No abstract available.
Female ; Humans ; Ovary*

PURPOSE: To analyze and compare the immunohistochemical distributions of HO-1 and HO-2 with the developmental process of retina, focusing on the time of birth and opening eyes because it is the time of the exposure to hyperoxia and light exposure. METHODS: The retina of 16-day-old embryo, 18-day-old embryo, 20-day-old embryo and postnatal rats at 0 day, 5 days, 10 days, 15 days, 20 days, 1 month, 2 months, 3 months were examined by hematoxylineeosin staining and immunohistochemistry of HO-1 and HO-2. RESULTS: Similar distribution of HO-1 and HO-2 from embryo to mature retina were observed. It was observed that HO-1 and HO-2 was contained in ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer and pigment layer of the mature retina. In the developmental process, reactivity was observed in the cell body of ganglion cells after 0 day of its birth. The reactivity was increased after 5 days of its birth, staining was observed in nerve cell and nerve fiber of ganglion cell layer, inner plexiform layer, inner segment of neuroblastic layer, pigment layer at this time. Reactivity of ganglion cell layer and pigment layer was increased intensively after 15 days of its birth and weak reactivity in some of horizontal cells and amacrine cells in inner plexiform layer was observed. The same distribution as that of mature retina was observed after 20 days of its birth. CONCLUSIONS: HO-1 and HO-2 expression was temporally and spatially correlated with the normal development of retina in rats. HO was concerned with the structure and function of retinal development by the activation of its products and with anti-oxidant mechanism on the time of birth and opening eyes.
Amacrine Cells ; Animals ; Embryonic Structures ; Ganglion Cysts ; Heme Oxygenase (Decyclizing)* ; Heme* ; Hyperoxia ; Immunohistochemistry ; Isoenzymes* ; Nerve Fibers ; Neurons ; Parturition ; Rats* ; Retina* ; Retinaldehyde

Neurosarcoidosis without systemic manifestation is vary unusual condition. Solitary lesion in the spinal dura is exceptional. The diagnosis of the neurosarcoidosis is very difficult, because the efficacy of Kveim test is low in neurosarcoidosis. The histologic examination is considered as confirmative diagnostic tool. The authors reported a case of neurosarcoidosis involving the dura of the cervical spine, in a fifty-nine year old female who had suffered from mid-back pain for six months and paraparesis for two weeks. There was a dumbbell shaped mass in the D4-5 dura. It showed tan gray color with rubbery consistency. With histological examination, it revealed diffuse non-caseating granuloma. Occasionally asteroid bodies were observed within the cytoplasm of the multinucleated giant cells. After operation, she was treated with steroid, and she has been well about nine month period.
Female ; Humans

Hemangioma of the kidney is a relatively uncommon tumor, which is most commonly located in the tip of the papilla. This lesion is usually small and has been found incidentally at postmorten examination. About 200 cases of renal hemangioma have been reported since Virchow's original report in 1876. In renal hemangioma, cavernous hemangioma is the most common type. They can create diagnostic problem for the clinician and the radiologist. We experienced a case of renal cavernous hemangioma in the medulla of the upper pole. The patient was a twenty-seven-year-old male who had gross hematuria and right flank pain. A nephrectomy was performed. An ill-defined mass, 4.5x3.0x1.5 cm, was observed around the pelvis. Microscopically, the tumor mass was hemangioma of the cavernous type.
Male ; Humans ; Hemangioma

BACKGROUND: Induction of anesthesia with propofol commonly associated with reduction in systemic arterial pressure, especially in elderly and high risk patients. This reduction is influenced by the dose and rate of propofol injection. The aim of this study was to examine the effect of different injection rate of propofol on vital signs, dose requirement and induction time during induction period. METHODS: Unpremedicated one hundred and twenty ASA physical status I and II patients aged 20~60 years scheduled for elective surgery were randomly allocated into one of four (150, 300, 600, 1200 ml/hr) groups according to speed of injection of propofol during induction period. Loss of verbal contact was taken as the end-point of induction. Vital signs, SpO2, dose requirement of propofol and induction time were checked. RESULTS: As the injection rate of propofol became slower, there were significant reduction in induction dose and increase in induction time (p<0.05). For example, induction dose and time were 1.82 mg/kg, 223 +/- 58 sec in 150 ml/hr group and 3.14 mg/kg, 50 +/- 11 sec in 1200 ml/hr group, respectively. Also, decrease in systolic and diastolic pressure were less marked at lower injection rates. CONCLUSIONS: Slower injection of propofol produces less vital sign changes and dose requirement for the induction of anesthesia.
Aged ; Anesthesia* ; Arterial Pressure ; Blood Pressure ; Humans ; Propofol* ; Vital Signs*

