1.Effects of the Expression of Leptin and Leptin Receptor (OBR) on the Prognosis of Early-stage Breast Cancers.
Yongnam KIM ; Si Young KIM ; Jae Jin LEE ; Jeongho SEO ; Youn Wha KIM ; Suck Hwan KOH ; Hwi Joong YOON ; Kyung Sam CHO
Cancer Research and Treatment 2006;38(3):126-132
PURPOSE: Obesity-related leptin and leptin receptor (OBR) have a relation to the development of cancer and metastasis and also the low survival rate for breast cancer patients. Leptin has been associated with increased aromatase activity and it displays functional cross-talk with estrogen. This study was designed to determine the relationship between the expression of leptin and OBR in breast cancer tissue and the prognosis of early-stage breast cancer patients, and especially for the tamoxifen-treated patients. MATERIALS AND METHODS: Ninety-five patients with early-stage breast cancer and who had undergone surgical treatment at Kyung Hee University Hospital between January 1994 and June 2004 were analyzed. The surgical specimens underwent immunohistochemical analysis for leptin and OBR. The patients' survival and clinical characteristics were obtained from the medical records. RESULTS: Of the 95 patients, 79 (83%) and 32 (33.7%) showed the expression of leptin and OBR in breast cancer tissue, respectively. The expression of leptin and OBR in breast cancer tissue was not significantly related to the clinicopathological characteristics, including obesity, the expression of hormonal receptor, the HER-2/neu expression, menopause, stage and the nuclear grade. The expression of leptin and OBR was not significantly related to the overall disease-free survival (DFS). For the tamoxifen-treated postmenopausal obese patients, the DFS of the leptin-positive group was higher than that of the leptin-negative group (p=0.017). CONCLUSION: The expression of leptin and OBR in breast cancer tissue may be not a prognostic factor for disease-free survival of breast cancer patients. In the future, further studies are needed to determine whether leptin expression could be a predictive factor for tamoxifen therapy in the postmenopausal obese subgroup among the early breast cancer patients.
Aromatase
;
Breast Neoplasms
;
Breast*
;
Disease-Free Survival
;
Estrogens
;
Female
;
Humans
;
Leptin*
;
Medical Records
;
Menopause
;
Neoplasm Metastasis
;
Obesity
;
Postmenopause
;
Prognosis*
;
Receptors, Leptin*
;
Survival Rate
;
Tamoxifen
2.Effect of Cyclooxygenase-2 Specific Inhibitor (SC-58635) on the Production of Nitric Oxide and Prostaglandin E2 in Lipopolysaccharide-stimulated Macrophage Cells.
Seung Jae HONG ; Hyung In YANG ; Hwi Joong YOON ; Myoung Soo LEE ; Hyo Jong KANG ; Wan Uk KIM ; Sang Heon LEE ; Chul Soo CHO ; Ho Youn KIM
Immune Network 2003;3(1):69-77
BACKGROUND: Celecoxib, a COX-2 specific inhibitor, has recently been used for the treatment of rheumatoid arthritis. However, the molecular and cellular mechanisms of celecoxib against RA inflammation remain to be defined. To elucidate the action mechanism of celecoxib on inflammatory cells, we investigated the effect of celecoxib on the production of two important mediators of inflammation, nitric oxide and PGE2 METHODS: RAW 264.7 cells stimulated with LPS were preincubated with various concentrations of celecoxib (from 10(-8) to 10(-5) M) and 10muM hydrocortisone, respectively. The production of NO and PGE2, the end products of iNOS and COX-2 genes, were estimated in culture supernatants by Greiss method and EIA, respectively. The expression of iNOS gene, COX-2 gene, NF-kappaB, and I-kappaB were determined by RT-PCR and western blot analysis. RESULTS: Celecoxib and hydrocortisone inhibited the production of NO and PGE2 in dose dependent manner, when RAW 264.7 cells were stimulated with LPS. The expression of iNOS was also down-regulated by celecoxib and hydrocortisone. Interestingly, COX-2 gene differentially expressed according to the dose of celecoxib, a decrease with lower dose (10(-8) M) but an increase with higher dose (10(-5) M). NF-kappaB binding activity was decreased by lower dose of celecoxib, whereas was not affected by higher dose of it. The expression of I-kappaB was suppressed by higher dose of celecoxib. CONCLUSION: The celecoxib strongly suppressed the production of NO and PGE2 in LPS-stimulated RAW264.7 cells. The decrease of NO seems to be linked to the inhibition of iNOS by celecoxib. The lower and higher dose of celecoxib differentially regulated the COX-2 expression and NF-kappaB activity
Arthritis, Rheumatoid
;
Blotting, Western
;
Celecoxib
;
Cyclooxygenase 2*
;
Dinoprostone*
;
Hydrocortisone
;
Inflammation
;
Inflammation Mediators
;
Macrophages*
;
NF-kappa B
;
Nitric Oxide*
3.A Case of Organizing Pneumonia Associated with Rituximab.
Chi Hoon MAENG ; Sang Ouk CHIN ; Byung Hyuk YANG ; Si Young KIM ; Hwi Joong YOUN ; Kyung Sam CHO ; Sun Kyung BAEK ; Sun LEE
Cancer Research and Treatment 2007;39(2):88-91
Rituximab is a human/murine chimeric anti-CD20 mono- clonal antibody used to treat CD20-positive B-cell non- Hodgkin's lymphoma (NHL). Although most of the adverse effects associated with rituximab are usually reversible and temporary infusion-related reactions, including fever, chills, flushing and skin reactions, there are several reports of pulmonary events after long-term administration of rituximab. We present a case of asymp-tomatic nodular organizing pneumonia occurring during rituximab-based chemotherapy in a patient with non- Hodgkin's lymphoma.
