1.Photodynamic Therapy with Verteporfin for Subfoveal Choroidal Neovascularization in Vogt-Koyanagi-Harada Syndrome.
Won Hyuck OH ; Hyeong Gon YU ; Hum CHUNG
Journal of the Korean Ophthalmological Society 2004;45(5):869-874
PURPOSE: We present a case of photodynamic therapy (PDT) with verteporfin for choroidal neovascularization (CNV) complicated by Vogt-Koyanagi-Harada syndrome. METHODS: A 46-year-old male who had bilateral subfoveal CNV complicated by Vogt-Koyanagi-Harada syndrome underwent 3 sessions of PDT with verteporfin in 1 year. RESULTS: After 3 sessions of PDT with verteporfin, maintenance of visual acuity was achieved without any complication as alteration of retinal pigment epithelium and aggravation of intraocular inflammation, but subfoveal fibrosis developed. CONCLUSIONS: PDT with verteporfin is a good treatment method without any complication for the CNV complicated by Vogt-Koyanagi-Harada syndrome, even though multiple sessions were needed.
Choroid*
;
Choroidal Neovascularization*
;
Fibrosis
;
Humans
;
Inflammation
;
Male
;
Middle Aged
;
Photochemotherapy*
;
Retinal Pigment Epithelium
;
Uveomeningoencephalitic Syndrome*
;
Visual Acuity
2.Recurrence of Retinal Detachment after Scleral Buckle Removal
Kyung Won KIM ; Un Chul PARK ; Hyeong Gon YU
Korean Journal of Ophthalmology 2020;34(6):454-461
Purpose:
To investigate the indications for scleral buckle removal and the risk factors for the recurrence of rhegmatogenous retinal detachment after scleral buckle removal.
Methods:
In this retrospective study, the medical records of all patients who underwent scleral buckle removal for the treatment of rhegmatogenous retinal detachment were reviewed.
Results:
Forty eyes (40 patients) were included in this study. The indications for scleral buckle removal included exposure without infection in 23 eyes (57.5%), exposure with infection in seven eyes (17.5%), elevated intraocular pressure in six eyes (15.0%), strabismus or diplopia in three eyes (7.5%), and migration of buckle material in one eye (2.5%). After the removal of the scleral buckle, the recurrence of rhegmatogenous retinal detachment was observed in four eyes (10.0%) during follow-up, and the retina was successfully reattached after pars plana vitrectomy in all the eyes. Most clinical and ocular factors of the eyes with and without the recurrence of retinal detachment during follow-up were not different, but the eyes that underwent encircling removal were more likely to have retinal detachment recurrence during follow-up than those that underwent segmental buckle removal (n = 4 / 16 [25.0%] vs. n = 0 / 24 [0.0%]; p = 0.020).
Conclusions
Scleral buckle removal can result in the recurrence of retinal detachment. The benefits and risks of scleral buckle removal should be carefully considered before surgery, and extensive monitoring during follow-up after scleral buckle removal is important, especially for patients who underwent encircling removal.
3.Recurrence of Retinal Detachment after Scleral Buckle Removal
Kyung Won KIM ; Un Chul PARK ; Hyeong Gon YU
Korean Journal of Ophthalmology 2020;34(6):454-461
Purpose:
To investigate the indications for scleral buckle removal and the risk factors for the recurrence of rhegmatogenous retinal detachment after scleral buckle removal.
Methods:
In this retrospective study, the medical records of all patients who underwent scleral buckle removal for the treatment of rhegmatogenous retinal detachment were reviewed.
Results:
Forty eyes (40 patients) were included in this study. The indications for scleral buckle removal included exposure without infection in 23 eyes (57.5%), exposure with infection in seven eyes (17.5%), elevated intraocular pressure in six eyes (15.0%), strabismus or diplopia in three eyes (7.5%), and migration of buckle material in one eye (2.5%). After the removal of the scleral buckle, the recurrence of rhegmatogenous retinal detachment was observed in four eyes (10.0%) during follow-up, and the retina was successfully reattached after pars plana vitrectomy in all the eyes. Most clinical and ocular factors of the eyes with and without the recurrence of retinal detachment during follow-up were not different, but the eyes that underwent encircling removal were more likely to have retinal detachment recurrence during follow-up than those that underwent segmental buckle removal (n = 4 / 16 [25.0%] vs. n = 0 / 24 [0.0%]; p = 0.020).
Conclusions
Scleral buckle removal can result in the recurrence of retinal detachment. The benefits and risks of scleral buckle removal should be carefully considered before surgery, and extensive monitoring during follow-up after scleral buckle removal is important, especially for patients who underwent encircling removal.
4.2DSpotDB: A Database for the Annotated Two-dimensional Polyacrylamide Gel Electrophoresis of Pathogen Proteins.
