The activity and growth of the accessory male sex gland depend on the androgen. The sex hormones effect on the growth of seminal vesicle and the prostate differently, but the relationship of the age and hormonal effect is not clear. To clarify the ageing effect on the male sex accessory gland, the morphometrical study has been done and the results analyzed with hormonal effect on the gland structure. Twenty-five seminal vesicle and prostate on bloc autopsy specimens[aged 22-68] were used. Middle portion of each side of the seminal vesicle and all blocks of the prostate horizontally divided at 3-5mm were embbeded in paraffin. Serial 7microm thick sections were prepared with hematoxiline and eosin, Gomori trichrome staining. For quantification, the image analyzer and the point counting method were used. There was not noticable change in the ratio of the parenchyma and the fibromuscular stroma in prostate until age of 60. At age of 20s, the actual ratio of the central, peripheral and transitional zone was accounted to 25%, 70%, 5% respectively, and it changed to 25%, 62%, 13% at 50`s. The percentage of the epithelial component in the glandual tissue was higher in the seminal vesicle. In the prostate, that was highest in the central zone. Stromal component was most abundant in the transitional zone. In both glands, the epithelial percentage decreased while the stromal percentage increased with age. The changing rate of the epitheilal and stromal compoenent was highest in the central zone. The luminal component changed only in the peripheral zone. The stromal component was most abundent in the transitional zone at all ages, even the increasing rate was highest in the central zone. The change in the proportion of each prostate zone and the different pattern of tissue compositional change in seminal vesicle and each prostate zone according to age represent the difference of hormonal and ageing effects on the seminal vesicle and each prostate zone.
Autopsy ; Eosine Yellowish-(YS) ; Gonadal Steroid Hormones ; Hematoxylin ; Humans* ; Male ; Paraffin ; Phenobarbital ; Prostate ; Seminal Vesicles

A morphometric study on the trigeminal ganglion and the intracranial portion of the ophthalmic, maxillary and mandibular nerves was done in 50 Korean adult cadavers. The shape of the ganglion was classified into 7 types and semicircular shape was most common (54%). Mean width of the trigeminal root at porus trieminus was 6.08mm. The length of the trigemnal root from porus to the trigeminal ganglion was 8.28mm at ophthalmic portion, 10.16mm at maxillary portion, and 8.90mm at mendibular portion. Maximum width of the ganglion was 15.48mm and the breadth of the ophthalmic, and maxillary portion were 5.25mm and 5.26mm, respectively, and that of the mandibular portion (4.92mm) was narrow than the other portion. Intracranial ophthalmic nerve was 4.30mm of width and 17.89mm of length, and this nerve inclined average 39.7。 (range 14.56。) from sagital plane. It was observed infrequently that the cavernous sinus extended to the lateral border of the maxillary nervw and the emissary sinus ran under the mandibular nerve.
Adult* ; Cadaver ; Cavernous Sinus ; Ganglion Cysts ; Humans ; Mandibular Nerve* ; Ophthalmic Nerve ; Trigeminal Ganglion*

The composition and the structure of the sacrum present the sexual and the racial difference. The variation of the structure is meaningful in the administration of caudal anesthesia which used one of the safest and the most valuable means of local anesthesia. In this study, a morphological investigation of the sacrum in Korean adults was done using 145 dry sacral bones. Non-metrical morphological variations were observed and ten measurements were undertaken. The results of the study were as follows. 1. The five segmented sacrum appeared most commonly (62.1%). Six segmented sacrum appeared 37.2% and the incidence tended to increse according to the age. Four segmented sacrum was noted in one case (0.7%). 2. In 9.7%, deficiences existed in the upper dorsal wall of the sacral canal. In 5.5%, deficiences existed in the middle of the dorsal wall of the sacral canal. 3. The apex of the sacral hiatus was found mostly (28.9%) at the upper third of the body of fifth sacral vertebra. 4. The sacral hiatus was classified into five groups by shape with triangular being the most frequent. 5. There was a significant sexual difference in the antero-posterior and transverse diameters of the first sacral vertebral body, the length of the sacrum, and the length of the sacral hiatus. 6. The average sacral index I was 98.2 in male, and 104.4 in female. Sacral index I was the relationship between the greaster breath to the length of the sacrum. 7. The average sacral index II was 46.6 in male, and 44.8 in female. Sacral index II was the relationship between the first sacral body diameter to the greaster breath of the sacrum. A thorough knowledge of the anatomical features of the dorsum of the sacrum including above results will lead to the decrease in the number of failures in administration of caudal anesthesia.
Adult* ; Anesthesia, Caudal ; Anesthesia, Local ; Female ; Humans ; Incidence ; Male ; Sacrum* ; Spine

