No abstract available.
Hemorrhage*

No abstract available.
Humans ; Spouses*

No abstract available.
Checklist* ; Child ; Child Behavior* ; Child* ; Conduct Disorder* ; Humans

Alzheimer's disease(AD) is associated with a characteristic neuropathology. The major hallmarks of AD are senile plaques(SPs) and neurofibrillary tangles(NFTs). beta-amyloid protein(Abeta) is derived from the proteolysis of amyloid precursor protein(APP) and then converted to SPs. Mature SPs produce cytotoxicity through direct toxic effects and activation of microglia and complement. NFTs are composed of paired helical filaments(PHFs) including abnormally phosphorylated form of the microtubule-associated protein(MAP) tau and increased tau level in cerebrospinal fluid may be observed in most AD. The aggregation of Abeta and tau formation are thought to be a final common pathway of AD. Acetycholine, dopamine, serotonin, GABA and their receptors are associated with AD. Especially, decreased nicotinic acetylcholine receptors(nAChRs) in AD are reported. Genetic lesions associated with AD are mutations in the structural genes for the APP located on chromosome 21, presenilin(PSN)1 located on chromosome 14 and PSN2 located on chromosome 1. Also, trisomy 21, Apo-E gene located on chromosome 19, PMF locus, low density lipoprotein receptor-related protein and alpha-macroglobulin increase risk of AD. In this article, we will review about the neurobioloby of AD and some newly developed research areas.
Acetylcholine ; Alzheimer Disease* ; Amyloid ; Amyloid beta-Peptides ; Apolipoproteins E ; Cerebrospinal Fluid ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 19 ; Chromosomes, Human, Pair 21 ; Complement System Proteins ; Dopamine ; Down Syndrome ; gamma-Aminobutyric Acid ; Genetics ; Lipoproteins ; Microglia ; Neurobiology* ; Proteolysis ; Serotonin

No abstract available.
Anterior Cruciate Ligament* ; Rupture*

The mirtazapine is a relatively new antidepressant that has noradrenergic and specific serotonin antagonist action(NaSSAs). This has been known as one of the most safest drugs because of its few side effects. Until now, there have been only one case report that mirtazapine causes a EPS side effect(restless leg syndrome). But the peculiar mechanism of this drug makes it impossible to explain the exact reasons why the mirtazapine could induce EPS symptoms. Authors obseved three cases of mirtazapine indeced akathisia. We could not explain the phenomenon the other way except akathisia. So here we presents the three case of mirtazapine induced akathisia and a few possible hypothesis of this phenomenon.
Leg ; Psychomotor Agitation* ; Serotonin

Authors experienced a case of human infection with Anisakis sp. in left tonsil. The case was 27 year Korean female who visited Department of Otolaryngology, Severance Hospital with the chief complaints of swollowing difficulty, and the sensation of a foreign body in the throat, on November 20th 1968. Physical examination of the oral cavity revealed that both palatin tonsil were chronically enlarged. A larval worm was found in crypt of the upper portion of the left palatin tonsil. Chief complaints of the patient was improved after removal of it by forceps. The greyish white living worm was fixed in lactophenol solution for morphological study. The worm measured 36 mm in length by 0.6 mm in width, 2.4 mm in esophageal length, 1.4 mm in ventricule, 0.1 mm in tail length, and 0.025 mm in caudal spine length, respectively and histological study was carried out from the serial section of the larva which was stained with hematoxylin eosin. Authors identified that the larva was Anisakis species.
parasitology-helminth-nematoda-Anisakis sp. ; case report ; tonsil ; swollowing difficulty

