1.The Economic Burden of Inflammatory Heart Disease in Korea.
Seul Ki KO ; Seok Jun YOON ; In Hwan OH ; Hye Young SEO ; Eun Jung KIM
Korean Circulation Journal 2011;41(12):712-717
BACKGROUND AND OBJECTIVES: The incidence of inflammatory heart diseases is not yet as high as those of other cardiovascular diseases; however, inflammatory heart diseases do have relatively high mortality rate. Therefore, update information on the economic burden of inflammatory heart diseases are necessary in order to appropriate policy making on these diseases. MATERIALS AND METHODS: This study used a number of resources to obtain data, national health insurance statistics, the Korean Health Panel, and the causes of death report by the Korean National Statistical Office. The total costs of inflammatory heart diseases were estimated as the sum of direct medical care costs, direct non-medical care and indirect costs. RESULTS: The total direct cost of inflammatory heart disease was higher in Korean men than that of Korean women and cost due to inpatient was higher than that of outpatients cost. The costs to cover premature death were highest among all of the components used to determine the total costs for inflammatory heart disease, representing 66.3% of these costs in Korea. CONCLUSION: Inflammatory heart disease has a relatively high mortality rate, and the costs that are associated with premature deaths consume the greatest proportion of the costs associated with this disease. In spite of some limitations of study, this could be a reliable evidence of economic burden of inflammatory heart disease.
Cause of Death
;
Cost of Illness
;
Endocarditis
;
Female
;
Health Care Costs
;
Heart
;
Heart Diseases
;
Humans
;
Incidence
;
Inflammation
;
Inpatients
;
Korea
;
Male
;
Mortality, Premature
;
National Health Programs
;
Outpatients
;
Policy Making
2.Combination of Non-Ablative Fractional Laser with Q-Switched Laser for the Treatment of Becker’s Nevus: Efficacy and Limitations
Hye Sung HAN ; Jun Ki HONG ; Kwang Ho YOO ; Seong Jun SEO
Annals of Dermatology 2023;35(1):56-60
Becker’s nevus (BN) is a benign hamartoma that may present as a distressing cosmetic problem. The treatment of BN poses a significant challenge as current therapeutic modalities are suboptimal and have an increased risk of adverse effects, such as scarring and dyspigmentation. We present the use of non-ablative fractional laser therapy combined with Q-switched Nd:YAG laser as a possible therapeutic option for BN treatment and review relevant literature to discuss its efficacy and limitations.
3.A Study on the Correlation of Skin Types with Genetic Factors and Environmental Factors in Koreans
Kui Young PARK ; Jun Ki HONG ; Sun Hye SHIN ; Young Gue KOH ; Hye Sung HAN ; Nam Ju MOON ; Gun Young AHN ; Seong Jun SEO
Korean Journal of Dermatology 2022;60(4):242-253
Background:
The Baumann skin type (BST) classification provides a new approach for clinical care of dermatologic patients.
Objective:
To investigate the correlation of skin types with genetic factors and environmental factors that have an important influence on Korean skin by comparing and analyzing the correlation between phenotype and genotype.
Methods:
From July to October 2016, 774 adults who visited the one online shopping mall were subjected to skin BST questionnaire and gene single-nucleotide polymorphism (SNP) tests. Oral epithelial cells of the subjects were collected using a Genoplan DNA analysis kit, and 14 genes were analyzed by a genetic analysis agency (Genoplan Inc., Fukuoka, Japan).
Results:
The most abundant skin type was OSNT (oily, sensitive, non-pigmented, tight) observed in 205 participants (26.5%). Of the filaggrin (FLG) SNPs, 143 participants (18.5%) had the GG (good) SNP; 391 (50.5%), GA (normal) SNP; and 240 (31.0%), AA (poor) SNP. Among those whose FLG SNP was GG (good), 121 (84.6%) were sensitive and 22 (15.4%) were resistant. Of those whose filaggrin (FLG) SNP was GA (normal), 337 (86.2%) were sensitive and 54 (13.8%) were resistant. Of those whose FLG SNP was AA (poor), 213 (88.8%) were sensitive and 27 (11.3%) were resistant. There was also a statistically significant difference in the fruit-vegetable consumption and use of a sunbathing bed between sensitive and resistant type in the groups that classified the FLG SNP as GA.
