Study on the therapeuctic effects of CV8 in 1614 uncomplicated malaria patients (878 P.falciparum and 736 P.vivax) in Binh Thuan district during 2002-2003. The patients were monitored for 28 days after treatment. The results showed that: the rate of re-appearance of parasite found during follow-up was 0.3% for P.falciparum and 0.5% for P.vivax. Using WHO guidelines, CV8 had high therapeutic efficacy, inconsiderable side effects and good compliance. The cure rate in patients infected P.falciparum was 99.7% and P.vivax was 99.5%
therapy ; malaria ; therapeutics ; malaria, falciparum

Background: Idiopathic or Immune Thrombocytopenic Pupura (ITP) is a common disease in Vietnamese children. This is a hemostatic disorder disease diagnosed by clinical symptoms combining with tests of platelet quantity in peripheral blood and other tests. Objectives: to study epidemiology, clinical, para-clinical characteristics and their relations in ITP disease. Subjects and methods: This was a prospective and retrospective study. The study included 579 pediatric patients from 3 months to 16 ages who were diagnosed and treated ITP disease in National Pediatric Hospital from 1/1/2003 to 12/31/2004. Results: Data were analyzed, including 191 infants from >3-<12 months (33.0%), 293 children from 1 - 10 ages (50.6%), 95 children >10-<16 ages (16.4%). The male/female ratio was highest in infants and decreased with age (P < 0.001). The disease occurred more in September, October and November with advantage factor being acute respiratory infection before 2 to 3 weeks. Subcutaneous hemorrhage ratio was highest with 557 cases (96.2%), intracranial hemorrhage happened in 7 cases (1.7%). There were differences among age groups about hemorrhage situation. Anemia level did not corresponding with the decrease of the platelet count. Conclusion: Characteristics of ITP depend on the number of platelet and age. \r\n', u'\r\n', u'\r\n', u'
Purpura ; Thrombocytopenic ; Idiopathic/ epidemiology

Background: Epilepsy is a chronic disease, the incidence of epilepsy was from 5/1000 to 10/1000 population. In developed countries the rate of epileptic patients are managed much higher than in developing countries due to the differences in socioeconomic conditions as well as understanding of epilepsy. In Vietnam, few epidemiological studies about epilepsy were published. Objectives: To reveal the prevalence of epilepsy in a rural community in Viet Nam and the relation between the prevalence and age, career, level of education, economic condition of the patient. Subjects and method: This was a cross-sectional described study. Door \ufffd?to \ufffd?door survey based on WHO\u2019s questionnaires was conducted by neurologists and student of Faculty of Public healthy of Hanoi Medical University on people at Phu Linh commune, Soc Son district, Hanoi city. Data was processed by SPSS 10.0 program. Results: Periodic prevalence was 7.5\ufffd?(5.5\ufffd?was active epilepsy). Generalized epilepsy: 79.66%, focal epilepsy: 16.95% indeterminate epilepsy: 3.39%. There was a significant relation between education and prevalence of epilepsy. Conclusion: Periodic prevalence of Epilepsy in Phu Linh (2003) was 7.5\ufffd? Toninco-colonique seizures were dominant. A significant relation between number of epileptic patients and level of education was found.
Epilepsy/ epidemiology ; Prevalence ;

Background: Intracranial haemorrhage is a common emergency with high mortality and neurological sequelae Objectives: The aim of study were to estimate the distribution of intracranial haemorrhage between the groups of age in children and the relationship of epidemiologic characteristics to the etiology.Subjects and method: We gathered prospectively data on 621 children (0-15 ans of age) with intracranial haemorrhage in 3 years (2000, 2001, 2002) hospital records in the National Hospital Pediatrics. Results: There are annual 200 patients (0-15 ans of age) of administration. 1) Neonatal infants consisted of 97 (15,6%) patients and 35 (36,1%) of death. Some of epidemiologic characteristics associated with the etiology were premature, asphyxial over 3500 gram birth weight, interventional birth infants and infants with congenital and acquis coagulation disorders. 2) Breastfed infants consisted of 469 (75,5%) patients of administration and 52 (11,1%) of death. Infants at 29 days to 3 months of age were the most frequence (92,3%). The etiology was associated with coagulation disorders (82,9%), cholestasis (6,2%). 3)Children (1-15ans) consisted of 55 (8,9%) and 7,3% of death, specially adolescent children (7-15ans) occupied 86,3% patients in this group. The etiology could be cerebral vasculare malfmation. Conclusion: There are different distribution of administration, mortality, etiology between neonate, breastfed infants, children (1-15 ans of age)
Intracranial Hemorrhages/ epidemiology ; Child ; Infant ; Infant ; Newborn ;

