1.Intraocular Pressure After Cataract Extraction in Silicone tube Implanted Glaucomatous eye.
Hye Rim CHO ; Chan Ju LEE ; Byung Chae CHO
Journal of the Korean Ophthalmological Society 1991;32(9):789-794
The functioning filtering bleb constructed after trabeculectomy in glaucomatous patient might be fail after cataract operation probably due to transient collapse during cataract extraction and inflammatiry reaction of the filtering bleb which result in unsuccessful intraocular pressure control. To compare if the results were identical in cases with the use of encircling band to enlarge the aqueous absorbing scar tissue to trabeculectomy, intraocular pressure was followed for more than 6 months after cataract extraction and posterior chamber lens implantation in 7 eyes that previously underwent silicone tube insertion with the use of encircling band. There were no cases with increased intraocular pressure needed to control postoperatively. Therefore it could be possible to concluded that inflammatory reaction of the filtering bleb or transient collapse during cataract extraction has no negative influences on intraocular pressure in silicone tube implanted eye using encircling band.
2.Hypersensitivity myocarditi caused by ceused by cafadroxil.
Tae Rim SHIN ; Hae Young CHOI ; Yoon Hye CHANG ; Young Joo CHO
Korean Journal of Allergy 1997;17(2):186-191
Hypersensitivity myocarditis is an inflammatory disease of the myocardium usually related to drug allergy. The clinical manifestation may be nonspecific, and the diagnosis is seldom suspected or established during the life. So in most of the reported patients, the diagnosis was made at autopsy. Although, retrospectively, more than 90% of the patients described have had clinically recognizable cardiac involvement before death, tole clinical suspicion of hypersensitivity myocarditis is rare. The presence of nonspecific cardiac finding in a patient receiving any drug associated with hypersensitivity should alert the clinician to the possibility of drug related myocarditis. We experienced a case of hypersensitivity myocarditis accompanying allergic skin lesion in a 58 years old man with a history of taking cefadroxil. Fortunately, the outcome was favorable, therefore we do not have histologic confirmation of the diagnosis.
Autopsy
;
Cefadroxil
;
Diagnosis
;
Drug Hypersensitivity
;
Humans
;
Hypersensitivity*
;
Middle Aged
;
Myocarditis
;
Myocardium
;
Retrospective Studies
;
Skin
3.Cutaneous Infection of Larval strongyloides stercoralis Manifesting Pseudolymphomatous Reactions.
Jin Hee SOHN ; Hye Rim PARK ; Kye Yong SONG ; Seung Yull CHO
Korean Journal of Pathology 1996;30(5):466-469
Larval nematodes belonging to genera Ancylostoma, Strongyloides, Rhabditis, Gnathostoma or microfilariae (Onchocerca volvulus)/adult filaria (Loa loa) can invade human skin, each making different lesion. In a 71-year old immunocompetent Koreanman with 23% eosinophilia and elevated serum IgG (2530 mg/dl), a skin biopsy was undertaken for a nodular lesion at abdominal wall. A longitudinal section of a larval nematode was recognized in mid-dermal tunnel surrounded by pseudolymphomatous diffuse lymphoreticular cell infiltration. The larval nematode, 15 um in maximum diameter, had outermost cuticular layer and pale intestinal cells. The nematode section was identified as a filariform larva of Strongyloides stercoralis mainly based on its maximum diameter. In Korea, this is the first description of a cutaneous larval nematode infection. This case did not show quick migration of lesion which is a typical manifestation of classical cutaneous larva migrans.
Adult
;
Male
;
Female
;
Humans
;
Biopsy
4.Glucose Homeostasis during Fetal and Neonatal Period.
Korean Journal of Perinatology 2016;27(2):95-102
Glucose is essential for energy metabolism in human, especially in brain, and is a source of energy storage in the form of glycogen, fat and protein. During fetal life, the predominant source of energy is also glucose, which crosses the placenta by facilitated diffusion. There is very little endogenous glucose production under normal circumstances during fetal life. During labor, the fetus is exposed to physiological challenges that require metabolic adaptation. A healthy infant successfully manages the postnatal transition by mobilizing and using alternative. After birth, there is a rapid surge in catecholamine and glucagon levels, and a steady decrease in insulin, as blood glucose levels decline. These hormonal changes induce enzyme activities that lead to glycogenolysis and gluconeogenesis. During the first 24-48 hours of life, plasma glucose concentrations of neonates are typically lower than later in life. Distinguishing between transitional neonatal glucose regulation in normal neonates and hypoglycemia that persists or occurs for the first time beyond the first 72 hours of life is important for prompt diagnosis and treatment to avoid serious consequences.
