1.Diabetic Ulcers Treated with Bi-layered Collagen Membrane.
Jung U SHIN ; Yoon Jin CHOI ; Mi Ryung ROH ; Kee Yang CHUNG ; Hwa l SUH
Korean Journal of Dermatology 2009;47(7):831-834
Diabetic foot ulcer is a serious clinical problem with significant medical and economic effects on health systems worldwide. Some patients undergo amputation and others experience disability for an extended period of time. Treatment of diabetic foot ulcer is complex and difficult. Even with proper management, the wounds may not heal as well as expected. To promote wound healing, many advanced topical dressing materials have been developed. Among them, bi-layered collagen membrane, which is composed of collagen and hyaluronic acid, is believed to enhance wound healing. Herein we report two cases of diabetic foot ulcer which were successfully treated using bi-layered collagen membranes.
Amputation
;
Bandages
;
Collagen
;
Diabetic Foot
;
Humans
;
Hyaluronic Acid
;
Membranes
;
Ulcer
;
Wound Healing
2.Diabetic Ulcers Treated with Bi-layered Collagen Membrane.
Jung U SHIN ; Yoon Jin CHOI ; Mi Ryung ROH ; Kee Yang CHUNG ; Hwa l SUH
Korean Journal of Dermatology 2009;47(7):831-834
Diabetic foot ulcer is a serious clinical problem with significant medical and economic effects on health systems worldwide. Some patients undergo amputation and others experience disability for an extended period of time. Treatment of diabetic foot ulcer is complex and difficult. Even with proper management, the wounds may not heal as well as expected. To promote wound healing, many advanced topical dressing materials have been developed. Among them, bi-layered collagen membrane, which is composed of collagen and hyaluronic acid, is believed to enhance wound healing. Herein we report two cases of diabetic foot ulcer which were successfully treated using bi-layered collagen membranes.
Amputation
;
Bandages
;
Collagen
;
Diabetic Foot
;
Humans
;
Hyaluronic Acid
;
Membranes
;
Ulcer
;
Wound Healing
3.The Closing-in Phenomenon in Alzheimer's Disease and Vascular Dementia.
Juhee CHIN ; Byung Hwa LEE ; Sang Won SEO ; Eun Joo KIM ; Mee K SUH ; Sue J KANG ; Duk L NA
Journal of Clinical Neurology 2005;1(2):166-173
BACKGROUND AND PURPOSE: The closing-in phenomenon is the tendency to draw near or on the target when copying figures, which has been found mostly in patients with Alzheimer's disease (AD). We attempted to quantify the degree of closing-in and to compare it between patients with AD and vascular dementia (VaD). METHODS: The subjects (55 AD, 39 VaD and 38 normal controls) were asked to copy the figure of alternating square and triangle, starting at the designated point and continuing from left to right. The patients with AD and VaD did not differ in age, education, severity of dementia or Rey Complex Figure Test copy score. The proximity (Y-axis) of the subject's drawing to the target was plotted at intervals of 2 mm along the X-axis and the degree of closing-in was computed from the slope of the regression line. RESULTS: The AD and VaD patients showed a steeper slope than the controls. There was no significant difference, however, in the magnitude of closing-in of the AD and VaD patients. When closing-in was defined as a slope that was greater than the mean+2SD of the slope observed for the controls, 32.7% of the AD and 25.6% of the VaD patients showed closing-in. CONCLUSIONS: Our study, using a new method of measuring the degree of closing-in, suggests that this phenomenon is not specific to AD.
Alzheimer Disease*
;
Dementia
;
Dementia, Vascular*
;
Education
;
Humans
4.Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): A Useful Tool for Assessing and Monitoring Cognitive Impairments in Dementia Patients.
