PURPOSE: This study aimed at uncovering the disabled adult's way of thinking and behavior due to their changed life style. METHOD: In depth interviews with 11 participants were held and analysed based on the Grounded Theory Methodology by Strauss and Corbin (1990). RESULT: This study showed us that the disabled are getting independent by selfconfidence through developing coping strategies for their physical, emotional, social, sexual problems. And in the process of creating these strategies, support structures, satisfaction for performance effect, financial burdens, and mobility had an effect on the intervening factors. Adults who become disabled go through many changes. First, they have vague hopes of improving. Second, they become discouraged. Third, they accept their disability. Next, they learn coping strategies and finally, they integrate the changes into their new life style. CONCLUSION: This study can be utilized in rehabilitation nursing so that the disabled can adapt to their changed life style quickly and lead independent and self-confident lives.
Adult* ; Hope ; Humans ; Life Style* ; Rehabilitation Nursing ; Thinking

PURPOSE: to test of the reliability and validity of the Disabled's Motivation for Rehabilitation Scale. which was developed in 2002. METHOD: An experimental version of the scale was distributed to a sample of 441 disabled with ages above 18 and below 80 years. The subjects of the test-retest were 60 disabled. RESULTS: revealed a satisfactory level of test-retest and internal consistency. The overall fit of the factor model to the data was good. Correlation among the subscales revealed a simple pattern that, in general. provides support for the self- determination continuum and the construct validity. In testing concurrent, criterion-validity, there was a positive correlation between the motivation scores for rehabilitation and the Health-Related Hardiness scores and a negative correlation between the motivation scores for rehabilitation and the Learned Helplessness scores. CONCLUSION: The Disabled's Motivation for Rehabilitation Scale revealed a useful instrument with a high degree of reliability and validity. In this sense, this instrument can be effectively utilized in rehabilitative nursing for the disabled.
Helplessness, Learned ; Motivation* ; Nursing ; Rehabilitation* ; Reproducibility of Results*

Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis.

There had been a continuous evolution of lymphoma classification and recently a Revised European-American Lymphoma Classification was proposed by the International Lymphoma Study Group. This new classification often requires information on immunophenotypic and molecular biologic markers in addition to the usual histologic findings. Recent advances in the production of commercially available monoclonal antibodies reactive on formalin-fixed paraffin-embedded tissues provide us a great help to classify the non-Hodgkin's lymphoma. We have analyzed 31 low grade B-cell lymphomas by the schemes proposed by the International Lymphoma Study Group using antibodies to CD3, CD5, CD20, CD23, CD43, cyclin D1, and bcl-2 protein, and have analyzed the immunophenotypic features. Among 31 low grade B-cell lymphomas, 8 small lymphocytic lymphomas, 5 mantle cell lymphomas, 7 follicle center lymphomas (2 grade I, 3 grade II, and 2 grade III), and 11 marginal zone B-cell lymphomas (all of which were extranodal) were identified. Among 8 small lymphocytic lymphomas, 5 cases were positive for CD5; 6 cases were positive for CD23; 7 cases were positive for CD43; all 8 cases were negative for cyclin D1; and 7 cases were positive for bcl-2. Among 5 mantle cell lymphomas, 4 cases were positive for CD5 and CD43; all five cases were negative for CD23; 4 cases were positive for cyclin D1 and bcl-2. All 7 follicle center lymphomas were negative for CD5, CD43 and cyclin D1 and 2 cases were positive for CD23; and 6 cases were positive for bcl-2. All marginal zone B-cell lymphomas were negative for CD5, CD23 and cyclin D1; 3 cases were positive for CD43 and 9 cases were positive for bcl-2. Diagnostic utility for CD5 antigen detection on paraffin embedded tissue has a limitation due to weak antigen expression in tumor cells of B-cell lymphomas; however, still be useful in differentiating small lymphocytic lymphoma and mantle cell lymphoma from other B-cell lymphomas when applied in conjunction with CD43. CD23, CD43, and cyclin D1 appear to be of great help in differentiating subgroups of low grade B-cell lymphomas. Bcl-2, as known, is found to be useful to rule out reactive follicular hyperplasia.
Antibodies ; Antibodies, Monoclonal ; Antigens, CD5 ; B-Lymphocytes* ; Biomarkers ; Classification ; Cyclin D1 ; Hyperplasia ; Immunohistochemistry* ; Leukemia, Lymphocytic, Chronic, B-Cell ; Lymphoma ; Lymphoma, B-Cell* ; Lymphoma, B-Cell, Marginal Zone ; Lymphoma, Mantle-Cell ; Lymphoma, Non-Hodgkin ; Paraffin*

PURPOSE: This study was conducted to identify the job competencies of HIV counseling nurses and to figure out the importance, level of difficulty, and performance frequency of the competencies. METHODS: The job competencies were drawn from 22 HIV counseling nurses by developing new models and utilizing specialist groups. The importance, level of difficulty, and performance frequency of the competencies were analyzed using the average and deviation. RESULTS: The results of this study identified 6 job competencies such as counseling performance, expertise utilization, cooperation, support, administration, and self-development, 28 sub-competencies, and 48 job descriptions. Out of the 6 job competencies, counseling performance recorded high levels in the importance, level of difficulty, and performance frequency CONCLUSION: The study results will be used as the basic data of the training programs for strengthening the job competencies of HIV counseling nurses. Furthermore, it is expected that the results will contribute to the prevention of HIV/AIDS transmission, the core of the national HIV/AIDS control programmes, and the improved health and quality of life in people living with HIV.
Counseling* ; Education ; HIV* ; Job Description ; Quality of Life ; Specialization

