Nocturia is usually considered to be just one of the symptoms included with lower urinary tract symptoms (LUTS) and is treated with therapy based on LUTS. Recent research suggests, however, that nocturia is not merely a simple symptom of LUTS but is a multifactorial condition with many contributing etiological factors. The causes of nocturia can be classified into bladder storage problems, increased urine output, sleep disturbance problems, and other potential diseases. The frequency-volume chart (FVC) is very important in evaluating and diagnosing nocturia. Patients usually record the volume and timing of voids for a period of 1 to 3 days on the FVC. The FVC data can provide information on voiding patterns and clues about the etiology and treatment of nocturia. It is doubtful that alpha-blockers will have clinical significance for treatment because the difference in nocturia episodes between treatment with alpha-blockers and placebo is too small. Antimuscarinics also exert no effect on nocturnal polyuria, and the evidence supporting the efficacy of antimuscarinics for the treatment of nocturia is limited. However, several randomized placebo-controlled trials have shown the efficacy of oral desmopressin in the treatment of adults with nocturia. Short-acting hypnotics may be helpful for patients with sleep disturbances. Although surgical or interventional therapy is not indicated for nocturia, transurethral resection of the prostate appears to confer a greater improvement in benign prostatic hyperplasia symptoms including nocturia. The management of nocturia may require a team approach by making optimal use of multidisciplinary expertise.
Adult ; Deamino Arginine Vasopressin ; Humans ; Hypnotics and Sedatives ; Lower Urinary Tract Symptoms ; Muscarinic Antagonists ; Nocturia ; Polyuria ; Prostate ; Prostatic Hyperplasia ; Urinary Bladder

We present two patients with a cerebral palsy who developed cervical myelopathy long from term involuntary movements. Frequently instability with a premature onset of spondylosis of the cervical spine is found in an athetoid cerebral palsy patient. These structural abnormalities appear to be related to the athetoid motion of neck in a cerebral palsy. The combination of a disk degeneration and listhetic instability with a narrow canal predisposes these patients for the relatively rapid progression to a devastating neurological defect. Early surgical management is a treatment of choice for the cervical myelopathy associated with an athetoid cerebral palsy.
Cerebral Palsy* ; Dyskinesias ; Humans ; Intervertebral Disc Degeneration ; Neck ; Spinal Cord Diseases* ; Spine ; Spondylosis

PURPOSE: The purpose of this study is to assess the clinical utility of multiplanar reformation images of helical CT in the evaluation of pancreatic diseases. MATERIALS AND METHODS: Helical CT scans of the pancreas were obtained in 30 patients with pancreatic diseases. Helical CT was performed with 5mm collimation at 5mm/sec table speed during rapid injection of intravenous contrast agent using power injector. After scanning, helical volume data were reconstructed at 2mm interval and then multiplanar reformation of the pancreas and adjacent structures was done. In both prospective reconstructed axial images and multiplanar reformation images, detection of pancreatic lesion, extent of lesion, and vascular and bile ductal changes were analyzed with a grading system of 1,2, 3. RESULTS: The mean grade of detection of pancreatic lesions was 2.37 in the prospective axial image and 2.83 in multiplanar reformation image, extent of diseases was 2.40 in prospective axial image and 2.97 in multiplanar reformation image, and vascular and bile ductal changes was 2.00 in the prospective axial image and 2.97 in multiplanar reformation image. All the differences were statistically significant (P<0.0001). CONCLUSION: Multiplanar reformation images of helical CT are useful in the evaluation of pancreatic diseases and especially in the demonstratibn of complex anatomic relationships between the pancreas and surrounding structures.
Bile Ducts ; Humans ; Pancreas ; Pancreatic Diseases* ; Prospective Studies ; Tomography, Spiral Computed*

We report a case of 4-year-old girl with erythematous papule and nodule on the right knee and left knee, respectively. Histopathologically, the findings of walls of the each cystic lesions were those of the epidermal cyst containing hair shafts of lanugo size on the right knee and the trichilemmal cyst on the left knee. The observation of hair shafts in a cystic cavity represents an important clue for identifying some unusual varieties of cystic lesions. We report a interesting case of epidermal cyst containing hair shafts and trichilemmal cyst simultaneously and independently occurred on the right knee and left knee, respectively.
Child, Preschool ; Epidermal Cyst* ; Female ; Hair* ; Humans ; Knee*

Solar urticaria is an uncommon disorder characterized by pruritus, erythema and whealing occurring minutes after exposure to sunlight or artificial radiation, and generally resolves in a few hours. A 46-year-old woman presented with a 2-year history of pruritus and whealing, which occurred immediately after exposure to sunlight. Phototesting elicited urticarial reactions in the UVA and visible sepectra. The results of passive and reverse passive transfer studies were all negative. The patient was treated with cetirizine, doxepin and prednisolone. After 2 months of the treatment, the symptoms did not appear.
Cetirizine ; Doxepin ; Erythema ; Female ; Humans ; Middle Aged ; Prednisolone ; Pruritus ; Sunlight ; Urticaria*

