OBJECTIVE: e To investigate the distribution of GHB in biological fluids and tissues and provide methodand information for detcetion of GHB in Biological Fluids and Tissues METHOD The concentrations of GHB in Biological Fluids and Tissues were analyzed by gas chromatography-mass spectrometry; Two groups of rats were fed with 1000 mg/kg of GHB and were killed at 1 hour and 3 hours post dose, respectively. RESULTS GHB concentrations of the administrated groups distributed in a degressive order of urine, stomach, blood, intestine, kidney, lung, spleen, heart, liver and brain. CONCLUSION Urine was the best specimen for the determination of GHB concentrations in biological fluids and tissues.
Acute Disease ; Administration, Oral ; Animals ; Gas Chromatography-Mass Spectrometry ; Gastric Mucosa/metabolism* ; Hydroxybutyrates/poisoning* ; Kidney/metabolism* ; Lung/metabolism* ; Male ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Substance Abuse Detection/methods* ; Tissue Distribution