This case report demonstrates correction of functional occlusion in a patient with unilateral cleft lip and palate, achieved through nonsurgical orthodontic treatment. An 18-year-old male with unilateral cleft lip and palate presented with posterior occlusion collapse, attributed to the lateral collapse of the right maxillary arch, severe lingual inclination of mandibular molars, and multiple missing teeth. With the usage of fixed orthodontic appliances and mini-implant anchors, functional posterior occlusion, proper anterior overjet, and improved soft tissue profile was achieved. This case exemplifies the impact of specialized orthodontic care in enhancing both function and aesthetics for patients with congenital oral conditions.