1.A child with type I ulnar ray deficiency.
Archives of Plastic Surgery 2018;45(2):191-193
2.An aortic dissection in pregnant woman - a case report -.
Hyeong Min LEE ; Eun Pyo HONG ; Dong Hyup LEE ; Jung Cheul LEE ; Sung Sae HAN ; Dong Gu SIN ; Young Jo KIM ; Bong Sup SHIM
Yeungnam University Journal of Medicine 1993;10(1):253-259
We have experienced a case of aortic dissecting aneurysm in pregnant woman. She felt initially severe chest pain which was radiated to the neck on the 3days before delivery. Thereafter dyspnea and generalized edema were developed for 1 month after delivery. She was diagnosed as aortic dissectLn, Debakey type-II. During cardiopulmonary bypass, the selective cerebral perfusion was done through the right and left commom carotid arteries. Aortic replacement with Hemashield vascular graft and reimplantation of innominate artery, resuspension of aortic valve, repair of intimal tear were performed. The postoperative course was uneventful.
Aneurysm, Dissecting
;
Aortic Valve
;
Brachiocephalic Trunk
;
Cardiopulmonary Bypass
;
Carotid Arteries
;
Chest Pain
;
Dyspnea
;
Edema
;
Female
;
Humans
;
Neck
;
Perfusion
;
Pregnant Women*
;
Replantation
;
Tears
;
Transplants
3.A Case of Amylase Producing Small Cell Lung Cancer.
Han Min LEE ; Young Gu SONG ; Tae Byung PARK ; Sung Chul HWANG ; Yi Hyeong LEE ; Myung Ho HAHN ; Hyun Ee YIM
Tuberculosis and Respiratory Diseases 1997;44(3):661-668
The majority of lung cancers associated with hyperamylasemia are adenocarcinomas. Here we report an unusual case of a 54-year-old male patient who complained of dyspnea, anterior chest wall discomfort and facial edema for one month, presenting with a huge mediastinal mass and hyperamylasemia complicated by pericardial effusion Histological evaluation of mediastinal mass revealed small cell carcinoma and pericardium showed nonspecific inflammation with fibrosis. The serum amylase had an electrophoretic mobility similar to that of salivary gland enzyme. There were no evidence of a salivary or pancreatic causes of hyperamylasemia. After chemotherapy, parenchymal lung lesions improved and hyperamylasemia disappeared. For the mannagement of peracardial effusion a pericardial window was forms(i. We concluded that the striking increase in serum amylase was due to the ectopic production of this enzyme by the tumor.
Adenocarcinoma
;
Amylases*
;
Carcinoma, Small Cell
;
Drug Therapy
;
Dyspnea
;
Edema
;
Fibrosis
;
Humans
;
Hyperamylasemia
;
Inflammation
;
Lung
;
Lung Neoplasms
;
Male
;
Middle Aged
;
Pericardial Effusion
;
Pericardium
;
Salivary Glands
;
Small Cell Lung Carcinoma*
;
Strikes, Employee
;
Thoracic Wall
4.The Effects of Fentanyl and Bupivacaine Mixture in Epidural Anesthesia for Cesarean Section .
Hyeong Gu LEE ; Mi Hee KIM ; Jun Rae LEE ; Young Jin HAN
Korean Journal of Anesthesiology 1989;22(3):424-430
This study was performed to investigate the effects of fentanyl in epidural bupivacaine anesthesia for Cesarean section. 45 patients were enrolled in this study. The patients in group I(N=15) received 0.9% NaC1 2ml mixed with 20ml of bupivacaine 0.5%, group II(N=15) received 0.9% NaC1 1ml and fentanyl 50 ug mixed with 20 ml of bupivacaine 0.5%, and group IlI(N =15) received fentanyl 100ug mixed with 20 ml of bupivacaine 0.5%. The time of onset, segmental spread of analgesia, duration of analgesia, changes in arterial blood pressure and heart rate, the incidence of side effects, Apgar score and early neonatal neurobehavioral scale were observed after epidural anesthesia. The results were as follows 1) The time of onset and segmental spread of analgesia were very significantly shorter in group III compared to group I and group lI. 2) The spread of sensory blockade at 30 minutes after epidural injection showed no significant differences among the three groups. 3) The mean duration of analgesia was significantly longer in group IlI compared to group I and II. 4) There were no significant differences in the occurence of side effects among the three groups. 5) There were no significant differences in the Apgar score and early neonatal neurobehavioral scale among the neonates of the three groups. The above results suggested that fentanyl 100ug can be used as a good adjuvant for epidural anesthesia with bupivacaine for Cesarean section.
