2.Effects of Dihydrochlorothiazide, Propranolol, and Prazosin on Serum Lipids in Patients with Essential Hypertension.
Seung Bum JIN ; Young Woo RHEE ; Seok Won CHANG ; Ki Cheol KIM ; Soek Pil KIM ; Chang Sup SONG
Korean Circulation Journal 1985;15(2):329-336
Three groups of patients with newely diagnosed hypertension, or with hypertension not optimally controlled by previous treatment, completed a comparative study on the effects of Dihydrochlorothiazide, propranolol, and prazosin on plasma lipids after three months therapy. The drugs showed equipotent antihypertensive effects(P<0.01). Dihydrochlorothiazide administration was associated with a significant elevation of total cholesterol(42%, P<0.05), and triglyceride(8.1%, P<0.01). Changes of HDL-C(5.1%), LDL-C(3.3%), and cholesterol ratio(-4.8%) were not significant. Propranolol administration was associated with significant elevation of total cholesterol(3.8%, P<0.05), triglyceride(14.5%, P<0.005), and LDL-C(5.6%, P<0.005). Reduction of HDL-C(-7.8%, P<0.05) and cholesterol ratio(-14.7%, p<0.005) was also statistically significant. Prazosin administration was associated with significant decrease in total cholesterol(-6.6%, P<0.005), triglycride(-9.6%, P<0.005), and LDL-C(-11.7%, P<0.005), and significant elevation of HDL-C(10.6%,P<0.005) and cholesterol ratio(24.2%, P<0.005) was noted.
Cholesterol
;
Humans
;
Hydrochlorothiazide*
;
Hypertension*
;
Plasma
;
Prazosin*
;
Propranolol*
3.Effect of Tamsulosin and Dichlozid on the Expected Treatment of Ureteral Calculi.
Woon Yong YOON ; Tae Yoong JEONG ; Sang Ik LEE ; Dong Jun KIM
Korean Journal of Urology 2009;50(12):1213-1218
PURPOSE: We evaluated the effect of tamsulosin and hydrochlorothiazide (Dichlozid) on the expulsion of ureteral stones. MATERIALS AND METHODS: A total of 132 patients with a single ureteral calculi less than 10 mm in diameter were enrolled and divided into 3 groups: group 1 (n=40) received tamsulosin (0.2 mg/day), group 2 (n=35) received Dichlozid (25 mg/day) and tamsulosin (0.2 mg/day), and group 3 (n=57) was the control. Proximal and distal ureteral stones were evaluated separately. Efficacy was evaluated in terms of the rate and duration of expulsion according to stone size (<5 mm, > or =5 mm) for a maximum period of 4 weeks. RESULTS: The mean stone diameters were 4.9+/-1.7 mm (group 1), 4.8+/-1.6 mm (group 2), and 5.3+/-1.8 mm (group 3). The overall expulsion rates were 70%, 74.3%, and 52.6%, respectively, and showed statistical significance. The mean durations of expulsion were 14.7+/-1.6, 12.8+/-1.5, and 18.0+/-2.0 days, respectively, and group 2 showed a significant decrease in the duration. There were no significant differences in the expulsion rate of proximal and distal ureteral stones in any group. Distal ureteral stones in groups 1 and 2 showed a significant reduction in the mean expulsion time (<5 mm: 13.6+/-0.5, 11.8+/-0.7, and 16.7+/-0.8 days in groups 1, 2, and 3, respectively; > or =5 mm: 15.0+/-1.4, 13.0+/-0.6, and 17.8+/-0.4 days in groups 1, 2, and 3, respectively). The mean expulsion time for smaller proximal stones (<5 mm) in groups 1 and 2 was reduced significantly (17+/-0.6, 15.2+/-0.8, and 19.3+/-0.6 days in groups 1, 2, and 3, respectively). CONCLUSIONS: Medical therapy with tamsulosin is time-saving and effective for treating ureteral calculi. In addition, adjunctive treatment with Dichlozid may reduce the duration of expulsion.
Diuretics
;
Humans
;
Hydrochlorothiazide
;
Sulfonamides
;
Ureter
;
Ureteral Calculi
4.Effect of KCI Continus Tablet(K-Contin(R)) on Serum K and Uric Acid Level during Hydrochlorotihiazide Therapy.
