1.The relationship of hyperuricemia to risk factors of atherosclerosis.
Kyeong Soo CHEON ; Hye Won JUNG ; Hye Soon PARK
Journal of the Korean Academy of Family Medicine 1993;14(12):774-786
No abstract available.
Atherosclerosis*
;
Hyperuricemia*
;
Risk Factors*
2.Platelet counts and size in normal pregnancy and pregnancy with preeclamsia or IUGR.
Hye Kyung KIM ; Eui Sik JUNG ; Hye Sung PARK ; Ok Kyung SON ; Chang Suh PARK ; Chang Yong PARK ; In Suh PARK
Korean Journal of Obstetrics and Gynecology 1993;36(7):3055-3061
No abstract available.
Blood Platelets*
;
Fetal Growth Retardation*
;
Platelet Count*
;
Pregnancy*
3.Clinical Value of Demonstration of Estrogen and Progesterone Receptors using Paraffin Wax Sections in Breast Carcinoma.
Hye Kyung AHN ; Yun Jung KIM ; Young Euy PARK
Korean Journal of Pathology 1996;30(2):89-93
This study aimed at assessing the usefulness of paraffin wax sections for demonstration of ER(estrogen receptor) and PR(progesterone receptor), using brief microwave processing rather than proteolytic predigestion. The receptor status of a breast cancer is often into consideration when planning treatment nowadays. As biochemical receptor assays require large amount of fresh tumor tissue and are not always available for all tumors, pathologists are now increasingly asked to provide a service for the assessment of the receptor status in tissue routine sections. Until recently, immunohistochemical demonstration of receptors was used in frozen sections. Therefore, routinely processed paraffin wax sections of 25 cases of breast carcinoma with known ER and PR concentrations, estimated by the standard DCC(dextran-coated charcoal) biochemical assay, were examined using the ABC immunoperoxidase technique. The results were assessed semiquantitably, using a five grade scoring system. Of the 25 cases examined, with DCC cutoff point being <10 fmol,71% and 75% in positivity of each ER, PR receptor is concordant. Statistic analysis demonstrates high relationship between scoring system of IH method and DCC value in ER (R=0.6061, p=0.001) and PR (R=0.5832, p=0.001). The IH method can provide easily assessed reliable positive information about ER, PR status of breast carcinoma using routinely processed paraffin wax sections.
Breast Neoplasms
4.Adenoid Cystic Carcinoma of the Breast: A case report.
Eun Ha JUNG ; Hye Rim PARK ; Jin Hee SOHN
Korean Journal of Pathology 1999;33(4):299-302
Adenoid cystic carcinoma (ACC) of the breast is an uncommon carcinoma accounting for less than 1% of the breast carcinoma. This type of carcinoma has a distinctive histology, such as cylindromatous, cribriform, glandlike space and solid pattern in the variable proportion. Prognosis is favorable with rare recurrence or metastasis and the guideline for therapy is not well established. We experienced a case of ACC of right breast in the 48 year-old woman. Cytologically, it showed numerous three-dimensional, well outlined cell clusters with central core of homogeneous, eosinophilic material. The mass was well demarcated, firm and measured 2.5 2.5 2 cm. Cut surface was yellowish white and granular with focal necrosis. Histologically, the tumor was composed of cylindromatous, adenoid and solid area with marked cellular atypia. Focal invasion was identified in the adipose tissue around the tumor. Histologic and nuclear grade was III by Kleer's grade. Nodal metastasis was not found.
Adenoids*
;
Adipose Tissue
;
Breast Neoplasms
;
Breast*
;
Carcinoma, Adenoid Cystic*
;
Eosinophils
;
Female
;
Humans
;
Middle Aged
;
Necrosis
;
Neoplasm Metastasis
;
Prognosis
;
Recurrence
5.Progression of Dermatofibrosarcoma Proruberans to Malignant Fibrous Histiocytoma: Report of a case.
