Although causative factors are not completely defined, carcinogenesis of colorectal cancer is attributed to multiple genetic alterations. The abnormal expressions of oncogenes are regarded to be responsible for the production of malignant phenotype, subsequent invasion and metastasis. From 63 surgically resectable colorectal adenocarcinoma patients, expression of oncogenes in colorectal cancer tissue was evaluated with immunohistochemical staining methods using monoclonal antibodies to products of the oncogenes. To evaluate the possibility of oncogenes as a prognostic factor, we studied the relationship between the expression of oncogenes and the clinicopathologic findings which are well known prognostic factors. Rates of expression in colorectal cancer tissue were 27% for c-myc, 74.6% for c-Ha-ras and 77.8% for c-erbB-2 oncogenes. The positive rate of c-erbB-2 oncogene was higher in the well differentiated group than in the poorly differentiated group. The rates of expression of c-myc and c-Ha-ras oncogenes were significantly correlated each other. Expression of these oncogenes in colorectal cancer were not correlated with the pathologic stage, location of cancer, DNA ploidy pattern and histologic differentiation except between c-erbB-2 and histologic differentiation. In conclusion, there seems to be a possibility that c-erbB-2 could be used as a prognostic factor of colorectal cancer. However, further and more intensive study seems to be required.
Adenocarcinoma ; Antibodies, Monoclonal ; Carcinogenesis ; Colorectal Neoplasms* ; DNA ; Humans ; Neoplasm Metastasis ; Oncogenes* ; Phenotype ; Ploidies

No abstract available.
Lip* ; Tooth*

Eccrine poromas mainly involve the non-hairy surfaces of the skin, however, have also been found on hair bearing areas. Pigmentation in the tumor cells is rare but has been mentioned in a few papers. The following case documents an example of a pigmented eccrine poroma which occurred in an unusual location; the posterior scalp.
Hair ; Pigmentation ; Poroma* ; Scalp* ; Skin

Percutaneous transluminal angioplasty(PTA) were performed in three patients with atherosclerotic stenosis of subclavian arteries. The arteries were successfully dilated without complications during the procedure. All patients were asymptomatic during follow-up periods ranging from eight months to fifteen months after PTA.
Angioplasty* ; Arteries ; Constriction, Pathologic ; Follow-Up Studies ; Humans ; Subclavian Artery*

Chordoma is relatively rare and slowly growing tumor arising from notochordal remnant. The tumor is locally infiltrative rather than metastatic. Distant metastasis occured in 5% of Gentil & Coley's cases and 43% of Higinbotham et als cases. Usual sites of metastasis sites were lung, liver adrenal gland and lymph nodes. In 1922, Stewart reported first case of extrapulmonary metastatic chordoma in muscle & subcutaneous layer, which was extremely rare. We have experienced a case of wide spread multiple metastasis to muscle & subcutaneous tissue from primary sacrococcygeal chordoma. The case was 26 years old man, who have had multiple metastatic lesions in trunk, upper & lower extremities. They located in muscle and subcutaneous fat layer. In some lesions neurovascular structure was involved. We have treated the metastatic lesions by complete surgical excision, and they were confirmed as soft tissue chordoma by histologic examination.
Adrenal Glands ; Chordoma ; Liver ; Lower Extremity ; Lung ; Lymph Nodes ; Neoplasm Metastasis ; Notochord ; Subcutaneous Fat ; Subcutaneous Tissue

No abstract available.
Ureter*

No abstract available.
Arnold-Chiari Malformation* ; Meningomyelocele*

No abstract available.
Otitis Externa*

PURPOSE: The purpose of this study is to assess the clinical utility of multiplanar reformation images of helical CT in the evaluation of pancreatic diseases. MATERIALS AND METHODS: Helical CT scans of the pancreas were obtained in 30 patients with pancreatic diseases. Helical CT was performed with 5mm collimation at 5mm/sec table speed during rapid injection of intravenous contrast agent using power injector. After scanning, helical volume data were reconstructed at 2mm interval and then multiplanar reformation of the pancreas and adjacent structures was done. In both prospective reconstructed axial images and multiplanar reformation images, detection of pancreatic lesion, extent of lesion, and vascular and bile ductal changes were analyzed with a grading system of 1,2, 3. RESULTS: The mean grade of detection of pancreatic lesions was 2.37 in the prospective axial image and 2.83 in multiplanar reformation image, extent of diseases was 2.40 in prospective axial image and 2.97 in multiplanar reformation image, and vascular and bile ductal changes was 2.00 in the prospective axial image and 2.97 in multiplanar reformation image. All the differences were statistically significant (P<0.0001). CONCLUSION: Multiplanar reformation images of helical CT are useful in the evaluation of pancreatic diseases and especially in the demonstratibn of complex anatomic relationships between the pancreas and surrounding structures.
Bile Ducts ; Humans ; Pancreas ; Pancreatic Diseases* ; Prospective Studies ; Tomography, Spiral Computed*

Pleomorphic adenoma in lacrimal gland is a rare disease. Injuries to capsule surrounding the tumor lead to recurrence or malignant transformation of tumor by seeding of tumor cells into adjacent tissues. Therefore complete removal of tumor without any injury to capsule is important. We present 2 cases of pleomorphic adenoma of lacrimal gland with symptoms of exophthalmos, hypophthalmos and supraduction limitation. We performed frontatemporal craniotomy and removed orbital roof for the exposure of the tumor located at superior portion of orbit. We removed the tumor with intact capsule avoiding any damage to superior levator palebral muscle and superior rectus muscle microscopically. Periosteum of superior orbital roof was repaired and frontal bone was repositioned. As a result, patients had no symptoms of exophthalmos, hypophthalmos and supraduction limitation. There are no complications of ptosis, diplopia, dry eye syndrome, symblepharon and scar on the face. Transcranial approach for removal of pleomorphic adenoma of lacrimal gland provides wide exposure of the tumor for complete removal of the mass without any damage to surrounding tissues and good cosmetic effects.
Adenoma, Pleomorphic* ; Cicatrix ; Craniotomy ; Diplopia ; Dry Eye Syndromes ; Exophthalmos ; Frontal Bone ; Humans ; Lacrimal Apparatus* ; Orbit ; Periosteum ; Rare Diseases ; Recurrence