1.A Case of Juvenile Chronic Myelogenous Leukemia Presented as Recurrent Erythema Nodosum-Like Lesions.
Ji Hwan HWANG ; Kyu Han KIM ; Byoung Kook KIM ; Hyeong Don BANG ; Kyoung Chan PARK
Annals of Dermatology 1996;8(2):125-128
No abstract available.
Erythema*
;
Leukemia, Myelomonocytic, Juvenile*
2.A Case of Malignant Histiocytosis Showing Papulosquamous Skin Lesions and Fever as Initial Manifestations.
Ji Hwan HWANG ; Kyu Han KIM ; Byoung Kook KIM ; Hyeong Don BANG ; Kyoung Chan PARK
Annals of Dermatology 1996;8(2):117-120
We report a case of malignant histiocytosis which began with intermittent fever and scaly skin lesions. A 3-year-old girl presented with erythematous scaly papules on the face and the trunk, and high fever for 3 months. The cutaneous lesions consisted of widespread coin-sized erythematous scaly papules with marginal brownish pigmentation. She was anemic and thrombocytopenic and had impairment of the liver function. Histopathologic study of the skin lesions showed non-specfic findings except for hyperkeratosis. However, bone marrow examination revealed an increased number of histiocytes, mostly immature with active phagocytosis of erythroid cells, myeloid cells, and platelets. She was diagnosed as having malignant histiocytosis and treated with cyclophosphamide and vincristine. She died the next day after the treatment had begun.
Bone Marrow Examination
;
Child, Preschool
;
Cyclophosphamide
;
Erythroid Cells
;
Female
;
Fever*
;
Histiocytes
;
Histiocytic Sarcoma*
;
Humans
;
Liver
;
Myeloid Cells
;
Phagocytosis
;
Pigmentation
;
Skin*
;
Vincristine
3.Correlation of Endoscopic Redness with Histological Findings in Superficial Gastritis.
Joon Mo CHUNG ; Yong Hwan CHOI ; Sung Kook KIM ; Chang Hyeong LEE ; Young Ok KWEON
Korean Journal of Gastrointestinal Endoscopy 1995;15(4):664-669
Superficial gastritis has been classified as a type of chronic gastritis, since a report of Schindler in GASTRLTIS, 1947. Howev~er, Benedict reported that superficial gastritis is only acute gastritis or shows normal mucosa histologically. The com mon endopical findings of chronic superficial gastritis were adherent mucus, edema, redness. The common redness which were encounterd are patchy redness and comb-like redness(Kammrotung). We studied the relationship between the redness of superficial gastritis and acute inflammatory changes histologically. Each case of superfieial gastritis was biopsied to redening and non-redening mucosa respectively. We collected 24 cases with 48 biopsy specimens. The results are as follows: Acute inflammatory changes were found only one case in redness and none in non-redness groups. There was no difference in acute inflammatory changes in two groups. The degree of mucosal atrophy were 62.5%, 66.7% in normal mucosa, 12.5%, 16.7~% in mild atrophy, 25%, 12.5% in moderate atrophy, 0%, 4.l% in severe atrophy with respect to redness and non-redness mucosa respectively. There was no difference in degree of mucosal atrophy in two groups. Mucosal atrophies were higher in older ages above 41 years old than below 40 and with increasing age, there was increasing tendency of mucosal atrophy. In conclusion, There was no relationships between mucosal redness and acute in flammatory changes histologically and also between mucosal redness and degree of atrophy.
Adult
;
Atrophy
;
Biopsy
;
Edema
;
Gastritis*
;
Humans
;
Mucous Membrane
;
Mucus
4.Identification of newly isolated Babesia parasites from cattle in Korea by using the Bo-RBC-SCID mice.