Analgesia
;
Anesthesia
;
Anesthesia, Epidural*
;
Apgar Score
;
Arterial Pressure
;
Bupivacaine*
;
Cesarean Section*
;
Female
;
Fentanyl*
;
Heart Rate
;
Humans
;
Incidence
;
Infant, Newborn
;
Injections, Epidural
;
Pregnancy
5.The Effects of Fentanyl and Bupivacaine Mixture in Epidural Anesthesia for Cesarean Section .
Hyeong Gu LEE ; Mi Hee KIM ; Jun Rae LEE ; Young Jin HAN
Korean Journal of Anesthesiology 1989;22(3):424-430
This study was performed to investigate the effects of fentanyl in epidural bupivacaine anesthesia for Cesarean section. 45 patients were enrolled in this study. The patients in group I(N=15) received 0.9% NaC1 2ml mixed with 20ml of bupivacaine 0.5%, group II(N=15) received 0.9% NaC1 1ml and fentanyl 50 ug mixed with 20 ml of bupivacaine 0.5%, and group IlI(N =15) received fentanyl 100ug mixed with 20 ml of bupivacaine 0.5%. The time of onset, segmental spread of analgesia, duration of analgesia, changes in arterial blood pressure and heart rate, the incidence of side effects, Apgar score and early neonatal neurobehavioral scale were observed after epidural anesthesia. The results were as follows 1) The time of onset and segmental spread of analgesia were very significantly shorter in group III compared to group I and group lI. 2) The spread of sensory blockade at 30 minutes after epidural injection showed no significant differences among the three groups. 3) The mean duration of analgesia was significantly longer in group IlI compared to group I and II. 4) There were no significant differences in the occurence of side effects among the three groups. 5) There were no significant differences in the Apgar score and early neonatal neurobehavioral scale among the neonates of the three groups. The above results suggested that fentanyl 100ug can be used as a good adjuvant for epidural anesthesia with bupivacaine for Cesarean section.
Analgesia
;
Anesthesia
;
Anesthesia, Epidural*
;
Apgar Score
;
Arterial Pressure
;
Bupivacaine*
;
Cesarean Section*
;
Female
;
Fentanyl*
;
Heart Rate
;
Humans
;
Incidence
;
Infant, Newborn
;
Injections, Epidural
;
Pregnancy
6.The Effect of D,L-6,8-Thioctic Acid on the Volume of Cerebral Infarction in Ischemic Rat Model.
Hyeong Joong YI ; Sang Gu LEE ; Woo Taek RHEE ; Kwang Myung KIM ; Young Soo KIM ; Yong KO
Journal of Korean Neurosurgical Society 2002;32(4):363-370
OBJECTIVE: The authors demonstrate neuroprotective effects of antioxidant in reperfusion injury using ischemic rat model and evaluate the clinical eligibility of this agent to ischemic cerebrovascular diseases. METHODS: Rat model was made according to Longa method. Thirty-six Sprague-Dawley rats were used and were equally divided into three groups;A) treated subcutaneously with D,L-6,8-Thioctic acid 30 minutes before occlusion, B) within one hour after occlusion, and C) with vehicle only. Neurologic examination was performed immediately and 24 hours after reperfusion. Twenty-four hours after reperfusion, brains were extracted and stained with 2% 2,3,5-Triphenyltetrazolim chloride in 2mm-thickness section. Then, fixed sections were digitalized and used for infarct area calculation. RESULTS: There was no significant statistical difference in recorded hemodynamic and physiologic parameters between three groups. The neurologic status taken immediately following reperfusion were A) 2.67+/-0.492, B) 2.75+/-0.452, and C) 2.83+/-0.389, and were improved to A) 1.67+/-0.898, B) 1.92+/-0.900, and C) 2.08+/-0.793 just before sacrificing. However, there was no statistically significant difference between three groups. Mean volume of cerebral infarction was A) 9.5+/-1.67%, B) 10.4+/-1.58%, and C) 11.3+/-1.12% with no significant difference. Any specific correlation between the neurologic status and the mean infarction volume was not observed. CONCLUSION: Any single agent does not seem to reduce the infarction volume holistically, therefore, the incoming therapeutic target should be the development of versatile neuroprotective agents or the selection of preexisting synergistic compounds without compromising patients' safety.
