Recently, duplex sonography has been used as a screening test for the evaluation of carotid arterial disease. If an occlusion of atherosclerosis is located at the bifurcation of the common carotid artery or the lower portion of the internal carotid artery, the luminal change may be directly visualized on high-resolution B-mode sonography or color-Doppler images. But when the lesion is located at the high cervical, petrous or cavernous protion of the internal carotid artery, it is difficult to directly visualize the lesion with the sonography. The purpose of this paper is to evaluate the indirect changes on the Doppler patterns of both common carotid arteries with clamping of an internal carotid artery. Thirty common carotid arteries in fifteen normal rabbits were examined with duplex ultrasonography using high-resolution real-time imaging and 7.5MHz pulsed-wave Doppler flow measurements with velocity waveform analysis. Systolic velocity (SV) was 45.4±8.4cm/sec, end-diastolic velocity (EDV) 15.3±4.9cm/sec and resistative index(RI) 0.66±0.08 in the common carotid artery before clamping of the internal carotid artery. SV was 26.3±7.8cm/sec, EDV 6.0±5.2cm/sec and RI 0.78±0.18 in the ipsilateral common carotid artery and SV was 56.6±13.0cm/sec, EDV 22.3±8.2cm. sec and RI 0.61±0.10 in the contralateral common carotid artery after clamping of the internal carotid artery. During clamping of the internal carotid artery, the difference between SV of bilateral common carotid arteries was 30.3±13.8cm/sec and EDV 16.3±9.2cm/sec. There was no difference of the velocity patterns of the common carotid artery between preclamping and declamping of the internal carotid artery. In conclusion, lower SV and EDV in a common carotid artery than that in contralateral side on Doppler patterns strongly suggests an occlusion of ipsilateral internal carotid artery.
Atherosclerosis ; Carotid Artery Diseases ; Carotid Artery, Common* ; Carotid Artery, Internal* ; Constriction* ; Mass Screening ; Phenobarbital ; Rabbits ; Ultrasonography

The authors analysed 2,653 cases of transthoracic fine needle aspiration cytology of the lung to evaluate the diagnostic accuracy and its limitation. A comparison was made between the original cytologic and the final histologic diagnoses on 1,149 cases from 1,074 patients. A diagnosis of malignancy was established in 38.3% benign in 48.1%, atypical lesion in 2.3%, and inadequate one in 11.9% of the cases. Statistical data on cytologic diagnoses were as follows; specificity 98.9%: sensitivity of procedure, 76.8%: sensitivity of diagnosis, 95.5%: false positive 5 cases: false negative 18 cases: predictive value for malignancy, 98.8%: predictive value for benign lesion, 79.5%: overall diagnostic efficiency, 87.5%: typing accuracy in malignant tumor, 80%.
Biopsy, Fine-Needle ; Diagnosis ; Diarrhea* ; Hemolytic-Uremic Syndrome* ; Humans ; Lung ; Sensitivity and Specificity

Evaluation of postpneumonectomy space (PPS) by CT in patients with lung cancer for operation-related complication or tumor recurrence is critical, but often difficult. We retrospectively analysed CT scans of 38 patients who underwent pneumonectomy for lung cancer. CT scans were obtained on 7-10th post-operative day for baseline image and at varying intervals of 2 to 24 months thereafter. Usual postoperative findings in patients without complication included mediastinal shifting, changes in subpleural space, changes in parietal pleura, and herniation of contralateral lung. Four patients had postoperative complications including empyema(n=3) and bronchopleural fistula(n=2). Twelve patients showed findings of tumor recurrence such as lymph node metastasis, local recurrence, and pericardial and contralateral pleural effusion. By comparing follow-up CT with baseline CT, we were able to detect early cancer recurrence and postoperative complications. Our results indicate that serial chest CT play an important role in the evaluation of the patients who underwent pneumonectomy for lung cancer.
Follow-Up Studies ; Humans ; Lung Neoplasms* ; Lung* ; Lymph Nodes ; Neoplasm Metastasis ; Pleura ; Pleural Effusion ; Pneumonectomy* ; Postoperative Complications ; Recurrence ; Retrospective Studies ; Thorax* ; Tomography, X-Ray Computed*