Hye Rim PARK ; Eun Ha JUNG ; Jin Hee SOHN
Korean Journal of Pathology 1997;31(12):1324-1327
A 52-year-old woman was admitted with a palpable mass on the abdominal wall. This tumor had developed at the same site of a previously resected dermatofibrosarcoma protuberans. The biopsy specimen from the recurrent tumor revealed malignant fibrous histiocytoma. Immunohistochemistry with anti-CD34 antibody revealed diffuse linear positivity on the tumor cells of dermatofibrosarcoma protuberans and negativity on malignant fibrous histiocytoma. Anti CD34 antibody was valuable for a differential diagnosis of these two lesions.
Abdominal Wall
;
Biopsy
;
Dermatofibrosarcoma*
;
Diagnosis, Differential
;
Female
;
Histiocytoma, Malignant Fibrous*
;
Humans
;
Immunohistochemistry
;
Middle Aged
6.Sequential Studies of Glomerular Crescent Formation in Rabbits with Anti-Glomerular Basement Membrane(GBM) Antibody Induced Glomerulonephritis(GN).
Hye Seon AHN ; Jung Woo NOH ; Moon Hyang PARK
Korean Journal of Pathology 1997;31(3):219-232
To investigate the mechanism of crescent formation, sequential pathologic changes from the New Zealand White rabbits with anti-GBM antibody induced GN by administration of guinea pig anti-GBM IgG were studied by light (LM), immunofluorescent (IF) and electron (EM) microscopy. Although no glomerular changes were observed in LM, swelling of the endothelial cells and the epithelial cells were noted in EM by day 2. By day 7, early and cellular crescents were evident. Proteinaceous materials and fibrins were noted in the glomerular capillary lumina (GCL) and Bowman's space (BS) associated with segmental hypercellularity. The GBM damage became progressively severe, followed by focal detachment of the visceral epithelial cells from the GBM. At day 14, fibrin strands, mononuclear cells and collagen fibrils were present between the proliferating extracapillary cells. At day 31, fibrocellular crescents were predominated. Elongated spindle cells, morphologically resembling myofibroblasts, were noted near the Bowman's capsule (BC). A degree of tubular atrophy, interstitial fibrosis, and inflammatory infiltrates increased as it did with fibrous organization of crescent. Intense linear IF staining for IgG and C3 were seen throughout the experiments along the GBM. In conclusion, the progression of crescent from an early "proteinaceous" stage through cellular, fibrocellular and fibrous stages was well documented in this study. Inflammatory cells and coagulation mechanism may activate the initiation of the GBM damage at the early stage. Activated periglomerular mononuclear cells may also cause disruption of BC which facilitates entry of activated periglomerular cells and fibroblasts into BS leading to progressive fibrous crescent formation.
Animals
;
Atrophy
;
Bowman Capsule
;
Capillaries
;
Collagen
;
Endothelial Cells
;
Epithelial Cells
;
Fibrin
;
Fibroblasts
;
Fibrosis
;
Glomerulonephritis
;
Guinea Pigs
;
Immunoglobulin G
;
Microscopy
;
Myofibroblasts
;
Rabbits*
7.A Case of Lichen Planus Treated with Griseofulvin.
Hye Ran JI ; Eun Jung CHUNG ; See Yong PARK
Korean Journal of Dermatology 1983;21(4):439-443
Improvement of lichen planus was achieved by 11 weeks of daily oral treatment with griseofulvin. The patient was 59-year-old male, has had hypertension and diabetes mellitus for 9 months, and history of various drug intake to these diseses for 6 months. Four months before first visit, symptome of lichen planus had developed suddenly. Because of treatment failure of oral antihistamine and topical steroid for 6 weeks, we began to use griseofulvin. Praspective studies are needed to better assess the affectiveness of griseafulvin in the treatment of lichen planus.
Diabetes Mellitus
;
Griseofulvin*
;
Humans
;
Hypertension
;
Lichen Planus*
;
Lichens*
;
Male
;
Middle Aged
;
Treatment Failure
8.Approximate Entropy: Analysis of Fetal Heart Rate Variability in Normal and Growth Retarded Fetuses.
