1.Effects of Normal Fibroblasts and Peripheral Blood Mononuclear Cells on Squamous Cell Carcinoma Cell Line ( SCL - 1 ).
Chang Hwa LEE ; Dong Lim KIM ; Seok Don PARK
Korean Journal of Dermatology 1989;27(3):254-262
Many carcinomas have an active mononuclear cell infiltrates surrounding tumor. Various in vitro assays have shown that cellular constituents of peripheral blood mononuclear cells(PBMC) can alter growth of carcinoma cell line. Author compared the effects of normal fibroblasts on squamous cell carcinoma cell line(SCL-1) along with those of sctivated and/or nonactivated PBMC on SCI 1 using a skin equivalent system. This system prevents direct cellular contact by growing SCL-1 on an overlying Millicell-HA membrane and normal fibroblast or supernatants of PBMC in a lower chamber. Normal fibroblasts enhanced the outgrowth of SCL-1 and induced a more organized phenotype of SCL-1. Supernatants from nonstimulated PBMC suppressed outgrowth of SCL 1, and concanavalin A stimulated PBMC supernatants alterd rnorphology of cultured SCL-1 from a disorganized phenotype to a more organized phenotype. It is concluded that fibroblasts and PBMC may affect the growth and differentiation of SCL-1 via their mediators(cytokines)
Carcinoma, Squamous Cell*
;
Cell Line*
;
Concanavalin A
;
Fibroblasts*
;
Membranes
;
Phenotype
;
Skin
2.Surgical Treatment of 100 Patients of Osmidrosis.
Chang Hwa LEE ; Hyung Sun SOHN ; Seok Don PARK
Korean Journal of Dermatology 1988;26(6):861-866
One hundred patients of osmidrosis were treated by surgical procedure at the Department of Dermatology, Wonkwang University Hospital. The methods of operative treatment were elliptical excision for 37(74), bipedicle incision with apocrine glancl undercutting for 14(28), and single incision wit.h apocrine gland undercutt,ing for 49 (98). The results were summarized as follows : 1. Of the 74 axillae treated by elliptical excision, one occurred recurrence, and 1.7 showed complication, hematoma in 6, infection and delayed union in 4, each necrosis and severe scar in one each, 2. Of the 28 axillae treated by bipedicle incision with apocrine gland undercutting, 6 showed complication; hematoma in 4, infection and delayed union in one each 3. Of t..he 98 axillae treated by single incision with apocrine gland undercutting, 5 showed complication, hematoma in 3, infection and delayed union in one each In conclusion, single incision with apocrine gland undercutting was found to be more excellent compared with the other surgical methods.
Apocrine Glands
;
Axilla
;
Cicatrix
;
Dermatology
;
Hematoma
;
Humans
;
Necrosis
;
Recurrence
3.A Case of Pseudomonas Gangrene.
Chang Hwa LEE ; Sang Yong KIM ; Seok Don PARK
Korean Journal of Dermatology 1988;26(1):90-93
Forytfour-year-old female inpatient, who was gravely ill, developed vesicobullae on the greenish patches surrounded by narrow red to brown halo in the left lower extremity. Two years ago, she had treated by surgical operation and radiation therapy for cervix cancer. Blood and bullous fluid cultures showed Pseudomonas aeruginosa. She developed gangrenous and mummificated skin lesions after septic shock therapy but died due to disseminated intravascular coagulation.
Disseminated Intravascular Coagulation
;
Female
;
Gangrene*
;
Humans
;
Inpatients
;
Lower Extremity
;
Pseudomonas aeruginosa
;
Pseudomonas*
;
Shock, Septic
;
Skin
;
Uterine Cervical Neoplasms
4.Unexpected Multiple Organ Infarctions in a Poisoned Patient.
