No abstract available.
Neck*

No Abstract Available.
Chondrocytes* ; Phenotype*

Although toothpick ingestion is rare, it can lead to fatal complications in the gastrointestinal tract. Diagnosing toothpick ingestion is difficult because most patients do not recall swallowing one. We report 2 cases of toothpick-ingestion-induced colon injury, mimicking diverticulitis. The first patient was a 47-year-old male who had received conservative treatment under the impression of his having diverticulitis in the cecum. Ultrasonography revealed a linear foreign body in the right lower abdomen; a subsequent laparoscopic examination revealed inflammation around the cecum, but no evidence of bowel perforation. A thorough investigation revealed a toothpick embedded in the subcutaneous fat and muscle layer of the lower abdominal wall; we removed it. The second patient was a 56-year-old male who had received conservative treatment under the impression of his having diverticulitis in the sigmoid colon. An explorative laparotomy revealed a toothpick piercing the sigmoid colon; we performed an anterior resection. Both patients were discharged without postoperative complications.
Abdomen ; Abdominal Wall ; Cecum ; Colon* ; Colon, Sigmoid ; Deglutition ; Diverticulitis ; Diverticulitis, Colonic* ; Eating ; Foreign Bodies ; Gastrointestinal Tract ; Humans ; Inflammation ; Laparotomy ; Male ; Middle Aged ; Postoperative Complications ; Subcutaneous Fat ; Ultrasonography

Bethanechol, a cholinergic agonist, has been recommended for the management of peripheral anticholinergic side effects during the treatment of antipsychotic medications. But there have been few studies which have evaluated the drug interactions of antipsychotics and bethanechol, even the treatment effects of bethanechol on anticholinergic side effects. So the authors have evaluated whether psychopathology and plasma haloperidol and reduced haloperidol concentrations are significantly changed or not when bethanechol was administrated with maintained doses of haloperidol and other coadministrated drugs(such a benztropine). Also we have evaluated the abating effects of bethanechol on anticholinergic side effects during the treatment with haloperidol. Fifteen schizophrenics with higher than 5 of total score of anticholinergic side effects of 'Rating scale for side effect' were assigned to two groups, and bethanechol 30mg/day and 60mg/day were applied on each group for 4 weeks. The daily haloperidol dosages were fixed before 2 weeks of study. We assessed anticholinergic side effects by 'Rating scale for side effect' and psychopathology by BPRS, and plasma haloperidol and reduced haloperidol concentrations by HPLC at baseline, 2nd week and 4th week. The results were as followed. 1) There was no significant change of plasma haloperidol and reduced haloperidol concentration. 2) At baseline, the dosage of haloperidol showed significant correlation with the total score of anticholinergic side effect, but not at 2nd week and 4th week. 3) In 60mg/day group, dry mouth and the total score of anticholinergic side effects were significantly improved, but not in 30mg/day group. 4) There was no significant change of BPRS except withdrawal at 2nd week. These results suggest that coadministration of bethanechol influenced neither on psychopathology nor on plasma haloperidol and reduced haloperidol concentrations and that improved dry mouth and total score of anticholinergic side effects at 60mg/day.
Antipsychotic Agents ; Bethanechol* ; Cholinergic Agonists ; Chromatography, High Pressure Liquid ; Drug Interactions ; Haloperidol* ; Mouth ; Plasma* ; Psychopathology ; Schizophrenia

Nuclear cardiology, similar to other fields of nuclear medicine, has experience rapid advancements. Myocardial perfusion imaging (MPI), an important component of nuclear cardiology that commenced in the 1970s, plays a crucial role in the non-invasive evaluation and management of coronary artery disease. Over the past decade, MPI has witnessed significant changes and advancements. The introduction of gamma cameras using cadmium zinc telluride (CZT) systems, accompanied by advancements in related software, represents a notable development in this nuclear cardiology. Ongoing research and development effects are actively exploring new radiopharmaceuticals, with a particular focus on their application in positron emission tomography (PET)-MPI. Furthermore, studies have been conducted highlighting the necessity and benefits of hybrid imaging. However, as with other cutting-edge technologies, the practical application of the latest equipment and techniques in nuclear cardiology faces challenges stemming from their high costs of equipment and examinations and limited accessibility, which continue to remain significant barriers in nuclear medicine.

Nuclear cardiology, similar to other fields of nuclear medicine, has experience rapid advancements. Myocardial perfusion imaging (MPI), an important component of nuclear cardiology that commenced in the 1970s, plays a crucial role in the non-invasive evaluation and management of coronary artery disease. Over the past decade, MPI has witnessed significant changes and advancements. The introduction of gamma cameras using cadmium zinc telluride (CZT) systems, accompanied by advancements in related software, represents a notable development in this nuclear cardiology. Ongoing research and development effects are actively exploring new radiopharmaceuticals, with a particular focus on their application in positron emission tomography (PET)-MPI. Furthermore, studies have been conducted highlighting the necessity and benefits of hybrid imaging. However, as with other cutting-edge technologies, the practical application of the latest equipment and techniques in nuclear cardiology faces challenges stemming from their high costs of equipment and examinations and limited accessibility, which continue to remain significant barriers in nuclear medicine.

Nuclear cardiology, similar to other fields of nuclear medicine, has experience rapid advancements. Myocardial perfusion imaging (MPI), an important component of nuclear cardiology that commenced in the 1970s, plays a crucial role in the non-invasive evaluation and management of coronary artery disease. Over the past decade, MPI has witnessed significant changes and advancements. The introduction of gamma cameras using cadmium zinc telluride (CZT) systems, accompanied by advancements in related software, represents a notable development in this nuclear cardiology. Ongoing research and development effects are actively exploring new radiopharmaceuticals, with a particular focus on their application in positron emission tomography (PET)-MPI. Furthermore, studies have been conducted highlighting the necessity and benefits of hybrid imaging. However, as with other cutting-edge technologies, the practical application of the latest equipment and techniques in nuclear cardiology faces challenges stemming from their high costs of equipment and examinations and limited accessibility, which continue to remain significant barriers in nuclear medicine.

The increasing prevalence of obesity globally underscores its pivotal role in the development of colorectal cancer (CRC). Epidemiological evidence consistently correlates obesity with CRC, implicating intricate pathways such as insulin resistance, chronic inflammation, and hormonal dysregulation. Understanding the impact of obesity on CRC recurrence, therapeutic efficacy, and overall survival is paramount. Lifestyle modifications, including weight reduction, offer promising avenues for mitigating CRC risk. Recognizing obesity as a modifiable risk factor highlights its importance in shaping CRC prevention and therapeutic paradigms.