No abstract available.
Charcoal* ; Drug Therapy* ; Mitomycin* ; Stomach Neoplasms*

No abstract available.
Antigen-Antibody Complex* ; Humans ; Interleukin-2* ; Ovarian Neoplasms*

BACKGROUND: Prior reports of umbilical vein variation were strongly associated with several congenital anomalies. This suggests that the incidence of umbilical vein anomaly was more frequently seen in dead fetuses than in liveborn infants because the leading causes of stillbirth are chromosomal and/or congenital anomalies. The developing liver exerts a profound influence in modifying the primitive vitelline and umbilical veins. This study was undertaken to identify the umbilical vein variations and the associated hepatic and perihepatic structural anomalies in dead fetuses. METHODS: Dissection was done in eighteen dead fetuses who had undergone delivery at Chonbuk National University Hospital between December 1996 and February 1998. The weight ratios of the liver to the body and the right to the left hepatic lobes and the distal attachment of umbilical vein, including the presence of hepatic fissures and ligaments, were examined. According to the gestational age, the cases were divided into two groups (group 1: < 32 weeks, 13 cases; group 2: > or = 32 weeks, 5 cases). RESULTS: The gestational age of the fetuses ranged from 19 to 39 weeks. The fetal liver constituted 3.7% and 4.0% of the total fetal body weight for group 1 and 2, respectively. The mean weight ratio of the right to the left hepatic lobe was between 1:1.4 and 1:1.5. There were no gross morphologic abnormalities in 9 cases. Eighteen kinds of chromosomal and congenital anomalies, including omphalocele, anomalous hepatic segmentation, hypogenesis of the hand and the foot, syndactyly, polycystic kidney, etc., were observed in 9 dead fetuses. A case of an abnormal distal attachment of the umbilical vein was identified. The umbilical vein drained into the dilated extrahepatic portal vein directly. The hepatic segments and fissures were completely normal, but ligamentum teres was not identified in this case. A peculiar hepatic segmental anomaly due to whole organ herniation through a defect in an omphalocele was observed. CONCLUSIONS: The weight of the liver of the dead fetuses was relatively small in both groups. No weight shift of left to right was recognized. The incidence of congenital anomalies was much higherin the dead fetuses (50%) than in the live births (0.7-1.98%). There were two hepatic anomalies (11.1%), including segmentation and distal attachment of the umbilical vein. The authors reviewed all reports of umbilical vein anomalies and propose a classification for umbilical vein variations focused on the distal points of attachment. All variations of the umbilical vein tend to fall into two main groups. In the first group, the veins have distal points of attachment into portal vein systems. In the second group, the veins have distal points of attachment into systemic veins.
Classification* ; Fetal Weight ; Fetus* ; Foot ; Gestational Age ; Hand ; Hernia, Umbilical ; Humans ; Incidence ; Infant ; Jeollabuk-do ; Ligaments ; Live Birth ; Liver ; Polycystic Kidney Diseases ; Portal Vein ; Stillbirth ; Syndactyly ; Umbilical Veins* ; Veins ; Vitellins

Angiosarcoma is a rare malignant vascular tumor of endothelial cell origin. Most lesions of cutaneous angiosarcoma occur over the face and scalp. We experienced a case of angiosarcoma of the scalp in a 63-year-old man. Multiple pea-sized erythematous papules and nodules developed on the forehead 6 months ago. Thereafter, the lesions have extended to make violaceous, compressible and hemorrhagic plaques. On histologic examination, there were irregular, often anastomosing vascular channels lined by the atypical endothelial cells in the dermis.
Dermis ; Endothelial Cells ; Forehead ; Hemangiosarcoma* ; Humans ; Middle Aged ; Scalp*

The malignant fibrous histiocytoma (MFH) was first introduced in 1963 to refer to a group of soft-issue tumors characterized by a storiform or cartwheel-ike growth pattern and predominantly fibroblastic appearance. It was postulated that they were derived from histiocytes that could assume the appearance and function of fibroblasts. MFH has been recognized to be the most common sarcoma in the soft tissue of late adult life which involves the deep fascia or skeletal muscles of the extremities or retroperitoneum. It has been noted in other organs, however, it rarely arises in the liver. We report two cases of primary malignant fibrous histiocytoma of the liver histopathologically confirmed after surgical resection-storiform pleomorphic and myxoid subtypes in the 55 year old male and 49 year old female patients, respectively, and describes the clinical courses, characteristics and pathologic aspects with review of the related literatures.
Adult ; Extremities ; Fascia ; Female ; Fibroblasts ; Histiocytes ; Histiocytoma, Malignant Fibrous* ; Humans ; Liver* ; Male ; Middle Aged ; Muscle, Skeletal ; Sarcoma

