1.Spindle Cell Carcinoma in Larynx: A case showing bone formation.
Hye Kyung AHN ; Hye Rim PARK ; Young Euy PARK
Korean Journal of Pathology 1993;27(3):293-295
Spindle cell carcinoma of the upper aerodigestive tract mucosa was usually presented as polypoid mass and shows squamous cell carcinoma or dysplasia in the surface and underlying spindle cell proliferation. The spindle cell area discloses a variable pattern of sarcoma including rare osteosarcoma of 0~20% incidence. The histogenetic origin of the spindle cell component is now considered a metaplasia of squamous cell carcinoma. We experienced a case of spindle cell carcinoma of larynx showing massive underlying bone formation with proliferation of osteoclast-like cells in 75 year-old man. The immunohistochemical study demonstrates positive reaction with cytokeratin in area of squamous cells and with vimentin in area of spindle cells and osteoclasts. There are very focal reactivity for high molecular weight cytokeratin in spindle cell area.
Incidence
2.A case of ovarian cystadenocarcinoma diagnosed by cervicovaginal smear.
Hye Rim PARK ; Joo Hyun NAM ; Young Euy PARK
Korean Journal of Cytopathology 1992;3(2):104-110
No abstract available.
Cystadenocarcinoma*
3.Cytolgic features of placental site trophoblastic tumor-a case report of cervico-vaginal smear-.
Hye Rim PARK ; Yong Woo LEE ; Young Euy PARK
Korean Journal of Cytopathology 1993;4(2):150-155
No abstract available.
Trophoblasts*
4.Carcinosarcoma of the stomach.
Bong Bai KIM ; Won Jin CHOI ; Hye Rim PARK
Journal of the Korean Surgical Society 1991;40(1):113-120
No abstract available.
Carcinosarcoma*
;
Stomach*
5.Progression of Dermatofibrosarcoma Proruberans to Malignant Fibrous Histiocytoma: Report of a case.
Hye Rim PARK ; Eun Ha JUNG ; Jin Hee SOHN
Korean Journal of Pathology 1997;31(12):1324-1327
A 52-year-old woman was admitted with a palpable mass on the abdominal wall. This tumor had developed at the same site of a previously resected dermatofibrosarcoma protuberans. The biopsy specimen from the recurrent tumor revealed malignant fibrous histiocytoma. Immunohistochemistry with anti-CD34 antibody revealed diffuse linear positivity on the tumor cells of dermatofibrosarcoma protuberans and negativity on malignant fibrous histiocytoma. Anti CD34 antibody was valuable for a differential diagnosis of these two lesions.
Abdominal Wall
;
Biopsy
;
Dermatofibrosarcoma*
;
Diagnosis, Differential
;
Female
;
Histiocytoma, Malignant Fibrous*
;
Humans
;
Immunohistochemistry
;
Middle Aged
6.A Case Report of Pleuropulmonary Blastoma in Childhood.
Hye Rim PARK ; Jin Hee SOHN ; Ki Woo HONG
Korean Journal of Pathology 1996;30(4):351-354
Classic pulmonary blastoma is a variant of carcinosarcoma which is seen almost exclusively in adults. By contrast, most cases of pulmonary blastoma in children have been described as having an exclusive mesenchymal composition, which was proposed as pleuropulmonary blastoma. Recently we experienced a case of pleuropulmonary blastoma, type 1. This 27-month-old male baby was transferred to our hospital due to the left tension pneumothorax. Chest CT revealed a subpleural pulmonary cystic lesion on the left upper lung and an open cystectomy was performed. Histologically the lesion was composed of variable-sized cystic structures lined with a single layer of respiratory-type epithelium. the underlying stroma was composed of sheets of small, round to oval, primitive tumor cells. Some of them had eccentric, eosinophilic cytoplasm, suggestive of rhabdomyoblastic differentiation. These rhabdomyoblastic cells were fuchsinophilic and positive with desmin and vimentin on immunohistochemistry.
Child
;
Adult
;
Male
;
Female
;
Humans
7.Clinicopathologic Analysis of Gastrointestinal Polyps.
Hye Rim PARK ; In Sun KIM ; Seung Yong PAIK
Korean Journal of Pathology 1988;22(3):232-243
Pathologists play an important role in proper evaluation of endoscopically removed polyps of the gastrointestinal tract. This study is purposed to reclassify the polyps and review the clinicopathologic features of each histologic subtypes and their malignant potential. Our material consists of total 345 gastrointestinal polyps obtained from Jan. 1986 to Dec. 1987. The results are as follows: 1) A total of 345 gastrointestinal polyps was removed from stomach is 151 cases, from colon in 180 cases, and from small intestine in 14 cases. 2) Hyperplastic polyps were the most common type of polyps I stomach (53.6%) whereas neoplastic polyps were the most common in colon (56.1%). 3) Hyperplastic polyps of the stomach occur in any age after the 3rd decade of life and neoplastic polyps predominantly developed between the 5th and 8th decades. Juvenile retention polyps were frequently noted before the 3rd decade of age. 4) Approximately 267 cases (77.4%) of patients had a single polyp and the remainders had multiple polyps. The gastric polyps were usually located at the antrum and the colonic polyps were at the sigmoid colon and rectum. 5) Epithelial atypia was exclusively noted in the neoplastic polyps of stomach (72.7%) and colon (72.3%). Malignancy in the polyp was observed in the neoplastic polyps only (13 cases). 6) Different types of polyp may occur in the same organ.
