No abstract available.
Granuloma, Pyogenic* ; Port-Wine Stain*

BACKGROUND: It is the Year of Rabbit in 1999 in Korea, so rabbit becomes an popular pet animal. At the same time, there seems to be an important increase in dermatophytoses in human as a result of frequent contact with rabbits in early 1999 in Taegu, Korea. OBJECTIVE: The purpose is to investigate the clinical and mycological features of rabbits and human, and their correlation. METHODS: Twenty-one cases with dermatophytoses, transmitted from infected rabbits, were evaluated from January to March, 1999. Mycological study were carried out from the lesions of rabbits and human. RESULTS: Trichophyton (T.) mentagrophytes, granulosum-asteroides form, were isolated from all the lesions of rabbits and human as an causative dermatophyte. The infected rabbits aged 8~12 weeks. The lesions showed 1.0?4.0 cm-sized, inflamed alopecia covered with whitish-gray crusts. Predominant sites were face, neck, abdomen, and legs. Human infections showed a high incidence of teens (76.2%), and female predominance (2 times), and mainly being tinea faciale and tinea corporis. The lesions were 0.5 ~ 4.0 cm-sized ring-shaped scaly patches with intense inflammation, averaging 4.5 in number per capita. The presumed incubation period was about 2 weeks. Experimental rabbit inoculation test with isolates of rabbits and human resulted in the same typical tinea lesions about 15~20 days after inoculation. It took almost 4 weeks for treatment of both rabbits and human infections. CONCLUSION: Zoophilic T. mentagrophytes, as an etiological source and/or reservoir in rabbits, can be frequently transmitted to human. In the epidemiologic respects, prevention of spread of dennatophytes from rabbits or other pet animals is the most important.
Abdomen ; Adolescent ; Alopecia ; Animals ; Arthrodermataceae ; Daegu ; Epidemiology ; Female ; Humans ; Incidence ; Inflammation ; Korea ; Leg ; Neck ; Rabbits* ; Tinea ; Trichophyton*

Dystrophic epidermolysis bullosa is a rare, chronic non-inflammatory bullous disease, which easily forms bullae by minor mechanical trauma or spontaneously, is inherited either in an autosomal dominant or autosomal recessive fashion. We report herein two cases which presented with bullae, erosions and ulcers on extremities, buttock, chest, abdomen and face and loss of all nail since birth in two sisters. Bulla occured bencath the basal lamina histopathologically, anchoring fibrils were almost absent on electron miaoscopy in both cases. The two sisters represented dystrophic epidermolysis bullosa considering the absence of family history inheritcd in an autosomal dominant fashion and the clinical, histological and electronmicroscopic findings.
Abdomen ; Basement Membrane ; Buttocks ; Epidermolysis Bullosa Dystrophica* ; Extremities ; Humans ; Parturition ; Siblings* ; Thorax ; Ulcer

A 28-year-old man presented with a 6.0 * 5.0 cm sized ulcer on the anterior chest and widespread copper-red colored maculopapular eruptions. There was no past or family history of syphilis sign or STS. He had been taken imposition of hands twice to treat chronic hepatitis about 4 months prior to presentation. Thereby, the ulcerative lesion on the anterior chest developed as a result of erosive trauma through contact with infected fingernails. The clinical features and serologic tests as well as biopsy findings were consistent with syphilis. Spirochetes were observed under the dark field examination of the anterior chest lesion. On Warthin-Starry staining, spirochetes were identified in the epidermal area of the papular lesion. We report a case of unusual transmission of syphilis.
Adult ; Biopsy ; Hand* ; Hepatitis, Chronic ; Humans ; Nails ; Serologic Tests ; Spirochaetales ; Syphilis* ; Thorax ; Ulcer

No abstract available.
Epidermal Cyst ; Pilomatrixoma

Secondary cutaneous cryptococcosis may occur earlier than other manifestations of disseminated cryptococcosis. A 68-year-old woman presented with multiple ulcerative lesions on the right calf of 2 weeks duration. She had been treated with antibiotics, but the lesions spread rapidly. The initial clinical impression was necrotizing fasciitis, but routine KOH mounting from the ulcerative lesions showed numerous budding yeast cells with peripheral clear zones and further investigations including a skin biopsy, tissue cultures and India ink preparations allowed a rapid and definitive diagnosis of cutaneous cryptococcosis. Studies for other evidence of infection elsewhere revealed an asymptomatic pulmonary lesion. We report a case of secondary cutaneous cryptococcosis clinically mimicking necrotizing fasciitis that occured before other manifestations of disseminated cryptococcosis.
Aged ; Anti-Bacterial Agents ; Biopsy ; Cryptococcosis* ; Diagnosis ; Fasciitis, Necrotizing* ; Female ; Humans ; India ; Ink ; Saccharomycetales ; Skin ; Ulcer

