No abstract available.
Nails

Recently developed new classifications (Holland, Van Nuys, modified Lagios) of ductal carcinoma in situ (DCIS) linked to outcome have emphasized the importance of nuclear morphology rather than architecture. We have evaluated these three classifications in ductal carcinomas composed of in situ and invasive carcinomas. The reproducibility of three classifications was assessed (n=49), and the histological grade of the DCIS was compared with the histologic differentiation (modified Bloom & Richardson method) and nuclear grade (modified Black method) of the coexisting invasive ductal carcinoma (n=45). According to Holland classification, the DCIS component was poorly differentiated in 51.0%, intermediately differentiated in 40.8%, and well differentiated in 8.2%. Using the Van Nuys classification, the DCIS component was group 3 (high grade with or without necrosis) in 44.9%, group 2 (non-high grade with necrosis) in 28.6%, and group 1 (non-high grade without necrosis) in 26.5%. According to the modified Lagios classification, the DCIS component was high-grade in 42.8%, intermediate-grade in 32.7%, and low-grade in 24.5%. The histologic grades of the three classifications revealed significant correlations between Holland and Van Nuys classification (p<0.0001) and between Holland and modified Lagios classification (p<0.0001), especially in poorly differentiated/group 3/high-grade DCIS. The reproducibility of classification of the DCIS was 71.4% in the Holland, 61.2% in the Van Nuys, and 55.1% in the modified Lagios classifications. The grade of the DCIS showed significant correlation with the grade of coexisting invasive ductal carcinoma (p<0.0001), especially in poorly differentiated/group 3/high-grade DCIS. In conclusion, DCIS grade, determined by the Holland, Van Nuys or modified Lagios classifications, is closely correlated with the histologic grade of the invasive ductal component in tumors composed of in situ and invasive ductal carcinoma, and may be a useful factor to estimate clinical behavior of DCIS. In our experience the Holland classification is recommended for DCIS classification due to its high reproducibility.
Breast* ; Carcinoma, Ductal* ; Carcinoma, Intraductal, Noninfiltrating* ; Classification* ; Netherlands

Kikuchi's disease is a self-limiting lymphadenitis, predomin;intly of young women who present with cervical lymphadenopathy. We present a case of Kikuchis disease in a 18-year-old female, representing multiple tender subcutaneous mass on her neck, left eyelid and posteriarcuricle. Histopathologically, the biopsied mass was a lymph node showing architectural effacement by necrotic focicomposed of nucear karyorrhexis and mononucl ar cell proliferation.
Adolescent ; Cell Proliferation ; Eyelids ; Female ; Histiocytic Necrotizing Lymphadenitis ; Humans ; Lymph Nodes ; Lymphadenitis ; Lymphatic Diseases ; Neck

Paragonimiasis is prevalent in Far East and a kind of endemic Korean disases. The primary site of humanparagonimiasis is the lung, but hte ectopic infection of lung fluke has been reported by many authors. Weexperienced one case of abdominal paragonimiasis in a 44 year old male with a complaint of left lowerquadrantpain. Physical examination, barium enema, and other data suggested the possibility of tumor originating from thewall of descending colon. (intramural tumor). Postoperative specimen taken from the solid tumorous lesion showedparasitic granuloma, characteristic of Paragonimus Westermani. Here, we report a case of very peculiar ectopicparagonimaisis involved descending colon wall simulating neoplastic tumor, and also review the literaturesbriefly.
Barium ; Colon ; Colon, Descending ; Enema ; Far East ; Granuloma ; Humans ; Lung ; Male ; Mesocolon ; Paragonimiasis ; Paragonimus westermani ; Physical Examination ; Trematoda

Agenesis of corpus callosum occurs sporadically and may be transmitted as sex-linked, or autosomal-dominant or recessive traits. It has been associated with different syndromes. Clinical pictures vary from severe intellectual and neurologic abnormalities to asymptomatic and normaly intelligent cases. Agenesis of corpus callosum may occur alone, but it is more frequently associated with a high incidence of other anomalies. We report a male infant with agenesis of corpus callosum who was diagnosed to have ileal atresia and duplication.
Agenesis of Corpus Callosum* ; Corpus Callosum* ; Humans ; Incidence ; Infant ; Male

Endometriosis at the site of episiotomy scar following vaginal delivery is rare condition among the extrapelvic endometriosis implantation. We have experienced a case of episiotomy scar endometriosis. The precise anatomical location of the endometriotic lesion is confirmed using preoperative anal endosonogarphy. We believe anal endosonography to be essential when history, digital examination, and proctoscopy are not conclusive in the differential diagnosis of perianal pain or mass. The treatment of choice is complete surgical excision of the lesion and the surgical excision usually obtain permanent cure. We report a case of endometriosis at the site of episiotomy scar.
Cicatrix* ; Diagnosis, Differential ; Endometriosis* ; Endosonography ; Episiotomy* ; Female ; Proctoscopy

