1.Cerebello-Pontine Angle Lipoma: Case Report and Review of the Literature .
Hong Ju PARK ; Jin Suk YOO ; Hyang Ae SHIN ; Sang Gyun LIM
Journal of the Korean Balance Society 2006;5(2):228-291
Intracranial lipomas located in the cerebellopontine angle are extremely rare. These tumors are maldevelopmental lesions which can cause slowly progessive neurological symptoms. The clinical management of these tumours differs significantly from other lesions in this region. A 45 year old man presented with a 3-month history of vertigo and tinnitus in the left ear. In T1-weighted magnetic resonance imaging, the lesion was hyperintense and did not enhance after application of gadolinium. The patient was treated with medical therapy with good response. We present a review of the literature, with particular regard to management. Conservative treatment is recommended and limited surgery is usually indicated if the patients suffer from disabling neurological symptoms and signs e.g., vertigo, nausea, trigeminal neuralgia, facial weakness or facial spasm.
Cerebellopontine Angle
;
Ear
;
Gadolinium
;
Humans
;
Lipoma*
;
Magnetic Resonance Imaging
;
Middle Aged
;
Nausea
;
Spasm
;
Tinnitus
;
Trigeminal Neuralgia
;
Vertigo
2.Analysis of PD-L1 expression in salivary duct carcinoma with its efficacy as a tumor marker
Yong Ju LEE ; Yoon Woo KOH ; Sun Och YOON ; Hyang Joo RYU ; Hye Ryun KIM ; Hyang Ae SHIN
Korean Journal of Head and Neck Oncology 2019;35(1):13-20
BACKGROUND/OBJECTIVES: Despite multiple approaches of treatments for salivary duct carcinoma, there has been a need for more successful treatment methods because of its poor prognosis. Treatment options like immunotherapy using new technologies have been attempted. Based on recent study results indicating that targeting programmed death receptors are effective in treating various cancers, this study aimed to identify the frequency of PD-L1 expression and its impact on survival rate in salivary duct carcinoma.MATERIALS #SPCHAR_X0026; METHODS: We studied 33 patients with salivary gland cancer who were available for histologic specimens. We examined the expression of PD-L1 in the tissues and analyzed the association with the survival rate and the association with various clinical parameters.RESULTS: According to this study and review of similar studies, we discovered that the expression of PD-L1 in salivary duct carcinoma was lower than other types of cancers. The impact of PD-L1 on survival rate also showed inconsistency in salivary duct carcinoma.CONCLUSION: Immunotherapy by PD-1/PD-L1 checkpoint blockade in salivary duct carcinoma needs further evaluation for clinical application.
Humans
;
Immunotherapy
;
Prognosis
;
Receptors, Death Domain
;
Salivary Ducts
;
Salivary Gland Neoplasms
;
Survival Rate
3.A Case of Multifocal MALT Lymphoma in Salivary Glands.
Hyang Ae SHIN ; Hison KAHNG ; Eun HWANG ; Chul Ho KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2008;51(12):1166-1169
Primary malignant lymphomas of the salivary glands are uncommon. The parotid gland was most frequently involved, followed by the submandibular gland, minor salivary glands and sublingual gland. The most common subtype is mucosa-associated lymphoid tissue (MALT) lymphoma. MALT lymphoma is a relatively indolent disease and tends to remain localized for prolonged period of time. But, we experienced a case of a multifocal salivary MALT lymphoma involving both parotid glands and right submandibular gland during its progression of disease. We report a case with a review of the literature.
Lymphoid Tissue
;
Lymphoma
;
Lymphoma, B-Cell, Marginal Zone
;
Parotid Gland
;
Salivary Glands
;
Salivary Glands, Minor
;
Sublingual Gland
;
Submandibular Gland
4.Results of Vestibular Function Tests in Patients with Cerebello-Pontine Aangle Tumors.
Hyang Ae SHIN ; Yong Soo JEONG ; Jin Suk YOO ; HongJu PARK
Journal of the Korean Balance Society 2006;5(2):253-261
BACKGROUND AND OBJECTIVES: Acoustic neuroma (AN) is commonly encountered in the cerebello-pontine angle (CPA) and AN arises principally from the vestibular division of the nerve, which can show not only hearing disturbance but also various vestibular symptoms and laboratory findings by affecting central and peripheral vestibular system. Vestibular testing is reported not to be a useful screening test for AN, but can be helpful in defining whether the tumor arises from the superior or inferior division and identifying the cause of dizziness or vertigo. MATERIALS AND METHOD: We are presenting four patients with CPA tumors accompanied by various abnormal findings of vestibular function tests including head-shaking nystagmus, vibration-induced nystagmus, hyperventilation- induced nystagmus and vestibular evoked myogenic potential and subjective visual vertical, which can enable us to understand the pathomechanism of the abnormal results. RESULTS: All patients presented hearing loss and mild dizziness. Caloric test, head thrust test and vibration-induced nystagmus was helpful in localizing the disease, but head-shaking nystagmus and hyperventilation-induced nystagmus was less helpful. Otolith tests did not always show abnormal results. CONCLUSION: We should consider abnormal results of the vestibular function tests in a whole to estimate the status of vestibular compensation in patients with CPA tumors.
