We experienced one case of severe pituitary dwarfism in a 16 years old male boy that magnetic resonance image(MRI) revealed transection of the pituitary stalk with the ectopic location of posterior pituitary gland and hypoplastic anterior pituitary gland. The serum growth horrnone(GH) response to clonidine and L-dopa revealed severe GH deficiency. The patient revealed normal response in TSH, prolactin and LH, FSH to TRH and LHRH respectively. So far, the primary cause of idiopathic pituitary dwarfism in many patients was due to hypoxic injury to hypothalmus by perinatal insults. In this patients, there was no history of perinatal insults and postnatal head trauma. We report a case of severe dwarfism due to hypogenesis of anterior pituitary gland.
Clonidine ; Craniocerebral Trauma ; Dwarfism ; Dwarfism, Pituitary ; Gonadotropin-Releasing Hormone ; Humans ; Levodopa ; Male ; Pituitary Gland ; Pituitary Gland, Anterior ; Pituitary Gland, Posterior ; Prolactin

This study was conducted to examine the effect of mefenamic acid for treatment of PDA in premature newborns. Ductus arteriosus is reopened by locally produced prostaglandin E2 in a premature newborn during hypoxia. Mefenamic acid is one of non-steroidal antiinflammatory drugs acting by inhibition of cyclo-oxygenase in the prostaglandin synthesis pathway. For three premature newborns with PDA, we administered mefenamic acid and evaluated them with echocardiography to study the effect of mefenmic acid for closure of PDA. In all three babies, ductus arteriosus was closed successfully. We feel that mefenamic acid is safe and effective medication for treatment of PDA in premature newborns, but further-study need to be conducted with larger numbers of cases to confirm this effect.
Anoxia ; Dinoprostone ; Ductus Arteriosus ; Echocardiography ; Humans ; Infant, Newborn* ; Mefenamic Acid* ; Prostaglandin-Endoperoxide Synthases

Cataract and refractive surgical procedures are now among the most common and successful in medicine. A clear understanding of the current situation and future trends in these fields has become increasingly important. Since 1995, we have annually surveyed the members of the Korean Society of Cataract and Refractive surgery(KSCRS) about cataract surgery technique, anesthesia, intraocular lens and refractive surgery. Third annual survey forms consisted of 71 multiple-choice questions were mailed in January 1998 to 180 ophthalmologist members of the KSCRS. Approximately 44% of the questionnaires mailed were returned by the February cutoff date. Current data were compared with data in previous annual survey. Over half of the respondents(52%) were in forties. Most of the cataract operation(83%) was carried out on hospitalized patients. Use of a retrobulbar with akinesia for cataract was 49%, and use of topical anesthesia increased from 5% in 1995 to 17% in 1996. Eight-one percent of surgeons used phacoemulsification for more than half of their patients. Selfsealing wound construction was main wound closure technique in phacoemulsification for 44%. The type of intraocular lens used for small incision cataract surgery included silicone(64%), small round PMMA(polymethyl methacrylate, 21%), and acrylic(11%). Sixty-three percent of surgery. From the answers to the survey, we found current trend and these results are valuable information to all ophthalmologists.
Anesthesia ; Cataract* ; Humans ; Lenses, Intraocular ; Phacoemulsification ; Postal Service ; Refractive Surgical Procedures* ; Wound Closure Techniques ; Wounds and Injuries ; Surveys and Questionnaires

