Search Results

1.The effect of electroconvulsive shock and cholinergic drugs on anterograde amnesia in albino rats.

4.Effects of Selective Serotonin Reuptake Inhibitors on the Retention of Passive Avoidance Learning after Chronic Mild Stress in Rats.

Journal of the Korean Society of Biological Psychiatry 1997;4(2):237-245

The study was designed to evaluate the significant roles of SSRI in rat of depression model. Chronic exposure to mild unpredictable stress has been found to depress the consumption of sweet 1% sucrose solutions in the Sprague-Dawley rats. We applied the variety of 11 types of stress regimens and identified depressive behavious(developed by Willner) in 70 Sprague-Dawley rats. Rats in experiments were stratified into 6 groups, i.e.; 3 kinds of SSRI(paroxetine, fluoxetine, sertraline), clomipramine, choline and saline control. Memory function was evaluated by passive avoidance learning and retention test. The authors determined how long memory retention would remain improved with 24 hour, 1 week, 2 weeks, 3 weeks, and 4 weeks at training-testing interval in depressive states of the Sprague-Dowley rats. The results were as follows; 1) There were to significant differences between the 6 groups at the 24 hour training-testing interval. 2) The paroxetine treated group showed significant differences from the control group at the 1 week and 2 weeks training-testing interval. 3) The paroxetine and the fluoxetine treated groups showed significant differences from the control group at 3 week training-testing interval. 4) The paroxetine and the choline treated groups showed significant differences from the control group 4 week training-testing interval. In summary, paroxetine had on effect on long term memory processing from 1st week to 4th week. Also, fluoxetine(or 3rd week) and choline(at 4th week) had effect on long term memory processing. Sertraline, clomipramine were ineffective on memory processing during 4 weeks observation. Possible explanations why paroxetine had early effect on memory processing than the other selective serotonin reuptake inhibitors are rapid bioavailability, which is the characteristics of pharmacokinetics of paroxetine. In clinical situation, author carefully suggest that SSRI would be beneficial to improve the memory function caused by depressive neurochemical changes.
Animals ; Avoidance Learning* ; Biological Availability ; Choline ; Clomipramine ; Depression ; Fluoxetine ; Memory ; Paroxetine ; Pharmacokinetics ; Rats* ; Rats, Sprague-Dawley ; Serotonin Uptake Inhibitors* ; Sertraline ; Sucrose

5.A study of the infuences of parental rearing on the psychopathology: A series of studies to establish psychiatric screening test for conscripts(5).

Dong Jae OH ; Sung Il JEON ; Hwan Il CHANG

Journal of Korean Neuropsychiatric Association 1993;32(6):896-903

6.Prevalence and physician's detection rate of alcoholism in patients of a general hospital.

Suk Koon CHO ; Kyung Bin KIM ; Hwan Il CHANG

Journal of Korean Neuropsychiatric Association 1993;32(6):904-912

7.A clinical study of seasonal affective disorder.

Kyung Kyu LEE ; Do Joon YOON ; Hwan Il CHANG

Journal of Korean Neuropsychiatric Association 1992;31(1):84-92

8.Anxiety, depression, and life satisfaction in the patients on hemodialysis and the patients with kidney transplantation.

Ok Geun LIM ; Hwan Il CHANG ; Myung Jae KIM

Journal of Korean Neuropsychiatric Association 1993;32(5):652-659

9.Differential diagnosis of lateralized cerebral dysfunction through the multiple discriminant function analysis of KWIS and MMPI responses.

Tae Ho YUM ; Jong Ho SONG ; Hwan Il CHANG

Journal of Korean Neuropsychiatric Association 1991;30(1):188-197

10.The psychiatric problems of infertile women by symptom check list-90-revision.

Hyeon Sang JUNG ; Hwan Il CHANG ; Byung Hee SUH

Journal of Korean Neuropsychiatric Association 1991;30(6):1032-1041

1.The effect of electroconvulsive shock and cholinergic drugs on anterograde amnesia in albino rats.

2.A Study of Correlation between Bilirubin Leel of Cord Blood and Neonatal Hyperbilirubinemia.

3.A Case of Cutaneous Lymphatic Rupture on Calf Secondary to Punch Biopsy.