3.Biliary Tract & Pancreas; A Case of Cholangiocarcinoma Suggested as Developing in the Patient with Primary Sclerosing Cholangitis.
Sun Young YI ; Mi Seung SHIN ; Hye Kyung JUNG
Korean Journal of Gastrointestinal Endoscopy 1997;17(1):99-104
Primary sclerosing cholangitis is a chronic disease of unknown cause, characterized by inflammation and fibrosis of the biliary tree with diffuse multifocal stricture formation. With increasing knowledge of primary sclerosing cholangitis, it is now recognized that in the setting of inflammatory bowel disease, cholangiocarcinoma is a complication of primary sclerosing cholangitis. We recently experienced a case of 41 year old female patient who had Crohns disease associated with primary sclerosing cholangitis and cholangioearcinoma. We report a case of primary sclerosing cholangitis with cholangiocarcinoma with literature review.
Adult
;
Biliary Tract*
;
Cholangiocarcinoma*
;
Cholangitis, Sclerosing*
;
Chronic Disease
;
Constriction, Pathologic
;
Crohn Disease
;
Female
;
Fibrosis
;
Humans
;
Inflammation
;
Inflammatory Bowel Diseases
;
Pancreas*
4.Superior mesenteric artery mycotic aneurysm complicating infective endocarditis.
Sun Hye SHIN ; Sun Hee LEE ; Kook Jin CHUN ; Chang Won KIM
Korean Journal of Medicine 2002;63(3):344-345
No abstract available.
Aneurysm, Infected*
;
Endocarditis*
;
Mesenteric Artery, Superior*
5.Detection of nasopharyngeal carriages in children by multiplex reverse transcriptase-polymerase chain reaction.
Ji Hye SHIN ; Hye Young HAN ; Sun Young KIM
Korean Journal of Pediatrics 2009;52(12):1358-1363
PURPOSE: The aim of this study was to determine the prevalence of asymptomatic nasopharyngeal carriages in children using a multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) assay kit. METHODS: We obtained nasopharyngeal swabs from 33 children without any underlying disease from July 25 to July 28, 2008. The children were free from the signs of respiratory tract infections at the time of sampling. DNA was extracted from the swabs and subjected to multiplex RT-PCR using a primer set for the detection of pneumococci (Seeplex(R) PneumoBacter ACE Detection Seegene, Seoul, Korea). The amplified PCR products were separated on 2% agarose gels and stained with either ethidium bromide or screen tape system (Lab901 Scotland, UK). RESULTS: A total of 33 children (male, 15 female, 18) aged between 3.2 and 16.3 (median, 8.2) years were included in this study. The mRT-PCR detected colonized bacteria (Streptococcus pneumoniae, Hemophilus influenzae, Chlamydia pneumoniae, and Bordetella pertussis) in 30 children (90.9%). Of these, 13 children (39.4%) showed more than 2 bacteria: 12 children were positive for 2 bacteria (S. pneumoniae and H. influenzae) and 1 child was positive for 3 bacteria (S. pneumoniae, H. influenzae, and C. pneumoniae). CONCLUSION: mRT-PCR was found to be a sensitive tool for the detection of asymptomatic nasopharyngeal carriages. Clinical significances of the bacteria detected by mRT-PCR will have to be evaluated in the future.
Aged
;
Bacteria
;
Bordetella
;
Child
;
Chlamydophila pneumoniae
;
Colon
;
DNA
;
Ethidium
;
Female
;
Gels
;
Haemophilus influenzae
;
Humans
;
Influenza, Human
;
Nasopharynx
;
Pneumonia
;
Polymerase Chain Reaction
;
Prevalence
;
Respiratory Tract Infections
;
Scotland
;
Sepharose
;
Streptococcus pneumoniae
6.Effect of Etanercept on Steroid Refractory Graft-versus-host Disease in Children.
Hye Young HAN ; Ji Hye SHIN ; Sun Young KIM
Korean Journal of Hematology 2009;44(4):212-219
BACKGROUND: Etanercept is a recombinant human soluble tumor necrosis factor-alpha (TNF-alpha) receptor fusion protein that inhibits TNF-alpha, a major mediator in the pathogenesis of graft-versus-host disease (GVHD). The purpose of our study was to evaluate the safety and efficacy of etanercept therapy in children with steroid-refractory acute GVHD (aGVHD) (n=5) and chronic GVHD (cGVHD) (n=3). METHODS: Five males and 3 females were enrolled and their median age was 14.4 years (range, 2.1~18.8). Etanercept 0.4 mg/kg per dose (maximum dose, 25 mg) was given subcutaneously twice weekly for 4 weeks followed by 0.4 mg/kg per dose (maximum dose, 25 mg) weekly for 4 weeks. At the time of initiation of etanercept, 5 patients had aGVHD grade III to IV (III=4, IV=1) and 3 patients had moderate to severe cGVHD (moderate=1, severe=2). RESULTS: Overall, 6 of 8 patients (75%) responded to the treatment with etanercept, including 5 patients with aGVHD [n=3 complete response (CR), n=2 partial response (PR)] and 1 patient with cGVHD [n=1 PR, n=2 no response (NR)]. Clinical responses were most commonly seen in patients with refractory gut aGVHD. CMV reactivation occurred in 2 patients, bacterial infection in 1 patient, and fungal infection in 1 patient. CONCLUSION: Our preliminary data indicate that etanercept is well tolerated and can induce a high response rate in patients with steroid refractory aGVHD, particularly in the setting of intestinal involvement.