The potent antioxidant and anti-hypertension activities have evidenced gastric enzymatic hydrolysates from flounder fish and their derived peptides. However, peptide composition and functional effect in various enzymatic hydrolysates differ by enzyme types, hydrolyzed times temperatures, etc. Therefore, we determined potential anti-hypertensive effect of hydrolysates produced from flounder fish using commercial enzymes such as Protamex, Flavourzyme, and Kojizyme which are common food grade proteases and characterized on its derived peptides. In this study, Protamex-mediated hydrolysate showed a more potent anti-hypertension effect than other commercial enzymes. Protamex-mediated hydrolysate was fractionated into three ranges of molecular weight (above 10 kDa (FPH-I), 5-10 kDa (FPH-II), and below 5 kDa (FPH-III)). The FPH-III exhibited the strongest anti-hypertensive effect, and it was revealed that three active peptides, valine-phenylalanine-serine-glycinetryptophan-alanine-alanine (VFSGWAA), leucine-histidine-phenylalanine (LHF) and tryptophan-proline-tryptophan (WPW) were contained. The activities were confirmed via angiotensin-converting enzyme (ACE) inhibition and molecular docking simulation. Among the three peptides, LHF and WPW have a molecular structure stability against the gastrointestinal digestion. LHF showed a significant anti-hypertension effect at 9 h after oral administration in spontaneously hypertensive rats (SHRs). Therefore, we suggest that Protamex-mediated hydrolysate would be an excellent anti-hypertensive agent due to the existence of stabilized functional peptides, including LHF and WPW.

OBJECTIVE: To evaluate the effect of midodrine, an alpha(1) agonist, on symptom and hemodynamic response during standing and arm bicycle ergometer exercise in patients with cervical cord injury. METHOD: Twelve cervical spinal cord injury patients with orthostatic hypotension symptoms and post-exercise hypo- tension were enrolled. They were positioned on a 90degrees standing frame for 3 minutes. After 15 minutes of resting on supine position, 5 minutes of arm bicycle ergometer exercise was done. These tests were done without midodrine initially, but, with 5 mg midodrine on the next day. Heart rate, self-perceived presyncope score (PPS), systolic and diastolic blood pressure were measured before, during and after the exercise. RESULTS: With 5 mg midodrine, the decrease of systolic and diastolic blood pressures after 3 minutes' standing was significantly smaller than without midodrine (p<0.05). PPS was also significantly decreased with midodrine on standing frame test. Arm ergometer exercise induced less systolic blood pressure decrease and better PPS on immediate and 5 minutes after exercise with midodrine (p<0.05). The change of diastolic blood pressure and heart rate was not significant after the exercise with midodrine. CONCLUSION: In cervical spinal cord injury patients with orthostatic and post-exercise hypotension, 5 mg midodrine significantly improved the symptoms and the systolic blood pressures.
Arm ; Blood Pressure ; Heart Rate ; Hemodynamics ; Humans ; Hypotension ; Hypotension, Orthostatic ; Midodrine ; Post-Exercise Hypotension ; Spinal Cord Injuries ; Supine Position ; Syncope

No abstract available.
Lutein* ; Lymphangioma, Cystic*

PURPOSE: To investigate the impact of post-processing on a PACS workstation before and after use of thedynamic range suppression method for the normal chest radiographs. MATERIALS AND METHODS: Forty normal chestradiographs of healthy adult volunteers aged 20 to 33 (average 27; M:F = 29:11) were acquired by FCR using adigital interface and then transferred to an in-house-developed PACS workstation. The image size of computed chestradiographs was 7.5MB with 1760 x 2140 matrix. An image enhancement processing named DRS, developed by theauthors, was applied to the acquired images and generated a total of 40 chest radiographs. These were presented tothree groups of observers, each consisting of one radiologist and one technician on the PACS workstation, whichhad two monitors of 1712 x 2100 resolution. So that external light would not affect the visibility of imagesduring observation, these were displayed in a light-controlled room. The J.J.Vucich method, suitably modified, wasused to evaluate the anatomical structures and physical parameters of processed and unprocessed radiographs. Usinga percentage scale, the observers evaluated both anatomical sections (seven anatomical items : cortical margins ofribs, left diaphragms, thoracic vertebrae, trachea, pulmonary vasculature, trabeculae of ribs and clavicle,diaphragm outline) and physical sections (four items : contrast, graininess, density, detail). The results for thethree groups, both before and after DRS processing, were then compared. RESULTS: There was a statisticallysignificant difference between the three groups: in the anatomical section, 78.64 before DRS and 82.55 after ; andin the physical section, 75.48 and 79.78 (p<0.05). The average values of all items were 77.06 before DRS and 81.17after (p<0.05). CONCLUSION: Post-processing of computed chest radiographs on the PACS workstation improves boththe visibility of anatomical features and general image quality. Thus, in a PACS environment, it can be a usefultool for enhancing the diagnostic efficacy of radiography.
Adult ; Diaphragm ; Humans ; Image Enhancement ; Radiographic Image Enhancement ; Radiography ; Radiography, Thoracic* ; Ribs ; Thoracic Vertebrae ; Thorax* ; Trachea ; Volunteers

