Objective To study the quality of life and influencing factors in children with epilepsy.Methods The psychology of 96 children with epilepsy and 50 normal children were evaluated with the American quality of life and the affecting factors were analyzed.Results The quality of life of the epilepsy children was remarkably lower than that of normal children.The main presentation was seizure worry,side effects of drugs and difficulty of social intercourse.The age of initial presentation.the course of ease and so on affected quality of life in children with epilepsy(P＜0.05 or P＜0.01).The factors such as depression,family.environment,memory function,drug influence and seizure worry played important roles in decreasing order of importance.Conclusion QOL of children with epilepsy was remarkablely lower than normal children.General comprehensive care should be applied to children with epilepsy.Adequate drug treatment to control the seizure attack was very important.