The purpose of this study were to find out the practical way to enlarged child-raising knowledge and to enhance their satisfaction with out-patient care by evaluating how effectively the education is done by nurses for mothers with ill-child and how their satisfaction with out-patient care changed. This study was designed as a Nonequivalent Control Group study. The subjects studied were consisted of the experimental and control group. Each consisted of 50 mothers with ill-child in pediatric department at one university hospital in Seoul. The period of this study is from May 20, 1996 to June 28, 1996. The first data were collected fro both of experimental and control groups in which mothers with ill-child come to the hospital for the first time. After this being done, the experimental group had been educated by the planned program and then the second data were collected from them. On the contrary, as for the control group, there had been no education and the second data were collected on the same method. The data analysis was done by SPSS program. The results of this study are as follow, 1. The child-raising knowledge level of mothers with education was higher than that of with no education.(t=18.84, df=49, p=0.000) 2. The satisfaction with out-patient care level of mothers with education was higher than that of no education.(t=10.51, df=49, p=0.000) Based on these results, I suggest as follow, 1. The research on the patients and their family should be made not only in pediatric department, but in every out-patient department. 2. For more effective education, it is required for all out-patient nurses to research the education demand of patients and their family. 3. To increase the effect of education, there must be the consultation room in out-patient department. 4. The meetings with the mothers with ill-child of the same illness have to be established and periodical education must be executed. 5. Audio-visual education programs like video tapes are needed to make use of waiting time for the medical treatment. 6. On-line consulting program are needed.
Education ; Humans ; Mothers* ; Outpatients* ; Seoul ; Statistics as Topic ; Child Health

The current classification of pituitary adenomas is based on cell type, largely ascertained by immunohistochemistry and electron microscopy. In an application of immunohistochemistry, pathologists have some problems in judging the results. An immunostaining result does not always correspond with a serum hormone level. It is also difficult to determine the nature of a tumor when a few cells are positive. We performed the immunohistochemical stains on 34 pituitary adenomas using polyclonal antibodies to six pituitary hormones [PRL (prolactin), GH (growth hormone), ACTH (adrenocorticotropic hormone), FSH (follicle-stimulating hormone), LH (luteinizing hormone), TSH (thyroid-stimulating hormone)] and compared with serum hormone level. The serum hormone level was increased in 14 cases (41.2%) of PRL, 7 cases (20.6%) of PRL & GH, 6 pleurihormonal cases (17.6%), 4 nonfunctioning cases (11.8%), 2 cases (5.9%) of FSH, and 1 case (2.9%) of GH. The most common immunohistochemical type of pituitary adenoma was 10 prolactinoma cases (38.5%), followed by 7 pleurihormonal cases (26.9%), 4 null cell cases (15.4%), 3 cases of mixed PRL & GH (11.5%), 1 case of ACTH (3.8%) and 1 FSH & LH case (3.8%). The corresponding rates of the serum hormone level and immunostaining results were 94.1% in GH, 88.9% in TSH, 85.7% in LH, 82.4% in ACTH, 66.7% FSH, and 61.8% in PRL. In the immunostaining for FSH, 12 cases showed less than 5% positivity and most of them exhibited the normal serum hormone level. In conclusion, the most common elevated serum hormone and immunohistochemical type of pituitary adenoma was prolactinoma. The corresponding rate of the serum hormone level and immunostaining result was the highest in GH cell adenoma and was the lowest in prolactinoma. The cells showing less than 5% positivity seem to be entrapped normal cells.
Adenoma ; Adrenocorticotropic Hormone ; Antibodies ; Classification ; Coloring Agents* ; Immunohistochemistry ; Luteinizing Hormone ; Lymphocytes, Null ; Microscopy, Electron ; Pituitary Hormones ; Pituitary Neoplasms* ; Prolactinoma

