PURPOSE: This study was performed to investigate the epidemiology of enterovirus (EV) infections in children at a secondary hospital during recent 5 years. METHODS: We collected the cerebrospinal fluid, stool and throat swab samples from the pediatric patients with suspected EV infections in KEPCO Medical Center, Seoul, Korea from July 2006 to September 2010. EV detection and genotype identification were performed by RT-PCR at Korea Centers for Disease Control and Prevention. RESULTS: A total of 386 samples were collected from 277 patients during study period. Ninety-eight patients (35.4%) were diagnosed with EV infections. The RT-PCR positive rate was the highest in throat swab samples (48.3%). The median age of patient was 4.7 years (range, 0.1-12.5 years). Aseptic meningitis (50, 51.0%) was the most common clinical manifestation; herpangina (22, 22.4%) and hand-foot-mouth disease (18, 18.4%). One hundred EVs were isolated from 98 patients and 20 genotypes of EV were identified; Echovirus 30 (28 cases, 28%), Enterovirus 71 (12 cases, 12%), Echovirus 25 (10 cases, 10%), Echovirus 9 (9 cases, 9%) and Coxsackievirus A6 (8 cases, 8%). Aseptic meningitis caused by Echovirus 30 was the most common manifestation in 2008. There was no complicated case caused by Enterovirus 71. CONCLUSION: This study showed the epidemiology of confirmed EV infection in children from 2006 to 2010. There is a need for continuous surveillance of EV infections and its clinical manifestations.
Centers for Disease Control and Prevention (U.S.) ; Child ; Echovirus 9 ; Enterovirus ; Enterovirus B, Human ; Enterovirus Infections ; Genotype ; Herpangina ; Humans ; Korea ; Meningitis, Aseptic ; Pharynx

Mostly of the sudden deaths, except in-hospital death and death within 48 hours of discharge, are declared in the emergency department by emergency physician. The purpose of this study is to review the protocol of cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrest by understanding the cause of sudden death from autopsy results. A retrospective analysis was performed by 48 months of medical records from emergency department of a tertiary hospital. The analysis was made from the patient group which gone through autopsy in the main office of National Institute of Scientific Investigation. In the emergency department, 1913 patients were declared death and 43 patients have received autopsy and 19 (1.0%) were natural death. 14 partients received CPR in the natural death group, and 13 were specified as cardiovascular disease. Result of this study represents the importance of prehospital CPR in case of unexpected cardiac arrest patients. However to generalize this result, all dead patients must go through autopsies for medical purpose which the frequency alse should be increased.
Autopsy ; Cardiopulmonary Resuscitation ; Cardiovascular Diseases ; Death, Sudden ; Emergencies ; Heart Arrest ; Humans ; Medical Records ; Out-of-Hospital Cardiac Arrest ; Retrospective Studies ; Tertiary Care Centers

Background: This study aimed at investigating the meal regularity, health, and oral health habits of single Korean households to understand the impact of these factors on the risk of metabolic syndrome, in addition to preventing and managing metabolic syndrome. Methods: Using raw data from the 8th Korea National Health and Nutrition Examination Survey (2019), 274 study subjects, aged 19 to 64, were selected primarily from single adult households. Complex sample statistical analysis was performed using the Predictive Analytics Software Statistics ver. 18.0 program. Results: Regarding the meal regularity in single-person households in Korea, the younger group outperformed the middle-aged group, and those who drank more than once a month performed better than those who drank less than once a month. In terms of oral health, regardless of the age and the income level, participants who ate three meals a day had a higher rate of speech problems and chewing difficulties than those who ate irregularly or regularly on a regular day. Factors influencing the risk of developing metabolic syndrome were age, speech problems, and frequency of toothbrushing. Compared to the younger group, there were 0.361 times more people in the middle-aged group; and compared to those without speech problems, there were 1.161 more people with speech problem. Compared to those who tooth brushed more than four times a day, there were 1.284 more people who tooth brushed 2 to 3 times a day and there were 5.673 times more people who tooth brushed less than once. Conclusion Based on the study results, it is necessary to implement a program that can plan and apply customized management measures and prevent metabolic syndrome by improving and correcting the health and oral health behaviors of single-person households in Korea. Therefore, active mediation measures, such as support and publicity at the local or national level, should be planned.