Bacterial Infections
;
Child
;
Female
;
Graft vs Host Disease
;
Hematopoietic Stem Cell Transplantation
;
Humans
;
Immunoglobulin G
;
Male
;
Receptors, Tumor Necrosis Factor
;
Tumor Necrosis Factor-alpha
;
Etanercept
7.Development of Management Competency Enhancement Program for Middle-Level Nursing Managers
Seulki KIM ; Ji Hye JEONG ; Hye Kyeong SHIN ; Sun Joo CHOI
Journal of Korean Clinical Nursing Research 2023;29(1):107-120
Purpose:
The purpose of this program is to develop an educational program to improve the nursing management competency of middle-level nursing managers.
Methods:
The program outline is based on the results of the Importance Performance Analysis (IPA) and Systematic Review (SR). Also performed the content validity accordingly.
Results:
The result of the concepts are derived from 6 competencies for planning process, 4 competencies for organizing process, 4 competencies for staffing process, 26 competencies for directing process, and 12 competencies for controlling process by integrating IPA and SR. This outline of the program was constructed according to the derived integrated concept and both content validity and structured outline were interpreted as valid.
Conclusion
This suggests that middle-level managers need a systematic program and support to effectively lead the organization by recognizing the importance rather than performance.
8.A Case of Severe Air Leak Syndrome Treated with High - Frequency Oscillatory Ventilation ( HFOV ).
Seong Hee SHIN ; Je Woo KIM ; Phil Soo OH ; Young Ah LEE ; Hye Sun YOON
Journal of the Korean Society of Neonatology 1999;6(1):121-126
In air leak syndrome, a significant portion of the volume delivered during a positive pressure breath can be lost through the leak. HFOV can achieve adequate ventilation at lower peak and/or mean intrapulmonary pressure than conventional mechanical ventilation (CMV) and has been an effective treatment of already established air leak syndrome. We report a 1-day-old male infant with severe respiratory failure from pneumothorax and pneumomediastinum, who was refractory to CMV with chest tube drainage. HFOV was applied to this patient for 114 hours, and improvement of oxygenation and ventilation as well as significant reduction of pneumothorax followed.
Chest Tubes
;
Drainage
;
Humans
;
Infant
;
Male
;
Mediastinal Emphysema
;
Oxygen
;
Pneumothorax
;
Respiration, Artificial
;
Respiratory Insufficiency
;
Ventilation*
9.Morphometric Study on the Sigmoid Sinus of the Korean Adults.
Hye Yeon LEE ; In Hyuk CHUNG ; Tai Sun SHIN ; Ho Suck KANG ; Byung Pil CHO
Korean Journal of Physical Anthropology 1989;2(1):25-31
The variations of the sigmoid sinus were studied in 50 Korean adults (average age 67). The classification of the shape and a measurement of the diameters of the sinus were done and the morpological. 1. The shape was classified into 4 types, and the round type was the most common in both sides. S shaped type was below 10% in both sides. 2. The breadth was regular in 54% of the right and in 70% of the left sinuses. According to the breadth change, the shape was classified into 4 shapes. 3. The average diameter was 8.6mm on the right side and 7.2mm on the left side. 4. Symmetry was present in 16% of all. 5. The right transverse sinus was absent in 1 case (2%) and the superior petrosal sinus did not open into the sigmoid sinus in 2 cases (4%). 6. Petrosqamous sinus was observed in 16%.
Adult*
;
Classification
;
Colon, Sigmoid*
;
Humans
10.Body image perception and self-reported weight control activities in adolescent girls.
Eun Kyung HONG ; Sait Byul PARK ; Young Sun SHIN ; Hye Soon PARK
Journal of the Korean Academy of Family Medicine 1997;18(7):714-721
BACKGROUND: Adolescent girls are interested in weight reduction, but effective and adequate education for weight reduction is not done in Korea. And so much information is accepted via mass media. We investigated body image perception, weight control activities and their side effects among adolescent girls. METHODS: We used questionnaire about body image and weight control activities of middle and high school girls in Seoul in Sep. 1995. RESULTS: 88.6% of girls were not satisfied with their own height and 85.1% of girls with their own weight. 66.3% underweight students(BMI<20kg/m2) thought they were too fat and 98% acceptable weight students(20kg/m2<_KBMI<25kg/m2) thought they were too fat. So most girls had body image disturbance. 42.4% of girls were trying to lose weight and 85.1% were trying to lose weight reason for attractiveness and 16.6% were trying to lose for health. Self reported weight reduction methods were exercise(31.6%), fasting(21.9%), diet(21.5%), monodiet(10.8 %), laxatives(2.3%), very low calorie diet(1.8%) etc. Students who tr ied to lose weight for attractiveness selected more undesirable methods than who tried to lose weight for health(P<0.01). Most common route is via magazine, TV and newspaper. 43.4% of girls who tried to lose weight experienced side effects after weight reduction, those were dizziness(71.3%), general weakness(51%), apathy(26.S%) etc. CONCLUSIONS: Most girls had body image distortions. Useless weight reduction activities were done or planned and most of information was accepted via mass media. It is important to educate the girls to get adequate body image and effective weight reduction program is needed for health in adolescent girls.
Adolescent*
;
Body Image*
;
Education
;
Female*
;
Humans
;
Korea
;
Mass Media
;
Periodicals
;
Periodicals as Topic
;
Self Report
;
Seoul
;
Thinness
;
Weight Loss
;
Weight Perception
;
Weight Reduction Programs
;
Surveys and Questionnaires