No abstract available.
Animals ; Nephrons* ; Population Characteristics* ; Rats*

No abstract available.
Humans*

Surgical intervention during the pregnancy is not rare and the impact of anesthesia and surgery during the pregnancy is doublefold, because the mother and the fetus in uterus are concerned. The anesthesiologist must know the progressive' maternal changes during the pregnancy and drug action on the fetus. The authors have experienced 50 cases of pregnant women undergoing various kinds of operation and have analyzed those cases according to the type of disease, the duration of gestation, physical status, premedication, anesthetic technics and agent used, and the outcome of the fetus and the patient during the period between March 1972 to August 1978 The results were as follows: 1) The most of patient, 32 cases were operated for the obstetric and gynecological :reason s. 2) 27 cases (54%) had undergone the operation during the second trimester. 3) Physical status class 2 including 28 cases (56%) was the most commonly found physical status of the patients. 4) Halothane was the main anesthetic agent for 39 cases (78%) and there were 3 cases of spinal anesthesia. 5) We could follow 27 cases among 50 cases about the outcome of the fetus. 17 spontaneous vaginal delivery, 8 Cesarean sections, 1 fetal death in uterus and 1 wanted D&C. 6) Among 5 premature deliveries, 2 premature infants died during the hospitalization. 7) The only maternal motality was the case of intrahepatic stone who expired 11 days postoperatively and delivered a 1,300 gm premature 7 days postoperatively.
Anesthesia ; Anesthesia, Spinal ; Cesarean Section ; Dilatation and Curettage ; Female ; Fetal Death ; Fetus ; Halothane ; Hospitalization ; Humans ; Infant, Newborn ; Infant, Premature ; Mothers ; Pregnancy ; Pregnancy Trimester, Second ; Pregnant Women ; Premedication ; Uterus

BACKGROUND: In two-kidney one clip Goldbaltt hypertensive rats(2K1C GHR), clipped kidney may be exposed to low pressure and unclipped kidney to high pressure. In addition, both kidneys may have a different amount of adenosine which is increased by ischemia and plays an important role for renin release. The aim of this study was to invstigate the responsmiveness for renin release to adenosine agonists and antagonist in clipped and unclipped kidney of 2K1C GHR. METHODS: Emplying kidney slices from both unclipped and unclipped kidney of 2K1C GHR, the alteration by adenosine agonists and antagonist of renin release was studied. RESULTS: The renal renin content and basal renin release from unclipped kidney slices were suppressed, whereas those from clipped kidney were augmented Adenosine Al receptor agonist, cyclohexyladenosne(CHA), phenylisopropyl adenosine(PIA) and adenosine caused a decrease in renin release from clipped kidney slices. Adenosine A2 receptor agonist, NECA, and nonspecific adenosine receptor aganist, 2-chloroadenosine(CA) caused an increase in renin release from clipped kidney slices. Adenosine receptor antagonist, 8-phenyltheophylline(8-PT) caused an increase in renin release from clipped kidney slices. In unclipped kidney, however, the renin release in response to NECA, CA or 8-PT was reversed and the decreasing effect of renin release to CHA and adenosine was slightly inereased. CONCLUSION: These results suggest that the responsiveness of adenosine receptors, which may participate in renin release is modified in clipped and unclipped kidney of 2K1C GHR.
Adenosine* ; Adenosine-5'-(N-ethylcarboxamide) ; Animals ; Hypertension, Renovascular ; Ischemia ; Kidney ; Rats* ; Receptors, Adenosine A2 ; Receptors, Purinergic P1 ; Renin*

Recently, duplex sonography has been used as a screening test for the evaluation of carotid arterial disease. If an occlusion of atherosclerosis is located at the bifurcation of the common carotid artery or the lower portion of the internal carotid artery, the luminal change may be directly visualized on high-resolution B-mode sonography or color-Doppler images. But when the lesion is located at the high cervical, petrous or cavernous protion of the internal carotid artery, it is difficult to directly visualize the lesion with the sonography. The purpose of this paper is to evaluate the indirect changes on the Doppler patterns of both common carotid arteries with clamping of an internal carotid artery. Thirty common carotid arteries in fifteen normal rabbits were examined with duplex ultrasonography using high-resolution real-time imaging and 7.5MHz pulsed-wave Doppler flow measurements with velocity waveform analysis. Systolic velocity (SV) was 45.4±8.4cm/sec, end-diastolic velocity (EDV) 15.3±4.9cm/sec and resistative index(RI) 0.66±0.08 in the common carotid artery before clamping of the internal carotid artery. SV was 26.3±7.8cm/sec, EDV 6.0±5.2cm/sec and RI 0.78±0.18 in the ipsilateral common carotid artery and SV was 56.6±13.0cm/sec, EDV 22.3±8.2cm. sec and RI 0.61±0.10 in the contralateral common carotid artery after clamping of the internal carotid artery. During clamping of the internal carotid artery, the difference between SV of bilateral common carotid arteries was 30.3±13.8cm/sec and EDV 16.3±9.2cm/sec. There was no difference of the velocity patterns of the common carotid artery between preclamping and declamping of the internal carotid artery. In conclusion, lower SV and EDV in a common carotid artery than that in contralateral side on Doppler patterns strongly suggests an occlusion of ipsilateral internal carotid artery.
Atherosclerosis ; Carotid Artery Diseases ; Carotid Artery, Common* ; Carotid Artery, Internal* ; Constriction* ; Mass Screening ; Phenobarbital ; Rabbits ; Ultrasonography