasality, nasal emission and decreased intelligibility of speech due to weak consonant production. In our study, we constructed speech aids prosthesis-Palatal lift in acquired idiophathic VPI patient and assessed velopharyngeal function with various diagnostic instruments which can evaluate the speech characteristics objectively.
Cerebral Palsy
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Humans
;
Muscles
;
Nasopharynx
;
Oropharynx
;
Palate
;
Palate, Soft
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Parkinson Disease
;
Pharynx
;
Sclerosis
;
Stroke