Lichen nitidus is a comparatively rare, asymptomatic, chronic disease displaying small, sharpIy defined, fresh colored papules usually localized on the penis, arms and the abdomen. Waisman found immunoglobulin at the dermo-epidermaI junction in lichen planus, but not in lichen nitidus. This settled the argument whether lichen nitidus is a variant of lichen planus. A 11 year old healthy girI was brought to the clinic because of many flesh colored discrete papules on the cubital fossae and the anterior chest. The papules are skin colored. pinhead sized, round, and flat-topped The lesions appeared first at the age of 8 on the antecubital folds and in the following years, increased in number and extended slowly to the upper arms and the anteior chest.
Abdomen ; Arm ; Child ; Chronic Disease ; Humans ; Immunoglobulins ; Lichen Nitidus* ; Lichen Planus ; Lichens* ; Male ; Penis ; Skin ; Thorax

Fundamental pathologic cianges of secondary syphilid are said to be swelling and proliferation of endothelials and a predominantly parivascular infiltrates composed chiefly of lymphoid cells and plasma cells. But recentIy this theory has heen challenged. We present bistologic observation made on 10 patients who agreed to go through a biopsy, during 2 years period. from 1975 to l977. Male to female ratio was 9: 1 The age of patient ranged from 20 to 33, with a mean of 26. 8. The duration of lesion before the visit to the department ranged frorn 6 weeks to 20 weeks, with a mean of 11.9. The lesions in 2 were classified as macule, 3 as papule (1 as moist papule), and 5 as papulo-squamous lesions. The VDRL titer was higher in papular type. Dark fieId examination was performed on all patient and 6 showed positive result. The edidermal changes consist of hyperkeratosis (in 6 cases), parakeratosis (in 5), acanthosis (in 6), elongation of rete ridges (in 8) and exocytosis (in 3). The dermis showed mild to severe perivascular infiltration consist chiefly of lymphoid cells and histiocytic cells (in 10), plama cells (in 7), eosinophils (in 4), neutrophils (in 2), chromatophores (in 4), extra vasation of RBC (in 5), and dilated bload vessels endothelial swellings (in 8). Of particular interest was the finding that plasma cell infiltration is more pronounced at the lower portion of dermal infiltrate and in 3 cases plasma cell infiltration was totally absent. Vascular changes were seen in 8 cases.
Biopsy ; Chromatophores ; Dermis ; Eosinophils ; Exocytosis ; Female ; Humans ; Lymphocytes ; Male ; Neutrophils ; Parakeratosis ; Plasma Cells ; Syphilis, Cutaneous*

No abstract available.
Adult ; *Fatty Liver/diagnosis/etiology/pathology ; Humans ; Male

In Korea where night soil used as fertilizer for crops and vegetables they may be contaminated simultaneously with infective stage of ascaris, hookworm and other helminthes. In this circumstance, the ascaris eggs and hookworm larvae may adhere to certain kinds of leafy vegetables(Chyu, 1957) and may remain viable even after pickling in brine or in other substances (Han and Ko, 1952; Soh, 1960). It has been shown that Heliogen(Thitasut, 1961) will kill the parasite eggs and larvae, and Sodium nitrite (Kozai, 1960; Kim and Soh 1964) and Thiabendazole (Kutsmi, 1964 and 1965; Kim et al., 1966) also had ovicidal action. The present study has been planned to study the ovicidal and larvicidal actions of several chemicals in Korean pickle juice(Kimchi) and the results are summarized as follows: Heliogen solution(iodine 100 ppm) did not destroy the ascaris and hookworm eggs within 30 minutes at the temperature of 15-30 C, but the hookworm larvae were killed within 3 minutes under the same conditions. Sodium nitrite which was added to pickle juice at the rate of 0.1 percent destroyed more than 90 percent of ascaris fresh eggs within 10 days and the embryonated eggs were destroyed within 2 days. Hookworm eggs were destroyed within 3 days and larvae were killed within 7 hours. Thiabendazole which was added to pickle juice at the rate of 0.1-0.025 percent inhibited the infectivity of ascaris embryonated eggs within 24 hours and hookworm eggs were destroyed in the same concentrations of the reagent. Hydrogen ion concentration of pickle juice which was mixed with Sodium nitrite (0.1 percent) was not changed for 10 days. 1.5 mg of Sodium nitrite or Thiabendazole produced no toxicity in kidney and intestine of mice but slight pathological changes in the liver of the same animal.
parasitology-helminth-nematoda ; Ascaris lumbricoides ; thiabendazole ; mouse ; sodium nitrite ; iodine

No abstract available.
Candidiasis* ; Drug Therapy* ; Lymphoma, Non-Hodgkin*

No abstract available.
Candidiasis* ; Drug Therapy* ; Lymphoma, Non-Hodgkin*

No abstract available.
Calcium* ; Diet* ; Hypercalciuria* ; Osteocalcin*

No abstract available.
Diagnosis*

The lysozyme activities of knee joint fluid in normal Korean people, patients with rheumatoid arthritis, and patients with degenerative arthritis have been reported by Lee in 1974. This time I have studied the chronologic changes of lysozyme activity of knee joint fluid in patients with rheumatoid arthritis following intra-articular injection of steroid preparation (6-methylprednisolone acetate). The results obtained were as follows. 1. The synovial concentration of lysozyme in patients with rheumatoid arthritis was found to be 10.88 mcg/ml which is higher than normal value of 8.69 mcg/ml. 2. The lysozyme activity of joint fluid obtained 5 days after intra-articular injection of steroid prepatation was variable ranging from 7.40 mcg/ml to 10.0mcg/ml with the average of 8.97 mcg/ml, which corresponded to the relief of clinical manifestations. 3. The lysozyme activity of joint fluid obtained 10 days after intra-articular injection of steroid preparation decreased to 8.36 mcg/ml on average with the range from 7.60 to 9.30 mcg/ml which was in accordance with much relief of clinical manifestations. 4. The lysozyme activity of joint fluid obtained 20 days after intra-articular steroid injection was 9.55 mcg/ml on average with the range from 8.25 to 11.25 mcg/ml which was in accordance with the aggravations of clinical manifestations.
Arthritis, Rheumatoid ; Humans ; Injections, Intra-Articular ; Joints ; Knee Joint ; Muramidase ; Osteoarthritis ; Reference Values

The development of inexpensive high throughput methods to identify individual DNA sequences is important to the future growth of medical genetics. This has become increasingly apparent as psychiatric geneticists focus more attention on the molecular basis of complex multifactorial diseases at which most of psychiatric disease is estimated. Furthermore, candidate gene approaches used in identifying disease associated genes necessitate screening large sequence blocks for changes tracking with the disease state. Even after such genes are isolated, large scale mutational analysis will often be needed for risk assessment studies to define the likely medical consequences of carrying a mutated gene. This review provide basic knowledge of up-to-date technology, cDNA microarray which enables above mentioned various research themes.
Base Sequence ; DNA, Complementary* ; Genetics, Medical ; Mass Screening ; Oligonucleotide Array Sequence Analysis* ; Risk Assessment