No abstract available.
Colostrum* ; Gastrins* ; Humans* ; Immunoglobulins* ; Milk*

BACKGROUND: Despite concern about treatment of sporotrichosis, little is known about the sensitivity of S. schenckii against antifungal agents. OBJECTIVE: The purpose of the study was to investigate minimal irihibitory concentration(MIC) of antifungal agents against S.chenckii. METHOD: The tested strains were seven in number. The tested antifngal agents were ketoconazole, itraconazole, amphotericin B, and potassium iodide. A various concentration of drugs were mixed into fluid media containing 50% ethanol, dimethyl sulfoxide, and distilled water. The inoculum consisted of 3mm block containing hyphae and spores. RESULTS: MIC ranges of ket.oconazole, itraconazole, amphotericin B, and potassium iodide were 0.39- 25pg/ml, 0.78-25pg/ml, 0.78-25pg/ml, and 75-550pg/ml, respectively. CONCLUSION: We find that ketoconazole is the most active drug against S. schenckii.
Amphotericin B ; Antifungal Agents* ; Dimethyl Sulfoxide ; Ethanol ; Hyphae ; Itraconazole ; Ketoconazole ; Potassium Iodide ; Spores ; Sporothrix* ; Sporotrichosis ; Water

The lupus band test(LHT) has been proposed as a diagnostic test for lupus erythematosus(LE), differentiating discoid I E from systemic LE and also has prognostic values. For the better understanding of relation between LBT and prognosis in SLE. a study was carried out in 32 SLE patients with skin lesions. Immunofluorescent study was done with biopsies taken from involved skin and uninvolved skin of patients with SLE. The results were as follows . 1) Incidences of a positive LBT were 84% in both involved and uninvolved skin and IgM was most frequently deposited(66% & 72%) in both, whereas IgA was least frequently deposited(34% & 19%) in both. 2) Deposits in DEJ of IgG, IgM, IgA and C were found with approximately same frequency in patients with different clinical manifestations and different laboratory findings. 3) Incidences of positive LBT in patients with renal disease were approximately same as in patients without renal disease. And deposits of all clssses of immuno glcbulins were found with about the same frequency in these two groups. 4) A positive LBT composed of IgG alone or IgG and other Igs were associated with an increase of anemia, ANA, anti-DNA and hypocomplementemia. Ten renal biopsies showed diffuse proliferative glomerulonephritis(GN) in focal proliferative GN in 3 and membranous CiN in 2 and no correlation to immune deposits.
Anemia ; Biopsy ; Diagnostic Tests, Routine ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Incidence ; Lupus Erythematosus, Systemic* ; Prognosis ; Skin

Our experience with 150 patients with congestive heart failure has been reviewed with particular reference to physical and laboratory findings on admission, precipitating factors and diagnostic clues. Congestive heart failure has been defined as that heart failure due to myocardial failure (primary or secondary). (1) Congestive heart failure was found in 3.65% of total medical admissions and in 24.0% of total cardiovascular patients. There was no difference between two sexes and incidence was peak in the 6th decade. (2) Rheumatic heart disease was the most common cause of congestive heart failure (41.0%). Hypertensive and/or atherosclerotic heart disease (36.5%), cor pulmonary (6.6%), postpartum heart failure (5.3%), pericardial disease (3.6%), thyrotoxic heart disease (2.0%) and congenital heart disease (0.6%) were the etiologies of the remainder. In male hypertensive and/or atherosclerotic heart disease was most common cause of congestive heart failure. (3) The precipitating factors of congestive heart failure were found in 31% and infection, pregnancy, discontinuation of digitalis and physical exertion were major causes. (4) Dyspnea, cervical vein distension, pulmonary rale, hepatomegaly and cardiac murmur were important symptoms and signs on admission. (5) Peripheral venous pressure was elevated in 883.2% and circulation time was prolonged in 90.9%. (6) Leucocytosis (39.8%) albuminuria (60.2%), elevated GOT (serum glntamin oxaloacetic transaminase) (12.0%) and azotemia (50%) were observed. (7) Chest X-ray on admission revealed increased vascularity including pulmonary edema (88.8%), cardiomegaly (83.3%) and hydrothorax (27.1%). (8) Electrocardiographic findings was abnormal in 99.4% and left ventricular hypertnophy (45.7%), atrial fibrillation (27.3%), Right ventricular hypertrophy and low voltage were frequently observed.
Albuminuria ; Atrial Fibrillation ; Azotemia ; Cardiomegaly ; Digitalis ; Dyspnea ; Electrocardiography ; Estrogens, Conjugated (USP)* ; Heart Defects, Congenital ; Heart Diseases ; Heart Failure* ; Heart Murmurs ; Hepatomegaly ; Humans ; Hydrothorax ; Hypertrophy, Right Ventricular ; Incidence ; Male ; Physical Exertion ; Postpartum Period ; Precipitating Factors ; Pregnancy ; Pulmonary Edema ; Respiratory Sounds ; Rheumatic Heart Disease ; Thorax ; Veins ; Venous Pressure