Blood Glucose
;
Brain
;
Diagnosis
;
Energy Metabolism
;
Facilitated Diffusion
;
Fetus
;
Glucagon
;
Gluconeogenesis
;
Glucose*
;
Glycogen
;
Glycogenolysis
;
Homeostasis*
;
Humans
;
Hypoglycemia
;
Infant
;
Infant, Newborn
;
Insulin
;
Parturition
;
Placenta
5.Massive gastrointestinal hemorrhage from the colonic varices: report of 1 case.
Chang Yong SONG ; Young Cheol LEE ; Hong Rae CHO ; Dong Kun KIM ; Sung KIM ; Won Jin CHOI ; Hye Rim PARK
Journal of the Korean Surgical Society 1993;44(6):923-928
No abstract available.
Colon*
;
Gastrointestinal Hemorrhage*
;
Varicose Veins*
6.A Comparison of the Posterior Vitreous Detachments in Normal and Diabetic Retinopathy.
Hye Rim CHO ; Jung Im LEE ; Young Bock HAN
Journal of the Korean Ophthalmological Society 1991;32(6):447-451
Among the panents who visited Ewha Womens Universty Hospital from Dec 1988 to Oct 1989, the authors investigated the presence of posterior vitreous detachment(PVD) in 181 eyes Wlth nomal fundus flnd1ngs and 160 eyes wlth diabetic retinopathy. In normal eyes, the incidence of complete PVD increased with age but that of partlal PVD was not related to age. In non prolderative diabetic retinopathy, complete PVD was 15.6% and partial PVD was 5.6%, And in proliferative diabetic retinopathy, complete PVD was 8.6% and partial PVD was 41.4%. It is suggested that there is a close relationship between proliferative diabetic retinopathy and partial PVD.
Diabetic Retinopathy*
;
Female
;
Humans
;
Incidence
;
Vitreous Detachment*
7.Prostaglandin E2 Induces IL-6 and IL-8 Production by the EP Receptors/Akt/NF-kappaB Pathways in Nasal Polyp-Derived Fibroblasts.
Jung Sun CHO ; In Hye HAN ; Hye Rim LEE ; Heung Man LEE
Allergy, Asthma & Immunology Research 2014;6(5):449-457
PURPOSE: Interleukin 6 (IL-6) and IL-8 participate in the pathogenesis of chronic rhinosinusitis with nasal polyps, and their levels are increased by prostaglandin E2 (PGE2) in different cell types. The purposes of this study were to determine whether PGE2 has any effect on the increase in the levels of IL-6 and IL-8 in nasal polyp-derived fibroblasts (NPDFs) and subsequently investigate the possible mechanism of this effect. METHODS: Different concentrations of PGE2 were used to stimulate NPDFs at different time intervals. NPDFs were treated with agonists and antagonists of E prostanoid (EP) receptors. To determine the signaling pathway for the expression of PGE2-induced IL-6 and IL-8, PGE2 was treated with Akt and NF-kappaB inhibitors in NPDFs. Reverse transcription-polymerase chain reaction for IL-6 and IL-8 mRNAs was performed. IL-6 and IL-8 levels were measured byenzyme-linked immunosorbent assay (ELISA). The activation of Akt and NF-kappaB was evaluated by western blot analysis. RESULTS: PGE2 significantly increased the mRNA and protein expression levels of IL-6 and IL-8 in NPDFs. The EP2 and EP4 agonists and antagonists induced and inhibited IL-6 expression. However, the EP4 agonist and antagonist were only observed to induce and inhibit IL-8 expression level. The Akt and NF-kappaB inhibitors significantly blocked PGE2-induced expression of IL-6 and IL-8. CONCLUSIONS: PGE2 increases IL-6 expression via EP2 and EP4 receptors, and IL-8 expression via the EP4 receptor in NPDFs. It also activates the Akt and NF-kappaB signal pathways for the production of IL-6 and IL-8 in NPDFs. These results suggest that signaling pathway for IL-6 and IL-8 expression induced by PGE2 might be a useful therapeutic target for the treatment of nasal polyposis.
Blotting, Western
;
Dinoprostone*
;
Fibroblasts*
;
Interleukin-6*
;
Interleukin-8*
;
Nasal Polyps
;
NF-kappa B
;
Prostaglandins E
;
RNA, Messenger
;
Signal Transduction
8.Expression of Osteoprotegerin and RANK Ligand in Breast Cancer Bone Metastasis.