Objective: Borderline personality disorder (BPD) is known to share characteristics with a variety of personality disorders (PDs) and exhibits diverse patterns of defense mechanisms. To enhance our understanding of BPD, it’s crucial to shift our focus from traditional categorical diagnostics to the dimensional traits shared with other PDs, as the borderline personality organization (BPO) model suggests. This approach illuminates the nuanced spectrum of BPD characteristics, offering deeper insights into its complexity. While studies have investigated the comorbidity of BPD with other PDs, research exploring the relationship between various personality factors and defense mechanisms within BPD itself has been scarce. The present study was undertaken to investigate the complex interrelationships between various personality factors and defense styles in individuals diagnosed with BPD. Methods: Using a network analysis approach, data from 227 patients diagnosed with BPD were examined using the Defense Style Questionnaire and Personality Disorder Questionnaire-4+ for assessment. Results: Intricate connections were observed between personality factors and defense styles. Significant associations were identified between various personality factors and defense styles, with immature defense styles, such as maladaptive and image-distorting being particularly prominent in BPD in the centrality analysis. The maladaptive defense style had the highest expected influence centrality. Furthermore, the schizotypal, dependent, and narcissistic personality factors demonstrated relatively high centrality within the network. Conclusion Network analysis can effectively delineate the complexity of various PDs and defense styles. These findings are expected to facilitate a deeper understanding of why BPD exhibits various levels of organization and presents with heterogeneous characteristics, consistent with the perspectives proposed by the BPO.

Left atrial wall calcification is frequently observed in patients with rheumatic valvular heart disease. However, massive left atrial wall calcification, so called porcelain or coconut atrium, with left atrium thrombi is very rare. Here, we describe the case of a 67-year-old male patient with porcelain atrium, recurrent left atrial thrombi, and a spontaneous axillary hematoma after mitral valve replacement and surgical thrombectomy due to rheumatic valvular heart disease. The patient underwent two valvular surgeries 20 years prior; therefore, we determined not to perform additional surgeries because of a high risk of morbidity, mortality, and the recurrence of atrial thrombi. The patient has been maintained on daily warfarin as an anti-thrombic therapy for more than 5 years without major embolic complications.
Aged ; Cocos ; Dental Porcelain ; Heart Atria ; Heart Valve Diseases ; Hematoma ; Humans ; Male ; Mitral Valve ; Recurrence ; Thrombectomy ; Thrombosis ; Warfarin

Left atrial wall calcification is frequently observed in patients with rheumatic valvular heart disease. However, massive left atrial wall calcification, so called porcelain or coconut atrium, with left atrium thrombi is very rare. Here, we describe the case of a 67-year-old male patient with porcelain atrium, recurrent left atrial thrombi, and a spontaneous axillary hematoma after mitral valve replacement and surgical thrombectomy due to rheumatic valvular heart disease. The patient underwent two valvular surgeries 20 years prior; therefore, we determined not to perform additional surgeries because of a high risk of morbidity, mortality, and the recurrence of atrial thrombi. The patient has been maintained on daily warfarin as an anti-thrombic therapy for more than 5 years without major embolic complications.
Aged ; Cocos ; Dental Porcelain ; Heart Atria ; Heart Valve Diseases ; Hematoma ; Humans ; Male ; Mitral Valve ; Recurrence ; Thrombectomy ; Thrombosis ; Warfarin

Molecular targeting may be defined as the specific concentration of a diagnostic or therapeutic tracer by its interaction with a molecular species that is distinctly present or absent in a disease state. Monoclonal antibody (mAb) is one of the successful agents for targeted therapy in cancer. To enhance the therapeutic effect, the concept of targeting radionuclides to tumors using radiolabeled mAbs against tumor-associated antigens, radioimmunotherapy, was proposed. The efficacy of radioimmunotherapy, however, has to be further optimized. Several strategies to improve targeting of tumors with radiolabeled mAbs have been developed, such as the use of mAb fragments, the use of high-affinity mAbs, the use of labeling techniques that are stable in vivo, active removal of the radiolabeled mAb from the circulation, and pretargeting strategies. Until now, however, there are many kinds of obstacles to be solved in the use of mAb for the targeted therapy. Major technical challenges to molecular targeting are related to the rapid and specific delivery of tracers to the target, the elimination of unwanted background activity, and the development of more specific targets to create a cytocidal effect. Further development of this field will be determined by success in solving these challenges.
Radioimmunotherapy* ; Radioisotopes

