In Vinh Bao district, Hai Phong city in the year 2001, 825 female subjects aged 18-35 years old with first pregnancy or one child, without abortion or immature delivery, were divided into 2 groups according to BMI (For CED group: BMI < 18.5 and normal group: BMI  18.5). The prevalence of chronical energy deficit (CED) before pregnancy was 29%, among them, 1st grade CED 21.2%, 2nd grade 6.3%, 3rd grade 1.5%. The prevalence of common diseases (cough, fever, headache, diarrhoea…) in CED - 40.2%, higher than normal group - 26.3%. In general, for both two groups, morbidity reduced progressively in the course of pregnancy: the prevalence was 18.6% in the first trimestre, 8.8% in the second trimestre and 8.4% in the terminal 3rd trimestre. Considering body weight, in the first trimestre the weight gained by 0.48kg (CED group: 1.19lg, normal group 0.19kg), in 2nd trimestre, the weight gained 2.46kg (CED group 2.91kg, normal group 2.28kg), in the last 3rd trimestre 4.08kg (CED group 4.28kg, normal group 4.0kg).
Nutritional Status ; Morbidity ; Body Weight ; Pregnant Women

Weight in average was 2911.4g (group of mothers with CED): 2905.6g; group of mothers without CED: 2913.8g, (boys: 2961g; girl: 2856g). Low birth weight rate was 11.6% (CED: 9.6%; normal: 12.4%); (boys: 10.4%; girls: 12.8%). Length of newborn babies in average was 48.3 cm (CED: 48.2 cm; normal: 48.4 cm), (boys: 48.6 cm; girls: 48 cm). Only 2.1% of newborn babies had length at birth lower 45 cm, nearly 98% had length at birth  45cm. Height of mother < 150 cm before pregnancy was high ralative risk to weight and length at birth of newborn babies.
Risk Factors ; Mothers ; Child ; Infant, Newborn ; Body Weight ; Body Height

Study on 825 pregnant women at Vinh Bao district – Hai Phong city in 2001 showed that: the practice of reproductive health of two groups of mothers ( Chronic Energy Deficiency (CDE) and nomal) was relatively good. Lack of nutrition status and anthropemetric indicators, especially height of mother were improved. The rate of CDE of woman before pregnancy was 29% (CDE: degree I: 21.2%; CDE degree II: 6,3%; CDE degree III: 1.5%). Weight in average: 44.96kg, height in avarage: 153.2cm. Weight gain were improved, weight in CDE group was higher than nomal group but lower than recommendation.
Nutritional Status ; Nutrition Surveys ; Pregnancy ; Weight Gain ; Morbidity

The study on the maternal risk factors affect to weight and height of their newborns among 813 newborns at Vinh Bao district, Hai phong city in 2001. Among these babies, 94 had low birth weight (<2500g), 719 with normal weight (>2500g). The results showed that mother’s height under 150 cm was highest risk factor related to weight and length of newborns, followed by mother’s weight under 45kg, mother’s head round under 54cm and placental weight under 500g. BMI of mother under 18.5 and weight increased less than 1 kg in first trimester only affected to the length of newborn babies
Risk Factors ; Infant, Newborn ; Birth Weight ; Body Height

An examination of 106 women with genital infection at the Khanh Son district, Khanh Hoa province was carried out, the results showed that: 39,6% were infected by Candida albicans and 15,1% of Trichomonas vaginalis.
Female Genital Diseases and Pregnancy Complications ; women ; infection

Subjects of this study were pregnant/nursing women aged from 15 to 49 years. Settings: 11 communes involved in Kim S¬n district (Ninh B×nh province), B×nh Lôc district (Hµ Nam province) and VÜnh B¶o district (H¶i Phßng City). 50 women were selected randomly from each commune. The results showed that there was difference between knowledge and practice in care and diet of pregnant women. All of subjects knew that they need to eat more during pregnant period, but in the fact they eat same or little than normal. There was not difference between concept and practice for restricted diet. Most of them knew that there is a relationship between pre-pregnant weight of mother and neonatal weight and improving the nutrition during pregnancy can help the fetus growing well.
Delivery of Health Care ; Pregnant Women ; Infant, Newborn ; Infant, Low Birth Weight