Dae Won KIM ; Won Gi YOO ; Myoung Ro LEE ; Yu Jung KIM ; Shin Hyeong CHO ; Won Ja LEE ; Jung Won JU
Genomics & Informatics 2011;9(4):197-199
The biological interpretation of two-dimensional (2D) gel electrophoresis experiments is a key step toward understanding the functions of biological systems. We here present a web-based integrated database, called 2DSpotDB, for the management of proteome data derived from several pathogens. The 2DSpotDB was established as a part of the management of a pathogen proteome project at the Korea National Institute of Health. The goals of the 2DSpotDB implementation are to store and define important pathogen genes, retrieve information obtained by 2D polyacrylamide gel electrophoresis and mass spectrometry, and create an integrated system to provide pathogen proteome information for biological scientists. This database currently contains 14 gels and information on 387 protein spots, among which 329 proteins were identified and annotated.
Acrylic Resins
;
Data Mining
;
Electrophoresis
;
Electrophoresis, Gel, Two-Dimensional
;
Electrophoresis, Polyacrylamide Gel
;
Gels
;
Korea
;
Mass Spectrometry
;
Proteins
;
Proteome
5.Chronic Subdural Hematoma in Young Adult: An Age Comparison Study.
Yu Deok WON ; Hyeong Joong YI ; Young Jun LEE ; Hyoung Joon CHUN ; Hyun CHO ; Koang Hum BAK
Korean Journal of Neurotrauma 2013;9(1):6-11
OBJECTIVE: Incidence of chronic subdural hematoma (CSDH) is gradually increasing in young adults for several reasons. In this study, we aimed to identify features of CSDH noted in young adults that distinguish the disease from CSDH diagnosed in the elderly. METHODS: One hundred eighty-two patients with CSDH who underwent a total of 218 surgical procedures between January 2003 and February 2010 were retrospectively reviewed with regard to clinical presentation, radiographic results and prognosis including recurrence. To compare younger patients with the elderly, patients were divided into three groups on the basis of age (Group A: < or =40, Group B: 41-64, Group C: > or =65 years). RESULTS: Group A showed a male predominance (p=0.0001), lower rate of recurrence (p=0.0012), shorter symptom duration (p=0.035), and fewer leading signs such as hemispheric symptoms (p=0.005) compared to Groups B and C. Radiologic findings such as maximal hematoma thickness (p<0.0001) and degree of midline shift (p=0.028) were less severe in Group A than Groups B and C. Alcoholism was the most prevalent illness in all three groups. When exempting infants with hematologic malignancy, non-recurrence, previous trauma history, headache as leading symptom, and no mortality were all common in younger adults (all p<0.05). CONCLUSION: Young adults with CSDH show less severe clinical and radiologic features as well as fewer recurrences than noted in the elderly population. Even if a clinician's index of suspicion of CSDH in young adults complaining of headache is not high, meticulous radiologic surveillance could find CSDH, leading to satisfactory results including less frequent recurrence.
Adult
;
Aged
;
Alcoholism
;
Headache
;
Hematologic Neoplasms
;
Hematoma
;
Hematoma, Subdural, Chronic
;
Humans
;
Incidence
;
Infant
;
Male
;
Prognosis
;
Recurrence
;
Retrospective Studies
;
Young Adult
6.Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones.
Hyeong Gon LEE ; Jae Won CHOI ; Yu Jin LEE ; Do Un JEONG
Psychiatry Investigation 2016;13(2):227-231
OBJECTIVE: REM sleep behavior disorder (RBD) is associated with psychiatric symptoms, such as anxiety and alexithymia. However, only a few studies on the relationship between depression and RBD have been published. In this study, we investigated the occurrence of depression and associated factors in patients with RBD. METHODS: In total 94 patients (mean age: 61.9±12.7 years, male: 70.2%) diagnosed as RBD were examined using detailed clinical histories, the Beck Depression Inventory (BDI), the Epworth Sleepiness Scale (ESS), and nocturnal polysomnography (PSG). RESULTS: The mean BDI score of all patients was 12.4±10.3 and 44.7% of RBD patients showed depressed mood (BDI >11 points). Depressed RBD patients were less able to recall enacted dreams than were non-depressed patients (61.9% vs. 86.5%, p=0.008). Logistic regression analysis showed that failure to recall enacted dreams was significantly associated with depression, after controlling for confounding variables including the respiratory disturbance index and a history of psychiatric disorders (odds ratio=0.323, p=0.041). CONCLUSION: In this study, 44.7% of RBD patients were found to suffer from depressed mood. And, depression was found to be associated with reduced ability to recall enacted dreams. We suggest that routine evaluation of depression be performed in RBD patients, particularly when failure to recall enacted dreams is evident. We speculate that such failure may be associated with emotional dysregulation or neurodegeneration.