PURPOSE: The purpose of this study was to investigate the relationship between eating disorders, and self esteem in female college students. METHOD: The survey was carried out on convenience sample of 388 college female students. The questionnaire consisted of each scale for eating disorder, self-esteem. The data was analyzed by the SPSS/PC using frequency, percentage, mean, standard deviation, ANOVA, and Spearman correlation coefficient. RESULT: More than 43% of the subjects perceived their weight as overweight, while 1.5% of the women were obese as defined by BMI. About 57.4% of subjects were not satisfied with their body shape. Frequency of eating disorder was 5.93%. The score of eating disorder was high when the subjects had negative perception and low satisfaction with their body shape. The high scores of self-esteem were shown among the group who had high satisfaction on body shape. There was negative correlation between eating disorder and self-esteem(r=-.194, p=.000). CONCLUSION: This study suggests that the nursing intervention was necessary for female college students to recognize healthier eating habits and increased their self-esteem.
Feeding and Eating Disorders* ; Eating* ; Female* ; Humans ; Nursing ; Overweight ; Surveys and Questionnaires ; Self Concept

PURPOSE: To Compare treatment results on silicone tube insertion according to the region and severity of resistance in lacrimal probing for functional nasolacrimal duct obstruction patients who complained of epiphora but are shown to be normal in lacrimal syringing and dacryocystography. METHODS: A retrospective study was conducted with 40 subjects (42 eyes) who had silicone tube insertion because of functional nasolacrimal duct obstruction. A comparison was made of post-operational patient satisfaction by grading (0~3) according to the region and the severity of resistance and whether the resistance region was singular or multiple resistance regions were found on probing. Success was defined as a grade of more than one point. RESULTS: Two eyes had no resistance regions, 28 eyes had one resistance region, and 12 eyes had more than two resistance regions on lacrimal probing. There was no statistical significance in the ranking of post-operative satisfaction among theses groups. There was also no difference among the groups for post-operative satisfaction according to obstruction site. CONCLUSIONS: Most functional nasolacrimal duct obstruction patients showed partial obstruction of the nasolacrimal duct on probing. Since functional nasolacrimal duct obstruction is not possible, we must treat patients for partial nasolacrimal duct obstruction, for wihch silicone tube insertion is thought to be effective.
Eye ; Humans ; Intubation ; Lacrimal Apparatus Diseases ; Nasolacrimal Duct ; Patient Satisfaction ; Retrospective Studies ; Silicones

We report a case of multicystic mesothelioma in the visceral peritoneum anterior of the ascending colon. A 39-year-old female patient visited hospital with a palpabel tender mass in the right flank. An ultrasonogram showed multiple cystic mass lesions in the right flank and CT scan showed a multicystic rative mass with enhancing wall and septum in front of the ascending colon. The patient underwent explolaparotomy and the mass. which inpathology turned out to be a benign multicystic masothelioma, was removed.
Colon, Ascending ; Female ; Humans ; Mesothelioma* ; Peritoneum* ; Tomography, X-Ray Computed

Since there have been very few studies on nucleolar signaling, an attempt was made to establish nucleolar signal pathways which link the cell membrane to the nucleolus for the transfer of extracellular signals. Two pathways were studied. One was the G alpha s mediated cAMP pathway where two signal molecules were yielded, including RII and protein kinase A. The other was the G alpha q mediated DAG/IP3 pathway which yields two signals including protein kinase C and IP3/Ca2+. By the studying isolated nucleoli from resting liver, regenerating liver or weak carcinogen thioacetamide treated liver, it was possible to detect protein kinase A (PKA), protein kinase C (PKC) and RII subunits. In addition, CK2 was detected. It was found that external signals transmitted through G protein coupled receptors could reach into the nucleolus and that physical translocation of signal molecules was an integral step involved in membrane-nucleolus linked pathways. When an in vitro assay of the above signal molecules was carried out using [gamma-32P]-ATP, most kinase dependent phosphorylation was via the major CK2 (more than 95%). Therefore, it is suggested that the major CK2 dependent pathway is involved in 'house keeping' for nucleolar integrity and the minor pathways, dependent on PKA, PKC and others, are involved in subtle regulatory mechanisms such as 'extra-house-keeping' activities by nucleolar chromosomal remodeling.
Animal ; Blotting, Western ; Cell Membrane/metabolism ; Cell Nucleolus/metabolism* ; Cyclic AMP-Dependent Protein Kinases/metabolism ; GTP-Binding Proteins/metabolism ; Immunoblotting ; Liver/metabolism ; Liver Neoplasms, Experimental ; Male ; Models, Biological ; Nuclear Proteins/metabolism* ; Phosphoproteins/metabolism ; Protein Kinase C/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Rats ; Rats, Sprague-Dawley ; Second Messenger Systems ; Signal Transduction* ; Thioacetamide/pharmacology ; Time Factors