Objectives: The purpose of this study was to explore the relationships among obstructive sleep apnea (OSA), dyspnea, and health-related quality of life (HRQOL), as well as the factorsinfluencing HRQOL. Methods: A total of 129 lung cancer survivors (mean age, 53.4 years; 77 men and 52 women; mean time since diagnosis, 1.6 years; and cancer stage [1/2/3/4/relapse], 43/31/19/34/2, respectively) completed a questionnaire that included demographic and clinical information, as well as questions about the severity of sleep apnea, dyspnea, and HRQOL. The severity of OSA, dyspnea, and HRQOL were assessed using the Berlin questionnaire, the Dyspnea-10 item (FACIT-Dyspnea), and the European Organization for Research and Treatment of Cancer QLQ-C30, respectively. Results: The severity of OSA and dyspnea exhibited negative correlations with HRQOL (p < 0.05).Multiple regression analysis revealed that several factors significantly impacted the HRQOLof lung cancer survivors. These included the extent of dyspnea (β = –0.369, p < 0.01), weight loss (β = 0.192, p < 0.01), OSA score (β = −0.215, p < 0.01), stage 2 cancer (β = −0.181, p < 0.01), and poor perceived health status (β = −0.179, p < 0.05). Conclusion These findings suggest that breathing difficulties, including OSA and dyspnea, contribute to decreased HRQOL. This study offers valuable insights for researchers and clinicians, aiding in the development of effective strategies to manage these issues in daily life.

Objectives: The purpose of this study was to explore the relationships among obstructive sleep apnea (OSA), dyspnea, and health-related quality of life (HRQOL), as well as the factorsinfluencing HRQOL. Methods: A total of 129 lung cancer survivors (mean age, 53.4 years; 77 men and 52 women; mean time since diagnosis, 1.6 years; and cancer stage [1/2/3/4/relapse], 43/31/19/34/2, respectively) completed a questionnaire that included demographic and clinical information, as well as questions about the severity of sleep apnea, dyspnea, and HRQOL. The severity of OSA, dyspnea, and HRQOL were assessed using the Berlin questionnaire, the Dyspnea-10 item (FACIT-Dyspnea), and the European Organization for Research and Treatment of Cancer QLQ-C30, respectively. Results: The severity of OSA and dyspnea exhibited negative correlations with HRQOL (p < 0.05).Multiple regression analysis revealed that several factors significantly impacted the HRQOLof lung cancer survivors. These included the extent of dyspnea (β = –0.369, p < 0.01), weight loss (β = 0.192, p < 0.01), OSA score (β = −0.215, p < 0.01), stage 2 cancer (β = −0.181, p < 0.01), and poor perceived health status (β = −0.179, p < 0.05). Conclusion These findings suggest that breathing difficulties, including OSA and dyspnea, contribute to decreased HRQOL. This study offers valuable insights for researchers and clinicians, aiding in the development of effective strategies to manage these issues in daily life.

Objectives: The purpose of this study was to explore the relationships among obstructive sleep apnea (OSA), dyspnea, and health-related quality of life (HRQOL), as well as the factorsinfluencing HRQOL. Methods: A total of 129 lung cancer survivors (mean age, 53.4 years; 77 men and 52 women; mean time since diagnosis, 1.6 years; and cancer stage [1/2/3/4/relapse], 43/31/19/34/2, respectively) completed a questionnaire that included demographic and clinical information, as well as questions about the severity of sleep apnea, dyspnea, and HRQOL. The severity of OSA, dyspnea, and HRQOL were assessed using the Berlin questionnaire, the Dyspnea-10 item (FACIT-Dyspnea), and the European Organization for Research and Treatment of Cancer QLQ-C30, respectively. Results: The severity of OSA and dyspnea exhibited negative correlations with HRQOL (p < 0.05).Multiple regression analysis revealed that several factors significantly impacted the HRQOLof lung cancer survivors. These included the extent of dyspnea (β = –0.369, p < 0.01), weight loss (β = 0.192, p < 0.01), OSA score (β = −0.215, p < 0.01), stage 2 cancer (β = −0.181, p < 0.01), and poor perceived health status (β = −0.179, p < 0.05). Conclusion These findings suggest that breathing difficulties, including OSA and dyspnea, contribute to decreased HRQOL. This study offers valuable insights for researchers and clinicians, aiding in the development of effective strategies to manage these issues in daily life.

