8.Mechanism by which statins influence insulin signaling pathway.
Min LI ; Enyuan ZHANG ; Xu ZHANG ; Guangping LI
Chinese Medical Journal 2014;127(20):3664-3668
9.Impact of statins on risk and survival of ovarian cancer.
Muhammad Shahzeb KHAN ; Kaneez FATIMA ; RAMEEZ
Journal of Gynecologic Oncology 2015;26(3):240-241
No abstract available.
Female
;
Humans
;
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
;
Ovarian Neoplasms/mortality/*prevention & control
;
Risk Factors
10.Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis.
Guizuo WANG ; Yonghong ZHANG ; Xinming XIE ; Dong HAN ; Yuanyuan WU ; Shaojun LI ; Fengjuan LI ; Manxiang LI
Journal of Southern Medical University 2014;34(7):988-993
OBJECTIVETo systematically review whether statins can reduce the risk of infection and infection-related mortality.
METHODSWe searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.
RESULTSSixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592).
CONCLUSIONStatins can significantly reduce the risk of infection but does not lower infection-related mortality.
Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; therapeutic use ; Infection ; epidemiology ; mortality ; Randomized Controlled Trials as Topic ; Risk Factors
Result Analysis
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