1.Completely Isolated Enteric Duplication Cyst Presenting as an Inguinal Hernia.
Jung Uee LEE ; Jong Ok KIM ; Say June KIM ; Hye Jung SUL
Korean Journal of Pathology 2010;44(2):204-206
Enteric duplication cysts are uncommon congenital anomalies whose embryogenesis remains unknown. We report here on an isolated enteric duplication cyst, that presents as an inguinal hernia. A 21-year-old woman was admitted with a month-long history of a palpable mass in the left groin. Radiologically, a computed tomography scan revealed a 3.5 x 2.5 cm sized cystic mass in subcutaneous layers of the left suprapubic area. Microscopically, the cystic wall resembled gut wall. The wall was composed of two distinct muscle layers with the presence of Auerbach's plexus. On examining the entire sections of the cyst wall very carefully, no epithelial lining was found on the inner surface. The submucosa was slightly fibrotic. The diagnosis was a completely isolated enteric duplication cyst.
Embryonic Development
;
Female
;
Groin
;
Hernia, Inguinal
;
Humans
;
Muscles
;
Myenteric Plexus
;
Pregnancy
;
Young Adult
2.Lung Cancer Occurring in a Worker Exposed to Coke Oven Emissions.
Hyun Sul LIM ; Jung Keun CHOI ; Eun Hye KWON ; Heon KIM
Korean Journal of Occupational and Environmental Medicine 2002;14(1):97-106
OBJECTIVES: We report a case of lung cancer (small cell carcinoma) occurring in a worker exposed to coke oven emissions. METHODS: We examined the chest CT and pathologic findings of the patient. We reviewed previous environmental measurements for coke oven emissions at the workers place of employment. Also we measured the airborne concentrations for coke oven emissions and total polycyclic aromatic hydrocarbons in the work area. Finally, we analyzed the 1-hydroxypyrene and 2-naphthol concentrations in the subjects urine and compared this with student controls. RESULTS: This case was a 56-year-old male who had worked in a coke oven plant within a steel manufacturing factory for 21 years (1977-1998). The airborne concentrations of coke oven emissions at the worksite were above the permissible exposure level (0.2 mg/m3) in 45 cases (33.1%) among 136 workers. The concentrations of 1-hydroxypyrene and 2-naphthol in the subjects urine were statistically significantly elevated as compared with those of controls (P<0.01). CONCLUSIONS: We confirmed that the lung cancer occurring in this patient was as an occupational disease due to exposure to coke oven emissions. To prevent occupational cancer in coke oven plant workers, we must remodel the engineering procedure, begin comprehensive medical surveillance, educate workers on risks and the benefits of smoking cessation, and increase awareness of safety regulations in the workplace.
Coke*
;
Employment
;
Humans
;
Lung Neoplasms*
;
Lung*
;
Male
;
Middle Aged
;
Occupational Diseases
;
Occupational Health
;
Plants
;
Polycyclic Hydrocarbons, Aromatic
;
Smoking Cessation
;
Social Control, Formal
;
Steel
;
Tomography, X-Ray Computed
;
Workplace
3.Identification of DNA Methylation Markers for NSCLC Using Hpall-Mspl Methylation Microarray.
