1.Introduction of Korean Senior Products and Standards
Kyuyeoun Lee ; Hyun Kyoon Lim ; Mie Choi ; Hyejin Lee ; Nora Lee ; Baohua WANG ; Chuan HE
Chinese Journal of Rehabilitation Theory and Practice 2011;17(6):592-594
It is aging fast in Korea like other Asian countries. Social care systems, human resources, and appropriate senior products for elderly people are important factors to keep the society ealthy and productive. In this paper, we introduce the current status of senior products and standards in Korea including the Korea Senior Product Association (KSPA); present general status of the senior industry in Korea,long-term care insurance program for the elderly as well as welfare items; discuss problems and importance of standardization in the senior industry, the scope of senior products, and the current status of standardization.
2.Complete resolution of the giant pulmonary bulla: a case of inflammatory autobullectomy
Sungrock PARK ; Hyejin SHI ; Sungho WANG ; Sangki LEE ; Yousang KO ; Yong Bum PARK
Kosin Medical Journal 2018;33(3):409-414
Giant pulmonary bulla (GPB) is a rare manifestation of emphysema and usually enlarges gradually over time, occasionally resulting in complications. Hence, more often than not, the surgical intervention of a Bullectomy is the standard method of treatment for GPB. However, there are case reports that show the complete resolution of GPB after its inflammation process even without surgical intervention. A 51-year-old man was admitted to our clinic due to pleuritic pain. After a chest X-ray and CT scan, a new air-fluid level within the GPB was revealed in the right upper lobe of his lung. His clinical status had improved promptly with intravenous antibiotics. A one-year follow-up study showed the GPB was completely resolved.
Anti-Bacterial Agents
;
Emphysema
;
Follow-Up Studies
;
Humans
;
Inflammation
;
Lung
;
Methods
;
Middle Aged
;
Thorax
;
Tomography, X-Ray Computed
3.Mixed Infection of Mycobacterium abscessus subsp. abscessus and Mycobacterium tuberculosis in the Lung.
Sungmin SOHN ; Sungho WANG ; Hyejin SHI ; Sungrock PARK ; Sangki LEE ; Kyoung Taek PARK
The Korean Journal of Thoracic and Cardiovascular Surgery 2017;50(1):50-53
A mixed infection of Mycobacterium abscessus subsp. abscessus (Mab) and Mycobacterium tuberculosis (MTB) in the lung is an unusual clinical manifestation and has not yet been reported. A 61-year-old woman had been treated for Mab lung disease and concomitant pneumonia, and was diagnosed with pulmonary tuberculosis (PTB). Despite both anti-PTB and anti-Mab therapy, her entire left lung was destroyed and collapsed. She underwent left pneumonectomy and received medical therapy. We were able to successfully treat her mixed infection by pneumonectomy followed by inhaled amikacin therapy. To the best of our knowledge, thus far, this is the first description of a mixed Mab and MTB lung infection.
Amikacin
;
Coinfection*
;
Female
;
Humans
;
Lung Diseases
;
Lung*
;
Middle Aged
;
Mycobacterium tuberculosis*
;
Mycobacterium*
;
Pneumonectomy
;
Pneumonia
;
Tuberculosis, Pulmonary
4.A Case of Multiple Cardiovascular and Tracheal Anomalies Presented with Wolff-Parkinson-White Syndrome in a Middle-aged Adult.
Hyejin SHI ; Sungmin SOHN ; SungHo WANG ; Sungrock PARK ; SangKi LEE ; Song Yi KIM ; Sun Young JEONG ; Changhwan KIM
Journal of Korean Medical Science 2017;32(12):2069-2072
Congenital cardiovascular anomalies, such as dextrocardia, persistent left superior vena cava (SVC), and pulmonary artery (PA) sling, are rare disorders. These congenital anomalies can occur alone, or coincide with other congenital malformations. In the majority of cases, congenital anomalies are detected early in life by certain signs and symptoms. A 56-year-old man with no previous medical history was admitted due to recurrent wide QRS complex tachycardia with hemodynamic collapse. A chest radiograph showed dextrocardia. After synchronized cardioversion, an electrocardiogram revealed Wolff-Parkinson-White (WPW) syndrome. Persistent left SVC, PA sling, and right tracheal bronchus were also detected by a chest computed tomography (CT) scan. He was diagnosed with paroxysmal supraventricular tachycardia (PSVT) associated with WPW syndrome, and underwent radiofrequency ablation. We reported the first case of situs solitus dextrocardia coexisting with persistent left SVC, PA sling and right tracheal bronchus presented with WPW and PSVT in a middle-aged adult. In patients with a cardiovascular anomaly, clinicians should consider thorough evaluation of possibly combined cardiovascular and airway malformations and cardiac dysrhythmia.