Conclusion
This is the first study to investigate the association of BST with genetic factors and environmental factors.
4.Clinical Spectrum of Neonatal Strokes.
Jun Chul BYUN ; Hye Eun SEO ; Heng Mi KIM ; Soonhak KWON
Journal of the Korean Child Neurology Society 2010;18(2):230-236
PURPOSE: Neonatal strokes are common and may be associated with various complications. However, few studies have been conducted on the clinical spectrum in Korea. This study aimed at investigating the clinical presentation and neurological outcome of neonatal strokes. METHODS: Twenty-seven neonates with neonatal stroke were enrolled in the neonatal intensive care unit at Kyungpook National University Hospital from January 2000 to December 2009. Their medical records and neuroradiological findings were retrospectively reviewed. RESULTS: The mean age of the subjects was 4+/-5.6 days. Sixteen patients were full term, nine were prematurite and six had low birth weights. The onset of symptoms was mostly within first week (85.2%) of life, especially in the first day of life (51.9%). The most common symptom was seizure (40.7%), which were focal clonic (38.5%) or multifocal clonic (38.5%). Nine patients showed abnormal EEG findings. Thirteen patients had subdural hemorrhage, seven showed intraventricular hemorrhage, and three revealed cerebral infarction. Among 12 patients who followed-up for one year, four had mild neurologic dysfunction and two had severe impairment. CONCLUSION: We found that the onset of symptom in neonatal strokes was mostly within the first day of life, and the most common symptom was focal seizure. We, therefore recommend that neuroimaging be done when newborns have seizures within their first week of life. However, further studies are needed to elucidate this further.
Cerebral Infarction
;
Electroencephalography
;
Hematoma, Subdural
;
Hemorrhage
;
Humans
;
Infant, Low Birth Weight
;
Infant, Newborn
;
Infarction
;
Intensive Care, Neonatal
;
Korea
;
Medical Records
;
Neuroimaging
;
Neurologic Manifestations
;
Retrospective Studies
;
Seizures
;
Stroke
5.A Case of Herpes Zoster Multiplex in Five Disparate Dermatomes.
Kui Young PARK ; Hye In LEE ; Ji Young KIM ; Kap Sok LI ; Seong Jun SEO ; Chang Kwun HONG
Korean Journal of Dermatology 2008;46(7):973-976
The skin lesion of herpes zoster is classically limited to single dermatomal area, and most cases of multidermatomal herpes zoster have contiguous skin lesions. Noncontigous multidermatomal herpes zoster is very rare in both immunocompetent and immunocompromised persons. The phenomenon of zoster occurring in two noncontiguous dermatomes has been referred to as zoster duplex unilateralis or bilateralis. We report a case of herpes zoster multiplex in five disparate dermatomes in a 71-year-old woman with non-Hodgkin's lymphoma.
Aged
;
Female
;
Herpes Zoster
;
Humans
;
Lymphoma, Non-Hodgkin
;
Skin
6.The Analysis of Indeterminate Category in Thyroid Fine Needle Aspiration.
Soo Kee MIN ; Jinwon SEO ; Sun Young JUN ; Kwangseon MIN ; Hye Rim PARK
Korean Journal of Pathology 2010;44(6):657-661
BACKGROUND: Descriptive diagnosis reports have been causing some problems in communication. Our institution decided to use the category diagnosis system since June, 2008. So we evaluated the effectiveness of this change. METHODS: The category system is composed of unsatisfactory, suboptimal for diagnosis but suggestive of, most probably benign, indeterminate, suspicious for malignancy and malignancy. We evaluated 1,525 cases from June, 2008 to September, 2009. We analyzed 159 cases of the indeterminate category. RESULTS: Among the 159 cases, 21 were re-aspirated and 63 underwent an operation. The diagnoses of the re-aspirated cases were 2 positive for malignancy, 5 indeterminate, 13 most probably benign, and 1 unsatisfactory. The surgical diagnoses were 39 malignancies, 2 follicular adenomas and 1 Hurthle cell adenoma, and 21 benign lesions. Re-aspiration for the indeterminate cases could help decide whether the lesions need to be operated or not at above 70%. The indeterminate category could predict the surgical diagnosis of the thyroid nodule with statistical significance when the subcategories were indicated (p < 0.001). CONCLUSIONS: The category diagnosis is replacing the descriptive diagnosis for the thyroid fine needle aspiration. The indeterminate category is useful and effective for making the decision to operate and especially when the indeterminate subcategories are used.