Pulmonary angiodysplasia indicates all forms of abnormal intrapulmonary arteriovenous comunication, usuallycalled pulmonary arteriovenous fistula. Most frequent form of pulmonary angiodysplasia is single or multiplediscrete nodular lesion, and diffuse telangiectatic type consists another variety. More than 50% of pulmonaryangiodysplasias are associated with hereditary hemorrhagic telangiectasia. And rearely chronic liver disease iscomplicated by pulmonary arteriovenous fistula which is called hepatogenic pulmonary angiodysplasia. Weexperienced 6 cases of pulmonary angiodysplasia confirmed by cardiac catheterization and angiography from 1977 to1983. 5 cases were children below 11 years of age exhibiting cyanosis except one who has pulmonary angiodysplasiasupplied by systemic arteries. 3 were hereditary hemorrhagic telangiectasia and one was hepatogenic pulmonaryangiodysplasia. Discrete nodular pulmonary lesion was present in 3 cases while remaining 3 cases were diffusetelangiectatic type. The clinical and radiological findings of pulmonary angiocysplasia is described with a briefreview of literature.
Angiodysplasia ; Angiography ; Arteries ; Arteriovenous Fistula ; Cardiac Catheterization ; Cardiac Catheters ; Child ; Cyanosis ; Humans ; Liver Diseases ; Telangiectasia, Hereditary Hemorrhagic

BACKGROUND: EGF and TGF-a are ligands for the EGF-receptor and act as mitogens for a variety of tissues. TGF-a, in particular, has been implicated as an autocrine growth factor for several cancer cell lines. TGF-B exerts an inhibitory effect on the growth of most epithelial cell types, and the loss of responsiveness to this growth inhibition has been implicated in the development of a variety of human cancers. In the present study, we evaluate whether EGF, TGF-a and TGF-B modulate apoptosis and cell cycle progression in cervical cancer cell lines. MATERIALS & METHODS: The effect of EGF, TGF-a and TGF-B on apoptosis and cell cycle such as CaSki and HeLa cell lines was analysed by flow cytometry RESULTS: 1. TGF-B did not induce apoptosis in CaSki and HeLa cell lines. 2. TGF-B as well as EGF, TGF-a, did not affect the process of apoptosis significantly. 3. The time to occur apoptosis was different between CaSki and HeLa cells treated by growth factots. 4. G1 phase was the checkpoint in CaSki and HeLa cells treated with TGF-B. CONCLUSION: These results suggest that TGF-B as well as EGF, TGF-a does not induce apoptosis and cell growth inhibition.
Apoptosis* ; Cell Cycle Checkpoints* ; Cell Cycle* ; Cell Line* ; Epidermal Growth Factor* ; Epithelial Cells ; Flow Cytometry ; G1 Phase ; HeLa Cells ; Humans ; Ligands ; Mitogens ; Uterine Cervical Neoplasms*