Shin Hyeong CHO ; Tong Soo KIM ; Hyeong Woo LEE ; Masayoshi TSUJI ; Chiaki ISHIHARA ; Jong Taek KIM ; Sung Hwan WEE ; Chung Gil LEE
The Korean Journal of Parasitology 2002;40(1):33-40
Attempts were made to isolate and identify Korean bovine Babesia parasite. Blood samples were collected from Holstein cows in Korea, and Babesia parasites were propagated in SCID mice with circulating bovine red blood cells for isolation. The isolate was then antigenically and genotypically compared with several Japanese isolates. The Korean parasite was found to be nearly identical to the Oshima strain isolated from Japanese cattle, which was recently designated as Babesia ovata oshimensis n. var. Haemaphysalis longicornis was the most probable tick species that transmited the parasite.
Animals
;
Arthropod Vectors/parasitology
;
Babesia bovis/genetics/*isolation & purification
;
Babesiosis/parasitology
;
Base Sequence
;
Cattle/*parasitology
;
Cattle Diseases/parasitology
;
DNA, Protozoan/genetics
;
DNA, Ribosomal/genetics
;
Erythrocytes/parasitology
;
Korea
;
Mice
;
*Mice, SCID
;
Molecular Sequence Data
;
Phylogeny
;
Ticks/parasitology
5.De Ritis Ratio (Aspartate Transaminase/Alanine Transaminase) as a Significant Prognostic Factor With Upper Urinary Tract Carcinoma Who Underwent Radical Nephroureterectomy and Adjuvant Chemotherapy
Jee Hwan YOON ; Chang Wook JEONG ; Cheol KWAK ; Hyeon Hoe KIM ; Ja Hyeon KU ; Ji Hyeong YU ; Hyeong Dong YUK
Korean Journal of Urological Oncology 2022;20(1):34-42
Purpose:
To investigate the correlation between preoperative De Ritis ratio (aspartate transaminase [AST]/alanine transaminase [ALT]) and postoperative clinical outcome in patients with upper urinary tract carcinoma (UTUC) who underwent radical nephroureterectomy (RNU) and adjuvant chemotherapy (ACH).
Materials and Methods:
We respectively analyzed the clinical and pathological data of 102 patients who underwent RNU and ACH for UTUC. Patients were divided into 2 groups, according to the optimal value of AST/ALT ratio. The effect of the AST/ALT ratio was analyzed by the Kaplan-Meier method and Cox regression hazard models for patients’ cancer-specific survival (CSS) and overall survival (OS).
Results:
Mean survival time was 50.5±41.2 months. Mean age was 61.4±9.7years. Forty-one of the patients (46.5%) were in the high AST/ALT group. According to receiver operating characteristic analysis, the optimal AST/ALT ratio was 1.2. In Kaplan-Meier analyses, the high AST/ALT group showed worse outcomes in OS (p=0.007) and CSS (p=0.011). Using Cox regression models of clinical and pathological parameters to predict OS, high AST/ALT ratio (hazard ratio [HR], 5.428; 95% confidence interval [CI]; 1.803–16.334; p=0.002), pathological T3 (pT3) or higher (HR, 1.464; 95% CI; 1.156-1.857; p=0.002), and to predict CSS, high AST/ALT ratio (HR, 4.417; 95% CI; 1.545–12.632; p=0.005), and pT3 or higher (HR, 1.475; 95% CI; 1.172–1.904; p=0.002) were determined as independent prognostic factors.
Conclusions
Pretreatment AST/ALT ratio is a significant independent predictor of CSS and OS in advanced UTUC patients receiving systemic ACH after RNU.
6.The Characteristics of Associative Learning of Reward Approach and Loss Aversion in Schizophrenia.