Adenoma
;
Biopsy, Fine-Needle
;
Thyroid Gland
;
Thyroid Nodule
7.The economic burden of stroke in 2010 in Korea.
Hyun Jin KIM ; Young Ae KIM ; Hye Young SEO ; Eun Jung KIM ; Seok Jun YOON ; In Hwan OH
Journal of the Korean Medical Association 2012;55(12):1226-1236
Stroke is a disease that causes a substantial economic burden. With the rapidly aging population in Korea, the prevalence of chronic diseases, including stroke, is expected to rise, along with associated health care expenditures. Therefore, we estimated the economic burden of stroke in Korea in 2010 using nationally representative data. We used a prevalence-based approach to estimate the cost of stroke by claims data from the Korean National Health Insurance. Data from the Korea Health Panel, the Korea National Statistical Office's records of causes of death, and Labor Statistics were used to calculate direct non-medical costs and indirect costs. Direct costs included direct medical costs and direct non-medical costs, and indirect costs were opportunity costs lost due to premature death and productivity loss. Total costs were estimated by adding age- and gender-specific costs. The total economic burden of stroke was $3.53 billion: $1.87 billion for hemorrhagic stroke and $1.66 billion for ischemic stroke. The direct costs were $1.74 billion and the indirect costs were $1.79 billion. By gender, males were burdened at $2.19 billion, while females bore $1.34 billion of the total burden. Stroke imposes a huge economic burden, as indicated by the fact that the costs of stroke increased by 4.4% from 2005 to 2010, and the estimated cost was 0.35% of gross domestic product. Therefore, effective prevention programs and treatments are needed to reduce the economic burden of stroke in Korea.
Aging
;
Cause of Death
;
Chronic Disease
;
Cost of Illness
;
Delivery of Health Care
;
Efficiency
;
Female
;
Gross Domestic Product
;
Health Expenditures
;
Humans
;
Korea
;
Male
;
Mortality, Premature
;
National Health Programs
;
Prevalence
;
Stroke
8.Economic Burden of Colorectal Cancer in Korea.
Ju Young BYUN ; Seok Jun YOON ; In Hwan OH ; Young Ae KIM ; Hye Young SEO ; Yo Han LEE
Journal of Preventive Medicine and Public Health 2014;47(2):84-93
OBJECTIVES: The incidence and survival rate of colorectal cancer in Korea are increasing because of improved screening, treatment technologies, and lifestyle changes. In this aging population, increases in economic cost result. This study was conducted to estimate the economic burden of colorectal cancer utilizing claims data from the Health Insurance Review and Assessment Service. METHODS: Economic burdens of colorectal cancer were estimated using prevalence data and patients were defined as those who received ambulatory treatment from medical institutions or who had been hospitalized due to colorectal cancer under the International Classification of Disease 10th revision codes from C18-C21. The economic burdens of colorectal cancer were calculated as direct costs and indirect costs. RESULTS: The prevalence rate (per 100 000 people) of those who were treated for colorectal cancer during 2010 was 165.48. The economic burdens of colorectal cancer in 2010 were 3 trillion and 100 billion Korean won (KRW), respectively. Direct costs included 1 trillion and 960 billion KRW (62.85%), respectively and indirect costs were 1 trillion and 160 billion (37.15%), respectively. CONCLUSIONS: Colorectal cancer has a large economic burden. Efforts should be made to reduce the economic burden of the disease through primary and secondary prevention.