No abstract available.
Suction* ; Tonsillectomy*

PURPOSE: As well as patient survival, the restoration of postoperative function such as ambulation is important in limb salvage operations for treatment of malignant bone tumors involving the proximal femur. The authors analyzed clinical outcomes of limb salvage operations using tumor prostheses for metastatic or primary malignant bone tumors in the proximal femur. MATERIALS AND METHODS: From February 2005 to January 2014, 20 cases (19 patients) with malignant bone tumor involving the proximal femur with pain or complicated pathologic fracture were treated with segmental resection and limb salvage operations with tumor prostheses. Mean age was 63.1 years (range 35-86). Fourteen patients were male and six ones were female. The mean follow-up period was 20 months (1-94 months). There were 15 cases of metastatic bone tumor, 4 cases of osteosarcoma, and 1 case of multiple myeloma. The primary tumors of the metastatic bone tumors included 4 lung cancers, 3 hepatocellular carcinomas, and 3 renal cell carcinomas. Other primary tumors were breast cancer, thyroid cancer, colon cancer, prostate cancer, and malignant spindle cell tumor, each in 1 case. Modular tumor prostheses were used in all cases; (Kotz's(R) Modular Tumor prosthesis (Howmedica, Rutherford, New Jersey) in 3 cases, MUTARS(R) proximal femur system (Implantcast, Munster, Germany) in 17 cases). Perioperative pain was assessed with Visual Analogue Scales (VAS). Postoperative functional outcome was assessed with Musculoskeletal Tumor Society (MSTS) grading system. RESULTS: Out of 20 cases (19 patients), 11 cases (10 patients) survived at the last follow-up. Average postoperative survival of the 9 deceased patients was 10.1 months (1-38 months). VAS score improved from pre-operative average of 8.40 (5-10) to 1.35 (0-3) after operation. Average postoperative MSTS function score was 19.65 (65.50%, 7-28). The associated complications were 2 local recurrences, 3 hematomas, 3 infections, 2 scrotal swellings, and 1 dislocation. There was no case of periprosthetic fracture or loosening. CONCLUSION: Limb salvage operation with tumor prosthesis is an appropriate treatment for early pain reduction and functional restoration in malignant bone tumors in the proximal femur with pain an/or complicated pathologic fractures.
Breast Neoplasms ; Carcinoma, Hepatocellular ; Carcinoma, Renal Cell ; Colonic Neoplasms ; Dislocations ; Female ; Femur* ; Follow-Up Studies ; Fractures, Spontaneous ; Hematoma ; Humans ; Limb Salvage* ; Lung Neoplasms ; Male ; Multiple Myeloma ; Osteosarcoma ; Periprosthetic Fractures ; Prostatic Neoplasms ; Prostheses and Implants* ; Recurrence ; Thyroid Neoplasms ; Walking ; Weights and Measures

EDAP-LT01 ESWL underwent 71 treatments in 20 patients with urinary stone of solitary kidney between February 25, 1987 and August 18, 1988. 1. The sex ratio was about 2:1, 13(65.0%) in male and 7(35.0%) in female patients. The average patient age was 50 years with a range of 23 to 65 years. The previous nephrectomy was owing to urinary tract stone in 19(95.0% ) and transitional cell carcinoma of renal pelvis in 1 (5.0%). 2. The duration of hospitalization was required from 2 to 7 days and the average post-ESWL stay was 1.5 days. 3. The treated stone locations were kidney in 18(90.0% ) ;calyx in 12(60.0% ) and renal pelvis in 6(30.0%) and ureter in 2(10.0%) ;upper ureter in 1(5.0% ) and lower ureter in 1(5.0%) There were multiple renal stones in 4(20.0% ).The average stone size was 1.6cm with a range of 0.7 to 4.1cm. 4. The average numbers of treatrnent were 2.7 sessions and the average treatment time was 30.2 minutes with a range of 17 to 42 minutes. The average storage was required 180 in one session. Of the patients, 4(20.0% ) were complained severe pain but treatment interruption or anesthesia were not required. 5. The success rate among 11 patients who completed ESWL treatment were 100.0% in 0.7-1.0cm, 60.0% in 1.0-2.0cm, 100.0% in 2.0-3.0cm and 77.8% in calyceal stones, 100.0% in renal pelvis stones. 100.0% in lower ureteral stones. Thus, the total average success rate was 81.8 %. 6. The method of pre-ESWL additional manipulation was used a upper ureteral stone 'push-up' in 1(5.0%). The post-ESWL additional measures were made in 4(20.0 % ) ;'push-up' & double -J stenting in 1(5.0% ) and double-J stenting in 3(15.0% ). The causes of failed ESWL were impacted stone in 1 and 'push-up' failure in 1. 7. None of the patients had significant changes in renal function by shock waves. ESWL complications were not required admission and medical management. Therefore, we confirmed that EDAP-LTOI piezoelectric ESWL is not influenced on renal function and is a safe, effective method for treatment of urinary stones in patients with a solitary kidney.
Anesthesia ; Carcinoma, Transitional Cell ; Female ; Hospitalization ; Humans ; Kidney Pelvis ; Kidney* ; Lithotripsy* ; Male ; Nephrectomy ; Sex Ratio ; Shock* ; Stents ; Ureter ; Urinary Calculi*