Objectives: The purpose of this study was to explore the relationships among obstructive sleep apnea (OSA), dyspnea, and health-related quality of life (HRQOL), as well as the factorsinfluencing HRQOL. Methods: A total of 129 lung cancer survivors (mean age, 53.4 years; 77 men and 52 women; mean time since diagnosis, 1.6 years; and cancer stage [1/2/3/4/relapse], 43/31/19/34/2, respectively) completed a questionnaire that included demographic and clinical information, as well as questions about the severity of sleep apnea, dyspnea, and HRQOL. The severity of OSA, dyspnea, and HRQOL were assessed using the Berlin questionnaire, the Dyspnea-10 item (FACIT-Dyspnea), and the European Organization for Research and Treatment of Cancer QLQ-C30, respectively. Results: The severity of OSA and dyspnea exhibited negative correlations with HRQOL (p < 0.05).Multiple regression analysis revealed that several factors significantly impacted the HRQOLof lung cancer survivors. These included the extent of dyspnea (β = –0.369, p < 0.01), weight loss (β = 0.192, p < 0.01), OSA score (β = −0.215, p < 0.01), stage 2 cancer (β = −0.181, p < 0.01), and poor perceived health status (β = −0.179, p < 0.05). Conclusion These findings suggest that breathing difficulties, including OSA and dyspnea, contribute to decreased HRQOL. This study offers valuable insights for researchers and clinicians, aiding in the development of effective strategies to manage these issues in daily life.

Objectives: The purpose of this study was to explore the relationships among obstructive sleep apnea (OSA), dyspnea, and health-related quality of life (HRQOL), as well as the factorsinfluencing HRQOL. Methods: A total of 129 lung cancer survivors (mean age, 53.4 years; 77 men and 52 women; mean time since diagnosis, 1.6 years; and cancer stage [1/2/3/4/relapse], 43/31/19/34/2, respectively) completed a questionnaire that included demographic and clinical information, as well as questions about the severity of sleep apnea, dyspnea, and HRQOL. The severity of OSA, dyspnea, and HRQOL were assessed using the Berlin questionnaire, the Dyspnea-10 item (FACIT-Dyspnea), and the European Organization for Research and Treatment of Cancer QLQ-C30, respectively. Results: The severity of OSA and dyspnea exhibited negative correlations with HRQOL (p < 0.05).Multiple regression analysis revealed that several factors significantly impacted the HRQOLof lung cancer survivors. These included the extent of dyspnea (β = –0.369, p < 0.01), weight loss (β = 0.192, p < 0.01), OSA score (β = −0.215, p < 0.01), stage 2 cancer (β = −0.181, p < 0.01), and poor perceived health status (β = −0.179, p < 0.05). Conclusion These findings suggest that breathing difficulties, including OSA and dyspnea, contribute to decreased HRQOL. This study offers valuable insights for researchers and clinicians, aiding in the development of effective strategies to manage these issues in daily life.

PURPOSE: To report a case of intralenticular triamcinolone complicated by intravitreal triamcinolone acetonide (IVTA) injection. METHODS: A 56-year-old man who presented with lens opacity in the right eye following IVTA injection as a treatment for the central retinal vein occlusion with macular edema was referred to our clinic. RESULTS: The visual acuity in his right eye was hand motion, which was not corrected. A slit lamp examination showed that the intralenticular crystalloid powder in the right eye was likely triamcinolone acetonide. Intralenticular crystalloid powder was detected during the phacoemulsification and the posterior capsule of the lens had been already ruptured. CONCLUSIONS: Lens opacity can be complicated by IVTA through intralenticular injection of triamcinolone acetonide.
Cataract ; Hand ; Humans ; Macular Edema ; Middle Aged ; Phacoemulsification ; Posterior Capsule of the Lens ; Retinal Vein ; Triamcinolone Acetonide* ; Triamcinolone* ; Visual Acuity

PURPOSE: As a sedative hypnotic agent, etomidate has a little side effect like respiratory depression and has an excellent pharmacokinetics and hemodynamics. The objective of this study is comparison of etomidate effect in the two groups, only lidocaine injection group and combinational administration group, during closed thoracostomy in the emergency department. METHODS: The patients with respiratory problems, which needed a closed thoracostomy, from March 1, 2003 to February 29, 2004 were enrolled in this prospective study. Thus, we were enrolled 68 patients. etomidate were used for 34 patients and only lidocaine local injection was used for 34 patients. Patients of combinational administration were randomized to receive intravenous boluses of etomidate (0.2 mg/kg) prior to fentanyl (1.0 ug/kg) during PSA (procedural sedation anesthesia). We recorded pre-administration and interval of 5 minute, 10 minute, 15 minute and transcutaneous oxygen saturation, heart rate, respiratory rate, blood pressure, degree of sedation, satisfaction of sedation, and side effects after administration. RESULTS: Of all combinational administration group, significant hemodynamic, as hypotension or bradycardia etc. and respiratory depression, as apnea or tachypnea etc. were absent. With comparison of two groups, significant clinical problems and statistics were not different and degree of sedation was fast and impaired conscious was effective in the combinational administration group. CONCLUSION: We conclude combinational administration with etomidate and fentanyl during procedural sedation is safty and excellent effectiveness. Therefore we recommened the use of etomidate for emergency procedural sedation in emergency department.
Apnea ; Blood Pressure ; Bradycardia ; Emergencies ; Emergency Service, Hospital ; Etomidate* ; Fentanyl* ; Heart Rate ; Hemodynamics ; Humans ; Hypnotics and Sedatives* ; Hypotension ; Lidocaine ; Oxygen ; Pharmacokinetics ; Prospective Studies ; Respiratory Insufficiency ; Respiratory Rate ; Tachypnea ; Thoracostomy*

