1.A study on the radiation effect on microvasculature of N-methyl-N-Nitrosourea-induced mammary carcinoma in rats
Sang Hoon BAE ; Kyoung Hwan KOH ; Chung Kie IM ; Sung Hwan HA ; Man Chung HAN
Journal of the Korean Radiological Society 1985;21(3):357-367
Mammary carcinoma was induced in rats by itravenous injection of N-methy-N-Nitrosourea. Microangiography was perfromed to evaluate the microvascular alterations in mammary carcinoma after irradiation. The tumors were givena single dose of 1.400 rads using Co-60 telethrapy unit with field size of 4 x 4 cm at 40 cm SSD. The dose ratewas 147.5 rads per minute. Microangiography was performed prior to irradiation and at one, two, and four weeksfollowing irradiation. The results are as follows: 1. Before irradiation, mammary carcinoma in rats tended to formlobules and the basic vasculature consisted of peripheral vascular pattern with central penetrating vessels. Theperipheral vascular pattern was always richer than that of the center. Irregular and tortuous vessles stretchedfrom the periphery into the center of lobule. 2. One week following irradiation, an increase in the number ofsmaller, tortuous vessels and decreased intervasular distance were obseved in the central portion of each lobule.This finding seems to be due to an improved filling of some previously existing but unfilled vessels. This maylead to improved metabolic changes and reoxygenation. 3. Later's changes of microvasculature after irradiation aretortuosity, irregularity, narrowing, abrupt tapering, fragmentation, and extravasation. These findings progressedafter a lapse of time. 4. The results can be considered as the microangiographic demonstration of the fact that reoxygenation after irradiation is mainly due to dilatation of the collapsed tumor vessels.
Animals
;
Dilatation
;
Microvessels
;
Radiation Effects
;
Rats
;
Silver Sulfadiazine
2.A case of deep venous thrombosis after transabdominal hysterectomy.
Kwang Hwy KIM ; Sae Hwan KIM ; Jae Hoon CHUNG
Korean Journal of Obstetrics and Gynecology 1991;34(7):1039-1047
No abstract available.
Hysterectomy*
;
Venous Thrombosis*
4.Acute Renal Failure in Children.
Chan Lak SON ; Sun Hwan CHUNG ; Yong Hoon PARK ; Kuhn Soo LEE ; Ja Hoon KOO
Journal of the Korean Pediatric Society 1984;27(2):146-155
No abstract available.
Acute Kidney Injury*
;
Child*
;
Humans
5.Eosinophilic Granuloma of the Adult Spine: Report of a Case.
Sung Soo CHUNG ; Chong Suh LEE ; Keung Hwan AHN ; Kwang Hoon CHUNG
Journal of Korean Society of Spine Surgery 1998;5(2):348-352
Eosinophilic granuloma of bone well-documented in the literature. This lytic bone disease most commonly occurs in children, but a fraction of the cases does occurs in adult. When the disease occurs in adults, the bone most often affected include the skull, ribs, mandible, clavicle, pelvis, and long bone of the extremities. We report the case of a 31-year old woman with isolated eosinophilic granuloma of the thoracic spine. She had a 1-month history of progressive back pain that radiated to the right anterior chest. Authors performed resection of vertebral body lesion and soft tissue lesion and anterior fusion from T7 to T9. Immunochemical staining showed a positive S100 protein stain. EM demonstrated characteristic Birbeck granule. Postoperatively, the patient underwent a 5-day course of RT to the T6-T10 spine with 200cGY fractions (total dose 1000cGY). Postoperatively, the patient's back and chest pain had disappeared. There is no evidence of local recurrence or distant metastasis at 18 months follow-up. Though rare, eosinophilic granuloma of the adult spine could be considered in the differential diagnosis of osteolytic lesions.
Adult*
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Back Pain
;
Bone Diseases
;
Chest Pain
;
Child
;
Clavicle
;
Diagnosis, Differential
;
Eosinophilic Granuloma*
;
Eosinophils*
;
Extremities
;
Female
;
Follow-Up Studies
;
Humans
;
Mandible
;
Neoplasm Metastasis
;
Pelvis
;
Recurrence
;
Ribs
;
Skull
;
Spine*
;
Thorax
6.Inhibition of IL-2 dependent DTLL-2 proliferation by immune complex from patient with ovarian cancer.
Sang Deuk CHUNG ; Chang Hwan PARK ; Yong Hoon CHUNG ; Kyung Hee KIM ; Yang Ja CHO
Journal of the Korean Society for Microbiology 1993;28(4):331-327
No abstract available.
Antigen-Antibody Complex*
;
Humans
;
Interleukin-2*
;
Ovarian Neoplasms*
7.Prevalence of Tardive Dyskinesia among the Hospitalized Schizophrenic Patients.