Hye Rim PARK ; Soo Kee MIN ; Hyun Deuk CHO ; Duck Hwan KIM ; Hyung Sik SHIN ; Young Euy PARK
Journal of Korean Medical Science 2003;18(4):541-546
Bone destruction is primarily mediated by osteoclastic bone resorption, and cancer cells stimulate the formation and activation of osteoclasts next to metastatic foci. Accumulating evidences indicate that receptor activator of NF-kB ligand (RANKL) is the ultimate extracellular mediator that stimulates osteoclast differentiation into mature osteoclasts. In contrast, osteoprotegerin (OPG) inhibits osteoclast development. In order to elucidate a mechanism for cancer-induced osteoclastogenesis, cells from a human breast cancer line, MDA-MB-231, were directly co-cultured with ST2, MC3T3-E1, or with primary mouse calvarial cells. Osteoclast-like cells and tartarate resistant acid phosphatase (TRAP) activities were then quantitated. We examined these cell lines and samples from breast cancer by RT-PCR for the expressions of OPG and RANKL mRNA. Compared to controls, co-culture of MDA-MB-231 cells with stromal or osteoblastic cells induced an increase in number of osteoclasts and TRAP activities. MDA-MB-231 cells alone or breast cancer samples did not express RANKL mRNA. However, co-culture of these cancer cells with stromal or osteoblastic cells induced RANKL mRNA expression and decreased OPG mRNA expression. These experiments demonstrate that direct interactions between breast cancer and stromal or osteoblastic cells induce osteoclastogenesis in vitro through modulating RANKL expression.
3T3 Cells
;
Acid Phosphatase/metabolism
;
Animals
;
Bone Neoplasms/*metabolism/*secondary
;
Breast Neoplasms/*pathology
;
Carrier Proteins/*biosynthesis
;
Cell Differentiation
;
Cell Line, Tumor
;
Cells, Cultured
;
Coculture
;
Culture Media, Conditioned/pharmacology
;
Glycoproteins/*biosynthesis
;
Human
;
Isoenzymes/metabolism
;
Male
;
Membrane Glycoproteins/*biosynthesis
;
Mice
;
Mice, Inbred C57BL
;
Neoplasm Metastasis
;
Osteoblasts/metabolism
;
Osteoclasts/metabolism
;
Protein Binding
;
RNA, Messenger/metabolism
;
Receptors, Cytoplasmic and Nuclear/*biosynthesis
;
Reverse Transcriptase Polymerase Chain Reaction
;
Time Factors
9.Congenital Bronchoesophageal Fistula Associated with Bronchogenic Cyst: one case report.
Sung Woo CHO ; Hyun Keun CHEE ; Hyun Sung ANN ; Ki Woo HONG ; Hye Rim PARK
The Korean Journal of Thoracic and Cardiovascular Surgery 2001;34(1):104-107
Congenital bronchoesophageal fistula in the adult is rare, especially Braimbridge type III is very rare. We experienced congenital bronchoesophageal fistula associated intrapulmonary bronchogenic cyst. The patient was a 38-year-old male with chief complaints of coughing and abdominal pain 3 days before admission. Esophagogram revealed a fistulous tract between esophagus and cystic lesion in RLL. Fistulectomy and right lower and middle bilobectomy was performed. The postoperative course was uneventful.
Abdominal Pain
;
Adult
;
Bronchogenic Cyst*
;
Cough
;
Esophagus
;
Fistula*
;
Humans
;
Male
10.Effect of internal stress on cyclic fatigue failure in .06 taper ProFile.
Hye Rim JUNG ; Jin Woo KIM ; Kyung Mo CHO ; Se Hee PARK
Restorative Dentistry & Endodontics 2012;37(2):79-83
OBJECTIVES: The purpose of this study was to evaluate the relation between intentionally induced internal stress and cyclic fatigue failure of .06 taper ProFile. MATERIALS AND METHODS: Length 25 mm, .06 taper ProFile (Dentsply Maillefer), and size 20, 25, 30, 35 and 40 were used in this study. To give the internal stress, the rotary NiTi files were put into the .02 taper, Endo-Training-Bloc (Dentsply Maillefer) until auto-stop by torque controlled motor. Rotary NiTi files were grouped by the number of induced internal stress and randomly distributed among one control group and three experimental groups (n = 10, Stress 0 [control], Stress 1, Stress 2 and Stress 3). For cyclic fatigue measurement, time for separation of the rotary NiTi files was recorded. The fractured surfaces were observed by field emission scanning electron microscope (FE-SEM, SU-70, Hitachi). The time for separation was statistically analyzed using two-way ANOVA and post-hoc Scheffe test at 95% level. RESULTS: In .06 taper ProFile size 20, 25, 30, 35 and 40, there were statistically significant difference on time for separation between control group and the other groups (p < 0.05). CONCLUSION: In the limitation of this study, cyclic fatigue failure of .06 taper ProFile is influenced by internal stress accumulated in the files.
Electrons
;
Fatigue
;
Intention
;
Torque