Jung Don SEO ; Wang Sung RYU ; Byung Hee OH ; Young Woo LEE
Korean Circulation Journal 1985;15(3):413-419
The effects of KCI continus tablet(K-Contin(R)) on the serum level of K and uric acid during hydrochlorothizide therapy(25mg/day) were evaluated in 30 patients with essential hypertensien. The results are as follows : 1) During hydrochlorothiazide therapy(25mg/day), 23% of all patients showed hypopotassemia(<3.5mEq/1) while no patient developed hypopotassemia after potassium supplement therapy(8 mEq/day). 2) During the period of K supplement, the level of serum uric acid showed less elevation. 3) The side reaction of KCI continus tablet were mild indigestion which developed in two patients and disappeared soon without any particular treatment. In conclusion, the KCI continus tablet is useful in the prevention of hypopotassemia during chronic diuretic therapy.
Dyspepsia
;
Humans
;
Hydrochlorothiazide
;
Hypokalemia
;
Potassium
;
Uric Acid*
5.Effects of Diuretics on Serum and Urinary Electrolytes in Patients with Hypertension.
Ki Cheol KIM ; Seok Pil KIM ; Young Min LEE ; Chi Myung SONG ; Sang Ki YANG ; Chang Sup SONG
Korean Circulation Journal 1986;16(2):263-270
In order to investigate electrolyte changes in serum and urine diuretic therapy, we studied 98 patients with hypertension not optimally controlled by previous treatment. After we divied the patients into three gorups in randomized trial, group A were given Amiloride 10mg/day, group B were given Dihydrochlorothiazide 50mg/day, group C were given Amiloride 5mg/day combined with Dihydrochlorothiazide 25mg/day for 7 days. Blood pressure and electrolyte changes in serum and urine after diuretic theraphy for 7 days were as follows. 1) Serum sodium concentrations were not significantly changed in all three groups(P>0.05). 2) Serum potassium concentrations were increased in group A and C (P<0.05), but there were no significant changes in group B(P<0.05). 3) Urinary sodium exceretions were increased in all three groups(P<0.05). 4) Urinary potassium excretion were decreased in group A and C (P<0.05), but there were increased in group B (P<0.05). 5) Blood pressure were decreased in all three groups(P<0.05).
Amiloride
;
Blood Pressure
;
Diuretics*
;
Electrolytes*
;
Humans
;
Hydrochlorothiazide
;
Hypertension*
;
Potassium
;
Sodium
6.Antihypertensive Effect of Captopril on Essential Hypertension.
Won Chang SHIN ; Ki Hwan KIM ; Suck Koo CHOI ; Won Sang YOO
Korean Circulation Journal 1988;18(1):145-151
The antihypertensive effect of captopril was evaluated in 15 patients with mild to moderate essestial hypertension(Mean age : 55, Mean blood pressure : 171/102mmHg). Captopril was administered 25 to 50mg twice daily with or without hydrochlorothiazide by mouth according to our protocol which was presented in the text. All the patients were followed up to 12 weeks. Captopril with or without hydrochlorothiazide significantly lowered the systolic and diastolic pressure in almost all patients. The mean systolic and diastolic pressure were reduced to 134/86mmHg(-37/-16mmHg ; -22/-16%)(p<0.001). Heart rate did not change significantly. No unwanted effects were observed. We conclude captopril has exellent antihypertensive effect in most patients with mild to moderate essential hypertension.
Blood Pressure
;
Captopril*
;
Heart Rate
;
Humans
;
Hydrochlorothiazide
;
Hypertension*
;
Mouth
7.A Case of Phototoxicity due to Hydrochlorothiazide.
Ki Deuk HAN ; Chee Won OH ; Tae Jin YOON ; Tae Heung KIM
Annals of Dermatology 1998;10(4):289-292
A 72-year-old woman developed pruritic erythematous patches on sun-exposed areas for 2 months following treatment with hydrochlorothiazide (Dichlozid) for hypertension. A phototest revealed a decreased minimal erythemal dose to UVA (MED(UVA)=2 J/cm²). A photopatch test with 0.5%, 1%, and 5% hydrochlorothiazide ointment revealed no response. Two weeks after discontinuation of hydrochlorothiazide, the skin lesions improved with complete loss of photosensitivity without any therapy. At that time, an oral provocation phototest with hydrochlorothiazide was performed and it showed a decreased MED to UVA (MED(UVA)=2 J/cm²).
Aged
;
Dermatitis, Phototoxic*
;
Female
;
Humans
;
Hydrochlorothiazide*
;
Hypertension
;
Skin
8.Clinical Effects and Safety of Delapril in Patients with Essential Hypertension.