Chung Goo RHEE ; Jeung Hwan PARK ; Tae Hwan LEE ; Young Hoon KIM
Journal of the Korean Society of Biological Psychiatry 2003;10(1):54-61
OBJECT: This cross-sectional study was performed in order to evaluate the prevalence of tardive dyskinesia among the hospitalized schizophrenic patients. METHODS: Four hundred nineteen hospitalized schizophrenic patients(male=263, female=156) were recruited for this study. They were treated with antipsychotics for more than 3 months. The prevalence of tardive dyskinesia was assessed by the Abnormal Involuntary Movement Scale. RESULTS: The prevalence of tardive dyskinesia was 35.6%(Male=36.9%, Female 33.3%). There were no significant differences in the prevalence of tardive dyskinesia among male and female schizophrenic patients. The prevalence of tardive dyskinesia among the patients over 30years old was much higher than those below 30years old. There were no significant correlations between the prevalence of tardive dyskinesia and the duration of hospitalization, the total amount of antipsychotics. The frequently involved parts of the body in the schizophrenic patients who have tardive dyskinesia were tongue, upper extremity, lips and perioral area, jaw, lower extremity, muscles of facial expression trunk, respectively. CONCLUSIONS: There was significant correlation between the age and the prevalence of tardive dyskinesia in the antipsychotic-treated schizophrenic patients.
Antipsychotic Agents
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Cross-Sectional Studies
;
Dyskinesias
;
Facial Expression
;
Female
;
Hospitalization
;
Humans
;
Jaw
;
Lip
;
Lower Extremity
;
Male
;
Movement Disorders*
;
Muscles
;
Prevalence*
;
Schizophrenia
;
Tongue
;
Upper Extremity
8.Incidence of Antithyroid Antibodies in Vitiligo Patients.
Un Cheol YEO ; Jae Hoon CHUNG ; Hwan Tae SUNG ; Eil Soo LEE ; Myung Hee SHIN
Annals of Dermatology 1997;9(2):132-138
BACKGROUND: Vitiligo is considered as an autoimmune disorder due to the generation and presence of autoantibodies directed against melanocyte antigens in the patients sera. Previous studies have revealed an increased incidence of organ-specific autoantibodies in vitiligo patients. A number of studies have demonstrated an increased frequency of thyroid autoantibodies in vitiligo patients and vitiligo is commonly seen in patients with clinical thyroid diseases. OBJECTIVE: The aim of this study is to investigate the incidence of antithyroid antibodies in vitiligo patients and to correlate the presence of these antibodies with factors such as sex, age, activity of the disease, duration of the disease and the type of vitiligo. Another aim of this study is to compare the incidence of abnormal thyroid function in those who have antithyroid antibody and those who don't. METHODS: One hundred and fifty seven vitiligo patients who visited vitiligo clinic in Samsung medical center from January of 1995 to November of 1996 were enrolled in this study. Detection and titration of antithyroid antibodies were performed by immunoradiometric assay. RESULTS: Among 157 patients tested, 17(10.8%) patients had antithyroglobulin antibodies and 10(6.4%) patients had antimicrosomal antibodies. Five patients had both antibodies. Statistically meaningful data are as follows; 1) Antimicrosomal antibody appeared less frequently in patients of childhood-onset. 2) Antithyroglobulin antibody was detected more frequently in active disease. Fifty nine out of 157 patients were examined for thyroid function. Four out of 22 patients with antithyroid antibody had abnormal thyroid function. None out of 37 patients without antithyroid antibody had abnormal thyroid function. CONCLUSION: The incidence of antithyroid antibodies according to onset age and activity is contradictory to previous reports, therefore large scaled study will be necessary to draw a conclusion.
Age of Onset
;
Antibodies*
;
Autoantibodies
;
Humans
;
Immunoradiometric Assay
;
Incidence*
;
Melanocytes
;
Thyroid Diseases
;
Thyroid Gland
;
Vitiligo*
9.Expression of human CTL?4 extracellular domain in escherichia coli.
Chang Hwan PARK ; Seung Hyun SEO ; Yong Hoon CHUNG ; Yang Ja CHO
Korean Journal of Immunology 1993;15(2):129-137
No abstract available.
Escherichia coli*
;
Escherichia*
;
Humans*
10.A Case of Congenital Lumbosacral Dermal Sinus Associated with Recurrent Meningitis(Case Report).
Seong Hoon LEE ; Nam Kyu KIM ; Hwan Yung CHUNG ; Kwang Myung KIM ; Suck Jun OH
Journal of Korean Neurosurgical Society 1989;18(7-12):1124-1128
Recurrent episode of meningitis in infants and children frequently constitute a frustrating and distressing, both in determination of course and treatment. The authors are reporting a infected case of congenital dermal sinus with dermoid cyst in the subarachnoid space of cauda equina and conus medullaris which was cured after complete removal of cyst and sinus tract.
Cauda Equina
;
Child
;
Conus Snail
;
Dermoid Cyst
;
Humans
;
Infant
;
Meningitis
;
Spina Bifida Occulta*
;
Subarachnoid Space