Jung Hye HWANG ; Moon Il PARK ; Myung Kul YUM
Korean Journal of Obstetrics and Gynecology 1997;40(1):92-99
OBJECTIVES: This study is aimed to quantify the complex dynamics of beat-to-beat fetal heart rate(FHR) fluctuations by using approximate entropy(ApEn) which is a recently developed mathematical formula quantifying regularity and also to determine the differences between normal fetuses and growth retarded fetuses. BACKGROUND: Recently, some measures of heart rate variability and nonlinear "complexity" of heart rate dynamics have been used as indicators fetal well-being. Approximate entropy is a new mathematical approach and formula to quantify regularity in data. It has been shown to provide new information in fetal heart rate analysis. Because growth retarded fetus accounts for a significant increase in perinatal morbidity and mortality, than normal fetus, we postulated that there existed important differences between normal fetuses and growth retarded fetuses. METHODS: We analyzed FHR tracings for 40 minutes, and approximately 5,000 points in normal fetuses(n=315) and growth retarded fetuses(n=76). The overall "complexity" of each FHR time series was quantified by its approximate entropy, measure of regularity derived from nonlinear dynamics, "chaos theory". RESULTS: Mean baseline FHR increased in growth retarded fetuses than normal fetuses. And the FHR ApEn significantly decreased in growth retarded fetuses(ApEn=0.623) compared to that of the normal fetuses(ApEn=0.868) throughout all gestational ages(p < 0.001). CONCLUSIONS: The ApEn of FHR decreased in growth retarded fetuses throughout all gestational ages. These findings indicated that decreased ApEn values of FHR are associated with sickness and the greater perinatal morbidity risks. Therefore ApEn quantifies subtle changes in FHR regularity and promises for new information in FHR analysis.
Entropy*
;
Female
;
Fetal Heart*
;
Fetus*
;
Gestational Age
;
Heart Rate
;
Heart Rate, Fetal*
;
Mortality
;
Nonlinear Dynamics
;
Pregnancy
9.Chromosomal analysis of abortus chorionic villi in case of recurrent spontaneous abortions.
Hye Ran HWANG ; Seong Sook SEO ; Shin Young LEE ; Jung Hye KIM ; Sook Ja PARK
Korean Journal of Obstetrics and Gynecology 1993;36(12):3897-3904
No abstract available.
Abortion, Spontaneous*
;
Chorion*
;
Chorionic Villi*
;
Female
;
Humans
;
Pregnancy
10.Detection of Viral Antigens in Stool Using EIA in Hospitalized Children and Clinical Implication.
Jung Hye MIN ; Jeong Wan SEO ; Hye Kyung PARK
Korean Journal of Pediatric Gastroenterology and Nutrition 2004;7(2):143-152
PURPOSE: The purpose of this study is to detect viral coproantigens in children who were hospitalized with acute diarrhea and to compare its association with clinical symptoms. METHODS: Seventy-four stool samples were collected from children admitted to Ewha Mokdong Hospital from March 1996 to December 1999. The samples were frozen and analyzed for rotavirus, adenovirus, enterovirus, astrovirus, and calicivirus by enzyme immunoassay (EIA) with monoclonal antibody. 53 stool samples were collected from patients with diarrhea (diarrheal group) and 21 stool samples from patients hospitalized for reasons other than diarrhea (control group). Clinical features and laboratory findings were reviewed in both groups. RESULTS: Among 74 stool samples, virus antigens were detected in 60 samples. Of the 60 virus-positive stool samples, 47 enterovirus, 26 rotavirus, 16 adenovirus, 11 astrovirus, and 11 calicivirus antigens were detected by EIA. Of the 60 virus-positive stool samples, 28 samples have one viral antigen, 30 samples have 2 or more viral antigens, and 2 samples showed a simultaneous infection of Salmonella group B and enterovirus. There was no relationship between the detected virus and clinical features. CONCLUSION: In this study, viral coproantigen and clinical symptoms were not associated. In the future, further larger scale studies are necessary.
Adenoviridae
;
Antigens, Viral*
;
Child
;
Child, Hospitalized*
;
Diarrhea
;
Enterovirus
;
Humans
;
Immunoenzyme Techniques
;
Rotavirus
;
Salmonella