Caloric Tests
;
Compensation and Redress
;
Dizziness
;
Head Impulse Test
;
Hearing
;
Hearing Loss
;
Humans
;
Mass Screening
;
Neuroma, Acoustic
;
Otolithic Membrane
;
Vertigo
;
Vestibular Function Tests*
5.Larynx-Preserving Partial Pharyngectomy via Lateral Pharyngotomy for the Treatment of Small (T1~2) Hypopharyngeal Squamous Cell Carcinoma.
Young Chang LIM ; Ha Min JEONG ; Hyang Ae SHIN ; Eun Chang CHOI
Clinical and Experimental Otorhinolaryngology 2011;4(1):44-48
OBJECTIVES: To evaluate the oncologic and functional results of larynx-preserving partial pharyngectomy (LPP) via lateral pharyngotomy approach as a primary treatment for small (T1 or T2) hypopharyngeal squamous cell carcinoma (HPSCC). METHODS: We performed a retrospective review of 23 patients who underwent LPP through lateral pharyngotomy approach for small HPSCC at the our department between January 1991 and June 2007. Fourteen (61%) patients had adjuvant postoperative radiotherapy. RESULTS: The 2-years and 5-years disease specific survival rate was 77% and 61%, respectively. Nine patients (39%) had tumor recurrence. The most common pattern of recurrence was isolated distant failure (n=4, 44%) followed by local (n=2, 22%) and loco-regional (n=3, 34%) recurrence. The ultimate cure rate of the primary tumor was 87% (20 of 23). Twenty-two of the 23 patients (95%) could be decannulated, tolerate an oral diet, and had acceptable postoperative phonatory function. CONCLUSION: LPP via lateral pharyngotomy approach appears to be a feasible procedure for selected small HPSCC patients in terms of both oncologic and functional outcomes.
Carcinoma, Squamous Cell
;
Diet
;
Humans
;
Hypopharyngeal Neoplasms
;
Pharyngectomy
;
Radiotherapy, Adjuvant
;
Recurrence
;
Retrospective Studies
;
Survival Rate
6.Larynx-Preserving Partial Pharyngectomy via Lateral Pharyngotomy for the Treatment of Small (T1~2) Hypopharyngeal Squamous Cell Carcinoma.
Young Chang LIM ; Ha Min JEONG ; Hyang Ae SHIN ; Eun Chang CHOI
Clinical and Experimental Otorhinolaryngology 2011;4(1):44-48
OBJECTIVES: To evaluate the oncologic and functional results of larynx-preserving partial pharyngectomy (LPP) via lateral pharyngotomy approach as a primary treatment for small (T1 or T2) hypopharyngeal squamous cell carcinoma (HPSCC). METHODS: We performed a retrospective review of 23 patients who underwent LPP through lateral pharyngotomy approach for small HPSCC at the our department between January 1991 and June 2007. Fourteen (61%) patients had adjuvant postoperative radiotherapy. RESULTS: The 2-years and 5-years disease specific survival rate was 77% and 61%, respectively. Nine patients (39%) had tumor recurrence. The most common pattern of recurrence was isolated distant failure (n=4, 44%) followed by local (n=2, 22%) and loco-regional (n=3, 34%) recurrence. The ultimate cure rate of the primary tumor was 87% (20 of 23). Twenty-two of the 23 patients (95%) could be decannulated, tolerate an oral diet, and had acceptable postoperative phonatory function. CONCLUSION: LPP via lateral pharyngotomy approach appears to be a feasible procedure for selected small HPSCC patients in terms of both oncologic and functional outcomes.
Carcinoma, Squamous Cell
;
Diet
;
Humans
;
Hypopharyngeal Neoplasms
;
Pharyngectomy
;
Radiotherapy, Adjuvant
;
Recurrence
;
Retrospective Studies
;
Survival Rate
7.A Case of Primary Chondrosarcoma of the Cricoid Cartilage.
