1.Analysis of blood transfused for past five years at Dongsan hospital.
Soo Jin PARK ; Dong Seok JEON ; Hyo Jin CHUN ; Jae Ryong KIM ; Dal Hyo SONG
Korean Journal of Blood Transfusion 1993;4(2):181-186
No abstract available.
2.Analysis of blood transfused for past five years at Dongsan hospital.
Soo Jin PARK ; Dong Seok JEON ; Hyo Jin CHUN ; Jae Ryong KIM ; Dal Hyo SONG
Korean Journal of Blood Transfusion 1993;4(2):181-186
No abstract available.
3.Amniotic fluid alpha-fetoprotein levels during midtrimester pregnancy (I).
Taek Hoon KIM ; Jong In KIM ; Hyo Jin CHUN
Korean Journal of Perinatology 1993;4(4):498-503
No abstract available.
alpha-Fetoproteins*
;
Amniotic Fluid*
;
Female
;
Humans
;
Pregnancy
;
Pregnancy Trimester, Second*
;
Pregnancy*
4.Clinical application of therapeutic plasma exchange.
Dong Seok JEON ; Bok Cheol HWANG ; Hyo Jin CHUN ; Jay Ryong KIM ; Dal Hyo SONG
Korean Journal of Blood Transfusion 1991;2(2):175-181
No abstract available.
Plasma Exchange*
;
Plasma*
5.Changes of fibrinogen and coagulation factor NIII in cryoprecipitate according to storage temperature and time after thawing.
Young Jae KIM ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Pyong KIM ; Dal Hyo SONG
Korean Journal of Clinical Pathology 1992;12(3):395-400
No abstract available.
Blood Coagulation Factors*
;
Fibrinogen*
6.Changes of fibrinogen and coagulation factor NIII in cryoprecipitate according to storage temperature and time after thawing.
Young Jae KIM ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Pyong KIM ; Dal Hyo SONG
Korean Journal of Clinical Pathology 1992;12(3):395-400
No abstract available.
Blood Coagulation Factors*
;
Fibrinogen*
7.Changes of Plasma Components by the Plasma Exchange.
Hyo Jin CHUN ; Jae Ryong KIM ; Gyoung Yim HA ; Dong Seok JEON ; Dal Hyo SONG
Korean Journal of Blood Transfusion 1995;6(2):141-154
Therapeutic plasma exchange is used in almost every condition in which there is a plasma factor thought possibly to the etiology or pathogenesis of a disease or one of its manifestations. In order to evaluate plasma exchange using fresh frozen plasma as replacement solution, eighty four therapeutic plasma exchanges were carried out in eighteen patients. In standardized procedures, 1.5 times the calculated plasma volume was replaced with a Hartman's solution and fresh frozen plasma. Anticoagulation was achieved using a whole venous blood to 2.5% trisodium citrate in the ratio of 10 to 1. Total calcium, phosphorus, glucose, urea nitrogen, creatinine, bilirubin, alkaline phosphatase, amylase, creatine kinase, IgG, C3, total white and red blood cell count, hemoglobin, and differential count were not significantly affected by the procedure. In contrast, serum cholesterol, total protein, albumin, aspartate aminotransferase, alanine aminotransferase, ionized calcium, IgM, C4 and platelet were significantly decreased by the plasma exchange. All these measurements had returned to the first pre-exchange level within 24 hours, while the C4 and platelet count took between 24 and 72 hours, and the IgM level, between 72 hours and 1 week. These data indicated that in an isovolemic plasma exchange there was a transient but rapidly reversible effect on all the components studied, with C4 and platelet count, returning more slowly to pre-exchange level than the others, and IgM levels responding the slowest. In summary, plasma exchanges using fresh frozen plasma as replacement solution were assumed to be not significantly affected the function of various organs.