Alcohol is frequently a factor affecting emergency department patients, and alcohol consumption is more common among those who are injured. In Korea, the socioeconomic impact of alcohol has been enormous because of traditional permissive attitudes toward alcohol. Juvenile drinking has increased recently; consequently, an increase in alcohol-related injuries is likely in this population. Therefore, we compared the characteristics and severity of alcohol-related injuries in adolescents and adults. All injured patients seen at six EDs throughout 2007 were included. We obtained data from the 'Development of a model for an in-depth injury surveillance system based on the emergency department' surveillance. The proportion of adolescents who drank was 5.0%. No significant alcohol-related difference in injuries was found between male and female adolescents (P = 0.14), whereas in adults, being male was strongly related to alcohol consumption (P < 0.001). Among traffic accidents, motorcycle-related injuries were strongly associated with alcohol use in adolescents (odds ratio [OR] 2.52, 95% confidence interval [CI] 1.09-5.83). Results also indicated that alcohol-related injuries in adolescents showed poor outcomes (OR 2.36, 95% CI 1.47-3.81) as compared with those in adults (OR 1.42, 95% CI 1.26-1.59). Preventive strategy on alcohol-related injuries in adolescents should focus on reducing motorcycle accidents.
*Accidents, Traffic ; Adolescent ; Adult ; Alcohol Drinking/epidemiology ; Alcohol-Related Disorders/*epidemiology ; Alcoholic Intoxication/*epidemiology ; *Emergency Medical Services ; Female ; Humans ; Male ; Middle Aged ; Motorcycles ; Republic of Korea ; Wounds and Injuries/*epidemiology

PURPOSE: The ultimate goals of wound management are to avoid infection and to achieve a functional and cosmetically cceptable scar. The authors intended to determine the infection rate, as well as the patients, and the wounds, characteristics, associated with wound infection and with suboptimal appearance after traumatic wound management. METHODS: This prospective study was performed from Dec. 2002 to Aug. 2003 at Ewha Womans University Mokdong Hospital. Structured data sheets were completed at the times of the patient's Emergency Department visit and the Out Patient Department (OPD) follow-ups. Infection was determined at the time of follow-up, and a cosmetic score was determined at the time of suture removal. A multivariate analysis was used to determine the adjusted odds ratio (OR) of infection. RESULT: Of the 401 patients enrolled, infection was developed in 43 patients (10.7%). The characteristics associated with wound infection on multivariate analysis were age (adjusted OR per years, 1.024; 95% CI=1.010 to 1.037) and bite wounds (adjusted OR 8.645; 95% CI=2.753 to 27.150). A wound location on the head was associated with a lower risk of infection (adjusted OR 0.294; 95% CI=0.150 to 0.563). Suboptimal wound appearance increased with infection (p<0.0001). CONCLUSION: Both the patients and the wound's characteristics have influence on the likelihood of infection in cases of traumatic wounds. We found that increasing age, and bite wounds were associated with high risk of infection. Wound on the head were associated with lower risk of infection. Education were provided to patients. Efforts are needed.
Cicatrix ; Education ; Emergency Service, Hospital ; Female ; Follow-Up Studies ; Head ; Humans ; Multivariate Analysis ; Odds Ratio ; Prospective Studies ; Risk Factors* ; Sutures ; Wound Infection ; Wounds and Injuries*

BACKGROUND/AIMS: The aim of this non-randomized study was to determine the role of photodynamic therapy (PDT) in a multimodal approach for the palliation of advanced esophageal carcinoma. METHODS: Twenty consecutive patients with obstructing esophageal cancer were enrolled in this study. Each subject had dysphagia, and nine could not swallow fluid. External beam radiotherapy or a self-expandable metal stent was used following PDT for dysphagia due to recurrence of the malignancy. RESULTS: At 4 weeks post-PDT, a significant improvement in the dysphagia score was observed in 90% of patients, from 2.75 +/- 0.91 to 1.05 +/- 0.83 (p < 0.05). Patients with recurrent dysphagia underwent stent insertion at an average of 63 days (range, 37 to 90). The rate of major complications was 10%. Two esophageal strictures occurred, which were treated by placement of a modified expandable stent across the stricture. The median survival in these cases was 7.0 +/- 0.6 months. One patient that was treated with PDT and radiotherapy is alive and showed a complete tumor response. CONCLUSIONS: PDT as a multimodality treatment is safe and effective for relieving malignant esophageal obstruction with minimal complications.
Adenocarcinoma/complications/mortality/*therapy ; Aged ; Aged, 80 and over ; Biopsy ; Carcinoma, Squamous Cell/complications/mortality/*therapy ; Deglutition Disorders/etiology/*therapy ; Esophageal Neoplasms/complications/mortality/*therapy ; Esophageal Stenosis/etiology/*therapy ; Esophagoscopy ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Metals ; Middle Aged ; *Neoplasm Recurrence, Local ; Palliative Care ; *Photochemotherapy/adverse effects ; Prospective Studies ; Prosthesis Design ; Radiotherapy, Adjuvant ; Stents ; Time Factors ; Treatment Outcome