Hyun Jung AHN ; Juhee CHIN ; Aram PARK ; Byung Hwa LEE ; Mee Kyung SUH ; Sang Won SEO ; Duk L NA
Journal of Korean Medical Science 2010;25(7):1071-1076
The Seoul Neuropsychological Screening Battery (SNSB) is one of the standardized neuropsychological test batteries widely used in Korea. However, it may be a bit too lengthy for patients with decreased attention span; and it does not provide the score of global cognitive function (GCF), which is useful for monitoring patients longitudinally. We sought to validate a dementia version of SNSB (SNSB-D) that was shorter than the original SNSB and contained only scorable tests with a GCF score of 300. We administered SNSB-D to patients with mild cognitive impairment (MCI) (n=43) and Alzheimer's disease (AD) (n=93), and normal controls (NC) (n=77). MCI and AD groups had GCF scores significantly different from NC group, and GCF scores were able to distinguish patients with Clinical Dementia Rating of 0.5 and 1. Test-retest reliability was high, with a correlation coefficient of 0.918 for AD, 0.999 for MCI, and 0.960 for NC. The GCF score significantly correlated with the Mini-Mental State Examination (MMSE). Through ROC-curve analysis, GCF scores were found to yield more accurate diagnoses than the MMSE. The SNSB-D is a valid, reliable tool for assessing the overall cognitive function, and can be used to monitor cognitive changes in patients with dementia.
Alzheimer Disease/diagnosis/physiopathology
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Cognition Disorders/*diagnosis/etiology/physiopathology
;
Dementia/complications/*diagnosis/physiopathology
;
Humans
;
Korea
;
*Neuropsychological Tests/standards
;
ROC Curve
;
Reproducibility of Results
;
Severity of Illness Index
5.Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea.
Kyung Hwa LEE ; Sang Won SEO ; Tae Sung LIM ; Eun Joo KIM ; Byeong Chae KIM ; Yeshin KIM ; Ho Won LEE ; Jae Pil JEON ; Sung Mi SHIM ; Duk L NA ; Gi Yeong HUH ; Min Cheol LEE ; Yeon Lim SUH
Yonsei Medical Journal 2017;58(5):1055-1060
To obtain an in-depth understanding of brain diseases, including neurodegenerative diseases, psychiatric illnesses, and neoplasms, scientific approach and verification using postmortem human brain tissue with or without disease are essential. Compared to other countries that have run brain banks for decades, South Korea has limited experience with brain banking; nationwide brain banks started only recently. The goal of this study is to provide provisional guidelines for brain autopsy for hospitals and institutes that have not accumulated sufficient expertise. We hope that these provisional guidelines will serve as a useful reference for pathologists and clinicians who are involved and interested in the brain bank system. Also, we anticipate updating the provisional guidelines in the future based on collected data and further experience with the practice of brain autopsy in South Korea.
Academies and Institutes
;
Autopsy*
;
Brain Diseases
;
Brain*
;
Dementia
;
Hope
;
Humans
;
Korea*
;
Neurodegenerative Diseases
;
Neuropathology
6.The Brain Donation Program in South Korea.
Yeshin KIM ; Yeon Lim SUH ; Seung Joo KIM ; Moon Hwan BAE ; Jae Bum KIM ; Yuna KIM ; Kyung Chan CHOI ; Gi Yeong HUH ; Eun Joo KIM ; Jung Seok LEE ; Hyun Wook KANG ; Sung Mi SHIM ; Hyun Joung LIM ; Young Ho KOH ; Byeong Chae KIM ; Kyung Hwa LEE ; Min Cheol LEE ; Ho Won LEE ; Tae Sung LIM ; William W. SEELEY ; Hee Jin KIM ; Duk L. NA ; Kyung Hoon LEE ; Sang Won SEO
Yonsei Medical Journal 2018;59(10):1197-1204
PURPOSE: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerative diseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerative disease and to broaden understanding thereof. MATERIALS AND METHODS: We recruited participants through two routes: from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET. RESULTS: We recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer's disease (AD), two with subcortical vascular dementia, two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia (FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET: two with AD, one with mixed dementia, one with FTD, and one with CJD. CONCLUSION: The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea.
Alzheimer Disease
;
Amyloid
;
Aphasia, Primary Progressive
;
Asia
;
Brain*
;
Cognition Disorders
;
Cohort Studies
;
Creutzfeldt-Jakob Syndrome
;
Dementia
;
Dementia, Vascular
;
Diagnosis
;
Frontotemporal Dementia
;
Humans
;
Korea*
;
Leukoencephalopathies
;
Magnetic Resonance Imaging
;
Memory
;
Neurodegenerative Diseases
;
Neurologic Examination
;
Neuropathology
;
Neuropsychological Tests