BACKGROUND: Rosacea is well recognized as a chronic cutaneous disorder primarily of the convexities of the central face. Despite its apparent high incidence, the nosology of rosacea is not well established in Korea. OBJECTIVE: The purpose of this epidemiological study was to investigate the clinical manifestations of Korean rosacea patients diagnosed by the US National Rosacea Society guidelines of US. METHODS: We performed a clinical study in 90 patients with rosacea who visited the Department of Dermatology, Korea University Ansan Hospital from January 2005 to December 2006. These patients were evaluated with regard to age, sex, primary/secondary features, clinical subtypes and predisposing factors. RESULTS: The ratio of males to females was 1 : 1.3. The age distribution showed a peak incidence in the fifth decade. Primary features of rosacea were telangiectasia (70.0%), nontransient erythema (68.9%), papules and pustules (62.2%) and flushing (61.1%). The most common secondary features of rosacea were burning and stinging (62.2%). Other secondary features were dry appearance (46.7%), edema (35.6%), plaque (20.0%), phymatous changes(18.9%), ocular manifestations (17.8%) and peripheral location (2.2%). The most common subtype was erythematotelangiectatic rosacea (51.1%), followed by papulopustular rosacea (34.4%), phymatous rosacea (12.2%) and ocular rosacea (2.2%). The majority of rosacea patients revealed mild symptoms (83.3%). Predisposing or exacerbating factors of rosacea were stress (52.2%), hot baths (46.7%), alcohol (44.4%), hot weather (42.2%), sun exposure (38.9%), exercise (35.6%), cold weather (25.5%), skin-care products (23.3%), spicy foods (21.1%), indoor heat (15.6%), heated beverages (12.2%) and humidity (4.4%). CONCLUSION: In this study, the National Rosacea Society classification system applied well to Korean patients. We identified female predominance, a peak in the fifth decade and the majority of Korean rosacea patients suffering from the erythrotelangiectatic type of rosacea. Other similarities and differences to previous reports were also discussed.
Age Distribution ; Baths ; Beverages ; Bites and Stings ; Burns ; Causality ; Classification ; Dermatology ; Edema ; Epidemiologic Studies ; Erythema ; Female ; Flushing ; Gyeonggi-do ; Hot Temperature ; Humans ; Humidity ; Incidence ; Korea ; Male ; Rosacea* ; Solar System ; Telangiectasis ; Weather

Herein we report a case of lentigo maligna that evolved into lentigo maligna melanoma. Fifteen years ago, the patient developed a pigmented lesion on the right cheek. The lesion progressed slowly, and 2 months ago, a black nodular lesion was developed in the periphery of the pigmented lesion. Histopathologic examination of the lesions revealed findings consistent with lentigo maligna and lentigo maligna melanorna. She had been performed wide excision and cheek flap for reconstruction.
Cheek ; Humans ; Hutchinson's Melanotic Freckle* ; Lentigo* ; Melanoma*

No abstract available.
Retinopathy of Prematurity* ; Risk Factors*

Koreans had an ill feeling against the only public isolation hospital, and their ill feeling was a cause the movement for establishing a private isolation hospital. The bad seating capacity and the nearness to downtown of public isolation hospital, and some violence caused in the course of taking a patient to the public isolation hospital were concrete causes of the movement for establishing a private isolation hospital. The three purposes of the movement for establishing a private isolation hospital are as follows. First, for the purpose of removing the national ill feeling, Koreans had to establish the isolation hospital by themselves. Second, for the purpose of curing the patients, doctors needed to use Oriental medicine together. Third, for the purpose of doing away with the anxiety of infection, the isolation hospital had to be located in a distant place from downtown. The movement for establishing a private isolation hospital didn't succeed. It only ended up establishing a contagious ward in Severance hospital. Because whenever an isolation hospital was planned to be constructed somehere, the residents worrying about the infection opposed to the construction, and enough money didn't be gathered. Abve all, rich pro-Japanese men didn't contribute enough money. The middle and lower classes contributed almost all of the money. The movement for estabishing a private isolation hospital was the extension of anti-Japanese national feeling that sprung from the March 1st movement. In view of strenghtening Korean ability, the movement for establishing a private isolation hospital had a common cause with the Shilryokyangsong movement in the early 1920s.
Cholera/*history ; Colonialism/*history ; Communicable Diseases/*history ; English Abstract ; History of Medicine, 20th Cent. ; Hospitals, Public/*history ; Hospitals, Special/*history ; Human ; Japan ; Korea ; Patient Isolation/*history ; Politics