This study is an attempt to investigate the effect of total Ginseng saponin (GTS) on the blood pressure of the rat and to elucidate its mechanism of action. GTS, when injeced into a femoral vein of the rat, caused dose-related fall in blood pressure with secondarily elevation of the blood pressure. The depressor effect of GTS was blocked by treatment of atropine and prazosin, but not affected by pretreatment with chlorisondamine or cyproheptadine. GTS inhibited significantly the pressor response evoked by norepinephrine. The pressor effect of GTS was not affected by treatment with atropine or cyproheptadine, but was attenuated markedly by pretreatment with chlorisondamine. From the above mentioned results, it is thought that GTS produces the pressor and the depressor actions in the rat, and that its depressor response is exerted partly through the stimulation of cholinergic muscaric receptors with the blockade of adrenergic alpha-receptors, and that its pressor response is revealed by stimulation of nicotinic receptors in autonomic ganglia.
Animals ; Atropine ; Blood Pressure* ; Chlorisondamine ; Cyproheptadine ; Femoral Vein ; Ganglia, Autonomic ; Norepinephrine ; Panax* ; Prazosin ; Rats* ; Receptors, Adrenergic, alpha ; Receptors, Nicotinic ; Saponins*

Polymicrobial peritonitis is a relatively uncommon complication and it's clinical characteristics, risk factor and optimal managernent remain controversial. To identify indications for catheter removal in polymicrobial peritonitis, we reviewed the 340 episodes that occured in 168 patients of CAPD peritonitis during past 7 years to identify those. Polymicribial peritonitis was the 18 epoisodes in 18 patients of all peritonitis. First, 18 patients with polymicrobial peritonitis (P-P) did not show significant differences in the demographic features compared to 130 patients with single organism peritonitis (S-P). In contrast to Staphylococcus in S-P, the most common causative organisrn in P-P was pseudomonas (23%). Also sgnificantly more catheters were removed in P-P than S-P (P=0.001). Second, we cornpared group I, the patients responded to antibiotics only, and group II, those who needed catheter removal. The group I was 7 (39%) and the group II was 11 (61%). No patient of group I died and two patients of group II died. Between group I and group II, there were no significant differences in the demographic features. However, patients whose dialysate-WBC counts were below 100 at 3rd day after start of antibiotics were more significantly frequent in group I than group II. Among combination of causative organisms in P-P, most of Pseudornonas (6/9) and fungus (4/4) were treated by catheter removal. In conclusion, more catheters were removed in P-P than S-P. When dialysate WBC at 3rd day after start of antibiotics were over 100 and causative organism included pseudomonas or fungus in P-P, catheter removal was needed. We suggest that the kinds of organisms isolated and early response to antibiotics influence on the outcome of polymicrobial peritonitis.
Anti-Bacterial Agents ; Catheters* ; Fungi ; Humans ; Peritoneal Dialysis, Continuous Ambulatory* ; Peritonitis* ; Pseudomonas ; Risk Factors ; Staphylococcus

We have experienced a case of aortic dissecting aneurysm in pregnant woman. She felt initially severe chest pain which was radiated to the neck on the 3days before delivery. Thereafter dyspnea and generalized edema were developed for 1 month after delivery. She was diagnosed as aortic dissectLn, Debakey type-II. During cardiopulmonary bypass, the selective cerebral perfusion was done through the right and left commom carotid arteries. Aortic replacement with Hemashield vascular graft and reimplantation of innominate artery, resuspension of aortic valve, repair of intimal tear were performed. The postoperative course was uneventful.
Aneurysm, Dissecting ; Aortic Valve ; Brachiocephalic Trunk ; Cardiopulmonary Bypass ; Carotid Arteries ; Chest Pain ; Dyspnea ; Edema ; Female ; Humans ; Neck ; Perfusion ; Pregnant Women* ; Replantation ; Tears ; Transplants