1.Assessment of Dental Noise Environment of a Pediatric Dentist
Hyeonmin CHO ; Ik-Hwan KIM ; Seunghyun CHO ; Je Seon SONG ; Jaeho LEE
Journal of Korean Academy of Pediatric Dentistry 2021;48(2):209-220
The noise is defined as unwanted sound that causes discomfort and physical changes. This study was conducted to evaluate intensity of noise in the pediatric dental clinic and to investigate noise environment of a pediatric dentist. Human ear shaped microphone and mobile noise level meter were used for recording noise and calculating intensity of noise.
By recording according to the method specified by Korea Occupational Safety and Health Agency (KOSHA) of Korea Ministry of labor and employment, the following results were obtained. For 16 experimental days, 8 hour time weighted average (8hr-TWA) was 49.33 dBA (A-weighted deci-Bell) on daily average with maximum 58.54 dBA and minimum 33.97 dBA. And Dose was 0.49% on daily average with maximum 1.28%, minimum 0.04%. These values are less than criteria of KOSHA standard (85 dBA, 100%). Comparing the highest noise level for each patient, pulp therapy group and Frankel grade I group were the highest.
The intensity of dental noise of pediatric dental clinic didn’t meet standard of KOSHA. It is necessary to re-evaluate noise environment by establishing new standards considering environment of pediatric dental clinic.
2.Effects of Essential Oil Containing Mouth Rinse in Children with Black Staining : Two Case Reports
Hyeonmin CHO ; Ik-Hwan KIM ; Chung-Min KANG ; Hyunjin CHUNG ; Jaeho LEE
Journal of Korean Academy of Pediatric Dentistry 2021;48(4):484-489
Black staining of the teeth in children and adolescents does not cause pain or serious illness, but it can be socially debilitating for esthetic reasons. Black staining is easily removed through periodic professional mechanical tooth cleaning and ultrasonic scaling, but it can easily recur within few months. Using essential oil-containing mouth rinses diluted at 50% twice per day could prevent the black staining from returning after it is removed, reducing the need for mechanical treatments and improving esthetics.
3.Primary Pancreatic Candidiasis Mimicking Pancreatic Cancer in an Immunocompetent Patient
Chung Hyoun KIM ; Hyeonmin LEE ; Chang Gok WOO ; Joung-Ho HAN ; Hanlim CHOI ; Seon Mee PARK
The Korean Journal of Gastroenterology 2021;77(1):45-49
Pancreatic candidiasis can develop in patients with acute pancreatitis, compromised immune responses, or iatrogenic intervention. This paper reports a case of pancreatic candidiasis presenting as a solid pancreatic mass in a patient without the risk factors. A previously healthy 37-year-old man visited the emergency department with left flank pain. Abdominal CT revealed a 5 cm, irregular heterogeneous enhancing mass accompanied by a left adrenal mass. Positron emission tomography-computed tomography and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) could not discriminate pancreatic cancer from infectious disease. A laparoscopic exploration was performed for an accurate diagnosis. After distal pancreatectomy with splenectomy and left adrenalectomy, pancreatic candidiasis and adrenal cortical adenoma were diagnosed based on the pathology findings. His condition improved after the treatment with fluconazole. This paper reports a case of primary pancreatic candidiasis mimicking pancreatic cancer in an immunocompetent patient with a review of the relevant literature.
4.Short- and long-term outcomes of local excision with adjuvant radiotherapy in high-risk T1 rectal cancer patients
Abdullah AL-SAWAT ; Jung Hoon BAE ; Hyun Ho KIM ; Chul Seung LEE ; Seung Rim HAN ; Yoon Suk LEE ; HyeonMin CHO ; Hong Seok JANG ; In Kyu LEE
Annals of Surgical Treatment and Research 2022;102(1):36-45
Purpose:
The standard of care for early rectal cancer is radical surgery; however, it carries high postoperative morbidity. This study aimed to assess the short-term and oncological outcomes of local excision and adjuvant radiotherapy in patients with high-risk pathological stage (p) T1 rectal cancer.
