No abstract available.
Atherosclerosis* ; Hyperuricemia* ; Risk Factors*

The technique of plssma exchange has been applied to a number of immune disorders in which c4eulating antibodies are present. We observed a patient with bullous pemphigoid and serious side effects of longterm use of steroid therspy. We applied ten times of plasmapheresis to him over six months period. After the plasmapheresis, clinical symptoms have greatly improved and steroid maintenance doses have been decreased. We have not observed any side effect of plasmapheresis such as thrambotopenia or hypogarnrnaglobulinemia during the whole therapeutic period.
Antibodies ; Humans ; Immune System Diseases ; Pemphigoid, Bullous* ; Plasmapheresis*

Rasch was the first to use the term carcinoma erysipelatoides in the dermatologic literature, and it is most frequently associated with breast carcinoma. This inflammatory type of rnetastatic carcinoma of the breast is an uncommon but well known entity. It occurrs almost exclusively in women, tends to appear in the anterior chest wall, and is usually found after recognition of the primary tumor which is usually adenocarcinoma or undifferentiated carcinoma. It has an acute inflammatory process with rapid progress, with many fatalities resulting in a short time. We report a case of carcinoma erysipela,toides originating from a breast carcinoma with characteristic clinical and histopathologic findings.
Adenocarcinoma ; Breast ; Breast Neoplasms ; Carcinoma ; Female ; Humans ; Skin* ; Thoracic Wall

Serum IgE values were determined in 100 patients vith atogic dermatitis in the Department of Dermatology at Severance Hospital, Yonsei University College of Medicine, from Oct. 1, 1978 to Mar. 31, 1980. Mean IgE value of patients is 293. 4 unit/ml which is significantly higher than reference value, and the following results were obtained. 1. The mean IgE value in adults with atopic dermatitis, 339.8 unit/ml, 30 cases: more tian 16 years old) was significantly higher than in children(251. 4 unit /ml, 70 cases). 2. Male patierts showed higher IgE va,lue (mean 324. 5 unit/ml, 62 cases,' than female patients (242.7 unit/ml, 38 cases). 3. No close correlation was demonstrated between IgE values and eosiniphils in blood. 4. Patients with parasitic infesta,tion (5 cases) showed relatively increased IgE values (mean; 116. 2 unit/ml;. 5. Patients wifh bronchial asthma (2 cases) showed high IgE values exceeding 1000 unit/ml, 6. IgE. values roughly correlated with severity of the dermatitis. Four cases with high IgE values exceeding 1000 unit/ml were included in the clinically severe group.
Adult ; Asthma ; Dermatitis ; Dermatitis, Atopic* ; Dermatology ; Female ; Humans ; Immunoglobulin E* ; Male ; Reference Values

No abstract available.
Nipples* ; Poroma*

PURPOSE: The purpose of this study was to identify the therapeutic effect of orbital reconstruction by transcaruncular approach on old medial orbital wall fracture. METHODS: We performed retrospective study on 23 eyes of 23 patients, who underwent orbital reconstruction with transcaruncular approach over six weeks after injury from July 1999 to August 2001. RESULTS: Nineteen cases had enophthalmos, preoperatively; five cases; 2 mm, seven cases; 3 mm, six cases; 4 mm, and one case; 5 mm, respectively. Postoperatively, we obtained enophthalmos less than 1 mm in 17 cases(89%). The exophthalmometry revealed that enophthalmos improved from 3.2+/-0.9 mm, preoperatively to 0.9+/-0.7 mm, postoperatively. Twelve cases had diplopia on the primary and downgaze, preoperatively. However, ten cases of them(83%) disappeared diplopia, postoperatively. Of the remaining two cases, one had persistent diplopia on the downgaze and the other had paralytic strabismus. CONCLUSIONS: We believe that the medial orbital wall repair through transcaruncular approach was a good way to correct enophthalmos and diplopia on old medial orbital wall fracture.
Diplopia ; Enophthalmos ; Humans ; Orbit* ; Retrospective Studies ; Strabismus

INTRODUTION: The gamma-aminobutyric acid type A (GABAA) receptor is an important pharmacological target of alcohol. The phamacological characteristics of the receptor are largely determined by its subunit composition. Compared with all other alpha subtypes, the alpha6- containing receptors are more sensitive to GABA and less sensitive to benzodiazepines. The purpose of this study was to address a role for GABAAalpha6 receptor subunit gene in the development of alcohol dependence. The differential manifestation of alcohol withdrawal symptoms related to GABAAalpha6 polymorphism in patients treating with benzodiazepines was also examined. METHODS: Eighty-seven inpatients with alcohol dependence, and sixty healthy controls were evaluated using CIWA-Ar scale. Each patient was genotyped for GABAAalpha6 subunit. Association between GABAAalpha6 polymorphism and severity of withdrawal symptom were determined. RESULTS: No significant difference was found in GABAAalpha6 receptor genetic type and allelic distribution between the alcohol dependent and control subject. Tremor was more severe in CC than TT type. TT type had higher degree of anxiety, agitation and headache than CC type. The GABAAalpha6 C allele increased the average score of tremor significantly, and T allele increased that of agitation. CONCLUSION: The results suggested that GABAAalpha6 genetic polymorphism was not associated with alcohol dependence and with severity of alcohol withdrawal symptoms. But in benzodiazepine treated patients, GABAAalpha6 polymorphism and allelic type show the difference in severity of each withdrawal symptom. These differences of severity are partly responsible for the unique pharmacological properties associated with the GABAAalpha6 subunit.
Alcoholism ; Alleles ; Anxiety ; Benzodiazepines ; Dihydroergotamine ; gamma-Aminobutyric Acid ; Headache ; Humans ; Inpatients ; Polymorphism, Genetic ; Receptors, GABA ; Substance Withdrawal Syndrome* ; Tremor