Animals
;
Brain
;
Cerebral Infarction*
;
Hemodynamics
;
Infarction
;
Models, Animal*
;
Neurologic Examination
;
Neuroprotective Agents
;
Rats*
;
Rats, Sprague-Dawley
;
Reperfusion
;
Reperfusion Injury
7.A Case of Hemolytic Uremic Syndrome Caused by Escherichia coli O8: Case Report.
Yun Hyeong CHO ; Hyo Jin PARK ; Kee Sup SONG ; Young Gu SONG ; Sang In LEE ; In Suh PARK
Korean Journal of Gastrointestinal Endoscopy 2002;25(4):213-216
Since 1982, many countries have reported outbreaks or sporadic cases by enterohemorrhagic Escherichia coli (E. coli) serogroup strains, mainly E. coli O157 : H7. Hemorrhagic E. coli induces hemolytic uremic syndrome (HUS) in 10 to 15% of cases in infants and young chilidren. HUS is a clinical syndrome of hemolytic anemia, acute renal failure, and thrombocytopenia. We experienced a case of E. coli O8 as the causative organism of hemorrhagic colitis and hemolytic uremic syndrome in 16 year-old man. Hemorrhagic colitis was diagnosed by the sigmoidoscopy and E. coli O8 was identified in the stool culture. Hemolytic uremic syndrome was clinically diagnosed. A conservative management including total parenteral nutrition, plasma exchange transfusion, hemodialysis and continuous arteriovenous hemofiltration with dialysis resulted in a complete recovery of the patient. We herein report this manifestations of E. coli O8 and discuss the therapeutic issues related to hemorrhagic colitis and hemolytic uremic syndrome.
Acute Kidney Injury
;
Adolescent
;
Anemia, Hemolytic
;
Colitis
;
Dialysis
;
Disease Outbreaks
;
Enterohemorrhagic Escherichia coli
;
Escherichia coli*
;
Escherichia*
;
Hemofiltration
;
Hemolytic-Uremic Syndrome*
;
Humans
;
Infant
;
Parenteral Nutrition, Total
;
Plasma Exchange
;
Renal Dialysis
;
Sigmoidoscopy
;
Thrombocytopenia
8.Spectral analysis of heart rate variability during passive standing after ethanol ingestion.
Hyeong Jin KIM ; Chun Duk HAN ; Eun Kyoung YANG ; Won Jung LEE
The Korean Journal of Physiology and Pharmacology 1999;3(6):605-613
The purpose of the present study was to evaluate cardiovascular regulation during passive standing (PS) after ethanol ingestion by spectral analysis of heart rate variability (HRV) in flushed and nonflushed subjects. Of 24 young male subjects, 8 belonged to flushed group (F) and 16 to nonflushed group (NF). Two sessions of 10-min PS were performed before and after ethanol (0.5 g/kg) ingestion. Powers of R-R interval variability in very low frequency (VLF, 0~0.05 Hz), low frequency (LF, 0.05~0.15 Hz) and high frequency (HF, 0.15~0.50 Hz) bands, normalized powers (LFn and HFn) and LF/HF ratio were obtained. After ethanol ingestion, F showed higher heart rate than NF. PS increased LFn (+ 22.9+/-3.6 in NF, + 12.8+/-4.7 in F, in normalized units) and LF/HF (+ 3.10+/-0.57 in NF, + 3.00+/-1.08 in F) and decreased HFn powers. Ethanol ingestion increased LFn and LF/HF and decreased HFn. PS after ethanol resulted in higher LFn and LF/HF and lower HFn than the prior PS. F showed a greater and more sustained HRV change than NF after ethanol. In conclusion, PS or ethanol ingestion increased LFn and LF/HF and decreased HFn. Flushed subjects showed an accentuated HRV response to ethanol.
