BACKGROUND: Recently, adolescent smoking has become one of the most serious problems in our society. In this study, we surveyed smoking status, family function by Korean family function assessment tool, history of abuse, and others to know the factors associated with smoking for high school students. METHODS: In May 2001, a total of 1,033 students from 2 male and 2 female general high schools located in Seoul were assessed with self-completing questionnaire. Among the total, there were 502 male and 533 female students. RESULTS: The percentage of male smokers was 27.7% and that of female smokers was 14.5%. The percentage of smokers was significantly higher in students with a history of physical abuse, psychological abuse or negligence (only in males) than in students without them. The family function score of the smokers was 127.3+/-20.3 and that of the non-smokers was 140.3+/-21.0 in males. The family function score of the smokers was 121.5+/-17.45 and that of the non-smokers was 140.9+/-22.1 in females. The family function score of the smokers was significantly lower than that of the non-smokers in males and females. In 6 factors (supportiveness, alienation, closeness, roles, sociality, authority (only in males)) each family function score of the smokers was significantly lower than that of the non-smokers in males and females. CONCLUSION: Adolescent smoking was associated with family function and history of abuse (physical, psychological and negligence (only in males)).
Adolescent* ; Emigrants and Immigrants ; Female ; Humans ; Male ; Malpractice ; Seoul ; Smoke* ; Smoking* ; Surveys and Questionnaires

BACKGROUND AND OBJECTIVES: Roflumilast, a selective inhibitor of phosphodiesterase type 4, has an anti-inflammatory property. It has been used in the treatment of chronic inflammatory airway diseases such as chronic obstructive pulmonary disease and asthma. However, the effect of roflumilast on mucus secretion in inflammatory airway epithelial cells has not been reported. Therefore, this study was aimed at investigating the effects of roflumilast on the inflammatory mediator-induced MUC5AC and MUC5B expression in human airway epithelial cells. MATERIALS AND METHOD: In human mucin-producing NCI-H292 airway epithelial cells and primary cultures of nasal epithelial cells, the effects of roflumilast on lipopolysaccharide (LPS)- and phorbl-12-myrsitate-13-acetate (PMA)-induced MUC5AC and MUC5B expression were analyzed by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. RESULTS: Roflumilast attenuated LPS-induced MUC5AC and MUC5B mRNA and glycoprotein expression in NCI-H292 cells. And roflumilast attenuated PMA-induced MUC5AC and MUC5B mRNA and glycoprotein expression in NCI-H292 cells. In addition, roflumilast attenuated LPS and PMA-induced MUC5AC and MUC5B mRNA expression in the primary cultures of nasal epithelial cells. CONCLUSION: These results suggest that roflumilast attenuates MUC5AC and MUC5B expressions in airway epithelial cells. Roflumilast may be a potentially ideal therapeutic agent for the control of mucus-hypersecretion in treating chronic inflammatory airway diseases.
Asthma ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells* ; Glycoproteins ; Humans ; Mucus ; Polymerase Chain Reaction ; Pulmonary Disease, Chronic Obstructive ; Reverse Transcription ; RNA, Messenger