Background : Korean Activities of Daily Living(K-ADL) scale and Korean Instrumental Activities of Daily Living(K-IADL) scale were developed to measure the function of the old. The evaluation through K-ADL and K-IADL is important for the optimal medical service to the disabled old people on the Sorokdo. This study was conducted to assess the functional disability of them and to find out the suitable medical service. Method : This research was collected from 731 Sorokdo residents in Oct, 2003. The data were compared by chi-square test, independent t-test and ANOVA test using SPSS(ver 10.0) with alpha-error=0.05. Result : Bathing-points and clothing-points on ADL scale are comparatively low: points of the women lower than those of the men; the group over 65 years than group under that age; the patients who have combined disease than the patients who have not; and the patients who have been hospitalized more than once than those who have not been. Besides, the points of the not-disabled are lower than those of disability, the lower one`s points on ADL scale. It is due to the fact that there are many not-disabled persons over 65 years old. Preparing-a-meal points and washing-points on IADL scale are comparatively low: points of the women lower than those of the men; the group over 65 years than group under that age; the patients who have combined disease than the patients who have not; the patients who have been hospitalized than those who have not been one a more; and the seriously- disabled and the slightly-disabled. The points on Barthel ADL scale are dwindling annually by 0.3 to 0.5, the decrease of the women being greater than that of the men. Conclusion : Special medical programs for the old patients and a rehabilitation health service will improve the reliability of medical service on Sorokdo hospital and increase quality of life.
Activities of Daily Living ; Aged ; Female ; Health Services ; Humans ; Leprosy ; Male ; Quality of Life ; Rehabilitation

PURPOSE: Soft tissue or muscle adhesion to the Porous Polyethylene Sheet Implant (PPSI) can cause postoperative extraocular motility disturbance after orbital fracture repairs using PPSI. This study was designed to examine the efficacy of amniotic membrane transplantation in the suppression of fibrosis between orbital connective tissue and PPSI. METHODS: Twelve New Zealand white rabbits were grouped as A, B, and C and conventional PPSI were implanted between orbital connective tissue and orbital floor in group A; PPSI with a barrier surface (PPSI-B) in group B; PPSI with amniotic membrane transplantation in group C. The implants were harvested at 8 weeks postoperatively, and stained with Masson trichrome and hemaoxylin and eosin staining techniques. RESULTS: In group A, the PPSI demonstrated dense adhesion on both the soft tissue implant and the bone implant interfaces. A lot of fibroblasts were observed on the surface of PPSI. In group B, the PPSI-B demonstrated less fibrosis over the barrier surface, and less fibroblasts than in group A. In group C, the PPSI with amniotic membrane transplantation manifested least fibrous adhesion among three groups. CONCLUSIONS: In orbital fracture repair, amniotic membrane transplantation could reduce the fibrosis between orbital connective tissue and PPSI, and might prevent the postoperative extraocualr motility disturbance.
Amnion* ; Connective Tissue* ; Eosine Yellowish-(YS) ; Fibroblasts ; Fibrosis* ; Orbit* ; Orbital Fractures ; Polyethylene* ; Rabbits

Background: This study aimed at investigating the meal regularity, health, and oral health habits of single Korean households to understand the impact of these factors on the risk of metabolic syndrome, in addition to preventing and managing metabolic syndrome. Methods: Using raw data from the 8th Korea National Health and Nutrition Examination Survey (2019), 274 study subjects, aged 19 to 64, were selected primarily from single adult households. Complex sample statistical analysis was performed using the Predictive Analytics Software Statistics ver. 18.0 program. Results: Regarding the meal regularity in single-person households in Korea, the younger group outperformed the middle-aged group, and those who drank more than once a month performed better than those who drank less than once a month. In terms of oral health, regardless of the age and the income level, participants who ate three meals a day had a higher rate of speech problems and chewing difficulties than those who ate irregularly or regularly on a regular day. Factors influencing the risk of developing metabolic syndrome were age, speech problems, and frequency of toothbrushing. Compared to the younger group, there were 0.361 times more people in the middle-aged group; and compared to those without speech problems, there were 1.161 more people with speech problem. Compared to those who tooth brushed more than four times a day, there were 1.284 more people who tooth brushed 2 to 3 times a day and there were 5.673 times more people who tooth brushed less than once. Conclusion Based on the study results, it is necessary to implement a program that can plan and apply customized management measures and prevent metabolic syndrome by improving and correcting the health and oral health behaviors of single-person households in Korea. Therefore, active mediation measures, such as support and publicity at the local or national level, should be planned.