This experiment was designed for the evaluation of the usefulness of enzyme histochemistry in the determination of the lapse of time in brain wound, and also for the establishment of medicolegal 'biological time table' on brain wound. Brain injury was made by contusion and laceration of meninges and brain itself in rats. The results were as follows; 1) By routine histological technique, estimation of the lapse of time in brain wound could be possible 4 hours after the infliction of wound. 2) The earliest change of enzyme activities was recognizable by the decreased activities of ATPase and succinic dehydrogenase 30 minutes after the injury. These decreased enzyme activities were not recovered up to the 4th day after the brain injury. 3) Increased acid phosphatase activity was noticed 1 hour, and beta-glucuronidase, 2 hours after the injury in a mild degree. Both increased activities were pronounced following the lapse of time in brain wound. 4) No significant change was seen in alkaline phosphatase, monoamine oxidase, non-specific esterase and leucine aminopeptidase activities throughout the experimental period up to the 4th day. So the enzyme histochemistry of these enzymes seemed to be little valuable for the study on the timing of wound in brain injury. In the light of these results it appeared that the enzyme histochemistry, in particular of ATPase, succinic dehydrogenase, and acid phosphatase, for the estimation of timing of brain wound not only shortened the histological "lag period" up to 30 minutes after the injury, but also provided a useful information in determining the biological time table following the brain injury.
Acid Phosphatase ; Adenosine Triphosphatases ; Alkaline Phosphatase ; Animals ; Brain Injuries* ; Brain* ; Carboxylesterase ; Contusions ; Glucuronidase ; Histological Techniques ; Lacerations ; Leucyl Aminopeptidase ; Meninges ; Monoamine Oxidase ; Rats ; Succinate Dehydrogenase ; Wounds and Injuries

Piper nigrum L. (Piperaceae), which is a well-known food seasoning, has been used as a traditional medicine for the treatment of vomiting, abdominal pain, diarrhea and anorexia in Korea, China and Japan. Methanol extract from the fruit of P. nigrum was successively partitioned as n-hexane, methylene chloride, ethyl acetate, n-butanol and H₂O soluble fractions. Among those fractions the ethyl acetate soluble fraction showed the most potent DPPH radical scavenging activity, and piperine was isolated from the ethyl acetate fraction. To know the antioxidant activity of piperine, we tested the activities of superoxide dismutase (SOD) and catalase together with oxidative stress tolerance and intracellular ROS level in Caenorhabditis elegans. To investigate whether piperine-mediated increased stress tolerance was due to regulation of stress-response gene, we quantified SOD-3 expression using transgenic strain including CF1553. Consequently, piperine enhanced SOD and catalase activities of C. elegans, and reduced intracellular ROS accumulation in a dose–dependent manner. Moreover, piperine-treated CF1553 worms exhibited significantly higher SOD-3::GFP intensity.
1-Butanol ; Abdominal Pain ; Anorexia ; Caenorhabditis elegans ; Caenorhabditis ; Catalase ; China ; Diarrhea ; Fruit ; Japan ; Korea ; Medicine, Traditional ; Methanol ; Methylene Chloride ; Oxidative Stress ; Piper nigrum ; Piper ; Seasons ; Superoxide Dismutase ; Vomiting

PURPOSE: To evaluate the average glandular absorption radiation dose(AGARD) that results from tube voltage, target/filter material of the X-ray tube, enterance skin exposure, breast thickness and patterns in routine mammography. MATERIAL AND METHOD: After obtaining craniocaudal views of left breasts of 114 women, entrance skin exposure was measured by dosimetry. Under identical conditions of tube voltage and target/filter material of theX-ray tube, we obtained half value layer (HVL) and also calculated exposure-to-absorbed dose conversion factor(DgN) by Wu's methods. AGARD was calculated by entrance skin exposure multiplied by exposure-to-absorbed dose conversion factor. We analyzed AGARDs according to tube voltage, target/filter material, breast thickness and pattern using ANOVA method of the SPSS statistical packages. RESULT: Breast patterns were divided into 4 groups such as DY (n=72), P1 (n=1), P2 (n=10), and N1 (n=31), respectively. Their AGARDs were 161.5, 180, 172.8, and195.2 mrad respectively and showed no significant difference among groups. When divided by breast thickness into three groups, namely below 3cm, 3cm to 4.5cm, and above 4.5cm, the AGARD of each group was 178.3, 178.1, and 112.4mrad respectively and the last one was significantly low. Concerning the effect of tube voltages, AGARDs gradually decreased by increasing kVp. Furthermore, AGARD was lower when rhodium (Rh) rather than when molybdenum(Mo) was used as filter/target materials. CONCLUSION: There was no difference in AGARDs by breast pattern. Asmore increasing KvP or using Rh/Rh as the target/filter material of the X-ray tube, we reduced AGARD for the patient with dense or thick breasts.
Absorption* ; Breast ; Female ; Humans ; Mammography* ; Rhodium ; Skin

PURPOSE: To evaluate the significance of mammographic findings in patients with paget's disease of the breast. MATERIALS AND METHODS: The clinical and mammographic records of ten patients with surgically-proved paget disease of the breast were retrospectively reviewed. RESULTS: Of these ten patients, the mammograms of two(20%) were normal, while those of six(60%) showed nipple or subareolar abnormalities, and those of six(60%) showed parenchymal abnormalities. Of six patients who had nipple change only, the mammograms of four showed nipple orsubareolar abnormalities and those of three showed parenchymal abnormalities. Of two patients who had nipple change and palpable mass, the mammograms of both showed nipple or subareolar and parenchymal abnormalities. Of two patients who had palpable mass only, the mammograms of both failed to show nipple or subareolar abnormalities and those of one showed parenchymal abnormalities. CONCLUSION: In Paget's disease of the breast, mammographic findings are nonspecific and are limited to an evaluation of the extension of the primary carcinoma. Therefore clinical findings should be correlated with mammographic findings.
Breast ; Humans ; Nipples ; Paget's Disease, Mammary* ; Retrospective Studies

We report herein two cases of cutaneous mucinosis in a 59 and a 55 year-old woman which occurred by asymptomatic cystic nodule on the previous biopsy scar site respectively. The histopathologic findings revealed focal accumulation of mucin and proliferation of fibroblasts in the dermis. We suppose that trauma may cause these cases.
Biopsy ; Cicatrix* ; Dermis ; Female ; Fibroblasts ; Humans ; Middle Aged ; Mucinoses* ; Mucins