B-Lymphocytes
;
Chills
;
Drug Therapy
;
Fever
;
Flushing
;
Hodgkin Disease
;
Humans
;
Lymphoma, Non-Hodgkin
;
Pneumonia*
;
Skin
;
Rituximab
4.Asymptomatic Myxoma Originating from the Right Ventricular Outflow Tract.
Dong Hwi KIM ; Jeong Eun YI ; Hyun Ji IN ; Minyeong JEONG ; Moon Sung KIM ; Joune Seup LEE ; Jong Hoon LEE ; Borami KANG ; Hae Ok JUNG ; Ho Joong YOUN
Journal of Cardiovascular Ultrasound 2013;21(4):186-188
Asymptomatic right ventricular outflow tract (RVOT) myxoma is quite rare. We report an unusual case of asymptomatic myxoma arising from the RVOT which was successfully surgically removed.
Echocardiography
;
Heart Ventricles
;
Myxoma*
5.Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology.
Dong Gyu NA ; Jung Hwan BAEK ; So Lyung JUNG ; Ji hoon KIM ; Jin Yong SUNG ; Kyu Sun KIM ; Jeong Hyun LEE ; Jung Hee SHIN ; Yoon Jung CHOI ; Eun Ju HA ; Hyun Kyung LIM ; Soo Jin KIM ; Soo Yeon HAHN ; Kwang Hwi LEE ; Young Jun CHOI ; Inyoung YOUN ; Young Joong KIM ; Hye Shin AHN ; Ji Hwa RYU ; Seon Mi BAEK ; Jung Suk SIM ; Chan Kwon JUNG ; Joon Hyung LEE
Korean Journal of Radiology 2017;18(1):217-237
Core needle biopsy (CNB) has been suggested as a complementary diagnostic method to fine-needle aspiration in patients with thyroid nodules. Many recent CNB studies have suggested a more advanced role for CNB, but there are still no guidelines on its use. Therefore, the Task Force Committee of the Korean Society of Thyroid Radiology has developed the present consensus statement and recommendations for the role of CNB in the diagnosis of thyroid nodules. These recommendations are based on evidence from the current literature and expert consensus.
Advisory Committees
;
Biopsy, Fine-Needle
;
Biopsy, Large-Core Needle*
;
Consensus*
;
Diagnosis
;
Humans
;
Methods
;
Thyroid Gland*
;
Thyroid Neoplasms
;
Thyroid Nodule
6.Prevalence of Primary Immunodeficiency in Korea.
Jung Woo RHIM ; Kyung Hyo KIM ; Dong Soo KIM ; Bong Seong KIM ; Jung Soo KIM ; Chang Hwi KIM ; Hwang Min KIM ; Hee Ju PARK ; Ki Soo PAI ; Byong Kwan SON ; Kyung Sue SHIN ; Moo Young OH ; Young Jong WOO ; Young YOO ; Kun Soo LEE ; Kyung Yil LEE ; Chong Guk LEE ; Joon Sung LEE ; Eun Hee CHUNG ; Eun Hwa CHOI ; Youn Soo HAHN ; Hyun Young PARK ; Joong Gon KIM
Journal of Korean Medical Science 2012;27(7):788-793
This study represents the first epidemiological study based on the national registry of primary immunodeficiencies (PID) in Korea. Patient data were collected from 23 major hospitals. A total of 152 patients with PID (under 19 yr of age), who were observed from 2001 to 2005, have been entered in this registry. The period prevalence of PID in Korea in 2005 is 11.25 per million children. The following frequencies were found: antibody deficiencies, 53.3% (n = 81), phagocytic disorders, 28.9% (n = 44); combined immunodeficiencies, 13.2% (n = 20); and T cell deficiencies, 4.6% (n = 7). Congenital agammaglobulinemia (n = 21) and selective IgA deficiency (n = 21) were the most frequently reported antibody deficiency. Other reported deficiencies were common variable immunodeficiencies (n = 16), X-linked agammaglobulinemia (n = 15), IgG subclass deficiency (n = 4). Phagocytic disorder was mostly chronic granulomatous disease. A small number of patients with Wiskott-Aldrich syndrome, hyper-IgE syndrome, and severe combined immunodeficiency were also registered. Overall, the most common first manifestation was pneumonia. This study provides data that permit a more accurate estimation PID patients in Korea.
Adolescent
;
Agammaglobulinemia/congenital/epidemiology
;
Age Distribution
;
Child
;
Child, Preschool
;
Common Variable Immunodeficiency/epidemiology
;
Female
;
Genetic Diseases, X-Linked/epidemiology
;
Humans
;
IgA Deficiency/epidemiology
;
IgG Deficiency/epidemiology
;
Immunologic Deficiency Syndromes/*epidemiology
;
Infant
;
Infant, Newborn
;
Job's Syndrome/epidemiology
;
Male
;
Prevalence
;
Questionnaires
;
Registries
;
Republic of Korea/epidemiology
;
Severe Combined Immunodeficiency/epidemiology
;
Sex Distribution
;
Wiskott-Aldrich Syndrome/epidemiology
;
Young Adult