Adult*
;
Arrhythmias, Cardiac
;
Bronchi
;
Catheter Ablation
;
Dextrocardia
;
Electric Countershock
;
Electrocardiography
;
Hemodynamics
;
Humans
;
Middle Aged
;
Pulmonary Artery
;
Radiography, Thoracic
;
Tachycardia
;
Tachycardia, Supraventricular
;
Thorax
;
Vena Cava, Superior
;
Wolff-Parkinson-White Syndrome*
5.The Flare Phenomenon in a Patient with Advanced Gastric Cancer with Bone Metastases.
Sangki LEE ; Hyejin SHI ; Sungmin SOHN ; Sungrock PARK ; Sungho WANG ; Jinkyung SONG ; Geundoo JANG
Korean Journal of Medicine 2016;91(3):321-324
Flare phenomenon refers to increased radiotracer uptake in bones despite clinical findings showing a positive response to treatment. Flare phenomena are most often observed in patients with breast or prostate cancer. Here, we present a case of bone flare in a 54-year-old male who had advanced gastric cancer with bone metastases. After three cycles of chemotherapy, a bone scan showed increased intensity, but the patient's bone pain was alleviated and abdominal computed tomography revealed a decrease in the size of the primary mass and metastatic lymph nodes. We therefore continued chemotherapy using the same regimen, and a follow-up bone scan revealed decreased intensity. A flare phenomenon after treatment is rare in cases of gastric cancer with bone metastasis. Although flare phenomena are not common, they should be considered in patients with gastric cancer when the clinical results are inconsistent with bone-scan findings.
Breast
;
Diagnostic Imaging
;
Drug Therapy
;
Follow-Up Studies
;
Humans
;
Lymph Nodes
;
Male
;
Middle Aged
;
Neoplasm Metastasis*
;
Prostatic Neoplasms
;
Stomach Neoplasms*
6.Pulmonary Vein Thrombosis Caused by Lobar Pneumonia.
Sungho WANG ; Sangki LEE ; Sungmin SOHN ; Sungrock PARK ; Hyejin SHI ; Jaewon CHOI ; Won Woo SEO
Korean Journal of Medicine 2016;91(3):283-286
Pulmonary vein thrombosis is a rare disease related to a lung malignancy or complication after lung surgery. Generally, it is caused by tumor invasion or localized stenosis of a vein anastomosis site after an operation. Here we report a case of pulmonary vein thrombosis that occurred in a patient with local thrombophlebitis due to lobar pneumonia.
Constriction, Pathologic
;
Humans
;
Lung
;
Pneumonia*
;
Pulmonary Veins*
;
Rare Diseases
;
Thrombophlebitis
;
Thrombosis*
;
Veins
7.DA-1241, a Novel GPR119 Agonist, Improves Hyperglycaemia by Inhibiting Hepatic Gluconeogenesis and Enhancing Insulin Secretion in Diabetic Mice
Youjin KIM ; Si Woo LEE ; Hyejin WANG ; Ryeong-Hyeon KIM ; Hyun Ki PARK ; Hangkyu LEE ; Eun Seok KANG
Diabetes & Metabolism Journal 2022;46(2):337-348
Background:
We investigated the antidiabetic effects of DA-1241, a novel G protein-coupled receptor (GPR) 119 agonist, in vitro and in vivo.
Methods:
DA-1241 was administrated to high-fat diet (HFD)-fed C57BL/6J mice for 12 weeks after hyperglycaemia developed. Oral/intraperitoneal glucose tolerance test and insulin tolerance test were performed. Serum insulin and glucagon-like peptide-1 (GLP-1) levels were measured during oral glucose tolerance test. Insulinoma cell line (INS-1E) cells and mouse islets were used to find whether DA-1241 directly stimulate insulin secretion in beta cell. HepG2 cells were used to evaluate the gluconeogenesis and autophagic process. Autophagic flux was evaluated by transfecting microtubule-associated protein 1 light chain 3-fused to green fluorescent protein and monomeric red fluorescent (mRFP-GFP-LC3) expression vector to HepG2 cells.
Results:
Although DA-1241 treatment did not affect body weight gain and amount of food intake, fasting blood glucose level decreased along with increase in GLP-1 level. DA-1241 improved only oral glucose tolerance test and showed no effect in intraperitoneal glucose tolerance test. No significant effect was observed in insulin tolerance test. DA-1241 did not increase insulin secretion in INS-1E cell and mouse islets. DA-1241 reduced triglyceride content in the liver thereby improved fatty liver. Additionally, DA-1241 reduced gluconeogenic enzyme expression in HepG2 cells and mouse liver. DA-1241 reduced autophagic flow in HepG2 cells.
Conclusion
These findings suggested that DA-1241 augmented glucose-dependent insulin release via stimulation of GLP-1 secretion, and reduced hepatic gluconeogenesis, which might be associated with autophagic blockage, leading to improved glycaemic control.