Background: In the period 2006-2010, a investigation on medical arthropod has been conducted\r\n', u'Objective: 1) To determine species composition and distribution of medical arthropod. 2) To find species transmitted disease \r\n', u'Subject and method: The cross sectional, descriptive and analytic investigation was conducted in 3 communes along the Ho Chi Minh road in Cao Bang province. \r\n', u'Results and conclusion: : A total of 3.437 of samples of medical arthropod belonging to 96 species have been collected including: three species of flea (Siphonaptera), two species of tick (Ixodoidea), four species of chigges (Trombiculidae), ten species of mites (Gamasoidea), twenty four species of flies (Muscoidea), and fifty-three species of mosquito (Culicidae). They belong to 39 genuses, 17 families, 3 orders: (Siphonaptera, Acarina and Diptera); two classes (Insecta and Arachnida). \r\n', u'Some species having epidemiological role such as Aedes albopictus, Culex tritaeniorhyncus, Cx. quinquefasciatus, Cx. vishnui ... were predominant at all study sites. Anopheles minimus, the main malaria vector, was mainly collected in cattle- sheds in Truong Ha and Bach Dang communes. \r\n', u'
Medical arthropod ; investigation

Background: Dementia is a common pathological condition that affects older people. Most causes of dementia are Alzheimer\u2019s disease and vascular dementia. Diagnosing these conditions mostly relied on clinical patterns, but some biomarkers have been mentioned as the indicators of this condition. Objectives: 1) To evaluate the alteration of some biomarkers in cerebrospinal fluid (CSF) samples from Alzheimer\u2019s patients. 2) To compare the concentration of biomarkers in CSF samples from patients with vascular dementia and Alzheimer\u2019s disease. Subjects and method: Case group involved 41 patients who were diagnosed as AD and vascular dementia based on DSM-IV criteria. 31 matched healthy people were included in control group. All subjects were given neuro-psychological tests and thorough clinical examination. Brain CT scan and MRI were done for both groups. CSF samples were taken from patients in the study group to measure levels of some biomarkers. Results. The levels of total taurine (T-tau) and phosphorylated taurine (P-tau) 181 proteins are higher in the dementia group. The concentration of Abeta-42 is significantly different between case and control groups, but similar between vascular dementia and Alzheimer\u2019s disease patients. Conclusion: Changes in biomarkers are valuable in different diagnosis of Alzheimer\u2019s disease and other types of dementia. However, findings of CSF studies have to be considered with findings from imaging studies and clinical examination.
Biomarker ; Dementia ; Alzheimer\u2019s disease

Background: Dihydroartemisinin 40mg and piperaquine phosphate 320mg (DHA-PQP) drug combination and piperaquin phosphate (PQP) material was first successfully produced in Vietnam \r\n', u'Objective: to study influences of the fixed combination antimalaria drug dihydroartemisinin plus piperaquine in reproductive progress of mice\r\n', u"Subjects and methods: This study was carried out at the Department of Malaria treatment and research, National Institute of Malariology, Parasitology and Entomology (NIMPE), between September, 2006 and March, 2007. The influences of the fixed combination antimalarial drug 40 mg dihydroartemisinin (DHA) plus 320 mg piperaquine phosphate (PQP), with PQP produced firstly in Vietnam, in mice's reproductive progresses were investigated in three generations (including the parent and FI, F2 child generations). \r\n", u'Results: In all three generations, study indices among the treated and control groups were not significantly different (the values P > 0.05). These indices included the rate of fecundation, numbers of fetuses of each mother mouse, numbers of offspring of each mother mouse, mean body weights of offspring. Early lethal fetuses, lately lethal fetuses, monsters and innate abnormally offspring were not found in P, FI and F2 generations. The necessary feeding - day numbers that offspring of P and F 1 generations reached their body weights about 20g were different insignificantly (the values P> 0.05) among the treated and control groups. \r\n', u'Conclusion: The combination DHA-PQP was found to cause no genome mutations in mice at the oral dose of 120 mg per kg per day for 5 consecutive days. \r\n', u'
Dihydroartemisinin ; piperaquine ; fixed combination antimalarial drug ; rate of fecundation ; early lethal fetuses ; lately lethal fetuses ; monsters and innate abnormally offspring ; genome mutations ; fetuses