Cutaneous metastasis from renal cell carcinoma is not unusual, occurring in 3 to 7%, although it may be overlooked. We report a case of metastatic renal cell carcinoma in a 74-year-old man who was presented with a 1.5 x 1.5 x 0.5 cm-sized nodule on the right zygoma for 3 months. A skin biopsy demonstrated the typical clear cell adenocarcinoma with PAS(+) granules in the cytoplasm and honeycombed or glandular configuration, compatible with metastatic renal cell carcinoma. Kidney ultrasonogram and abdomina1 CT scanning showed a large cystic mass on the upper pole of the left kidney. Furthermore radiologic studies revealed multiple metastatic lesions in the lung, liver and brain. He died 4 months later.
Adenocarcinoma, Clear Cell ; Aged ; Biopsy ; Brain ; Carcinoma, Renal Cell* ; Cytoplasm ; Humans ; Kidney ; Liver ; Lung ; Neoplasm Metastasis ; Skin ; Tomography, X-Ray Computed ; Ultrasonography ; Zygoma*

Nevus sebaceus is a common hamartoma that has a variety of appendage tumors. We report a case of nevus sebaceus with multiple appendage tumors on the scalp of a 43-year-old male. The exudative inflamed patches were admixed with darkly pigmented small nodules which had developed secondarily within a 4.0 × 1.5cm lesion 2 years previously. Histologically, on serial sectioning, there were various types of basal cell carcinoma, syringocystadenoma papilliferum, tubular apocrine adenoma and sebaceous adenoma. Some parts of a biopsy specimen, showed a tumor of the follicular infundibulum-like epidermal changes. There were also calcium depositions in the stroma and apocrine tumors, There was no relapse at 1-year follow-up after surgical treatment.
Adenoma ; Adult ; Biopsy ; Calcium ; Carcinoma, Basal Cell ; Follow-Up Studies ; Hamartoma ; Humans ; Male ; Nevus* ; Recurrence ; Scalp

A 63-year-old Korean man presented with generalized, asymptomatic, discrete papules and coalescent annular plaques for one year. Interestingly, the patient complained of conjunctival congestion, concurrently with aggravation of the skin lesion. Histopathologic findings of the skin lesion and conjunctiva revealed giant cells engulfing fragmented elastic fibers, and a diagnosis of actinic granuloma with ocular involvement was made. Ten months later, the patient revisited with a two-week history of bilateral temporal headache, neck pain, intermittent jaw claudication, and blurred vision. Biopsy of the temporal artery confirmed the clinical diagnosis of temporal arteritis. Both actinic granuloma and temporal arteritis show similar pathologic process, and this case supports the hypothesis that actinically degenerated elastic tissue is likely to be the antigenic basis of actinic granuloma of the skin and temporal arteritis.
Actins* ; Biopsy ; Conjunctiva ; Diagnosis ; Elastic Tissue ; Estrogens, Conjugated (USP) ; Giant Cell Arteritis* ; Giant Cells ; Granuloma* ; Headache ; Humans ; Jaw ; Middle Aged ; Neck Pain ; Skin ; Temporal Arteries

Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies, which result in congenital heart block or cutaneous eruptions similar to lesions of subacute cutaneous lupus erythematosus. We report a case of a 29 day-old-male infant who presented with multiple, targetoid lesions with an edematous margin on the scalp, face, neck, and extremities. His serological tests revealed high titers of anti-La/SSB and antinuclear antibodies. His healthy mother also showed the same high titer of antibodies. Yet, the anti-Ro/SSA antibodies were negative in both of them.
Antibodies ; Antibodies, Antinuclear ; Autoantibodies ; Extremities ; Heart Block ; Humans ; Infant ; Lupus Erythematosus, Cutaneous ; Mothers ; Neck ; Scalp ; Serologic Tests