Text mining has become an important research method in biology, with its original purpose to extract biological entities, such as genes, proteins and phenotypic traits, to extend knowledge from scientific papers. However, few thorough studies on text mining and application development, for plant molecular biology data, have been performed, especially for rice, resulting in a lack of datasets available to solve named-entity recognition tasks for this species. Since there are rare benchmarks available for rice, we faced various difficulties in exploiting advanced machine learning methods for accurate analysis of the rice literature. To evaluate several approaches to automatically extract information from gene/protein entities, we built a new dataset for rice as a benchmark. This dataset is composed of a set of titles and abstracts, extracted from scientific papers focusing on the rice species, and is downloaded from PubMed. During the 5th Biomedical Linked Annotation Hackathon, a portion of the dataset was uploaded to PubAnnotation for sharing. Our ultimate goal is to offer a shared task of rice gene/protein name recognition through the BioNLP Open Shared Tasks framework using the dataset, to facilitate an open comparison and evaluation of different approaches to the task.
Benchmarking ; Biology ; Data Mining ; Dataset ; Machine Learning ; Methods ; Molecular Biology ; Natural Language Processing ; Oryza ; Plants

OBJECTIVE: The feasibility and usefulness of transradial catheterization for coronary and neuro-intervention are well known. However, the anatomical change in the catheterized radial artery (RA) is not well understood. Herein, we present the results of ultrasonographic observation of the RA after routine transradial cerebral angiography (TRCA).METHODS: Patients who underwent routine TRCA with pre- and post-procedure Doppler ultrasonography (DUS) of the catheterized RA were enrolled. We then recorded and retrospectively reviewed the diameter and any complicated features of the RA observed on DUS, and the factors associated with the diameter and complications were analyzed.RESULTS: A total of 223 TRCAs across 181 patients were enrolled in the current study. The mean RA diameter was 2.48 mm and was positively correlated with male gender (p < 0.001) and hypertension (p < 0.002). The median change in diameter after TRCA was less than 0.1 mm (range, -1.3 to 1.2 mm) and 90% of changes were between -0.8 and +0.7 mm. Across 228 procedures, there were 12 cases (5.3%) of intimal hyperplasia and 22 cases (9.6%) of asymptomatic local vascular complications found on DUS. Patients with abnormal findings on the first procedure had a smaller pre-procedural RA diameter than that of patients without findings (2.26 vs. 2.53 mm, p=0.0028). There was no significant difference in the incidence of abnormal findings for the first versus subsequent procedures (p=0.68).CONCLUSION: DUS identified the pre- and post-procedural diameter and local complications of RA. Routine TRCA seems to be acceptable with regard to identifying local complications and changes in RA diameter.
Catheterization ; Catheters ; Cerebral Angiography ; Follow-Up Studies ; Humans ; Hyperplasia ; Hypertension ; Incidence ; Male ; Radial Artery ; Retrospective Studies ; Ultrasonography ; Ultrasonography, Doppler

Melanogenesis is the production of melanin from tyrosine by a series of enzyme-catalyzed reactions, in which tyrosinase and DOPA oxidase play key roles. The melanin content in the skin determines skin pigmentation. Abnormalities in skin pigmentation lead to various skin pigmentation disorders. Recent research has shown that the expression of EMP2 is much lower in melanoma than in normal melanocytes, but its role in melanogenesis has not yet been elucidated. Therefore, we investigated the role of EMP2 in the melanogenesis of MNT1 human melanoma cells. We examined TRP-1, TRP-2, and TYR expression levels during melanogenesis in MNT1 melanoma cells by gene silencing of EMP2. Western blot and RT-PCR results confirmed that the expression levels of TYR and TRP-2 were decreased when EMP2 expression was knocked down by EMP2 siRNA in MNT1 cells, and these changes were reversed when EMP2 was overexpressed. We verified the EMP2 gene was knocked out of the cell line (EMP2 CRISPR/Cas9) by using a CRISPR/Cas9 system and found that the expression levels of TRP-2 and TYR were significantly lower in the EMP2 CRISPR/Cas9 cell lines. Loss of EMP2 also reduced migration and invasion of MNT1 melanoma cells. In addition, the melanosome transfer from the melanocytes to keratinocytes in the EMP2 KO cells cocultured with keratinocytes was reduced compared to the cells in the control coculture group. In conclusion, these results suggest that EMP2 is involved in melanogenesis via the regulation of TRP-2 expression.

This article describes Viet Nam Ministry of Health’s (VMoH) activities to prepare for and respond to the threat Zika virus (ZIKV), including the adaptation of existing surveillance systems to encompass ZIKV surveillance.