Sung Wook PARK ; Sang Kyoon HAN ; Seok Ran YEOM ; Soon Chang PARK ; Sung Hwa LEE
Korean Journal of Critical Care Medicine 2015;30(3):227-230
Predisposing factors for venous thrombosis can be identified in the majority of patients with established venous thromboembolism (VTE). However, an obvious precipitant may not be identified during the initial evaluation of such patients. In the present case, a 47-year-old female presented to the emergency department of our hospital after ingesting multiple drugs. She had no VTE-related risk factors or previous episodes, nor any family history of VTE. After admission to the intensive care unit sudden hypoxemia developed, and during the evaluation cerebral, renal, and splenic infarctions with pulmonary embolisms were diagnosed. However, the sources of the emboli could not be identified by transthoracic echocardiography or computed tomography angiography. Protein C deficiency was identified several days later. We recommend that hypercoagulable states be taken into consideration, especially when unexplained thromboembolic events develop in multiple or unusual venous sites.
Angiography
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Anoxia
;
Causality
;
Echocardiography
;
Emergency Service, Hospital
;
Female
;
Humans
;
Infarction*
;
Intensive Care Units
;
Middle Aged
;
Protein C Deficiency
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Pulmonary Embolism
;
Risk Factors
;
Splenic Infarction
;
Thrombophilia
;
Venous Thromboembolism
;
Venous Thrombosis
5.Three Cases of Parameatal Urethral Cyst.
Jung Won KO ; Hyung Sun SOHN ; Seok Don PARK ; Chang Hwa LEE
Korean Journal of Dermatology 1986;24(6):877-881
We herein report three cases of pararneatal urethral cyst, which developed on the male urethral meatus. These cysts occurred since birth or childhood, and did not interfere with urinary of sexual function. Histologically, these cysts were lined by pseudostratified columnar epithelium with variable thickness. No recurrence was evident after simple excision.
Epithelium
;
Humans
;
Male
;
Parturition
;
Recurrence
6.Clinical significance of serum progesterone level on day of human chorionic gonadotropin injection following gonadotropin releasing hormone agonist combined superovulation.
Yong Sang SONG ; In Hwa ROH ; Seok Hyun KIM ; Jung Gu KIM ; Shin Yong MOON ; Jin Yong LEE ; Yoon Seok CHANG
Korean Journal of Obstetrics and Gynecology 1991;34(10):1416-1424
No abstract available.
Chorionic Gonadotropin*
;
Gonadotropin-Releasing Hormone*
;
Gonadotropins*
;
Humans*
;
Progesterone*
;
Superovulation*
8.Adenoid Squamous Cell Carcinoma of the Vulva: Report of a case.
Chang Ok KIM ; Ki Hwa YANG ; Seok Jin GANG ; Ahn Hee LEE ; Byoung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1991;25(1):54-58
In 1947, Liver described adenoid squamous cell carcinoma under the title of "adenoacanthoma of sweat gland". This tumor is not rare, but reported cases in literatures were relatively few. The tumor were frequently found in the sun-exposed skin; such as face, ear, neck etc.. The cases involving non-sun-exposed area, such as oral and labial mucosa, nosopharynx and vulva etc., were also reported. Therefore, the relation between the pathogenesis of adenoid squamous cell carcinoma and sun damage has been still debated. Immunohistochemical studies have recently suggested that this tumor is squamous cell carcinoma undergoing acantholysis. The authors experienced a case of adenoid squamous cell carcinoma of the vulva in a seventy-one year old female patient. She had suffered from itching sensation on vulva for 10 years, and palpable mass on vulva for 1 month. On gross examination, a pale gray pigmentation and erosion, was noted at the right labia major, the minor extending left labia major and minor. On microscopic examination, nests of atypical epithelial cells extending into the cornium showed an adenoid architecture. These were composed of a peripheral layers of cuboidal cell in a lacy pattern. And the glandular spaces contained dyskeratotic acantholytic tumor cells in central portion. Therefore we diagnosed this case as adenoid squamous cell carcinoma of the vulva.
Female
;
Humans
9.The Dietary Intake and Nutritional Status of Fatty Liver Patients.