Mi Hye KWON ; Go Eun LEE ; Sun Jung KWON ; Eugene CHOI ; Moon Jun NA ; Hyun Min CHO ; Young Jin KIM ; Hye Jung SUL ; Young Jun CHO ; Ji Woong SON
Tuberculosis and Respiratory Diseases 2008;65(6):495-503
BACKGROUND: Epigenetic alterations in certain genes are now known as at least important as genetic mutation in pathogenesis of cancer. Especially abnormal hypermethylation in or near promoter region of tumor suppressor genes (TSGs) are known to result in gene silencing and loss of gene function eventually. The authors tried to search for new lung cancer-specific TSGs which have CpG islands and HpaII sites, and are thought to be involved in carcinogenesis by epigenetic mechanism. METHODS: Tumor tissue and corresponding adjacent normal tissue were obtained from 10 patients who diagnosed with non small cell lung cancer (NSCLC) and underwent surgery in Konyang university hospital in 2005. Methylation profiles of promoter region of 21 genes in tumor tissue & non-tumor tissue were examined with HpaII-MspI methylation microarray (Methyl-Scan DNA chip(R), Genomic tree, Inc, South Korea). The rates of hypermethylation were compared in tumor and non-tumor group, and as a normal control, we obtained lung tissue from two young patients with pneumothorax during bullectomies, methylation profiles were examined in the same way. RESULTS: Among the 21 genes, 10 genes were commonly methylated in tumor, non-tumor, and control group. The 6 genes of APC, AR, RAR-b, HTR1B, EPHA3, and CFTR, among the rest of 11 genes were not methylated in control, and more frequently hypermethylated in tumor tissue than non-tumor tissue. CONCLUSION: In the present study, HTR1B, EPHA3, and CFTR are suggested as possible novel TSGs of NSCLC by epigenetic mechanism.
Carcinoma, Non-Small-Cell Lung
;
CpG Islands
;
DNA
;
DNA Methylation
;
Epigenomics
;
Gene Silencing
;
Genes, Tumor Suppressor
;
Humans
;
Lung
;
Methylation
;
Oligonucleotide Array Sequence Analysis
;
Pneumothorax
;
Promoter Regions, Genetic
;
Small Cell Lung Carcinoma
4.Radiologic Placement of Subcutaneous Infusion Ports in Cancer Patients: Analysis of 45 Cases.
Seok Goo CHO ; Sang Heum KIM ; Ha Hun SONG ; Sun Hwa SONG ; Kwan Hyong LEE ; Dae Young CHUNG ; Hye Jung LEE ; Sul Hye KIM ; Ki Tae KIM ; Chun Choo KIM
Journal of the Korean Cancer Association 2000;32(6):1115-1121
PURPOSE: We undertook this study to evaluate the usefullness of radiologic placement of subcutaneous infusion ports (SIP). MATERIALS AND METHODS: Between August 1999 and May 2000 we performed 45 implantations of SIP in radiologic suite. Both sonography and fluoroscopy were used for venipuncture and to guide port insertion. We prospectively evaluated 45 systems in 45 patients with solid tumors. RESULTS: Median follow-up time was 189 days (61~352 days). Technical success rate is 100% without any venipuncture-related complications. Early complication rate within 30 days of procedure was 4.4%, including wound dehiscence (n=1) and pocket hematoma and local infection (n=1). Catheter-related infection rate was 6.7% and catheter-related venous thrombosis rate was 4.4%. Mean duration of catheter use was 208 96 days (total, 9,381 days). Overall port survival rate was 38.5%, and four systems (8.9%) were prematurely removed because of catheter tunnel infection (n=1), pocket infection (n=1), and central venous thrombosis (n=2). CONCLUSION: Radiologic placement of SIP had higher success rate and equal or lower complication rate compared with reported conventional surgical technique using anatomical landmarks. Moreover, clinical convenience, resulting from ease of scheduling could make it replace surgical method.
Catheter-Related Infections
;
Catheters
;
Fluoroscopy
;
Follow-Up Studies
;
Hematoma
;
Humans
;
Infusions, Subcutaneous*
;
Phlebotomy
;
Prospective Studies
;
Survival Rate
;
Venous Thrombosis
;
Wounds and Injuries
5.Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells.
Woon Ki KIM ; Ok Ju SUL ; Jung Sook KWAK ; Hye Young HUR ; Anne M LATOUR ; Beverly H KOLLER ; Byoung S KWON ; Choon Soo JEONG
Experimental & Molecular Medicine 2010;42(12):805-810
Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2 gene expression, we studied the upstream region of the gene. Gel supershift assays revealed inducible binding of nuclear factor of activated T cells (NFAT) to a putative NFAT site within the TR2 promoter. Furthermore, cotransfection of a dominant negative NFAT construct, or siRNA for NFAT, resulted in increased expression of a TR2 reporter gene. Our findings demonstrate that NFAT negatively regulates TR2 expression in activated T cells.