Background: Piperaquin (PQ) is an anti-malaria drug, which belong to bisquinoline class. Vietnam has successfully produced PQ (both base and phosphate) since 2004. Objective: To evaluate acute oral toxicities of Piperaquine phosphate and the fixed combination anti-malarial drug Dihydroartemisinin plus Piperaquine in mice. Subject and Method: This study was conducted at National Institute of Malariology, Parasitology and Entomology between June and October, 2005. The acute oral toxicities of piperaquine phosphate (PQP) and the fixed combination anti-malaria drug (40 mg dihydroiutemisinin plus 320 mg piperaquine phosphate (DHA-PQP), with the materials produced by Institute of chemistry) in mice were investigated. Result: PQP had a medium toxicity. Inhibition of mice's central nervous systems was the main toxicity exhibition. At the high doses of PQP, mice's convulsion was observed before their deaths. The infralethal dose (LDo), absolute lethal dose (LD100) and mean lethal dose (LD50) of PQP were 900, 2300 and 1643.98 (1537.6 \u2013 1758.92) mg/kg, respectively. The fixed combination DHA-PQP had a less toxicity than PQP powder, with LDo, LD100 and LD50 were 1400, 2800 and 2050.06 (1943.63 \u2013 2157.14) mg per kg of body weight, respectively. Conclusion: At the high doses of DHA-PQP, this combination also inhibited mice's central nervous systems. Mice convulsed strongly before their deaths. All died mice were operated for observing visually their organs such as hearts, livers, kidneys, lungs, vesicles and intestines. No abnormal signals were found.
Piperaquine phosphate ; toxicity ; Dihydroartemisinin

Background: Rotavirus type A is the most common cause of acute gastrointestinal inflammatory in children under 5 years old, especially in age groups 6 and 36 months. Some rotavirus strains are common; seen recently in Vietnam are G1, G2, G3, G4 and G9, P4, P6 and P8. Objective: Surveillance of epidemiological characteristics of rotavirus induced diarrhea in the National Pediatric Hospital from September, 2007 to March, 2008. Subject and methods: Collection of 322 stool specimens of pediatric patients with acute diarrhea (including 213 specimens from male, 109 specimens from female), who were treated in the National Pediatric Hospital. All of these specimens were determined for causes of rotavirus with the enzyme immunoassay (EIA). Results and Conclusion: Among these 322 stool specimens, there were 195 rotavirus positive specimens, accounted for 60.56%. The rate of monthly distribution of rotavirus diarrhea from September, 2007 to March, 2008 were 76%, 56%, 62%, 61%, 64%, 56% and 44%, respectively. Number of rotavirus positive cases in male and female was 56 (26.29%) and 79 (72.48%), respectively. The rate of rotavirus positive children compared to total number of specimens with the age 0-3 months, 3-6 months, 6-12 months, 12-24 months, 24-36 months and over 36 months was 7.69%, 15.9%, 41.54%, 32.82%, 1.54% and 0.51%, respectively. The results of type identification indicated that phenotypes of 37 among 40 specimens were identified (92.5%) in which there were 5 specimens of G1P8 (12.5%), 20 specimens of G3P8 (50%), 1 specimen of G9P8 (2.5%), 2 specimens of G1Pmixed (5%), 9 specimens of G3Pmixed (22.5%), 1 specimen of G unidentified-type P8 (2.5%) and 2 specimens of G3 P unidentified-type (5%).
rotavirus ; diarrhea ; epidemiology

Background: Non-Hodgkin's lymphoma is a malignant (cancerous) growth of B or T white blood cells (lymphocytes) in the lymph system. Many lymphoma classifications were proposed. All were based by groups of the original cells, histopathological appearances and clinical features. Purpose: Histological classification of lymph node malignant non - \r\n", u'Hodgkin lymphoma based on the new WHO 2001 classification. Objectives: To apply new WHO 2001 classification of 165 cases of malignant non Hodgkin lymphoma were histopathologically and immunohisto chemically studied at K hospital in Hanoi. Subjects and method: The study included 165 patients with malignant non Hodgkin lymphoma were examined and treated at K hospital in Hanoi from 2000 to 2003. Results: The study based on new WHO 2001 classification of 165 cases of malignant non Hodgkin lymphoma showed results B lymphoma: Diffuse large B - cell lymphoma accounts for 63.3%, follicular lymphoma: 17.5%, small lymphocytic lymphoma: 12.5%, mantle cell lymphoma: 1.7% and the others are at low rate. T lymphoma: large T-cell lymphoma accounts for 35.0%, T lymphoblastic lymphoma: 30.0%, angioimmunoblastic T-cell lymphoma: 12.5%, peripheral T- cell lymphoma, unspecified: 10.0%, the others are at low rate. Conclusion: We concluded that new WHO classification of malignant non Hodgkin is reproducible in our practice and should be useful in the treatment decision. \r\n', u'
Lymphoma ; Non-Hodgkin/ pathology ; epidemiology Neoplasms by Histologic Type