Alanine Transaminase
;
Alkaline Phosphatase
;
Amylases
;
Aspartate Aminotransferases
;
Bilirubin
;
Blood Platelets
;
Calcium
;
Cholesterol
;
Citric Acid
;
Creatine Kinase
;
Creatinine
;
Erythrocyte Count
;
Glucose
;
Humans
;
Immunoglobulin G
;
Immunoglobulin M
;
Nitrogen
;
Phosphorus
;
Plasma Exchange*
;
Plasma Volume
;
Plasma*
;
Platelet Count
;
Urea
8.Acute Lymphoblastic Leukemia with Philadelphia Chromosome and Monosomy 7.
Gui Jeon CHOI ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Ryong KIM ; Myung Soo HYUN
Korean Journal of Clinical Pathology 1997;17(4):519-529
BACKGROUND: The combination of Philadelphia chromosome (Ph) and monosomy 7(-7) was rarely observed in acute lymphoblastic leukemia (ALL). With the results from immunophenotyplc and molecular analysis, Philadelphia chromosome positive ALL with monosomy 7[Ph(+)/-7] has been considered that it may be derived from neoplastic transformation at the pluripotent stem cell level. We compared the clini-cal, laboratory, and hematological findings between 5 cases of Ph(+)/-7 and 5 cases of Ph(+) without monosomy 7 [Ph (+) /N7]. METHODS: During the period from January, 1995 to December, 1996, total 72 cases of ALL were confirmed among 259 cases of hematologic malignancy with bone marrow cytogenetic analysis. Among 72 ALL cases, 5 cases of Ph(+)/-7(monosomy 7 or 7q abnormalities) were compared with Ph only or Ph without monosomy 7(ph(+)/N7] on the hematological, immunophenotypic, other laboratory, clinical findings and event ree survival (EFS) The karyotyping of the bone marrow specimens was analysed byshort-term unsynchronized culture methods such as overnight colcemid treatment and 24 hours incubation following ethidium bromide treatment. RESULTS: The mean age of Ph(+)/-7 was 30.6+/-12.8 years, and it was significantly different from that of Ph(+)/N7 (p=0.009), Four cases of Ph(+)/-7 were classified as ALL L2 subtype, and 2 cases revealed CNS involvements. Immunophenotyping was positive in CD10, CDl9, CD2O, CD22 and HLA-DR. But one case revealed e-B-lymphoid lineage with positivity in CD34, CDl3, and CD33. The response to chemotherapy and EFS was very poor in Ph(+)/-7 group, and the mean EFS was 3.2+/-1.9 months(p=0.014). All of cases showed induction on failure in chemotherapy, relapsed with bone marrow, CNS and extramedullary involvements, and expired due to sepsis. CONCLUSIONS: Ph(+)/-7 ALL had very Poor clinical course with being resistant to chemotherapy and unfavorable prognosis, revealed L2 subtype by FAB classification, and was slightly older in ages compared with Ph(+)/N7 ALL.
Bone Marrow
;
Classification
;
Cytogenetic Analysis
;
Demecolcine
;
Drug Therapy
;
Ethidium
;
Hematologic Neoplasms
;
HLA-DR Antigens
;
Hydrogen-Ion Concentration
;
Immunophenotyping
;
Karyotyping
;
Monosomy*
;
Philadelphia Chromosome*
;
Pluripotent Stem Cells
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
;
Prognosis
;
Sepsis
9.A Case of Myeloid Blast Crisis of Ph-positive Chronic Myeloid Leukemia with t(3;21)(q26;q22).