Animals
;
Base Sequence
;
CD4-Positive T-Lymphocytes/metabolism
;
Cells, Cultured
;
Down-Regulation
;
Mice
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
NFATC Transcription Factors/*physiology
;
Receptors, Tumor Necrosis Factor, Member 14/*biosynthesis
;
T-Lymphocytes/*metabolism
6.Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis.
Woon Ki KIM ; Jin Chun KIM ; Hyun Jung PARK ; Ok Joo SUL ; Mi Hyun LEE ; Ji Soon KIM ; Hye Seon CHOI
Experimental & Molecular Medicine 2012;44(7):432-439
Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by modulating oxidative stress. Intragastric administration of PtNP reduced ovariectomy (OVX)-induced bone loss with a decreased level of activity and number of osteoclast (OC) in vivo. PtNP inhibited OC formation by impairing the receptor activator of nuclear factor-kappaB ligand (RANKL) signaling. This impairment was due to a decreased activation of nuclear factor-kappaB and a reduced level of nuclear factor in activated T-cells, cytoplasmic 1 (NFAT2). PtNP lowered RANKL-induced long lasting reactive oxygen species as well as intracellular concentrations of Ca2+ oscillation. Our data clearly highlight the potential of PtNP for the amelioration of bone loss after estrogen deficiency by attenuated OC formation.
Animals
;
Metal Nanoparticles/*administration & dosage
;
Mice
;
Mice, Inbred C57BL
;
NFATC Transcription Factors/metabolism
;
*Osteoclasts/drug effects/physiology
;
Osteoporosis/drug therapy
;
Ovariectomy/adverse effects
;
Oxidative Stress/drug effects
;
Platinum/*administration & dosage
;
*RANK Ligand/genetics/metabolism
;
Reactive Oxygen Species/metabolism
;
Signal Transduction
7.A Case of Mucous Gland Adenoma of the Trachea.
Han Jin KWON ; Jae Il SUL ; Su Yup CHAE ; Hye Young CHOI ; Min Sup UM ; Hyun Il KIM ; Yong Leul OH ; Ho CHO ; Hui Jung KIM ; Jong Hwan LEE ; Hyo Jin LEE
Tuberculosis and Respiratory Diseases 2000;48(1):91-95
Mucous gland adenoma of the bronchus is a rare benign tumor arising from the bronchial mucous gland. It accounts for less than 0.5 % of all lung tumors. In adults, tracheal tumors are most often malignant. Among benign tumors arising in the trachea, mucous gland adenoma of the trachea is extremely rare. First case was reported by Ferguson and Cleeland in 1988, as "Mucous gland adenoma of the trachea". Microscopic study shows it to arise from normal submucosal mucous glands forming glandular or tubular structures composed of mucous secreting cells. Common symptoms were cough, hemoptysis, recurrent and protracted pneumonia, shortness of breath, and wheeze. Duration of symptoms before diagnosis varied from a few weeks to 10 years with prolonged symptoms being usual. Management of these tumors should be complete excision, including pulmonary resection because two instances of recurrence after local excision have been reported.
Adenoma*
;
Adult
;
Bronchi
;
Cough
;
Diagnosis
;
Dyspnea
;
Hemoptysis
;
Humans
;
Lung
;
Pneumonia
;
Recurrence
;
Trachea*
8.FAS (Fatty acid synthase) expression in breast cancer.