BACKGROUND/AIMS: Chronic hepatitis C virus (HCV) infection is often associated with extrahepatic autoimmune disease, and autoantibodies such as anti-nuclear antibody (ANA) or anti-smooth muscle antibody (ASA). The presence of autoantibodies may make discrimination between chronic hepatitis C with autoimmune features and type 1 autoimmune hepatitis difficult. We studied the prevalence of autoantibodies in patients with chronic HCV infection and their clinical significance. MATERIALS AND METHODS: ANA, ASA, anti-mitochondrial antibody (AMA), anti-microsomal antibody (AmA), rheumatoid factor (RF), anti-cardiolipin antibody (aCL) and lupus anti-coagulant (LA) were tested in 116 patients (80 chronic hepatitis C, 36 liver cirrhosis). Genotypes of HCV were determined in 25 patients by INNO LiPA. RESULTS: The overall prevalence of autoantibody was 65.5%. The most common autoantibody was aCL (34.5%), followed by ANA (25%), RF (18%), LA (15.5%), ASA (6.9%), anti-microsomal antibody (6%) and AMA (1%). The positive rate of either ANA or ASA was 30.2%, but both were positive in 1.7% only. There was no difference in the demographic features, biochemistry, HCV genotypes and disease status between autoantibody-positive and autoantibody-negative patients. CONCLUSIONS: Autoantibodies were commonly found in patients with chronic HCV infection. But, the presence of autoantibodies may be a non-specific finding in chronic hepatitis C infection without clinical significance.
Autoantibodies* ; Autoimmune Diseases ; Biochemistry ; Discrimination (Psychology) ; Genotype ; Hepacivirus ; Hepatitis C, Chronic* ; Hepatitis, Autoimmune ; Hepatitis, Chronic* ; Humans ; Liver ; Prevalence* ; Rheumatoid Factor

Purpose: This study examined nursing students' experiences of using digital healthcare applications in terms of the source and demand of socio-psychological needs, expectations, exposures, use satisfaction, and derivative effects based on the components of use satisfaction theory. Methods: This study was conducted using focus group interviews, and data were collected from 12 nursing students enrolled in two universities located in Seoul and Gyeonggi Province from April 1 to May 31, 2023. Results: The nursing students mainly used digital healthcare applications to address needs such as sleep, exercise, goal setting, social support, and motivation, which included the need for physical well-being, growth and development, emotional stability, and social needs. Participants met various needs such as achieving goals, feeling of achievement, enhancing self-confidence, and acquiring helpful information through digital healthcare applications. The satisfaction gained in setting and achieving goals was the driving force for motivation. Conclusion Nursing students value intuitive interfaces, personalized features, and appropriate notifications. Step-by-step rewards and reasonable pricing are also vital for using digital healthcare apps.These findings should be incorporated into developing programs to improve nursing students' health management and digital healthcare skills.

Purpose: This study examined nursing students' experiences of using digital healthcare applications in terms of the source and demand of socio-psychological needs, expectations, exposures, use satisfaction, and derivative effects based on the components of use satisfaction theory. Methods: This study was conducted using focus group interviews, and data were collected from 12 nursing students enrolled in two universities located in Seoul and Gyeonggi Province from April 1 to May 31, 2023. Results: The nursing students mainly used digital healthcare applications to address needs such as sleep, exercise, goal setting, social support, and motivation, which included the need for physical well-being, growth and development, emotional stability, and social needs. Participants met various needs such as achieving goals, feeling of achievement, enhancing self-confidence, and acquiring helpful information through digital healthcare applications. The satisfaction gained in setting and achieving goals was the driving force for motivation. Conclusion Nursing students value intuitive interfaces, personalized features, and appropriate notifications. Step-by-step rewards and reasonable pricing are also vital for using digital healthcare apps.These findings should be incorporated into developing programs to improve nursing students' health management and digital healthcare skills.

Purpose: This study examined nursing students' experiences of using digital healthcare applications in terms of the source and demand of socio-psychological needs, expectations, exposures, use satisfaction, and derivative effects based on the components of use satisfaction theory. Methods: This study was conducted using focus group interviews, and data were collected from 12 nursing students enrolled in two universities located in Seoul and Gyeonggi Province from April 1 to May 31, 2023. Results: The nursing students mainly used digital healthcare applications to address needs such as sleep, exercise, goal setting, social support, and motivation, which included the need for physical well-being, growth and development, emotional stability, and social needs. Participants met various needs such as achieving goals, feeling of achievement, enhancing self-confidence, and acquiring helpful information through digital healthcare applications. The satisfaction gained in setting and achieving goals was the driving force for motivation. Conclusion Nursing students value intuitive interfaces, personalized features, and appropriate notifications. Step-by-step rewards and reasonable pricing are also vital for using digital healthcare apps.These findings should be incorporated into developing programs to improve nursing students' health management and digital healthcare skills.

Purpose: This study examined nursing students' experiences of using digital healthcare applications in terms of the source and demand of socio-psychological needs, expectations, exposures, use satisfaction, and derivative effects based on the components of use satisfaction theory. Methods: This study was conducted using focus group interviews, and data were collected from 12 nursing students enrolled in two universities located in Seoul and Gyeonggi Province from April 1 to May 31, 2023. Results: The nursing students mainly used digital healthcare applications to address needs such as sleep, exercise, goal setting, social support, and motivation, which included the need for physical well-being, growth and development, emotional stability, and social needs. Participants met various needs such as achieving goals, feeling of achievement, enhancing self-confidence, and acquiring helpful information through digital healthcare applications. The satisfaction gained in setting and achieving goals was the driving force for motivation. Conclusion Nursing students value intuitive interfaces, personalized features, and appropriate notifications. Step-by-step rewards and reasonable pricing are also vital for using digital healthcare apps.These findings should be incorporated into developing programs to improve nursing students' health management and digital healthcare skills.