Seok Hwa LEE ; Choon Sunk KEE ; yu Kung CHANG
Korean Journal of Community Nutrition 1998;3(4):622-629
This study was performed to investigate the effect of dietary intakes and nutritional status for fatty liver male patients with fatty livers. General characteristics, nutritional knowledge, and dietary intakes were obtained from fatty liver male patients aged 20-60yr living in Seoul and Kyunggi province by individual interview and blood samples. The Results were as follows : the mean age of the subjects was 39yrs. Old and over half the subjects were overweight. Although nutritional knowledge, recognition, and accuracy scores were good, these did not affect the subject's health. The average alcohol intake of subjects was 79.8g/day and the drinking duration was 5-40yrs(averge : 17yrs). The subjects drank alcohol over 4tiles/week and preferred Soju. Most side dishes taken with alcohol drinking by the subjects were foods from animal sources. Half of the subjects also drank alcohol the next day for breakfast as a hangover-chaser. The reasons for drinking were due to social relationships and by habit. Vitamin D and folate were lower than the RDA for Koreans, and other nutrient amounts were higher than the RDA. The amounts of aspartate aminotransferase(AST), Alanine amino-transferase(ALT), gamma-glutamyl transpeptidase(gamma-GTP), Triglyceride(TG) for the subjects were higher. In conclusion, fatty liver patients drank excessively and frequently. It seems that heavy alcohol drinking is more prone to overweight or obese people and contributes to fatty livers. Therefore, the subjects need to be taken effectively educated about alcohol-induced liver damage and the importance of a balanced diet for on healthy liver.
Alanine
;
Alcohol Drinking
;
Animals
;
Aspartic Acid
;
Breakfast
;
Diet
;
Drinking
;
Fatty Liver*
;
Folic Acid
;
Gyeonggi-do
;
Humans
;
Liver
;
Male
;
Nutritional Status*
;
Overweight
;
Seoul
;
Vitamin D
10.Safety and Efficacy of Bipolar TURP in Large Volume Prostate.
Hwa Su LIM ; Hong Seok SHIN ; Hee Chang JUNG
Journal of the Korean Continence Society 2007;11(2):125-130
PURPOSE: With the development of bipolar device, which complement the weak points of conventional monopolar device, TURP became more appliable in large volume prostate. We evaluated the possibility and effectivity of bipolar TURP in large volume prostate by analysing treatment results. MATERIALS AND METHODS: Total 78 male patients who received bipolar TURP in our center between April 2004 and December 2006, were divided into two groups based on prostate volume (>75g = large volume prostate group, <75g = control group). We compared each of age, prostate volume, resection volume, operation time, IPSS, Qmax, change of serum Na+ & hemoglobin, and perioperative complications. RESULTS: There was no statistical difference between preoperative IPSS and postoperative IPSS between the both groups. In preoperative status, Qmax was statistically higher in small volumed prostate group. But, after bipolar TURP, Qmax of each group were significantly improved, and statistical difference between the two groups were disappeared. Patient age, prostate volume, resection weight, hemoglobin down, hospitalization day, catheterized duration were statistically higher in the large volume prostate group. But, in the clinical aspect, these differences were acceptable. Immediate postoperative hematuria and hypothermia were more frequent in large volume prostate group. Long term complication rates were almost the same in two groups, and there was no TUR syndrome in both groups. CONCLUSION: Transurethral resection of large volume prostate (>75g) using bipolar device is as effective as of general (<75g) prostate hyperplasia. Bipolar TURP can be another therapeutic option of large volume prostate, which in the past indicated open prostatectomy, to escape from higher surgical morbidity.
Catheters
;
Complement System Proteins
;
Hematuria
;
Hospitalization
;
Humans
;
Hyperplasia
;
Hypothermia
;
Male
;
Prostate*
;
Prostatectomy
;
Transurethral Resection of Prostate*
;
United Nations