Granuloma is a chronic inflammatory process associated with non-infectious agents or infectious diseases such as tuberculosis. It is well known that AFB staining, which has been used to determine the etiology of the granulomatous inflammation, lacks both sensitivity and specificity. Due to the slow growth rate of most pathogenic mycobacteria, culturing of organisms can take up to eight weeks. It is not uncommon for specific therapy to be delayed, or for an inappropriate treatment be given to patients without mycobacterial infections or with infections caused by atypical mycobacteria. Determination of the causative agent in Papanicolaou stained cytology specimens gives pathologists even more difficulties when only necrotic material has been aspirated from the center of the granuloma. In recent years, the use of a polymerase chain reaction for the amplification of DNA has appeared promising in terms of speed, efficiency, sensitivity, and specificity. Since a polymerase chain reaction permits the sensitive genetic analysis of small amounts of tissue, it is ideally suited to the genetic analysis of cytologic specimens. A polymerase chain reaction is easily performed on unfixed and unstained cells, however, an analysis of ethanol fixed and Papanicolaou-stained archival smears has also been described. We have recently established a method to detect Mycobacterium tuberculosis organism by a nested polymerase chain reaction with primers in the insertion sequence IS 6110, using cellular digests of ethanol-fixed and Papanicolaou-stained archival specimens aspirated from the lymph nodes, lungs, thyroid, etc. Inhibitors present in Papanicolaou stained material was removed by destaining the slides with 0.5% HCl solution for 10-30 minutes. Eight out of ten cases which have shown the epithelioid granulomas revealed a positive reaction and four out of ten cases which have shown lymphohistiocytic cells in a necrotic background without any evidence of granuloma revealed a positive reaction. This study showed that it was possible to employ a polymerase chain reaction to detect Mycobacterium tuberculosis in Papanicolaou stained archival cytology specimens.
Communicable Diseases ; DNA* ; Ethanol ; Granuloma ; Humans ; Inflammation ; Lung ; Lymph Nodes ; Mycobacterium tuberculosis* ; Mycobacterium* ; Nontuberculous Mycobacteria ; Polymerase Chain Reaction ; Sensitivity and Specificity ; Thyroid Gland ; Tuberculosis

PURPOSE: The purpose of this study was to investigate the relationship between eating disorders, and self esteem in female college students. METHOD: The survey was carried out on convenience sample of 388 college female students. The questionnaire consisted of each scale for eating disorder, self-esteem. The data was analyzed by the SPSS/PC using frequency, percentage, mean, standard deviation, ANOVA, and Spearman correlation coefficient. RESULT: More than 43% of the subjects perceived their weight as overweight, while 1.5% of the women were obese as defined by BMI. About 57.4% of subjects were not satisfied with their body shape. Frequency of eating disorder was 5.93%. The score of eating disorder was high when the subjects had negative perception and low satisfaction with their body shape. The high scores of self-esteem were shown among the group who had high satisfaction on body shape. There was negative correlation between eating disorder and self-esteem(r=-.194, p=.000). CONCLUSION: This study suggests that the nursing intervention was necessary for female college students to recognize healthier eating habits and increased their self-esteem.
Feeding and Eating Disorders* ; Eating* ; Female* ; Humans ; Nursing ; Overweight ; Surveys and Questionnaires ; Self Concept

PURPOSE: to develop an instrument to assess the rehabilitation motivation and to test its reliability and validity. METHOD: The data was collected with in-depth interviews of nine participants that include adults with disabilities acquired after they reached 18 years' of age. The development of the preliminary items was based on the theory of self-determination proposed by Deci and Ryan (1985) and the results from the analysis of the data. After these, appropriate specialists clarified the validity of the contents of the preliminary items twice. A test to reliability and validity was conducted with 186 disabled. A principal axis factor analysis with oblimin rotation was performed on 29 items. RESULT: Finally 27 items were selected. The 5-factor solution emerged as the most appropriate model for the data. The different types of motivation for rehabilitation were identified as: task-oriented motivation, change- oriented motivation, obligatory motivation, external motivation, and amotivation. The alpha coefficient of internal consistency was .85. CONCLUSION: The results of this study suggest that the instrument to measure motivation for the rehabilitation of the disabled may be a useful instrument with a high degree of reliability and validity.
Adult ; Axis, Cervical Vertebra ; Disabled Persons ; Factor Analysis, Statistical ; Humans ; Motivation* ; Rehabilitation* ; Reproducibility of Results ; Specialization

No abstract available.
Cyclosporine* ; Scleredema Adultorum*

Colorectal cancer (CRC) affects largely elderly populations. However, older patients with CRC are generally excluded from randomized clinical trials, and the healthy subjects who are recruited are not representative of the general elderly patient population. Nevertheless, recent data from clinical trials specifically targeting elderly patients and related subgroup analyses indicate that well-selected elderly patients can have a similar response to that of younger patients. Chronological age should not determine the candidacy for adjuvant or palliative chemotherapy in elderly patients with CRC. The appropriate management of healthy elderly patients would mean that they could receive aggressive chemotherapy in a similar regimen to that of younger patients, whereas the care of frail elderly patients and those with a short life expectancy should focus on palliation. The use of a comprehensive geriatric assessment could allow the use of safe and beneficial chemotherapy regimens in elderly patients with CRC.
Aged* ; Colorectal Neoplasms* ; Drug Therapy* ; Frail Elderly ; Geriatric Assessment ; Humans ; Life Expectancy