Arterial Pressure
;
Dizziness
;
Eating*
;
Ethanol*
;
Flushing
;
Heart Rate*
;
Heart*
;
Humans
;
Male
9.Does Albumin Infusion Enhance the Diuretic Action of Furosemide in NePhrotic Syndrome?.
Doe Hyeong KIM ; Jae Ho EARM ; Jin Suk HAN ; Hye Young KIM ; Tae Geun OH ; Wooseong HUH ; Jung Sang LEE ; In Jin JANG ; Sang Gu SHIN
Korean Journal of Nephrology 1998;17(4):567-573
There have been controversies on the effect of albumin in treating edema in nephrotic syndrome patients. We evaluated the additive diuretic effect of coadministration of furosernide with albumin in the six patients with nephrotic syndrome. We administered 160mg of furosemide intravenously for 1 hour with 100rnl of 20% albumin or 5% dextrose by random cross-over design. The urine and plasma furosemide concentrations were measured by HPLC. After the administration of furosemide alone, urine volume, urinary excretions of sodium and chloride were increased significantly compared to those of basal state (P<0.05). But, coadministration of furose-mide with albumin did not increase significantly the urine voume (2285+/-445ml vs. 3023+/-715ml), urinary excretions of sodium (194+/-58rnmol/day vs. 282+/-85 mmol/day) and chloride (213+/- 54mmoVday vs. 286+/- 74mmoVday) comparing to those of furosemide only cases. Addition of albumin to furosemide did not significantly changed pharmacokinetic parameters such as AUC (28.3+/-5.5ug/ml hr vs 36.0+/-6.7ug/ml hr), total plasma clearance (115+/-30mVmin vs 108+/-41ml/min), volume of distribution (0.13+/-0.02L/kg vs 0.10+/- 0.01L/kg), elirnination half life (1.4+/-0.3hr vs 1.5+/-0.3hr), and urine furosemide excretion (44+/-8% vs 43+ 10%). We concluded that albumin infusion did not enhance the diuretic action of furosemide pharmacodynamically and pharmacokinetically in patients with nephrotic syndrome.
Area Under Curve
;
Chromatography, High Pressure Liquid
;
Cross-Over Studies
;
Diuretics
;
Edema
;
Furosemide*
;
Glucose
;
Half-Life
;
Humans
;
Nephrotic Syndrome*
;
Pharmacokinetics
;
Plasma
;
Sodium
10.Tissue transglutaminase-interleukin-6 axis facilitates peritoneal tumor spreading and metastasis of human ovarian cancer cells.
Keunhee OH ; Hyeong Gon MOON ; Dong Sup LEE ; Young Bok YOO
Laboratory Animal Research 2015;31(4):188-197
Inflammation has recently been implicated in cancer formation and progression. As tissue transglutaminase (TG2) has been associated with both inflammatory signaling and tumor cell behavior, we propose that TG2 may be an important link inducing interleukin-6 (IL-6)-mediated cancer cell aggressiveness, including cancer stem cell-like characteristics and distant hematogenous metastasis. We evaluated the effect of differential TG2 and IL-6 expression on in vivo distant metastasis of human ovarian cancer cells. IL-6 production in human ovarian cancer cells was dependent on their TG2 expression levels. The size and efficiency of tumor sphere formation were correlated with TG2 expression levels and were dependent on TG2-mediated IL-6 secretion in human ovarian cancer cells. Primary tumor growth and propagation in the peritoneum and distant hematogenous metastasis into the liver and lung were also dependent on TG2 and downstream IL-6 expression levels in human ovarian cancer cells. In this report, we provide evidence that TG2 is an important link in IL-6-mediated tumor cell aggressiveness, and that TG2 and downstream IL-6 could be important mediators of distant hematogenous metastasis of human ovarian cancer cells. Intervention specific to TG2 and/or downstream IL-6 in ovarian cancer cells could provide a promising means to control tumor metastasis.
Axis, Cervical Vertebra*
;
Humans*
;
Inflammation
;
Interleukin-6
;
Liver
;
Lung
;
Neoplasm Metastasis*
;
Ovarian Neoplasms*
;
Peritoneum