Gui Jeon CHOI ; Hyo Jin CHUN ; Dong Seok JEON ; Jae Ryong KIM ; Ki Young KWON
Korean Journal of Clinical Pathology 1997;17(1):21-27
The t(3;21) (q26;q22) is associated with chronic myelogenous leukemia in blast crisis, leukemia evolving from therapy-related myelodysplasia, and with leukemia following other hematopoietic proliferative diseases. The t(3;21) is rare secondary aberration in blast crisis of Philadelphia(Ph)-positive chronic myeloid leukemia, which may be restricted to patients entering myeloid blast crisis. We report here in one case of chronic myeloid leukemia in blast crisis which reveals both t(9;22) (q34;q11), and t(3;21) (q26 ;q22). A 62-year-old male was diagnosed as chronic myeloid leukemia 5 years ago, received hydroxyurea therapy, and admitted because of gingival bleeding and fever. On examination, splenomegaly and leukocytosis with proliferated blasts(91%) in peripheral blood were noted. Bone marrow aspirate showed hypercellularity with severe blast proliferation(92.5%) which revealed all negative in peroxidase and PAS stain. Cytogenetic study of bone marrow cells showed the karyotype 46, XY, t(3;21) (q26;q22), t(9;22) (q34;q11), which might be suspected as myeloid blast crisis. Above finding was confirmed by the result of immunophenotyping(CD13 43.6%, CD34 68.2%, HLA-DR 91.6%). He received intensive chemotherapy, but still sustained proliferation of blasts was noted . The follow up cytogenetic study was as follows: 46, XY, 4(3;21) (q26:22), t(9;22) (q34;q11)/46, XY, t(3;21)(q26;q22), del(8) (q22), t(9:22) (q34,q11)/46, XY (16/3/1). He died soon from severe pancytopenia and sepsis.
Blast Crisis*
;
Bone Marrow
;
Bone Marrow Cells
;
Cytogenetics
;
Drug Therapy
;
Fever
;
Follow-Up Studies
;
Hemorrhage
;
HLA-DR Antigens
;
Humans
;
Hydroxyurea
;
Karyotype
;
Leukemia
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
;
Leukocytosis
;
Male
;
Middle Aged
;
Pancytopenia
;
Peroxidase
;
Sepsis
;
Splenomegaly
10.A Case of Barrett's Esophageal Ulcer following Esophagomyotomy for Achalasia.
In Suh PARK ; Hyo Jin PARK ; Chun Kyon LEE ; June Hyun SONG
Korean Journal of Gastrointestinal Endoscopy 1995;15(3):486-493
We report a patient who developed a Barrett,s esophageal ulcer 10 years after esophagomyotomy for achalasia. A-59-year-old female was admitted to the hospital with dysphagia for 2 months. In 1982, she had undergone a modified Heller esophagomyotomy for achalsia. After esophagogram, esophageal manometry, 24hr esophageal pH monitoring, esophagoscophy achalasia and Barrett,s esophageal ulcer was diagnosed. So, she had been treated with omeprazole and sucralfate and has been followed up in a asymtomatic state currently. In Barrett,s esophagus, there is a metaplasia of the normal stratified squamous mucosa to columnar epithelium, caused by the reflux of acid. It appears in approximately 10% of patients with chronic gastroesophageal reflux and is associated with increased probability of adenocarcinoma of the esophagus. Among the predis- posing factors of gastroesophageal reflux, there is treatment of esophageal achalsia by forceful dilatation or by the esophagomyotomy. The resultant ralaxation of lower esophageal sphinter, combined with deficient propulsive esophageal peristalsis, predisposed to gastroesophageal reflux. Actually an increased incidence of gastroesophageal reflux, esophagitis and stricture are well-known complications after esophagomyotomy. But in spite of higher risk of gastroesophageal reflux after esophagomyotomy the development of Barrett,s mucosa has been rarely reported and only recently recognized. Diagnosis of Barrett,s esophagus in such patients is difficult and the cumulative effects of achalasia and Barrett's esophagus predispose these patient to higher risk of developing esophageal carcinoma. So, high index of awareness and regular endoscopic surveillance are required.
Adenocarcinoma
;
Barrett Esophagus
;
Constriction, Pathologic
;
Deglutition Disorders
;
Diagnosis
;
Dilatation
;
Epithelium
;
Esophageal Achalasia*
;
Esophageal pH Monitoring
;
Esophagitis
;
Esophagus
;
Female
;
Gastroesophageal Reflux
;
Humans
;
Incidence
;
Manometry
;
Metaplasia
;
Mucous Membrane
;
Omeprazole
;
Peristalsis
;
Sucralfate
;
Ulcer*