Affective Symptoms
;
Anxiety
;
Confounding Factors (Epidemiology)
;
Depression
;
Dreams*
;
Humans
;
Logistic Models
;
Male
;
Polysomnography
;
REM Sleep Behavior Disorder*
;
Sleep, REM*
7.Neonatal vitelline vein aneurysm with thrombosis: prompt treatment should be needed.
Soo Hong KIM ; Hyeong Won YU ; Hyun Young KIM ; Heui Seung JO
Annals of Surgical Treatment and Research 2015;89(6):334-337
Vitelline veins are a pair of embryonic structures. The veins develop the portal vein system. Serious problems occur if the vitelline vein does not regress and becomes an aneurysm. Thrombus formation in the vitelline vein aneurysm could lead to portal vein thrombosis and portal hypertension unless promptly and correctly treated. Though vitelline vein aneurysm is an extremely rare anomaly, it rapidly progresses to portal vein thrombosis that requires prompt diagnosis and treatment. We reported a case of neonatal vitelline vein aneurysm and thrombosis that was cured by prompt operation.
Aneurysm*
;
Diagnosis
;
Embryonic Structures
;
Humans
;
Hypertension, Portal
;
Infant, Newborn
;
Portal Vein
;
Thrombosis*
;
Veins*
;
Venous Thrombosis
;
Vitellins*
8.Oncoplastic Thyroid Surgery Using A Bilateral Axillo-Breast Approach.
Chan Yong SEONG ; Hyeong Won YU ; Young Jun CHAI ; Kyu Eun LEE
Journal of Minimally Invasive Surgery 2017;20(2):51-57
Since the first use of the robot da Vinci system for thyroid surgery in 2007, robotic thyroidectomy (RT) via a bilateral axillo-breast approach (BABA) has become a popular surgical alternative for patients who wish to avoid scars on the neck. BABA RT provides excellent cosmetic satisfaction with surgical safety and oncologic completeness. Recently, the use of BABA RT has expanded beyond benign thyroid nodules and small-sized papillary thyroid carcinoma (PTC) to Graves' disease, relatively large PTCs, and PTC with lateral neck metastasis. Unfortunately, there are concerns about the use of this procedure for these additional indications. This review article summarizes postoperative outcomes of BABA RT for thyroid carcinoma, including quality of life, as well as expanding indications for BABA RT.
Cicatrix
;
Graves Disease
;
Humans
;
Laryngeal Nerves
;
Neck
;
Neoplasm Metastasis
;
Quality of Life
;
Robotic Surgical Procedures
;
Thyroid Gland*
;
Thyroid Neoplasms
;
Thyroid Nodule
;
Thyroidectomy
9.The short video lecture for robotic bilateral axillo-breast approach to lateral neck lymph node dissection
Hyeong Won YU ; Jee-Hye CHOI ; Ja Kyung LEE ; Woochul KIM ; June Young CHOI
Journal of Minimally Invasive Surgery 2022;25(2):80-83
Lateral neck lymph node dissection (LND) along with total thyroidectomy is the standard treatment for thyroid cancer patients with metastases to the lateral neck lymph nodes. In general, lateral neck LND removes lymph nodes located at levels II to V ipsilateral to the thyroid cancer and preserves the spinal accessory nerve, internal jugular vein, and sternomastoid muscle during surgery. This video article was written to introduce the robotic bilateral axillo-breast approach for lateral neck LND and to describe the surgical method
10.Observation of changes in quality of life for 5 years after thyroid surgery: an observational cross-sectional study in Korean population
Woochul KIM ; Ja Kyung LEE ; Hyeong Won YU ; Su-jin KIM ; Young Jun CHAI ; June Young CHOI ; Kyu Eun LEE
Annals of Surgical Treatment and Research 2023;105(5):264-270
Purpose:
As thyroid cancer patients are experiencing longer disease-free survival periods, evaluating their quality of life after surgery has become crucial. However, studies on this topic have primarily focused on Western populations, leaving a gap in understanding the Korean patient population’s experiences and needs. This study aims to address this gap and provide insights into the quality of life of thyroid cancer patients in Korea.
Methods:
This cross-sectional study evaluated the quality of life of Korean thyroid cancer patients who underwent thyroid lobectomy or total thyroidectomy. Patients were surveyed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30, ver. 3.0) during outpatient clinic visits from January to September 2015. The results were analyzed by comparing them to scores of the general population and based on the time elapsed since surgery. This approach allowed for a comprehensive evaluation of the quality-of-life outcomes in this patient population.
Results:
The study found that thyroidectomy had a notable impact on patients’ role and cognitive functions. Patients also experienced worsened symptoms such as fatigue, dyspnea, and constipation, which improved over time and returned to normal levels. However, there were no significant changes in other functions and symptoms after surgery.
Conclusion
The study’s findings showed that thyroidectomy had a relatively minor impact on the functional and symptomatic well-being of patients. Therefore, the results suggest that thyroid surgery may be a safe and effective treatment option for thyroid cancer patients seeking to maintain a good quality of life.