Calcareous corpuscles are a characteristic structure found in larval and adult stage cestodes. These corpuscles are known to contain several protein components and to possess protein-binding activity. However, the proteins bound to calcareous corpuscles in situ have not been studied. The present study was undertaken to identify the proteins on calcareous corpuscles. Calcareous corpuscles were purified from the plerocercoids (= spargana) of Spirometra erinacei, and serially dissolved using 0.1 M sulfamic acid solution. Collected supernatants were examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and silver staining. The results showed that only the fraction remaining after the 19th dissolved fraction contained proteins. A total of 20 protein molecules were detected in gel, with major bands at 56, 53, 46, 40, 35, 29, 28, 24.5, 21, 19, 16, 13, 10 and 8 kDa. In particular, the proteins corresponding to the 21 and 16 kDa bands were most abundant. Our results demonstrated for the first time the protein contents of the calcareous corpuscles of spargana. Further studies on the functions of these proteins are required.
Animals ; Centrifugation ; Electrophoresis, Polyacrylamide Gel ; Helminth Proteins/analysis/*metabolism ; Molecular Weight ; Protein Binding ; Research Support, Non-U.S. Gov't ; Silver Staining ; Sparganum/isolation & purification/*metabolism ; Spirometra/*metabolism ; Sulfonic Acids

The diagnosis of calcifying epithelioma is more easily made on the basis of the histopathological findings than the clinical manifestations. Calcifying epidermal cyst is only one that must be differentiated from calcifying epitheIioma because of its similarity in histopathological findings. 9 cases of calcifying epithelioma which have been collected at Seoul National University Hospital for the past ten years, frorn October 1960 to September 1970, are reported. Summary of the clinical and histopathological findings are as follows; 1) Range of age: one to sixty years old. 2) Ratio of sex: nearly equal in both sexes (5 male, 4 female.) 3) The final diagnosis of all of the cases was made not on the clinical basis but on the histopathological findings. 4) Only one case out of nine showed multiple skin lesions.
Carcinoma* ; Diagnosis ; Epidermal Cyst ; Humans ; Male ; Seoul ; Skin

BACKGROUND: Vitiligo is considered as an autoimmune disorder due to the generation and presence of autoantibodies directed against melanocyte antigens in the patients sera. Previous studies have revealed an increased incidence of organ-specific autoantibodies in vitiligo patients. A number of studies have demonstrated an increased frequency of thyroid autoantibodies in vitiligo patients and vitiligo is commonly seen in patients with clinical thyroid diseases. OBJECTIVE: The aim of this study is to investigate the incidence of antithyroid antibodies in vitiligo patients and to correlate the presence of these antibodies with factors such as sex, age, activity of the disease, duration of the disease and the type of vitiligo. Another aim of this study is to compare the incidence of abnormal thyroid function in those who have antithyroid antibody and those who don't. METHODS: One hundred and fifty seven vitiligo patients who visited vitiligo clinic in Samsung medical center from January of 1995 to November of 1996 were enrolled in this study. Detection and titration of antithyroid antibodies were performed by immunoradiometric assay. RESULTS: Among 157 patients tested, 17(10.8%) patients had antithyroglobulin antibodies and 10(6.4%) patients had antimicrosomal antibodies. Five patients had both antibodies. Statistically meaningful data are as follows; 1) Antimicrosomal antibody appeared less frequently in patients of childhood-onset. 2) Antithyroglobulin antibody was detected more frequently in active disease. Fifty nine out of 157 patients were examined for thyroid function. Four out of 22 patients with antithyroid antibody had abnormal thyroid function. None out of 37 patients without antithyroid antibody had abnormal thyroid function. CONCLUSION: The incidence of antithyroid antibodies according to onset age and activity is contradictory to previous reports, therefore large scaled study will be necessary to draw a conclusion.
Age of Onset ; Antibodies* ; Autoantibodies ; Humans ; Immunoradiometric Assay ; Incidence* ; Melanocytes ; Thyroid Diseases ; Thyroid Gland ; Vitiligo*