Methods:
Fifty-five patients underwent local excision with adjuvant radiotherapy or radical resection for high-risk T1 rectal cancer. Patients with adenocarcinoma within 10 cm from the anal verge; pT1 with high-risk features (grade 3–4); a tumor size of ≥3 cm; a positive margin; a lymphovascular or perineural invasion; or a submucosal invasion depth of ≥SM2 were included.
Results:
The rates of postoperative complications and stoma formation were higher in the radical surgery group (P = 0.021 and P = 0.003, respectively). No significant differences were observed in the overall survival and disease-free survival (DFS) between the 2 groups (P = 0.301 and P = 0.076, respectively). Vascular invasion was a significantly poor prognostic factor for DFS (P = 0.033). The presence of 3 or more high-risk features was associated with a poor DFS (P = 0.002).
Conclusion
Local excision with adjuvant radiotherapy significantly reduces the risk of complications and stoma formation. It is also an alternative option for patients with fewer than 3 high-risk features.
5.Structural Insights for β-Lactam Antibiotics
Dogyeoung KIM ; Sumin KIM ; Yongdae KWON ; Yeseul KIM ; Hyunjae PARK ; Kiwoong KWAK ; Hyeonmin LEE ; Jung Hun LEE ; Kyung-Min JANG ; Donghak KIM ; Sang Hee LEE ; Lin-Woo KANG
Biomolecules & Therapeutics 2023;31(2):141-147
Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription antibiotic market. They inhibit the synthesis of the peptidoglycan layer in the bacterial cell wall by mimicking the D-Ala-D-Ala in the pentapeptide crosslinking neighboring glycan chains. To date, various β-lactam antibiotics have been developed to increase the spectrum of activity and evade drug resistance. This review emphasizes the three-dimensional structural characteristics of β-lactam antibiotics regarding the overall scaffold, working mechanism, chemical diversity, and hydrolysis mechanism by β-lactamases. The structural insight into various β-lactams will provide an in-depth understanding of the antibacterial efficacy and susceptibility to drug resistance in multidrug-resistant bacteria and help to develop better β-lactam antibiotics and inhibitors.
6.Duodenal Loop Obstruction as an Unusual Cause of Acute Pancreatitis: A Case Series.
Hyeonmin LEE ; Yonghyeok CHOI ; Hyewon JEONG ; Jae Kyu LIM ; Taeyoung JUNG ; Joung Ho HAN ; Seon Mee PARK
The Korean Journal of Gastroenterology 2016;68(6):326-330
Duodenal loop obstruction is an unusual cause of acute pancreatitis. Increased intraluminal pressure hinders pancreatic flow, causing dilatation of the pancreatic duct and inducing acute pancreatitis. We experienced three cases of acute pancreatitis that resulted from duodenal loop obstruction after (1) an esophagectomy with gastric pull-up procedure for esophageal cancer, (2) a gastrectomy with Billroth I reconstruction for gastric cancer, and (3) a gastrojejunostomy for abdominal trauma. An abdominal CT scan revealed a distended duodenal loop, dilated pancreatic duct, and inflamed pancreas with fluid collection. Acute pancreatitis with duodenal loop obstruction was diagnosed by abdominal pain, elevated serum amylase/lipase, and abdominal CT findings. Immediate decompression with a nasogastric tube was performed, and all patients showed improvement within one week after admission. Each patient was followed up for more than two years without recurrence. Our findings suggest the usefulness of nasogastric tube decompression as the first line of treatment for acute pancreatitis related to duodenal loop obstruction.
Abdominal Pain
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Decompression
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Dilatation
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Duodenal Obstruction
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Esophageal Neoplasms
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Esophagectomy
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Gastrectomy
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Gastric Bypass
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Gastroenterostomy
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Humans
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Pancreas
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Pancreatic Ducts
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Pancreatitis*
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Recurrence
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Stomach Neoplasms
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Tomography, X-Ray Computed