No abstract available.
Eczema* ; Herpes Simplex* ; Kaposi Varicelliform Eruption* ; Simplexvirus*

We describe four patients with herpes-associated erythema multiforme, who had clinical and histopathological features consistent with the so-called erythema multiforme minor. The appearance of lesions of herpes simplex were followed with intervals between 6 and 10 days by the recurrent developments of erythema multiforme several times in a year in each patient. Sinee herpes simplex virus infection is considered one of the major factors provocating erythema multiforme one may have to pay more attention to patient's history to define the nature of erythema multiforme.
Erythema Multiforme* ; Erythema* ; Herpes Simplex ; Humans ; Simplexvirus

Fibroelastolytic papulosis of the neck(FEPN) was introduced by Balus et al in 1997. Before this term was used, white fibrous papulosis of the neck(WFPN) and pseudoxanthoma elasticumlike papillary dermal elastolysis(PDE) had differently been used. These two disease entities had clinical similarities such as asymptomatic, white to yellow discolored, papular eruptions on the neck in elderly persons. As names implicated, however, they showed variable histological findings, for examples, fibrosis in WFPN or elastolysis in PDE or both in FEPN. Taken into ac-count together, instead of using WFPN or PDE separately, FEPN might be preferred to describe these two kinds of skin diseases. We report a case of a 36-year-old male patient with papules compatible with FEPN, whose biopsy mainly showed elastolysis.
Adult ; Aged ; Biopsy ; Fibrosis ; Humans ; Male ; Neck* ; Skin Diseases

The patient was a sixty-year-old obese woman with the long history of hypertension, amenorrhea and occasional psychic disturbances. She had eigbt, thumb to adult-fist sized, slightly movable, relatively soft, and painful subcutaneous nodules with tenderness and paresthcsia, of which overlying skin appeared to be normal except senile changes, on the abdomen and both upper extremities for 10 years. There was no evidence of inheritance in her family. Laboratory data revealed no abnormalities in lipid metabolism or in a variety of endocrinological functions. Microscopically, an excised mass from the forearm showed thin connective tissue capsule encircling numerous lobules cornposed entirely of the mature fat. cells vith minimal focal capillary proliferatios.
Abdomen ; Adiposis Dolorosa* ; Amenorrhea ; Capillaries ; Connective Tissue ; Female ; Forearm ; Humans ; Hypertension ; Lipid Metabolism ; Skin ; Thumb ; Upper Extremity ; Wills

This survey was made on 1462 cases in different age groups, from the neonate to the age of 15, to analyse the data statistically concerning the prevalence, size, shape, site and color of Mongolian spot. The results were as follows: 1) Of 1462 cases, Mongolian spot(s) was(were) present in 759(51. 9%) with the sex ratio of male to female, 1: l. 2. The prevalence could be divided into 3 stages, high(neonate to 3years), abruptly declined(4 to 9year), steadily declined (10 to 15years) 2) The mean and standard deviation of diameter represented 4. 56+2. 96cm(M +SD), ranging from 0. 5 to 21 cm. 3) The two most common shapes were ovoid(45. 5%,) and irregularly circular (31.4%). 4) The two most common sites were sacrococcygeal(80. 1%,) and gluteal(75. 1%). 5) The two most common colors were blue(75. 1 %) and purple-blue(13. 5%).
Female ; Humans ; Infant, Newborn ; Male ; Mongolian Spot ; Prevalence ; Sex Ratio ; Statistics as Topic*

The investigation was aimed to determine prognostic factors related to postherpetic neuralgia (PHN), and treatment options for preventing PHN. The data showed 34 (17.0%) out of 188 patients with herpes zoster had severe pain after 4 weeks, and 22 (11.7%) after 8 weeks, compared with 109 (58.0%) at presentation. The age (>or=50 yr), surface area involved (>or=9%), and duration of severe pain (>or=4 weeks) might be the main factors that lead to PHN. On the other hand, gender, dermatomal distribution, accompanied systemic conditions, and interval between initial pain and initiation of treatment might not be implicated in PHN. The subjects were orally received antiviral (valacyclovir), tricyclic antidepressant (amitriptyline), and analgesic (ibuprofen) as the standard treatment in the group 1. In addition to the standard medication, lidocaine solution was sub- and/or perilesionally injected in the group 2, while lidocaine plus prilocaine cream was topically applied to the skin lesions in the group 3. The rates of PHN in the 3 treatment groups were not significantly different, suggesting adjuvant anesthetics may not be helpful to reduce the severity of pain.
Acyclovir/administration & dosage/*analogs & derivatives ; Adolescent ; Adult ; Aged ; Amitriptyline/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Antidepressive Agents, Tricyclic/administration & dosage ; Antiviral Agents/administration & dosage ; Child ; Drug Therapy, Combination ; Female ; Herpes Zoster/*complications/drug therapy/physiopathology ; Humans ; Ibuprofen/administration & dosage ; Male ; Middle Aged ; Neuralgia/drug therapy/*etiology/physiopathology/prevention & control ; Prognosis ; Time Factors ; Valine/administration & dosage/*analogs & derivatives