The reference study was performed to describe the trend and characteristics & studies related to dying and death of the elderly. The data were collected from 44 article in foreign literature. There results were as follows: 1. The research subjects related to the ares of dying and death of the elderly were death(death attitude, death anxiety), suicide, morbidity and mortality, dying(ethics at the end of life, right-to-die), and bereavement etc. 2. The selected studies were published in 24 health related Journal, including Journal of the American Geriatrics Society, American Journal of Psychiatry, Japanese Journal of Geriatrics, and International Psychogeriatrics, etc. 3. The published year of the article was between 1992 and 1996. 4. The frequently used research designs were survey, cohort study(retrospective study), records analysis, review, case studies and epidemiologic studies. 5. Questionnaires, medical records, interview, review, case studies, observation, and test were mainly used for the data collection for the selected studies.
Aged* ; Asian Continental Ancestry Group ; Bereavement ; Cohort Studies ; Epidemiologic Studies ; Geriatric Psychiatry ; Geriatrics ; Humans ; Medical Records ; Mortality ; Research Design ; Research Subjects ; Suicide ; Surveys and Questionnaires

Tumor angiogenesis, the development of new blood vessels by tumor, is a widely observed phenomenon associated with the growth of human solid tumors. To investigate how tumor angiogenesis correlates with other prognostic features i.e. menopause status, tumor size, lymph node metastasis, mitosis, angioinvasion, estrogen receptor (ER), p53 protein expression, histologic grade and clinical stage, we counted microvessels by immunohistochemistry using antibody for CD34 antigen in 56 cases of invasive breast carcinoma (27 with and 29 without axillary lymph node metastases) and 20 cases of non-inflammatory benign breast lesion. CD34 antigen is expressed on the surface of hematopoietic progenitor cells and more sensitively expressed than factor VIII in vascular endothelial cells. Microvessel count (MVC) was performed at a single hot field of 200x magnification (0.74 mm2 per field). The results are summarized as follows; 1) The mean MVC of invasive carcinoma and benign breast lesion were 92.0+/-54.4 (range, 7-237) and 20.7+/-16.6 (range, 4-73), respectively (p<0.0001). 2) Although MVC had no correlation with all other prognostic factors i.e. menopause status, tumor size, lymph node metastasis, mitosis count, angioinvasion, ER, p53 protein expression, histologic grade, and clinical stage (p>0.05), MVC had a tendency to increase in tumors with axillary LN metastasis or without ER expression. 3) Without correlation with MVC, ER (+), angioinvasion (-) and higher histologic grade correlate to significantly higher mitosis count (p<0.0005). Also, angioinvasion correlate to a significantly higher histologic grade (p<0.05). In conclusion, angiogenesis is related to tumorigenesis, but MVC may not be related to other clinicopathologic factors.
Antigens, CD34 ; Blood Vessels ; Breast Neoplasms* ; Breast* ; Carcinogenesis ; Endothelial Cells ; Estrogens ; Factor VIII ; Female ; Hematopoietic Stem Cells ; Humans ; Immunohistochemistry ; Lymph Nodes ; Menopause ; Microvessels* ; Mitosis ; Neoplasm Metastasis

No abstract available.
Anesthesia* ; Animals ; Guinea Pigs* ; Guinea*

No abstract available.
Humans ; Peptic Ulcer*

Epiderniologic description of the tinea capitis of adults was made for the cases detected in Taegu city for 11 years from January 1978 to December 1988. 1. Totalnumber of adult patients(20 years or older) were 41(2.0%) out of 2,029 cases of all tiena capitis. Among 41 patients, 34 cases were detected between 1983 and 1988. 2. Clinically 24 patients were superficial tinea capitis and 17 patients were kerion celsi. 3. Age of the patients ranged from 21 to 85 years with an average of 58.5 years and mode interval of 61-70 years. Patients over 50 years of age accounted for 70.7% of all csses. 4. Sex distribution of the cases was 39 females(95.1%) and 2 males(4.9%). 5. Causative agents isolated from the patients were Microsporum canis in 36 cases, Trichophyton verrucosum in 2 cases, T. mentagrophytes, T. ferrugineum and T. rubrum in 1 case, respectively. 6. Solitary lesion was most common and alopecia was not prominent in most of the cases. The most frequent site of involvement was frontal and posterior scalp. At initial exarnination, 5 cases were misdiagnosed as seborreic dermatitis and 1 case as multiple folliculitis. 7. Sources of infection were presurned to be cat in ll cases, cattle in 2 cases and the rests were unidentified. Interfarnilial infection was observed in 5 cases.
Adult* ; Alopecia ; Animals ; Cats ; Cattle ; Daegu* ; Dermatitis ; Folliculitis ; Humans ; Microsporum ; Scalp ; Sex Distribution ; Tinea Capitis* ; Tinea* ; Trichophyton

We described here-in a 36-year-old male patient (case 1) with a severe form of keratosis palmaris et plantaris(Thost-Unna type) which was diffuse hyperkeratosis with hyperhidrosis on the entire surface of the palms and soles. His son, 8-year- old boy, showed symmetrical distribution of hyperkeratotic patches on the inner sides of both great toes(case 2). Therefore, it was suggested this genodermatosis occured in two generations of a family. The biopsy taken from the right palm of case 1 showed features of epidermal hyperplasia with hyperkeratosis, hypergranulosis and acanthosis. We tried the oral Vit. A therapy(50,000 unit, daily) in case 2. The hyperkeratotic lesions became slightly improved in 4 months after therapy.
Adult ; Biopsy ; Family Characteristics ; Humans ; Hyperhidrosis ; Hyperplasia ; Keratoderma, Palmoplantar* ; Keratosis* ; Male