Tae Young KOO ; Dae Kyung GO ; In Suk CHOI ; Won Jun CHOI ; Dae Sung YOON ; Hye Jung SUL ; Yoon Mi KIM ; Bum Kyung KIM
Journal of Breast Cancer 2005;8(2):40-44
PURPOSE: Fatty acid synthase (FAS) is a multi-enzyme molecule that plays a role in the de novo biosynthesis of fatty acids. FAS is expressed at low levels in most normal human tissues because, cells preferentially utilize circulating lipids for the synthesis of new structural lipids. Recent studies have demonstrated that high levels of FAS occur in a subset of human cancers (such as breast, ovary, and prostate cancer etc) and these high FAS levels are associated with a poor prognosis. The aim of this study was to investigate the expression of FAS in breast cancer and to examine the relationship between FAS and the clinicopathological data. METHODS: We reviewed clinical profiles [clinical data and short term outcome (recurrence)] of 67 breast cancer patients by reviewing their medical records. The average followed-up period was 22.6 month. FAS expressions were evaluated by immunohistochemistry on the formalin-fixed paraffin-embedded tissues. RESULTS: FAS expression of breast cancer was nonspecifically high, but there was no statistical importance between the FAS expression, the clinicopathological data and the short term recurrence (p > 0.05). CONCLUSION: The overexpression of FAS in breast cancer patients may not be a reliable marker for a poor prognosis. However, further studies are required in order to define the biological significance and the specific role of FAS in breast cancer development, growth, and invasion. Also, inhibition of FAS may be a target treatment for breast cancer.
Breast Neoplasms*
;
Breast*
;
Fatty Acids
;
Female
;
Humans
;
Immunohistochemistry
;
Medical Records
;
Ovary
;
Prognosis
;
Prostatic Neoplasms
;
Recurrence
9.FAS (Fatty acid synthase) expression in breast cancer.
Tae Young KOO ; Dae Kyung GO ; In Suk CHOI ; Won Jun CHOI ; Dae Sung YOON ; Hye Jung SUL ; Yoon Mi KIM ; Bum Kyung KIM
Journal of Breast Cancer 2005;8(2):40-44
PURPOSE: Fatty acid synthase (FAS) is a multi-enzyme molecule that plays a role in the de novo biosynthesis of fatty acids. FAS is expressed at low levels in most normal human tissues because, cells preferentially utilize circulating lipids for the synthesis of new structural lipids. Recent studies have demonstrated that high levels of FAS occur in a subset of human cancers (such as breast, ovary, and prostate cancer etc) and these high FAS levels are associated with a poor prognosis. The aim of this study was to investigate the expression of FAS in breast cancer and to examine the relationship between FAS and the clinicopathological data. METHODS: We reviewed clinical profiles [clinical data and short term outcome (recurrence)] of 67 breast cancer patients by reviewing their medical records. The average followed-up period was 22.6 month. FAS expressions were evaluated by immunohistochemistry on the formalin-fixed paraffin-embedded tissues. RESULTS: FAS expression of breast cancer was nonspecifically high, but there was no statistical importance between the FAS expression, the clinicopathological data and the short term recurrence (p > 0.05). CONCLUSION: The overexpression of FAS in breast cancer patients may not be a reliable marker for a poor prognosis. However, further studies are required in order to define the biological significance and the specific role of FAS in breast cancer development, growth, and invasion. Also, inhibition of FAS may be a target treatment for breast cancer.
Breast Neoplasms*
;
Breast*
;
Fatty Acids
;
Female
;
Humans
;
Immunohistochemistry
;
Medical Records
;
Ovary
;
Prognosis
;
Prostatic Neoplasms
;
Recurrence
10.A Cytogenetic Survey of 1788 Genetic Amniocenteses.
Sin Yong MOON ; Gyung Hoon GWON ; Nam Hee SONG ; Hye Won SUL ; Mi Gyung RO ; Hee Jung KO ; Sun Gyung OH ; Jung Ho HAN ; Gyu Hong CHOI ; Sun Mi KIM ; Joong Sin PARK ; Jong Gwan JEON ; Young Min CHOI ; Bo Hyun YOON ; Hee Chul SHIN ; Jin Yong LEE
Korean Journal of Obstetrics and Gynecology 2000;43(8):1486-1491
No abstract available.
Amniocentesis*
;
Cytogenetics*