No abstract available.
Humans ; Infant* ; Infant, Very Low Birth Weight*

No abstract available.
Humans ; Infant* ; Infant, Very Low Birth Weight*

No abstract available.
Bronchitis, Chronic* ; Child* ; Humans ; Lung* ; Perfusion*

No abstract available.
Aluminum Oxide* ; Dental Porcelain*

OBJECTIVE: Lithium inhibits the action of inositol monophosphatase(IMPase) in phosphoinositide(PI) signal transduction system at therapeutically relevant concentration. The depletion of inositol by lithium itself cannt explain the lithium's therapeutic effect. However, attention has focused on the abnormality of PI signal transduction system as the pathophysiology of bipolar affective disorder(BPD). We investigated whether IMPase mRNA levels of lymphocytes would be different between BPD patients(n=16) and age, sex-matched normal controls(n=16). We also investigated the change of IMPase mRNA level by lithium during 4 weeks to probe the possibility that IMPase mRNA levels could predict the therapeutic response to lithium and clinical course. METHOD: Relative IMPase mRNA levels in lymphocyte were quantified by reverse transcriptase(RT)-PCR in sixteen drug-free BPD patients and sex, age-matched normal controls. The psychopathology of patients were measured using YMRS(Young Mania Rating Scale) and CGI(Clinical Global Impression). RESULTS: There was no significant difference in IMPase mRNA levels between BPD patients and normal controls. And the IMPase mRNA levels were not significantly changed by 4 week treatment with lithium. However, the basal IMPase mRNA levels were negatively correlated with the changes of CGI after 4 weeks. Furthermore, the patients with relatively high basal IMPase mRNA levels showed much more improvement during 4 weeks. CONCLUSIONS: BPD patients and normal controls were not distinguished by lymphocyte IMPase mRNA level. Although we do not support the hypothesis that lymphocyte IMPase activity would be related with the pathogenesis of BPD and the action of lithium, these data raise the possibility that lymphocyte IMPase mRNA levels could function as a predictor of therapeutic response and clinical course of BPD.
5'-Nucleotidase ; Bipolar Disorder ; Humans ; Inositol* ; Lithium* ; Lymphocytes* ; Mood Disorders* ; Psychopathology ; RNA, Messenger* ; Signal Transduction

PURPOSE: To examine the clinical effects of early dexamethasone treatment from postnatal age of 1 week to ventilated preterm infants with respiratory distress syndrome. METHODS: 14 one-week-old ventilator-dependent infants were enrolled. Seven received dexamethasone and another 7 did not receive. The doses of dexamethasone used were 0.25mg/kg twice daily for 3 days, 0.125mg/kg twice for 1 day, then 0.125mg/kg once for 1 day. Blood gases were measured and ventilatory efficiency index (VEI) and arterial/alveolar oxygen tension ratio (a/A PO2) were calculated every 12 hours from 48hours before to 72 hours after administration. Mean arterial blood pressures were noted and urine output was measured every 24 hours during the study. RESULTS: Following dexamethasone, the values of PaO2 improved significantly during 72 hours of treatment (P<0.05) and the values of PaCO2 tended to decrease during the study but those were not significant changes. VEI and a/A PO2 ratio improved significantly for 48 hours following dexamethasone (P<0.05). After receiving dexamethasone, the urine output increased significantly during 72 hours of treatment (P<0.05). The average extubation time in dexamethasone-treated group was significantly earlier than that seen in control group (P<0.05). Also the average duration of oxygen therapy and mechanical ventilation of dexamethasone-treated infants were significantly shorter compared with those of control infants. CONCLUSION: I conclude that early dexamethasone therapy from postnatal age of 1 week has beneficial effects in ventilated preterm infants with respiratory distress syndrome.
Arterial Pressure ; Dexamethasone* ; Gases ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Oxygen ; Respiration, Artificial ; Respiratory Distress Syndrome, Newborn*

Clinincal and radiological findings were analysed in 63 patiets with Osgood-schlatter Disease diagnosed atNational Police Hospital during the period from Jan. 1975 to 1981. The results were obtained as follows; 1. Thedisease was most common between 16 and 20 years, being 39 cases in a total of 63 cases. 2. The ratio of male andfemale was 31:1. 3. Involvement was more often unilateral (45 cases ) than bilateral (18 cases), and the left side(29 cases) was more common than the right side (16 cases). 4. Roentgenogram revealed one or two separated bonyfragments in most cases. 5. Type II by Woolfry and Chandler classification was most common type. 6. The mostcommon clinical findings were pain and tenderness on tibial tuberosity. 7. Trauma history was positive in 11 casesin a total of 63 cases.
Classification ; Humans ; Male ; Osteochondrosis ; Police

Cardiovascular measurement on PA teleroentgenogram of the chest is simple, but very useful in the diagnosis,prognosis, and therapy of hypertensive patients. The authors have measured and calculated cardiothoracic ratio,Lt, to Rt. cardiac diameter ratio, and Lt, aortic knob width to thoracic diameter ration for evaluation of theeffect of blood pressure and age in hypertensive group. We used materials of 70mm fluorography of 255 hypertensivemen above 150/90mmHg chosen from national police hospital during Jan. from Aug. 1981. Their age ranged from 20 to50 yeras. The results were as follows. 1. Cardiomegaly (above 50 percents in cardiothoracic ration) ofhypertensive men is 26%. 2. The cardiothoracic ration increased progressively with blood pressure and age, butpooly correlated between cardiothoracic ration and age than blood pressure. 3. The Lt. to Rt. cardiac diameterration gave similar trend to the cardiothoracic ration. It indicates that hypertensive cardiac enlargement mainlydepned on Lt. Ventricular enlargement. 4. The Lt. aortic knob width to thoracic diameter ration increasedprogressively with blood pressure and age, and had linear correlationship with blood pressure and age. Therefore,prominence of aortic knob is the most significant finding in hypertensive cardiovascular disease.
Blood Pressure ; Cardiomegaly ; Cardiovascular Diseases ; Humans ; Male ; Multiple Endocrine Neoplasia Type 1 ; Police ; Thorax

No abstract available.
Amenorrhea* ; Female

No abstract available.
Arnold-Chiari Malformation* ; Meningomyelocele*