OBJECTIVE: To evaluate the clinical effect and reproductive outcome of pelviscopic ovarian drilling in infertile patients with polycystic ovarian syndrome resistant to clomiphene citrate. METHODS: Twenty two patients involved in this study were taken pelviscopic ovarian drilling with needle electrocautery. Change of characteristic LH/FSH ratio before and after operative treatment, ovulation and pregnancy success were followed up. Paired t-test was applied for hormonal change (p<0.05). RESULTS: Thirteen of 14 patients (93%) treated only with pelviscopic ovarian drilling showed successful ovulation with or without clomiphene citrate and among these 10 patients (71%) were success in pregnancy and 9 patients delivered full term babies. When including patients who needed other assisted reproductive technique and specific medication of endometriosis 17 of 22 patients (77%) were successfully pregnant and 15 patients (68%) delivered healthy babies. The mean LH/FSH ratio 2.0+/-0.5 before treatment were decreased to 1.26+/-0.37 after treatment (p<0.05). Interestingly, among 22 patients, various degree endometriosis were found during pelviscopy and specific medication with GnRH analogue were followed. CONCLUSION: Pelviscopic ovarian drilling showed successful ovulation rate and effective reproductive outcome in clomiphene-resistant infertile patients with PCO. This surgical technique seems to be an alternative step for the management of clomiphene-resistant infertile patients with PCO and also for the diagnosis of possible high rate of endometriosis in these patents.
Clomiphene* ; Diagnosis ; Electrocoagulation ; Endometriosis ; Female ; Gonadotropin-Releasing Hormone ; Humans ; Needles ; Ovulation ; Polycystic Ovary Syndrome* ; Pregnancy ; Reproductive Techniques, Assisted

The complexily in development of the dural sinus may result in many variations. Studies are being done on the variation of the straight sinus for clinical application of neurological diagnosis and operation. However, no data is available on Koreans, which made this study necessary. The present study was made on 50 Korean adult cadavers (average age of 67). The results were as followlng. 1. A bulbous formation of the rostral aspects of the straight sinus was present in 22 cases(44%). 2. Complete double straight sinus was present in 3 cases(6%). 3. Partial septum was observed in 8 cases (16%) with varied position and length. 4. The straight sinus terminated into both transverse sinuses(52%), the left transverse sinus(24%), the confluence of sinuses (18%), and the right transverse sinus(6%). 5. Average length and width of the straight sinus were 48.5mm and 5.9mm, respectively. 6. Nineteen cases(38%) showed no tentorial sinus drainage into the straight sinus on both sides. Number, size and terminationes.
Adult* ; Cadaver ; Diagnosis ; Drainage ; Humans

The propose of the study is to try to support the practice of caring suitable for our cultural emotion by cognating the meaning of caring related to health which is melted in korean culture. Concrete purposes were as followings; to first, confirm the caring of civilian in Kangwon-do, to secondly search the caring in the traditional culture idea, and to thirdly present the conceptual frame about the caring. The methodology of this research is the ethnography to use the depth interview and the participative observation. The geographical area of this research was in Wichon-ri, Songsan- myon, Kangnung-shi, Kangwon-do. Study participants were, 6men and 18women, totally 24 persons. Their average age was 72.6 years old. The period of data collection was from January, 1998 to April, 1999, which original data became saturation. Data collection was done after accept allowance of the participants, their stories were recorded in cassettee, by the way of the Spradley analysis was applied and adjusted. The results which was analyized as domain, category and property were as following; First, the category was the life serving other persons, which is the for mind, the benefiting one, the comprehensive one, the respective one, on soon. Second, the category was the controling life, and its property was the moderate mind, that is, vegetables were tried to be fed moderately, pleasantly and comfortable. Thirdly, the category was the eagerness life, and the properties were diligent mind, and mind which accomplished the complete resposibility. Fourth, the category was a happy life, and the properties were positive mind, satisfying one, thankful one, one of their ancestors benefit, and supplicatory one. Fifth, the category was the accepting life, and the properties were the submissive mind, resign one. Sixth, the category was the joint life all together and the properties were the harmonized mind, and the mutual helping one. Seventh, the category was the ruling life, and the properties were the pure mind, the ones which controls the body, the mind, the nature; which could surely confirmed the source of the life that lived with the nature, the native idea of our people. Eighth, the category was the retaining life, and the properties were the inherits the native custom, and the one that keep public morals. According to the result of examining the caring in ethnography, the general caring was performed the conceptual frame about the caring which is related to health was found in the principle of consideration, harmony, compliance, and transcendence.
Anthropology, Cultural* ; Compliance ; Surveys and Questionnaires ; Gangwon-do* ; Humans ; Joints ; Korea* ; Morals ; Vegetables