PURPOSE: To investigate the impact of post-processing on a PACS workstation before and after use of thedynamic range suppression method for the normal chest radiographs. MATERIALS AND METHODS: Forty normal chestradiographs of healthy adult volunteers aged 20 to 33 (average 27; M:F = 29:11) were acquired by FCR using adigital interface and then transferred to an in-house-developed PACS workstation. The image size of computed chestradiographs was 7.5MB with 1760 x 2140 matrix. An image enhancement processing named DRS, developed by theauthors, was applied to the acquired images and generated a total of 40 chest radiographs. These were presented tothree groups of observers, each consisting of one radiologist and one technician on the PACS workstation, whichhad two monitors of 1712 x 2100 resolution. So that external light would not affect the visibility of imagesduring observation, these were displayed in a light-controlled room. The J.J.Vucich method, suitably modified, wasused to evaluate the anatomical structures and physical parameters of processed and unprocessed radiographs. Usinga percentage scale, the observers evaluated both anatomical sections (seven anatomical items : cortical margins ofribs, left diaphragms, thoracic vertebrae, trachea, pulmonary vasculature, trabeculae of ribs and clavicle,diaphragm outline) and physical sections (four items : contrast, graininess, density, detail). The results for thethree groups, both before and after DRS processing, were then compared. RESULTS: There was a statisticallysignificant difference between the three groups: in the anatomical section, 78.64 before DRS and 82.55 after ; andin the physical section, 75.48 and 79.78 (p<0.05). The average values of all items were 77.06 before DRS and 81.17after (p<0.05). CONCLUSION: Post-processing of computed chest radiographs on the PACS workstation improves boththe visibility of anatomical features and general image quality. Thus, in a PACS environment, it can be a usefultool for enhancing the diagnostic efficacy of radiography.
Adult ; Diaphragm ; Humans ; Image Enhancement ; Radiographic Image Enhancement ; Radiography ; Radiography, Thoracic* ; Ribs ; Thoracic Vertebrae ; Thorax* ; Trachea ; Volunteers

OBJECTiVE We investigate the effects of multiple attempts of embryo transfer because of retained embryos in the catheter and of contaminated mucus on the transferred catheter. MATERiALS AND METHODS: We respectively analysed data between November 1998 and August 2002 from 305 patients of 369 cycles who underwent iVF-ET. Of these patients, 47 patients of 50 cycles (Group 2) were required multiple trial of embryo transfer. They were compared with an age-matched control groups (Group 1) with female factor infertility. Pearson's c2 and Fisher's tests were used to compare proportions between discrete variables. Non-categorical data were compared using t-test. Statistical significance was set at p<0.05. RESULTS: Embryos were significantly more likely to be retained when catheter was contaminated with mucus (Group 1: 22.4%; Group 2: 44.0%). The clinical pregnancy rates, however, for the contaminated mucus or not, were 46.8%, 43.5% respectively. There was no significant difference clinical pregnancy rate between those who had all their embryos transferred at the first attempt (45.4%) and those who required more than one attempt (48.0%). CONCLUSiONS: Contaminated mucus in the catheter is associated with failed embryo transferred at the first attempt. Embryo transfers, however, that are repeated attempts do not adversely affect pregnancy rates following iVF-ET.
Catheters ; Embryo Transfer* ; Embryonic Structures* ; Female ; Fertilization* ; Humans ; Infertility ; Mucus* ; Pregnancy Rate* ; Pregnancy*

Hypertrophic neuropathy is a non-specific consequence of repeated demyelination and remyelination, encountered in a wide range of inherited and acquired disorders. We report an 11-year-old boy with HMSN III, a kind of hypertrophic neuropathy, with clinical, electrophysiologic and pathologic data. The electrophysiologic studies show complete conduction block in the upper and lower extremities with severe abnormal spontaneous activities. The pathologic findings of sural nerve reveal prominent hypomyelination, onion bulb formation, and severe endoneurial collagenization. Complete conduction block with the preservation of fair to good grade muscle strength is an unusual finding in hypertrophic neuropathy and other peripheral neuropathies, in general.
Case Report ; Child ; Hereditary Motor and Sensory Neuropathies/pathology/*physiopathology ; Human ; Hypertrophy ; Male ; *Neural Conduction