Se Ick OH ; Hyung Gon KIM ; Gwang Ho CHUNG ; Suck Koo CHOI ; Won Sang YOO
Korean Circulation Journal 1992;22(4):676-682
BACKGROUND: To evaluate depressure effect and safety of delapril, a new ACE inhibitor, in Korea. METHOD: Thirty three patients, aged 37-69, with mild to moderate essential hypertension were first observed for 2 weeks with placebo followed by administration of 15mg of delapril twice daily for 2 weeks, then doubled dosage to 30mg b.i.d. and combined with 25mg of dihydrochlorothiazide if optimal BP were not obtained at the end of 4th week, continued the same dose until the end of 10 week's trial period. RESULT: BP dropped 15/9mmHg inaverage at the end of 10th week rewarding 70% of cumulative effectiveness. Most frequent side reaction was dry cough, occurred in 9% of patients followed by chest tightness, headache, constipation and transient elevation of GPT. CONCLUSION: Delapril 15-30mg twice daily as monotheraphy or combined with diuretics is well tolerated and effective in the treatment of mild to moderate essential hypertension.
Constipation
;
Cough
;
Diuretics
;
Headache
;
Humans
;
Hydrochlorothiazide
;
Hypertension*
;
Korea
;
Reward
;
Thorax
9.Clinical Study on the Effects of Antihypertensive Drugs.
Korean Circulation Journal 1973;3(2):45-56
Evaluation of several antihypertensive regimens involving reserpine, hydrochlorothiazide (Esidrex(R)) and clonidine (Catapres(R)) was conducted on 230 subjects with mild to severe hypertension. Chlordiaxepoxide (Librium(R)) which is a sedative was also administered to observe the effect in patients with mild labile hypertension. The results obtained were as follows; 1. All five regimens of chlordiazepoxide, reserpine, hydrochlorothiazide, hydrochlorothiazide plus reserpine and hydrochlorothiazide plus clonidine produced a significant decrease in average mean arterial pressure (systolic+diastolicc pressure/2) compared to control values (p<0.01). 2. Hydrochlorothiazide plus clonidine was the most effective pressure lowering regimen, resulting in an average fall of 39.3 mmHg in average mean arterial pressure and obtaining excellent result in 28.6% of the cases. 3. The order in the pressure lowering effect was hydrochlorothiazide plus clonidine, hydrochlorothiazide plus reserpine, hydrochlorothiazide, reserpine, and chlordiazide 4. There was no significant difference between hydrochlorothiazide plus clonidine and hydrochlorothiazide plus reserpine (p>0.1). 5. More reduction in diastolic pressure than systolic was observed with hydrochlorothiazide plus clonidine. 6. The results of hydrochlorothiazide alone, hydrochlorothiazide-reserpine and hydrochlorothaizide-clonidine were better than those of chlordiazepoxide and reserpine alone in patients with fundoscopic findings of Keith-Wagener Grade II. 7. There was difference in pressure lowering effect with hydrochlorothiazide plus clonidine between the group with and without albuminuria. 8. Hydrochlorothiazide plus clonidine were extremely effective in patients with severe hypertension, hydrochlorothiazide plus reserpine in patients with moderately severe hypertension, and reserpine and hydrochlorothiazide alone in patients with mild hypertension.
Albuminuria
;
Antihypertensive Agents*
;
Arterial Pressure
;
Blood Pressure
;
Chlordiazepoxide
;
Clonidine
;
Humans
;
Hydrochlorothiazide
;
Hypertension
;
Reserpine
10.A Case of Congenital Partial Nephrogenic Diabetes Insipidus.
Eun Ha MO ; In Hye NAM ; Min Ja CHUNG ; Jae Hong YU
Journal of the Korean Pediatric Society 2002;45(7):902-905
The most common form of genetic nephrogenic diabetes insipidus(NDI), a rare inherited disorder, is congenital and is transmitted in an X-linked recessive mode. It is refractory to the antidiuretic effect of normal to moderately increased levels of plasma arginine vasopressin(AVP) but, in some cases, may respond to high levels of the hormone or its analogue, deamino-D-arginine vasopressin(DDAVP). X-linked congenital NDI has now been linked to over 128 different mutations in diverse coding regions of the AVP receptor 2(AVPR2) gene. The functional effects of these mutations vary from complete loss of responsiveness to a simple shift to the right in the dose response curve. We report a case of congenital partial NDI, with transversion of A to G at codon 280 of the AVPR2 gene, resulting in a subsequent change of amino acid from tyrosine to cysteine, and that has been effective with hydrochlorothiazide and high dose of DDAVP.
Antidiuretic Agents
;
Arginine
;
Clinical Coding
;
Codon
;
Cysteine
;
Deamino Arginine Vasopressin
;
Diabetes Insipidus, Nephrogenic*
;
Hydrochlorothiazide
;
Plasma
;
Tyrosine