Jae Won CHANG ; Hyang Ae SHIN ; Ha Min JUNG ; Eun Chang CHOI
Korean Journal of Otolaryngology - Head and Neck Surgery 2010;53(6):378-382
Laryngeal chondrosarcoma is a cartilaginous malignant tumor which is rarely encountered in the head and neck. They occur most often in the paranasal sinus, mandibule, and larynx. The cricoid cartilage is the most common site of the laryngeal chondrosarcoma. Complete surgical resection and postoperative radiotherapy are generally recommended. Almost all cases of the laryngeal chondrosarcoma are detected early because of the rapid development of symptoms such as dyspnea, dysphagia and hoarseness, which are caused by the anatomic location. Authors experienced a case of laryngeal chondrosarcoma that originated from the cricoid cartilage in a 67 year-old male without any symptoms. The mass was found on a routine esophagogastroduodenoscopy examination. Hemicricoidectomy with complete excision of tumor was performed via laryngofissure approach. The patient did not undergo radiotherapy, since all margins of the resected mass were tumor-free. There was no evidence of recurrence or metastasis 12 months after surgery.
Chondrosarcoma
;
Cricoid Cartilage
;
Deglutition Disorders
;
Dyspnea
;
Endoscopy, Digestive System
;
Head
;
Hoarseness
;
Humans
;
Larynx
;
Male
;
Neck
;
Neoplasm Metastasis
;
Recurrence
8.Hereditary Angioneurotic Edema of the Larynx: A Case Report and Literature Review.
Dae Bo SHIM ; Young Chang LIM ; Hyang Ae SHIN ; Jin Kook KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2006;49(4):464-467
Hereditary angioneurotic edema (HAE) is an autosomal dominant disease that results from the deficiency of C1 esterase inhibitor (C1-INH) function. Urgent proper intervention of the upper airway is warranted to save the life of patients with the disease, which often causes acute airway obstruction. We present, with a review of literature, a case of 37-year old woman with HAE of larynx.
Adult
;
Airway Obstruction
;
Angioedema
;
Angioedemas, Hereditary*
;
Female
;
Hereditary Angioedema Types I and II
;
Humans
;
Larynx*
9.A Case of Huge Substernal Goiter Causing Acute Respiratory Failure.
Hyang Ae SHIN ; Sung Pyo HONG ; In Kyung SOHN ; Chul Ho KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2009;52(7):616-619
Substernal goiter is defined as a thyroid mass of which more than half is located below the thoracic inlet. As substernal goiter enlarges within the bony thoracic cavity, and vascular and visceral structures may slowly become compressed and compromised. Airway obstruction can occur due to the compression or the displacement of the trachea. Tracheal compression may rarely lead to severe respiratory compromise. Recently, we experienced a case of huge substernal goiter causing acute respiratory failure in a 63-year old female. We present this case with a review of the literature.
Airway Obstruction
;
Bays
;
Displacement (Psychology)
;
Female
;
Goiter, Substernal
;
Humans
;
Respiratory Insufficiency
;
Thoracic Cavity
;
Thyroid Gland
;
Trachea
10.Cervical Sympathetic Chain Schwannoma Mimicking Carotid Body Tumor.
Sang Chul PARK ; Yong Ju LEE ; Yee Jeong KIM ; Hyang Ae SHIN
Korean Journal of Otolaryngology - Head and Neck Surgery 2014;57(7):473-476
Schwannoma arising from cervical sympathetic chain is relatively uncommon and can be occasionally misdiagnosed as carotid body tumor. On MR images, schwannoma shows generally hypointense features on the T1-weighted images and hyperintense features on the T2-weighted images. Occasionally, however, contrast administration, which lets schwannoma show marked enhancement, may make it difficult to differentiate schwannoma from carotid body tumor. A 41-year-old woman presented a neck mass on the left. MR images of the neck and carotid angiography revealed a well-enhancing ovoid tumor, which separated the internal carptod arteries from the external carotid arteries at the level of carotid bifurcation. Complete tumor resection was performed and histopathology findings confirmed a schwannoma originating from the sympathetic chain. Postoperatively, miosis and facial anhydrosis of the left side were noted without ptosis, enophthalmos or other neurologic deficits. We report this case with a review of the literatures.
Adult
;
Angiography
;
Arteries
;
Carotid Artery, External
;
Carotid Body Tumor*
;
Enophthalmos
;
Female
;
Humans
;
Linear Energy Transfer
;
Miosis
;
Neck
;
Neurilemmoma*
;
Neurologic Manifestations