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Child
;
Child, Preschool
;
Colorectal Neoplasms/*economics/epidemiology
;
*Cost of Illness
;
Female
;
Health Care Costs
;
Health Expenditures
;
Humans
;
Infant
;
Infant, Newborn
;
Male
;
Middle Aged
;
Prevalence
;
Republic of Korea
;
Young Adult
9.Food allergic reactions in the community: a questionnaire survey of caregivers.
An Deok SEO ; Jun Yeol LEE ; Song I YANG ; Hye Ran LEE ; So Yeon LEE
Allergy, Asthma & Respiratory Disease 2017;5(1):27-33
PURPOSE: Food allergies are adverse immune reactions to food. Despite their importance, there have only been a few studies conducted on situations that may cause food allergies in Korean children. This study aims to obtain basic data that are necessary to provide information on food allergies to both patients and caregivers. METHODS: In this study, a survey was conducted on 97 caregivers of patients below 18 years old. The patients' situation upon occurrence of food allergy was examined by a questionnaire. RESULTS: Approximately 89.7% of the patients were at 6 years of age or younger. The most common allergens were eggs (37%) and milk (28%) in a total of 163 cases, including multiple responses. Skin symptoms were most common (77.8%). At the time of occurrence, 85% of the patients were with their parents. As for the exposure place, house was 65%, followed by restaurant (16%), nursery (7%), and relative's or neighbor's house (4%). Exclusive of unknown cases, the most common reason of exposure was the caregiver giving the food to the patient for reconfirmation (13.6%). CONCLUSION: It is concluded that the understanding of food allergies based on this research will assist in the management of patients with food allergies.
Allergens
;
Caregivers*
;
Child
;
Education
;
Eggs
;
Food Hypersensitivity
;
Humans
;
Hypersensitivity*
;
Milk
;
Nurseries
;
Ovum
;
Parents
;
Restaurants
;
Skin
10.Comparison of Ramosetron Plus Dexamethasone with Ramosetron Alone on Postoperative Nausea, Vomiting, Shivering and Pain after Thyroid Surgery.
Myeong Jong LEE ; Kyu Chang LEE ; Hye Young KIM ; Won Sang LEE ; Won Jun SEO ; Cheol LEE
The Korean Journal of Pain 2015;28(1):39-44
BACKGROUND: Postoperative nausea and vomiting (PONV), postanesthetic shivering and pain are common postoperative patient complaints that can result in adverse physical and psychological outcomes. Some antiemetics are reported to be effective in the management of postoperative pain and shivering, as well as PONV. We evaluated the efficacy of dexamethasone added to ramosetron on PONV, shivering and pain after thyroid surgery. METHODS: One hundred and eight patients scheduled for thyroid surgery were randomly allocated to three different groups: the control group (group C, n = 36), the ramosetron group (group R, n = 36), or the ramosetron plus dexamethasone group (group RD, n = 36). The patients were treated intravenously with 1 and 2 ml of 0.9% NaCl (group C); or 2 ml of 0.15 mg/ml ramosetron plus 1 ml of 0.9% NaCl (group R); or 2 ml of 0.15 mg/ml ramosetron plus 1 ml of 5 mg/ml dexamethasone (group RD) immediately after anesthesia. RESULTS: Incidence of nausea and the need for rescue antiemetics, verbal rating scale (VRS) 1 hour pain value, ketorolac consumption, and incidence of shivering were significantly lower in group R and group RD, than in group C (P < 0.05). Moreover, these parameters were significantly lower in group RD than in group R (P < 0.05). CONCLUSIONS: Combination of ramosetron and dexamethasone significantly reduced not only the incidence of nausea and need for rescue antiemetics, but also the VRS 1 hour pain value, ketorolac consumption, and the incidence of shivering compared to ramosetron alone in patients undergoing thyroid surgery.
Anesthesia
;
Antiemetics
;
Dexamethasone*
;
Humans
;
Incidence
;
Ketorolac
;
Nausea
;
Pain, Postoperative
;
Postoperative Nausea and Vomiting*
;
Shivering*
;
Thyroid Gland*
;
Vomiting*