Sunyoung PARK ; Seok Hyeong KIM ; Il Ho PARK ; Jung Hwan KIM ; Jae Jin KIM ; Min Seong KOO ; Jungeun SONG
Korean Journal of Schizophrenia Research 2012;15(2):59-65
OBJECTIVES: Schizophrenia patients have deficits of prediction and learning related to dopaminergic dysfunction. It is hypothesized that there would be different characteristics in associative learning of reward approach and loss aversion between controls and patients. METHODS: Participants were 23 healthy participants and 20 out-patients fulfilling criteria for schizophrenia according DSM-IV-TR. Using a monetary incentive contingency reversal task, successful learning rates, numbers of trials and errors till learning, numbers of trials of maintaining learning, response times were measured. Characteristics of learning were compared between controls and patients. RESULTS: Physical anhedonia and PANSS negative symptom scores correlated with the number of trials while loss aversion was maintained. Overall correct response rates were decreased in patient group, particularly during reward approach learning. Patients required more trials and errors to learn reward approach than controls. There were no significant differences in learning performance and reaction times between groups during loss avoidance learning. CONCLUSION: These results support previous reports of deficits in reward-driven learning in schizophrenia. However, anhedonia and negative symptoms were associated with the preserved function of loss avoidance learning.
Anhedonia
;
Avoidance Learning
;
Humans
;
Learning
;
Motivation
;
Outpatients
;
Reaction Time
;
Reinforcement (Psychology)
;
Reward
;
Schizophrenia
7.Effect of the Correction of Metabolic Acidosis on Muscle Energy Metabolism in Patients with Chronic Renal Failure. A 31P-NMR Spectroscopic Study.
Soon Bae KIM ; Hyeong Ho KIM ; Tae Hwan LIM
Korean Journal of Nephrology 1997;16(2):302-308
Patients with chronic renal failure(CRF) suffer from muscular dysfunction of varying degrees. 31P-nuclear magnetic resonance(NMR) spectroscopic studies of skeletal muscle have shown that these patients have less energy reservoir. Chronic metabolic acidosis has been known to decrease intracellular pH in rat muscle. We investigated the effect of correction of metabolic acidosis with sodium bicarbonate on muscle energy metabolism. Eight patients(6M, 2F) with CRF(creatinine clearance <20ml/min/1.73m2) who were clinically stable and had serum bicarbonate level less than 18mEq/L were included. The median age was 48 years (range; 29-56 years). The patients were treated with daily doses of 3 gram sodium bicarbonate for 3 months. Phosphocreatine to inorganic phosphate ratio(PCr/Pi) and intracellular pH were measured with 31P-NMR spectroscopy, at resting, nadir and maximum recovery state after all-out exercise, before and after correction of acidosis. Plasma bicarbonate level increased from 16.2+/-0.9 to 21.9+/-1.1mmol/L(p<0.05). Creatinine clearance, hematocrit and serum albumin did not change during the study period. The exercise capacity, as measured by the time holding the weight, did not improve with sodium bicarbonate treatment. PCr/Pi ratio at resting state was 7.0+/-1.9 before treatment, which did not change after treatment, 6.2+/-0.8, although plasma bicarbonate level increased significantly. The ratio reached bottom immediately after the all-out exercise(the nadir state) and then recovered toward preexercise value. The PCr/Pi ratio at nadir and maximum recovery state were not different between before and after treatment. The intracellular pH became more acidotic immediately after exercise, but no difference was found between before and after sodium bicarbonate treatment in resting state, nadir or maximum recovery state. With our results, we conclude that the partial correction of acidosis does not improve energy reserve and serum albumin in CRF patients.
Acidosis*
;
Animals
;
Creatinine
;
Energy Metabolism*
;
Hematocrit
;
Humans
;
Hydrogen-Ion Concentration
;
Kidney Failure, Chronic*
;
Muscle, Skeletal
;
Phosphocreatine
;
Plasma
;
Rats
;
Serum Albumin
;
Sodium Bicarbonate
;
Spectrum Analysis
8.Endoscopic Variceal Ligation for Treatment of Esophageal Variceal Bleeding.