Although it is debatable whether Helicobacter pylori may play a role in the pathogenesis of rosacea, some authors suggested that the treatment of H. pylori might have a beneficial effect. The aim of this investigation was to compare the prevalence of H. pylori between rosacea patients and controls, and to evaluate an effect of H. pylori eradication on rosecea by a 2-week triple therapy that was composed of amoxicillin, clarithromycin and omeprazole. H. pylori was detected by using gastroscopic biopsy with Warthin-Starry stain. Forty-two (84%) of 50 patients with rosacea and 39 (78%) of 50 controls had H. pylori, showing no significant difference in prevalence. The cure rates of H. pylori in rosacea patients and controls were 80% (16/20) and 85% (17/20), respectively. There was no significant decrease in the intensity of erythema in active treatment and placebo groups both during and after the treatment. Temporary improvement in papulopustules exclusively during the treatment (within 2 weeks) could be independent of H. pylori eradication. Overall, no significant reduction in the number of papulopustules was observed in active treatment and placebo groups after the treatment (in 2 months). Taken together, our study found no significant lessening of rosacea lesions by treating H. pylori infection, which conclusively does not concur with a view that H. pylori may be related to rosacea.
Acne Rosacea/microbiology* ; Acne Rosacea/epidemiology* ; Adult ; Amoxicillin/administration & dosage ; Anti-Ulcer Agents/administration & dosage ; Antibiotics, Macrolide/administration & dosage ; Biopsy ; Clarithromycin/administration & dosage ; Cohort Studies ; Erythema/microbiology ; Erythema/epidemiology ; Female ; Follow-Up Studies ; Helicobacter Infections/pathology ; Helicobacter Infections/epidemiology* ; Helicobacter Infections/drug therapy* ; Helicobacter pylori* ; Human ; Male ; Middle Age ; Omeprazole/administration & dosage ; Penicillins/administration & dosage ; Prevalence

Fifty six year old woman with liver cirrhosis and 31 year old man in good health had similar skin lesions which were well-defined, round to oval, isolated or confluent, scaly brown patches on her lower back, and his trunk and thighs, respectively, without any symptom. The biopsy specimens taken from the lesions showed slight hyperkeratosis with occasional follicular pluggings, presence of a granular layer, and epidermal flattening in case 1; increased melanin pigment in the basal layer in case 2. In both cases, the upper dermis revealed minirnal perivascular lymphohistiocytic inf iltration. We, therefore, present two cases of pityriasis rotunda and review the literature.
Adult ; Biopsy ; Dermis ; Female ; Humans ; Liver Cirrhosis ; Melanins ; Pityriasis* ; Skin ; Thigh

Rud's syndrome (RS), basically composed of ichthyosis, mental deficiency and hypogonadism, is a rare hereditary disease. Some varying dermatologic, neurologic, endocrinologic, ophthalmologic and musculoskeletal abnormalities have coincided with RS. No case of RS has been documented from Asian countries except one from Japan. We describe a 16-year-old girl who presented with lamellar ichthyosis, mental retardation, hypogonadism, short stature, alopecia, sparse eyebrows, strabismus, cataracts, and congenital dislocation of the hip. To our knowledge, RS coexisting congenital dislocation of the hip herein is the first case in English literature.
Adolescent ; Alopecia ; Asian Continental Ancestry Group ; Cataract ; Dislocations ; Eyebrows ; Female ; Genetic Diseases, Inborn ; Hip ; Humans ; Hypogonadism ; Ichthyosis ; Ichthyosis, Lamellar ; Intellectual Disability ; Japan ; Musculoskeletal Abnormalities ; Strabismus

From November 18 to December 31, 1986, seventy-five male patients with unconplicated gonococcal urethritis at the Venereal Disease Clinic of Choong-ku Public Health Center in Seoul were allocated randomly into one of two treatment regimens, and seventy patients were followed. All thirty-five patients including PPNG infections, treated with single oral dose of norfloxacin 600mg, were recovered(100%). One of thirty-five patients treated with a single oral dose of norfloxacin 800mg, failed. This failed case was one of eighteen nonPPNG infections (failure rate of 5.6%). Susceptibility test with disks containing norfloxacin 10ug showed the inhibition zone greater than 30mm. It is suggested that a single oral dose of 600mg or 800mg norfloxacin has good effect in the treatment of gonococcal urethritis with minimal side effects. Because of high prevalence of PPNG, it can be recommended as the first line treatment for gonorrhoea in Korea.
Humans ; Korea ; Male* ; Norfloxacin* ; Prevalence ; Public Health ; Seoul ; Sexually Transmitted Diseases ; Urethritis*