1.Causes of necrotic features in fine-needle aspirates from cervical lymph nodes
Young Jin SEO ; Hyeongchan SHIN ; Hye Won LEE ; Hye Ra JUNG
Journal of Pathology and Translational Medicine 2021;55(1):60-67
Background:
Lymph node fine-needle aspiration (LN FNA) cytology indicates necrosis in various diseases. Dominant necrotic features make the diagnosis of underlying conditions very difficult.
Methods:
We retrospectively reviewed 460 patients who underwent cervical LN aspiration cytology that revealed necrotic findings at Keimyung University Dongsan Hospital in Daegu, Korea, from 2003–2017. Each specimen was evaluated and analyzed in association with the clinical findings, biopsy findings, and/or other ancillary tests, including acid-fast bacilli staining and molecular testing for Mycobacterium tuberculosis.
Results:
When necrotic features were noted upon cervical LN FNA cytology, the most common pathologic LN FNA category was necrosis alone (31.5%). The second most common category was granulomatous inflammation (31.3%), followed by Kikuchi disease (20.0%) and malignant neoplasm (8.7%). In cases where the cervical LN FNA revealed necrosis alone, the most common final diagnosis was tuberculosis. In young patients, Kikuchi disease should be considered as one cervical LN FNA category, while metastatic carcinoma should be suspected in older patients.
Conclusions
Even when necrosis alone is observed in LN FNA cytology, it is important to determine the cause through further evaluation.
2.Strategic model of national rabies control in Korea.
Yeotaek CHEONG ; Bongjun KIM ; Ki Joong LEE ; Donghwa PARK ; Sooyeon KIM ; Hyeoncheol KIM ; Eunyeon PARK ; Hyeongchan LEE ; Chaewun BAE ; Changin OH ; Seung Yong PARK ; Chang Seon SONG ; Sang Won LEE ; In Soo CHOI ; Joong Bok LEE
Clinical and Experimental Vaccine Research 2014;3(1):78-90
Rabies is an important zoonosis in the public and veterinary healthy arenas. This article provides information on the situation of current rabies outbreak, analyzes the current national rabies control system, reviews the weaknesses of the national rabies control strategy, and identifies an appropriate solution to manage the current situation. Current rabies outbreak was shown to be present from rural areas to urban regions. Moreover, the situation worldwide demonstrates that each nation struggles to prevent or control rabies. Proper application and execution of the rabies control program require the overcoming of existing weaknesses. Bait vaccines and other complex programs are suggested to prevent rabies transmission or infection. Acceleration of the rabies control strategy also requires supplementation of current policy and of public information. In addition, these prevention strategies should be executed over a mid- to long-term period to control rabies.
Acceleration
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Korea*
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Rabies*
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Raccoon Dogs
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Vaccines