8.Clinicopathologic Analysis of Gastrointestinal Polyps.
Hye Rim PARK ; In Sun KIM ; Seung Yong PAIK
Korean Journal of Pathology 1988;22(3):232-243
Pathologists play an important role in proper evaluation of endoscopically removed polyps of the gastrointestinal tract. This study is purposed to reclassify the polyps and review the clinicopathologic features of each histologic subtypes and their malignant potential. Our material consists of total 345 gastrointestinal polyps obtained from Jan. 1986 to Dec. 1987. The results are as follows: 1) A total of 345 gastrointestinal polyps was removed from stomach is 151 cases, from colon in 180 cases, and from small intestine in 14 cases. 2) Hyperplastic polyps were the most common type of polyps I stomach (53.6%) whereas neoplastic polyps were the most common in colon (56.1%). 3) Hyperplastic polyps of the stomach occur in any age after the 3rd decade of life and neoplastic polyps predominantly developed between the 5th and 8th decades. Juvenile retention polyps were frequently noted before the 3rd decade of age. 4) Approximately 267 cases (77.4%) of patients had a single polyp and the remainders had multiple polyps. The gastric polyps were usually located at the antrum and the colonic polyps were at the sigmoid colon and rectum. 5) Epithelial atypia was exclusively noted in the neoplastic polyps of stomach (72.7%) and colon (72.3%). Malignancy in the polyp was observed in the neoplastic polyps only (13 cases). 6) Different types of polyp may occur in the same organ.
9.Immunohistochemical Study of Acantholytic Cells of the Squamous Cell Carcinoma of the Skin.
Jong Min KIM ; Hye Rim PARK ; Ho Gyun LEE
Korean Journal of Dermatology 1994;32(4):669-674
BACKGROUND: Acantholysis can be seen occasionally in the cutanous squamous cell carcinoma(SCC) as a result of degenerative changes of neoplastic cells. OBJECTIVE: This study was done to investigate the keratin attern and a wide range of immunohistochemical features of acantholytic cells of cutaneous SCC. METHODS: Seventeen cases of SCC showed acantholytic cells histoloieally and formalin-fixed, paraf-finembedded biopsy specimens from them were stained by ABC(avidin-biotin-peroxidase complex) staining. Fourteen biopsy specimens from 14 cases of SCC were staincd with 3 monoclonal anti-keratin antibodies(CAM 5.2, MAK-6, and 34bE12) and 17 biopsy spec:mcns from 17 cases of SCC were stained with antibodies agairist CEA(carcinoembryonic antigen), vitamin, S-100 protein, Factor VIII-R Ag, LCA(leukocyte common antigen), and lysozyme. RESULT & CONCLUSION: Acantholytic cells of 14 cases of SCC showed consistently negative staining with CAM 5.2. The acatholytic cells showed a wide range of reactivity with MAK-6 from negative to moderately strong positivity and with 34pE12 from negative to strong positivity. A few acantholytic cells of 6 cases of SCC showed weakly positive staining with anti-CEA antibody, but acantholytic cells of all 17 cases showed consistently negative staining wit,h the other antibodies.
Acantholysis
;
Antibodies
;
Biopsy
;
Carcinoma, Squamous Cell*
;
Muramidase
;
Negative Staining
;
S100 Proteins
;
Skin*
;
Vitamins
10.Immunohistochemical Study of Acantholytic Cells of the Squamous Cell Carcinoma of the Skin.
Jong Min KIM ; Hye Rim PARK ; Ho Gyun LEE
Korean Journal of Dermatology 1994;32(4):669-674
BACKGROUND: Acantholysis can be seen occasionally in the cutanous squamous cell carcinoma(SCC) as a result of degenerative changes of neoplastic cells. OBJECTIVE: This study was done to investigate the keratin attern and a wide range of immunohistochemical features of acantholytic cells of cutaneous SCC. METHODS: Seventeen cases of SCC showed acantholytic cells histoloieally and formalin-fixed, paraf-finembedded biopsy specimens from them were stained by ABC(avidin-biotin-peroxidase complex) staining. Fourteen biopsy specimens from 14 cases of SCC were staincd with 3 monoclonal anti-keratin antibodies(CAM 5.2, MAK-6, and 34bE12) and 17 biopsy spec:mcns from 17 cases of SCC were stained with antibodies agairist CEA(carcinoembryonic antigen), vitamin, S-100 protein, Factor VIII-R Ag, LCA(leukocyte common antigen), and lysozyme. RESULT & CONCLUSION: Acantholytic cells of 14 cases of SCC showed consistently negative staining with CAM 5.2. The acatholytic cells showed a wide range of reactivity with MAK-6 from negative to moderately strong positivity and with 34pE12 from negative to strong positivity. A few acantholytic cells of 6 cases of SCC showed weakly positive staining with anti-CEA antibody, but acantholytic cells of all 17 cases showed consistently negative staining wit,h the other antibodies.
Acantholysis
;
Antibodies
;
Biopsy
;
Carcinoma, Squamous Cell*
;
Muramidase
;
Negative Staining
;
S100 Proteins
;
Skin*
;
Vitamins