Woo Won SHIN ; Sang Young HAN ; Du Hyeong KIM ; Myung Hwan ROH ; Dong Ho KAM ; Seok Reoyl CHOI
Korean Journal of Gastrointestinal Endoscopy 1996;16(3):406-413
Endoscopic variceal ligation(EVL) is newly developed method to manage esophageal variceal bleeding. This study asse initial control rate of active variceal bleeding, incidence of rebleeding and complications in EVL. From June in l992 to December in 1994, this study was performed on 70 patients who had visited to our medical center for melena or hematemesis by acute esophageal variceal bleeding. In all of 70 cases, eradication of esophageal varix was performed and variceal bleeding was controlled well. And first session was performed successfully with EVL. But rebleeding was occured in 12 cases(11 cases caused by esoyhageal varix and 1 case caused by esophageal ulcer) during follow-up period, so EVL therapy was performed repeatedly and 8 cases were eradicated and 4 cases were uncontrolled and died, and then 94% hemostatic effect was achieved during follow-up period. Complications of EVL therapy were mild(substernal discomfort in 12 cases, substernal pain in 4 cases, fever in 3 cases, mild dysphagia in 2 cases) and well controlled. Superficial esaphageal ulcer was shown in 18 cases by follow-up endoscopy after 1 week. These results show that EVL is a good therapeutic method to control active variceal bleeding and eradication of varix with repeat treatment. In conclusion, EVL is an effective and safe method of treatment and prevention for esophageal variceal bleeding.
Deglutition Disorders
;
Endoscopy
;
Equidae
;
Esophageal and Gastric Varices*
;
Fever
;
Follow-Up Studies
;
Hematemesis
;
Humans
;
Incidence
;
Ligation*
;
Melena
;
Ulcer
;
Varicose Veins
9.Evaluation of Anterior Chest Wall Implanted Port: Technical Aspects, Results, and Complications.
Joo Hyeong OH ; Yup YOON ; Si Young KIM ; Young Hwan JEON
Journal of the Korean Radiological Society 2000;43(1):47-52
PURPOSE: To evaluate the technical aspects, results and complications of patients with implanted anterior chest wall port. MATERIALS AND METHODS: Between April 1997 and June 1999, a total of 63 implanted ports were placed at the anterior chest wall of 63 consecutive patients by interventional radiologists. The indications were chemotherapy in 61 patients and total parenteral nutrition in two. The peripheral portion of the subclavian vein was punctured under fluoroscopic guidance via ipsilateral peripheral vein during venography. A central venous catheter was placed in the superior vena cava, and using the subcutaneous tunneling method, a connected infusion port was implanted at the anterior chest wall. Results and complications were reviewed, and by means of Kaplan-Meier survival analysis, the expected patency of the port was determined. RESULTS: The technical success rate for implanted port at the anterior chest wall was 100%(63/63 patients). In two patients, hematoma and oozing were treated by compression. The duration of port implantation ranged from 12 to 855(mean, 187) days, and the port patency rate was 305.7 +/-47.6 days. In seven patients [completed chemotherapy (n=3), central venous thrombosis (n=3) catheter-related infection (n=1)], the port was re-moved. Catheter obstruction occurred in two patients, and in one, the use of urokinase led to successful re-canalization. Sixteen patients died of an underlying malignancy, but no catheter-related death was noted. CONCLUSION: Implantation of an anterior chest wall port is a safe and useful procedure, with long patency, for patients requiring chemotherapy and long-term venous access.
Catheter Obstruction
;
Catheter-Related Infections
;
Central Venous Catheters
;
Drug Therapy
;
Fluoroscopy
;
Hematoma
;
Humans
;
Parenteral Nutrition, Total
;
Phlebography
;
Subclavian Vein
;
Thoracic Wall*
;
Thorax*
;
Urokinase-Type Plasminogen Activator
;
Veins
;
Vena Cava, Superior
;
Venous Thrombosis
10.correlation between the concentrations of follicular fluid epidermal growth factor and estradiol in IVF program.
Hyeong Soon KIM ; Sung Sik HAN ; Kyung Hwan CHANG ; In Cheol CHOI ; Won Il PARK ; Dong Jae CHO ; Chan Ho SONG
Korean Journal of Fertility and Sterility 1993;20(3):209-216
No abstract available.
Epidermal Growth Factor*
;
Estradiol*
;
Female
;
Follicular Fluid*